GMPS cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GMPS
Entrez Gene ID	8833
Full Name	guanine monophosphate synthase
Synonyms	GATD7
General protein information	Preferred Names guanine monophosphate synthase Names GMP synthase [glutamine-hydrolyzing] GMP synthase GMP synthetase MLL/GMPS fusion protein glutamine amidotransferase guanine monophosphate synthetase guanosine 5'-monophosphate synthase testicular tissue protein Li 82
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q25.31
Summary	In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008].
Disorder MIM:	600358

mRNA and Protein(s)

mRNA	Protein	Name
NM_003875.2	NP_003866.1	GMP synthase [glutamine-hydrolyzing]
XM_017007422.1	XP_016862911.1	GMP synthase [glutamine-hydrolyzing] isoform X2
NM_003875.3	NP_003866.1	GMP synthase [glutamine-hydrolyzing]
XM_011513263.2	XP_011511565.1	GMP synthase [glutamine-hydrolyzing] isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	GMPS	XP_534316.2
Gallus gallus (chicken)	GMPS	NP_001006556.1
Homo sapiens (human)	GMPS	NP_003866.1
Drosophila melanogaster (fruit fly)	bur	NP_620114.3
Mus musculus (house mouse)	Gmps	NP_001028472.2
Rattus norvegicus (Norway rat)	Gmps	NP_001019925.1
Caenorhabditis elegans (roundworm)	M106.4	NP_001076631.1
Xenopus tropicalis (tropical clawed frog)	gmps	XP_002933290.2
Pan troglodytes (chimpanzee)	GMPS	XP_003310106.1
Danio rerio (zebrafish)	gmps	NP_956881.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010139	XP_319294.4
	GMPS	XP_001105046.1
Bos taurus (cattle)	GMPS	NP_001193365.1

Gene Ontology
Bibliography

Related articles in PubMed

Methylation and expression analyses of Pallister-Killian syndrome reveal partial dosage compensation of tetrasomy 12p and hypomethylation of gene-poor regions on 12p.
Davidsson J, Johansson B
Epigenetics11(3)194-204(2016 03)

Nucleotide biosynthetic enzyme GMP synthase is a TRIM21-controlled relay of p53 stabilization.
Reddy BA, van der Knaap JA, Bot AG, Mohd-Sarip A, Dekkers DH, Timmermans MA, Martens JW, Demmers JA, Verrijzer CP
Molecular cell53(3)458-70(2014 Feb)

Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase.
Faesen AC, Dirac AM, Shanmugham A, Ovaa H, Perrakis A, Sixma TK
Molecular cell44(1)147-59(2011 Oct)

Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data.
Jia P, Wang L, Meltzer HY, Zhao Z
Schizophrenia research122(1-3)38-42(2010 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Three genes-ATP6V1G1 in 9q32, GMPS in 3q25.31, and TBX5 in 12q24.21-exhibited concomitant hypermethylation and decreased expression. The i(12p)-positive cells displayed global hypomethylation of gene-poor regions on 12p, a footprint previously associated with constitutional and acquired gains of whole chromosomes as well as with X-chromosome inactivation in females
Title: Methylation and expression analyses of Pallister-Killian syndrome reveal partial dosage compensation of tetrasomy 12p and hypomethylation of gene-poor regions on 12p.

Cytoplasmic sequestration of GMPS requires ubiquitylation by TRIM21.
Title: Nucleotide biosynthetic enzyme GMP synthase is a TRIM21-controlled relay of p53 stabilization.

analysis of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase
Title: Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase.

Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data.

Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Human variation in alcohol response is influenced by variation in neuronal signaling genes.

The following GMPS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GMPS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24154	NM_003875.3 Latest version!	Homo sapiens guanine monophosphate synthase (GMPS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
OHu62227	XM_011513263.2 Latest version!	Homo sapiens guanine monophosphate synthase (GMPS), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
OHu62228	XM_017007422.1 Latest version!	Homo sapiens guanine monophosphate synthase (GMPS), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
View Old Accession Versions >>
OHu24154	NM_003875.2	Homo sapiens guanine monophosphate synthase (GMPS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GMPS ( NM_003875.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003866.1 Homo sapiens guanine monophosphate synthase (GMPS), mRNA.

Price & Availability↑

CloneID	OHu24154
Clone ID Related Accession (Same CDS sequence)	NM_003875.2 , NM_003875.3
Accession Version	NM_003875.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2082bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	GMP synthase [glutamine-hydrolyzing]
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG721087.1, BC012178.1 and CB159072.1. This sequence is a reference standard in the RefSeqGene project. On Oct 4, 2004 this sequence version replaced NM_003875.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HM005395.1, SRR1660803.110329.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCTGT GCAACGGAGA CTCCAAGCTG GAGAATGCTG GAGGAGACCT TAAGGATGGC 
CACCACCACT ATGAAGGAGC TGTTGTCATT CTGGATGCTG GTGCTCAGTA CGGGAAAGTC 
ATAGACCGAA GAGTGAGGGA ACTGTTCGTG CAGTCTGAAA TTTTCCCCTT GGAAACACCA 
GCATTTGCTA TAAAGGAACA AGGATTCCGT GCTATTATCA TCTCTGGAGG ACCTAATTCT 
GTGTATGCTG AAGATGCTCC CTGGTTTGAT CCAGCAATAT TCACTATTGG CAAGCCTGTT 
CTTGGAATTT GCTATGGTAT GCAGATGATG AATAAGGTAT TTGGAGGTAC TGTGCACAAA 
AAAAGTGTCA GAGAAGATGG AGTTTTCAAC ATTAGTGTGG ATAATACATG TTCATTATTC 
AGGGGCCTTC AGAAGGAAGA AGTTGTTTTG CTTACACATG GAGATAGTGT AGACAAAGTA 
GCTGATGGAT TCAAGGTTGT GGCACGTTCT GGAAACATAG TAGCAGGCAT AGCAAATGAA 
TCTAAAAAGT TATATGGAGC ACAGTTCCAC CCTGAAGTTG GCCTTACAGA AAATGGAAAA 
GTAATACTGA AGAATTTCCT TTATGATATA GCTGGATGCA GTGGAACCTT CACCGTGCAG 
AACAGAGAAC TTGAGTGTAT TCGAGAGATC AAAGAGAGAG TAGGCACGTC AAAAGTTTTG 
GTTTTACTCA GTGGTGGAGT AGACTCAACA GTTTGTACAG CTTTGCTAAA TCGTGCTTTG 
AACCAAGAAC AAGTCATTGC TGTGCACATT GATAATGGCT TTATGAGAAA ACGAGAAAGC 
CAGTCTGTTG AAGAGGCCCT CAAAAAGCTT GGAATTCAGG TCAAAGTGAT AAATGCTGCT 
CATTCTTTCT ACAATGGAAC AACAACCCTA CCAATATCAG ATGAAGATAG AACCCCACGG 
AAAAGAATTA GCAAAACGTT AAATATGACC ACAAGTCCTG AAGAGAAAAG AAAAATCATT 
GGGGATACTT TTGTTAAGAT TGCCAATGAA GTAATTGGAG AAATGAACTT GAAACCAGAG 
GAGGTTTTCC TTGCCCAAGG TACTTTACGG CCTGATCTAA TTGAAAGTGC ATCCCTTGTT 
GCAAGTGGCA AAGCTGAACT CATCAAAACC CATCACAATG ACACAGAGCT CATCAGAAAG 
TTGAGAGAGG AGGGAAAAGT AATAGAACCT CTGAAAGATT TTCATAAAGA TGAAGTGAGA 
ATTTTGGGCA GAGAACTTGG ACTTCCAGAA GAGTTAGTTT CCAGGCATCC ATTTCCAGGT 
CCTGGCCTGG CAATCAGAGT AATATGTGCT GAAGAACCTT ATATTTGTAA GGACTTTCCT 
GAAACCAACA ATATTTTGAA AATAGTAGCT GATTTTTCTG CAAGTGTTAA AAAGCCACAT 
ACCCTATTAC AGAGAGTCAA AGCCTGCACA ACAGAAGAGG ATCAGGAGAA GCTGATGCAA 
ATTACCAGTC TGCATTCACT GAATGCCTTC TTGCTGCCAA TTAAAACTGT AGGTGTGCAG 
GGTGACTGTC GTTCCTACAG TTACGTGTGT GGAATCTCCA GTAAAGATGA ACCTGACTGG 
GAATCACTTA TTTTTCTGGC TAGGCTTATA CCTCGCATGT GTCACAACGT TAACAGAGTT 
GTTTATATAT TTGGCCCACC AGTTAAAGAA CCTCCTACAG ATGTTACTCC CACTTTCTTG 
ACAACAGGGG TGCTCAGTAC TTTACGCCAA GCTGATTTTG AGGCCCATAA CATTCTCAGG 
GAGTCTGGGT ATGCTGGGAA AATCAGCCAG ATGCCGGTGA TTTTGACACC ATTACATTTT 
GATCGGGACC CACTTCAAAA GCAGCCTTCA TGCCAGAGAT CTGTGGTTAT TCGAACCTTT 
ATTACTAGTG ACTTCATGAC TGGTATACCT GCAACACCTG GCAATGAGAT CCCTGTAGAG 
GTGGTATTAA AGATGGTCAC TGAGATTAAG AAGATTCCTG GTATTTCTCG AATTATGTAT 
GACTTAACAT CAAAGCCCCC AGGAACTACT GAGTGGGAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003866.1
CDS	336..2417
Translation	MALCNGDSKLENAGGDLKDGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEIKKIPGISRIMYDLTSKPPGTTEWE

Target ORF information:

RefSeq Version	NM_003875.2
Organism	Homo sapiens(human)
Definition	Homo sapiens guanine monophosphate synthase (GMPS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003875.2

ORF Insert Sequence:

ATGGCTCTGT GCAACGGAGA CTCCAAGCTG GAGAATGCTG GAGGAGACCT TAAGGATGGC 
CACCACCACT ATGAAGGAGC TGTTGTCATT CTGGATGCTG GTGCTCAGTA CGGGAAAGTC 
ATAGACCGAA GAGTGAGGGA ACTGTTCGTG CAGTCTGAAA TTTTCCCCTT GGAAACACCA 
GCATTTGCTA TAAAGGAACA AGGATTCCGT GCTATTATCA TCTCTGGAGG ACCTAATTCT 
GTGTATGCTG AAGATGCTCC CTGGTTTGAT CCAGCAATAT TCACTATTGG CAAGCCTGTT 
CTTGGAATTT GCTATGGTAT GCAGATGATG AATAAGGTAT TTGGAGGTAC TGTGCACAAA 
AAAAGTGTCA GAGAAGATGG AGTTTTCAAC ATTAGTGTGG ATAATACATG TTCATTATTC 
AGGGGCCTTC AGAAGGAAGA AGTTGTTTTG CTTACACATG GAGATAGTGT AGACAAAGTA 
GCTGATGGAT TCAAGGTTGT GGCACGTTCT GGAAACATAG TAGCAGGCAT AGCAAATGAA 
TCTAAAAAGT TATATGGAGC ACAGTTCCAC CCTGAAGTTG GCCTTACAGA AAATGGAAAA 
GTAATACTGA AGAATTTCCT TTATGATATA GCTGGATGCA GTGGAACCTT CACCGTGCAG 
AACAGAGAAC TTGAGTGTAT TCGAGAGATC AAAGAGAGAG TAGGCACGTC AAAAGTTTTG 
GTTTTACTCA GTGGTGGAGT AGACTCAACA GTTTGTACAG CTTTGCTAAA TCGTGCTTTG 
AACCAAGAAC AAGTCATTGC TGTGCACATT GATAATGGCT TTATGAGAAA ACGAGAAAGC 
CAGTCTGTTG AAGAGGCCCT CAAAAAGCTT GGAATTCAGG TCAAAGTGAT AAATGCTGCT 
CATTCTTTCT ACAATGGAAC AACAACCCTA CCAATATCAG ATGAAGATAG AACCCCACGG 
AAAAGAATTA GCAAAACGTT AAATATGACC ACAAGTCCTG AAGAGAAAAG AAAAATCATT 
GGGGATACTT TTGTTAAGAT TGCCAATGAA GTAATTGGAG AAATGAACTT GAAACCAGAG 
GAGGTTTTCC TTGCCCAAGG TACTTTACGG CCTGATCTAA TTGAAAGTGC ATCCCTTGTT 
GCAAGTGGCA AAGCTGAACT CATCAAAACC CATCACAATG ACACAGAGCT CATCAGAAAG 
TTGAGAGAGG AGGGAAAAGT AATAGAACCT CTGAAAGATT TTCATAAAGA TGAAGTGAGA 
ATTTTGGGCA GAGAACTTGG ACTTCCAGAA GAGTTAGTTT CCAGGCATCC ATTTCCAGGT 
CCTGGCCTGG CAATCAGAGT AATATGTGCT GAAGAACCTT ATATTTGTAA GGACTTTCCT 
GAAACCAACA ATATTTTGAA AATAGTAGCT GATTTTTCTG CAAGTGTTAA AAAGCCACAT 
ACCCTATTAC AGAGAGTCAA AGCCTGCACA ACAGAAGAGG ATCAGGAGAA GCTGATGCAA 
ATTACCAGTC TGCATTCACT GAATGCCTTC TTGCTGCCAA TTAAAACTGT AGGTGTGCAG 
GGTGACTGTC GTTCCTACAG TTACGTGTGT GGAATCTCCA GTAAAGATGA ACCTGACTGG 
GAATCACTTA TTTTTCTGGC TAGGCTTATA CCTCGCATGT GTCACAACGT TAACAGAGTT 
GTTTATATAT TTGGCCCACC AGTTAAAGAA CCTCCTACAG ATGTTACTCC CACTTTCTTG 
ACAACAGGGG TGCTCAGTAC TTTACGCCAA GCTGATTTTG AGGCCCATAA CATTCTCAGG 
GAGTCTGGGT ATGCTGGGAA AATCAGCCAG ATGCCGGTGA TTTTGACACC ATTACATTTT 
GATCGGGACC CACTTCAAAA GCAGCCTTCA TGCCAGAGAT CTGTGGTTAT TCGAACCTTT 
ATTACTAGTG ACTTCATGAC TGGTATACCT GCAACACCTG GCAATGAGAT CCCTGTAGAG 
GTGGTATTAA AGATGGTCAC TGAGATTAAG AAGATTCCTG GTATTTCTCG AATTATGTAT 
GACTTAACAT CAAAGCCCCC AGGAACTACT GAGTGGGAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GMPS ( NM_003875.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003866.1 Homo sapiens guanine monophosphate synthase (GMPS), mRNA.

Price & Availability↑

CloneID	OHu24154
Clone ID Related Accession (Same CDS sequence)	NM_003875.2 , NM_003875.3
Accession Version	NM_003875.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2082bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	GMP synthase [glutamine-hydrolyzing]
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG721087.1, BC012178.1, CB159072.1 and AC067721.22. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_003875.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.185387.1, SRR1803614.158947.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000496455.7/ ENSP00000419851.1 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTCTGT GCAACGGAGA CTCCAAGCTG GAGAATGCTG GAGGAGACCT TAAGGATGGC 
CACCACCACT ATGAAGGAGC TGTTGTCATT CTGGATGCTG GTGCTCAGTA CGGGAAAGTC 
ATAGACCGAA GAGTGAGGGA ACTGTTCGTG CAGTCTGAAA TTTTCCCCTT GGAAACACCA 
GCATTTGCTA TAAAGGAACA AGGATTCCGT GCTATTATCA TCTCTGGAGG ACCTAATTCT 
GTGTATGCTG AAGATGCTCC CTGGTTTGAT CCAGCAATAT TCACTATTGG CAAGCCTGTT 
CTTGGAATTT GCTATGGTAT GCAGATGATG AATAAGGTAT TTGGAGGTAC TGTGCACAAA 
AAAAGTGTCA GAGAAGATGG AGTTTTCAAC ATTAGTGTGG ATAATACATG TTCATTATTC 
AGGGGCCTTC AGAAGGAAGA AGTTGTTTTG CTTACACATG GAGATAGTGT AGACAAAGTA 
GCTGATGGAT TCAAGGTTGT GGCACGTTCT GGAAACATAG TAGCAGGCAT AGCAAATGAA 
TCTAAAAAGT TATATGGAGC ACAGTTCCAC CCTGAAGTTG GCCTTACAGA AAATGGAAAA 
GTAATACTGA AGAATTTCCT TTATGATATA GCTGGATGCA GTGGAACCTT CACCGTGCAG 
AACAGAGAAC TTGAGTGTAT TCGAGAGATC AAAGAGAGAG TAGGCACGTC AAAAGTTTTG 
GTTTTACTCA GTGGTGGAGT AGACTCAACA GTTTGTACAG CTTTGCTAAA TCGTGCTTTG 
AACCAAGAAC AAGTCATTGC TGTGCACATT GATAATGGCT TTATGAGAAA ACGAGAAAGC 
CAGTCTGTTG AAGAGGCCCT CAAAAAGCTT GGAATTCAGG TCAAAGTGAT AAATGCTGCT 
CATTCTTTCT ACAATGGAAC AACAACCCTA CCAATATCAG ATGAAGATAG AACCCCACGG 
AAAAGAATTA GCAAAACGTT AAATATGACC ACAAGTCCTG AAGAGAAAAG AAAAATCATT 
GGGGATACTT TTGTTAAGAT TGCCAATGAA GTAATTGGAG AAATGAACTT GAAACCAGAG 
GAGGTTTTCC TTGCCCAAGG TACTTTACGG CCTGATCTAA TTGAAAGTGC ATCCCTTGTT 
GCAAGTGGCA AAGCTGAACT CATCAAAACC CATCACAATG ACACAGAGCT CATCAGAAAG 
TTGAGAGAGG AGGGAAAAGT AATAGAACCT CTGAAAGATT TTCATAAAGA TGAAGTGAGA 
ATTTTGGGCA GAGAACTTGG ACTTCCAGAA GAGTTAGTTT CCAGGCATCC ATTTCCAGGT 
CCTGGCCTGG CAATCAGAGT AATATGTGCT GAAGAACCTT ATATTTGTAA GGACTTTCCT 
GAAACCAACA ATATTTTGAA AATAGTAGCT GATTTTTCTG CAAGTGTTAA AAAGCCACAT 
ACCCTATTAC AGAGAGTCAA AGCCTGCACA ACAGAAGAGG ATCAGGAGAA GCTGATGCAA 
ATTACCAGTC TGCATTCACT GAATGCCTTC TTGCTGCCAA TTAAAACTGT AGGTGTGCAG 
GGTGACTGTC GTTCCTACAG TTACGTGTGT GGAATCTCCA GTAAAGATGA ACCTGACTGG 
GAATCACTTA TTTTTCTGGC TAGGCTTATA CCTCGCATGT GTCACAACGT TAACAGAGTT 
GTTTATATAT TTGGCCCACC AGTTAAAGAA CCTCCTACAG ATGTTACTCC CACTTTCTTG 
ACAACAGGGG TGCTCAGTAC TTTACGCCAA GCTGATTTTG AGGCCCATAA CATTCTCAGG 
GAGTCTGGGT ATGCTGGGAA AATCAGCCAG ATGCCGGTGA TTTTGACACC ATTACATTTT 
GATCGGGACC CACTTCAAAA GCAGCCTTCA TGCCAGAGAT CTGTGGTTAT TCGAACCTTT 
ATTACTAGTG ACTTCATGAC TGGTATACCT GCAACACCTG GCAATGAGAT CCCTGTAGAG 
GTGGTATTAA AGATGGTCAC TGAGATTAAG AAGATTCCTG GTATTTCTCG AATTATGTAT 
GACTTAACAT CAAAGCCCCC AGGAACTACT GAGTGGGAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003866.1
CDS	222..2303
Translation	MALCNGDSKLENAGGDLKDGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEIKKIPGISRIMYDLTSKPPGTTEWE

Target ORF information:

RefSeq Version	NM_003875.3
Organism	Homo sapiens(human)
Definition	Homo sapiens guanine monophosphate synthase (GMPS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003875.3

ORF Insert Sequence:

ATGGCTCTGT GCAACGGAGA CTCCAAGCTG GAGAATGCTG GAGGAGACCT TAAGGATGGC 
CACCACCACT ATGAAGGAGC TGTTGTCATT CTGGATGCTG GTGCTCAGTA CGGGAAAGTC 
ATAGACCGAA GAGTGAGGGA ACTGTTCGTG CAGTCTGAAA TTTTCCCCTT GGAAACACCA 
GCATTTGCTA TAAAGGAACA AGGATTCCGT GCTATTATCA TCTCTGGAGG ACCTAATTCT 
GTGTATGCTG AAGATGCTCC CTGGTTTGAT CCAGCAATAT TCACTATTGG CAAGCCTGTT 
CTTGGAATTT GCTATGGTAT GCAGATGATG AATAAGGTAT TTGGAGGTAC TGTGCACAAA 
AAAAGTGTCA GAGAAGATGG AGTTTTCAAC ATTAGTGTGG ATAATACATG TTCATTATTC 
AGGGGCCTTC AGAAGGAAGA AGTTGTTTTG CTTACACATG GAGATAGTGT AGACAAAGTA 
GCTGATGGAT TCAAGGTTGT GGCACGTTCT GGAAACATAG TAGCAGGCAT AGCAAATGAA 
TCTAAAAAGT TATATGGAGC ACAGTTCCAC CCTGAAGTTG GCCTTACAGA AAATGGAAAA 
GTAATACTGA AGAATTTCCT TTATGATATA GCTGGATGCA GTGGAACCTT CACCGTGCAG 
AACAGAGAAC TTGAGTGTAT TCGAGAGATC AAAGAGAGAG TAGGCACGTC AAAAGTTTTG 
GTTTTACTCA GTGGTGGAGT AGACTCAACA GTTTGTACAG CTTTGCTAAA TCGTGCTTTG 
AACCAAGAAC AAGTCATTGC TGTGCACATT GATAATGGCT TTATGAGAAA ACGAGAAAGC 
CAGTCTGTTG AAGAGGCCCT CAAAAAGCTT GGAATTCAGG TCAAAGTGAT AAATGCTGCT 
CATTCTTTCT ACAATGGAAC AACAACCCTA CCAATATCAG ATGAAGATAG AACCCCACGG 
AAAAGAATTA GCAAAACGTT AAATATGACC ACAAGTCCTG AAGAGAAAAG AAAAATCATT 
GGGGATACTT TTGTTAAGAT TGCCAATGAA GTAATTGGAG AAATGAACTT GAAACCAGAG 
GAGGTTTTCC TTGCCCAAGG TACTTTACGG CCTGATCTAA TTGAAAGTGC ATCCCTTGTT 
GCAAGTGGCA AAGCTGAACT CATCAAAACC CATCACAATG ACACAGAGCT CATCAGAAAG 
TTGAGAGAGG AGGGAAAAGT AATAGAACCT CTGAAAGATT TTCATAAAGA TGAAGTGAGA 
ATTTTGGGCA GAGAACTTGG ACTTCCAGAA GAGTTAGTTT CCAGGCATCC ATTTCCAGGT 
CCTGGCCTGG CAATCAGAGT AATATGTGCT GAAGAACCTT ATATTTGTAA GGACTTTCCT 
GAAACCAACA ATATTTTGAA AATAGTAGCT GATTTTTCTG CAAGTGTTAA AAAGCCACAT 
ACCCTATTAC AGAGAGTCAA AGCCTGCACA ACAGAAGAGG ATCAGGAGAA GCTGATGCAA 
ATTACCAGTC TGCATTCACT GAATGCCTTC TTGCTGCCAA TTAAAACTGT AGGTGTGCAG 
GGTGACTGTC GTTCCTACAG TTACGTGTGT GGAATCTCCA GTAAAGATGA ACCTGACTGG 
GAATCACTTA TTTTTCTGGC TAGGCTTATA CCTCGCATGT GTCACAACGT TAACAGAGTT 
GTTTATATAT TTGGCCCACC AGTTAAAGAA CCTCCTACAG ATGTTACTCC CACTTTCTTG 
ACAACAGGGG TGCTCAGTAC TTTACGCCAA GCTGATTTTG AGGCCCATAA CATTCTCAGG 
GAGTCTGGGT ATGCTGGGAA AATCAGCCAG ATGCCGGTGA TTTTGACACC ATTACATTTT 
GATCGGGACC CACTTCAAAA GCAGCCTTCA TGCCAGAGAT CTGTGGTTAT TCGAACCTTT 
ATTACTAGTG ACTTCATGAC TGGTATACCT GCAACACCTG GCAATGAGAT CCCTGTAGAG 
GTGGTATTAA AGATGGTCAC TGAGATTAAG AAGATTCCTG GTATTTCTCG AATTATGTAT 
GACTTAACAT CAAAGCCCCC AGGAACTACT GAGTGGGAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GMPS ( XM_011513263.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011511565.1 Homo sapiens guanine monophosphate synthase (GMPS), transcript variant X1, mRNA.

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CloneID	OHu62227
Clone ID Related Accession (Same CDS sequence)	XM_011513263.2
Accession Version	XM_011513263.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2100bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	GMP synthase [glutamine-hydrolyzing] isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011513263.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTTTGG AGAGTTCAAA TATTCAATTT TCCGTTCAAA AAAAGCTGGA GAATGCTGGA 
GGAGACCTTA AGGATGGCCA CCACCACTAT GAAGGAGCTG TTGTCATTCT GGATGCTGGT 
GCTCAGTACG GGAAAGTCAT AGACCGAAGA GTGAGGGAAC TGTTCGTGCA GTCTGAAATT 
TTCCCCTTGG AAACACCAGC ATTTGCTATA AAGGAACAAG GATTCCGTGC TATTATCATC 
TCTGGAGGAC CTAATTCTGT GTATGCTGAA GATGCTCCCT GGTTTGATCC AGCAATATTC 
ACTATTGGCA AGCCTGTTCT TGGAATTTGC TATGGTATGC AGATGATGAA TAAGGTATTT 
GGAGGTACTG TGCACAAAAA AAGTGTCAGA GAAGATGGAG TTTTCAACAT TAGTGTGGAT 
AATACATGTT CATTATTCAG GGGCCTTCAG AAGGAAGAAG TTGTTTTGCT TACACATGGA 
GATAGTGTAG ACAAAGTAGC TGATGGATTC AAGGTTGTGG CACGTTCTGG AAACATAGTA 
GCAGGCATAG CAAATGAATC TAAAAAGTTA TATGGAGCAC AGTTCCACCC TGAAGTTGGC 
CTTACAGAAA ATGGAAAAGT AATACTGAAG AATTTCCTTT ATGATATAGC TGGATGCAGT 
GGAACCTTCA CCGTGCAGAA CAGAGAACTT GAGTGTATTC GAGAGATCAA AGAGAGAGTA 
GGCACGTCAA AAGTTTTGGT TTTACTCAGT GGTGGAGTAG ACTCAACAGT TTGTACAGCT 
TTGCTAAATC GTGCTTTGAA CCAAGAACAA GTCATTGCTG TGCACATTGA TAATGGCTTT 
ATGAGAAAAC GAGAAAGCCA GTCTGTTGAA GAGGCCCTCA AAAAGCTTGG AATTCAGGTC 
AAAGTGATAA ATGCTGCTCA TTCTTTCTAC AATGGAACAA CAACCCTACC AATATCAGAT 
GAAGATAGAA CCCCACGGAA AAGAATTAGC AAAACGTTAA ATATGACCAC AAGTCCTGAA 
GAGAAAAGAA AAATCATTGG GGATACTTTT GTTAAGATTG CCAATGAAGT AATTGGAGAA 
ATGAACTTGA AACCAGAGGA GGTTTTCCTT GCCCAAGGTA CTTTACGGCC TGATCTAATT 
GAAAGTGCAT CCCTTGTTGC AAGTGGCAAA GCTGAACTCA TCAAAACCCA TCACAATGAC 
ACAGAGCTCA TCAGAAAGTT GAGAGAGGAG GGAAAAGTAA TAGAACCTCT GAAAGATTTT 
CATAAAGATG AAGTGAGAAT TTTGGGCAGA GAACTTGGAC TTCCAGAAGA GTTAGTTTCC 
AGGCATCCAT TTCCAGGTCC TGGCCTGGCA ATCAGAGTAA TATGTGCTGA AGAACCTTAT 
ATTTGTAAGG ACTTTCCTGA AACCAACAAT ATTTTGAAAA TAGTAGCTGA TTTTTCTGCA 
AGTGTTAAAA AGCCACATAC CCTATTACAG AGAGTCAAAG CCTGCACAAC AGAAGAGGAT 
CAGGAGAAGC TGATGCAAAT TACCAGTCTG CATTCACTGA ATGCCTTCTT GCTGCCAATT 
AAAACTGTAG GTGTGCAGGG TGACTGTCGT TCCTACAGTT ACGTGTGTGG AATCTCCAGT 
AAAGATGAAC CTGACTGGGA ATCACTTATT TTTCTGGCTA GGCTTATACC TCGCATGTGT 
CACAACGTTA ACAGAGTTGT TTATATATTT GGCCCACCAG TTAAAGAACC TCCTACAGAT 
GTTACTCCCA CTTTCTTGAC AACAGGGGTG CTCAGTACTT TACGCCAAGC TGATTTTGAG 
GCCCATAACA TTCTCAGGGA GTCTGGGTAT GCTGGGAAAA TCAGCCAGAT GCCGGTGATT 
TTGACACCAT TACATTTTGA TCGGGACCCA CTTCAAAAGC AGCCTTCATG CCAGAGATCT 
GTGGTTATTC GAACCTTTAT TACTAGTGAC TTCATGACTG GTATACCTGC AACACCTGGC 
AATGAGATCC CTGTAGAGGT GGTATTAAAG ATGGTCACTG AGATTAAGAA GATTCCTGGT 
ATTTCTCGAA TTATGTATGA CTTAACATCA AAGCCCCCAG GAACTACTGA GTGGGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011511565.1
CDS	16..2115
Translation	MALESSNIQFSVQKKLENAGGDLKDGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEIKKIPGISRIMYDLTSKPPGTTEWE

Target ORF information:

RefSeq Version	XM_011513263.2
Organism	Homo sapiens(human)
Definition	Homo sapiens guanine monophosphate synthase (GMPS), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011513263.2

ORF Insert Sequence:

ATGGCTTTGG AGAGTTCAAA TATTCAATTT TCCGTTCAAA AAAAGCTGGA GAATGCTGGA 
GGAGACCTTA AGGATGGCCA CCACCACTAT GAAGGAGCTG TTGTCATTCT GGATGCTGGT 
GCTCAGTACG GGAAAGTCAT AGACCGAAGA GTGAGGGAAC TGTTCGTGCA GTCTGAAATT 
TTCCCCTTGG AAACACCAGC ATTTGCTATA AAGGAACAAG GATTCCGTGC TATTATCATC 
TCTGGAGGAC CTAATTCTGT GTATGCTGAA GATGCTCCCT GGTTTGATCC AGCAATATTC 
ACTATTGGCA AGCCTGTTCT TGGAATTTGC TATGGTATGC AGATGATGAA TAAGGTATTT 
GGAGGTACTG TGCACAAAAA AAGTGTCAGA GAAGATGGAG TTTTCAACAT TAGTGTGGAT 
AATACATGTT CATTATTCAG GGGCCTTCAG AAGGAAGAAG TTGTTTTGCT TACACATGGA 
GATAGTGTAG ACAAAGTAGC TGATGGATTC AAGGTTGTGG CACGTTCTGG AAACATAGTA 
GCAGGCATAG CAAATGAATC TAAAAAGTTA TATGGAGCAC AGTTCCACCC TGAAGTTGGC 
CTTACAGAAA ATGGAAAAGT AATACTGAAG AATTTCCTTT ATGATATAGC TGGATGCAGT 
GGAACCTTCA CCGTGCAGAA CAGAGAACTT GAGTGTATTC GAGAGATCAA AGAGAGAGTA 
GGCACGTCAA AAGTTTTGGT TTTACTCAGT GGTGGAGTAG ACTCAACAGT TTGTACAGCT 
TTGCTAAATC GTGCTTTGAA CCAAGAACAA GTCATTGCTG TGCACATTGA TAATGGCTTT 
ATGAGAAAAC GAGAAAGCCA GTCTGTTGAA GAGGCCCTCA AAAAGCTTGG AATTCAGGTC 
AAAGTGATAA ATGCTGCTCA TTCTTTCTAC AATGGAACAA CAACCCTACC AATATCAGAT 
GAAGATAGAA CCCCACGGAA AAGAATTAGC AAAACGTTAA ATATGACCAC AAGTCCTGAA 
GAGAAAAGAA AAATCATTGG GGATACTTTT GTTAAGATTG CCAATGAAGT AATTGGAGAA 
ATGAACTTGA AACCAGAGGA GGTTTTCCTT GCCCAAGGTA CTTTACGGCC TGATCTAATT 
GAAAGTGCAT CCCTTGTTGC AAGTGGCAAA GCTGAACTCA TCAAAACCCA TCACAATGAC 
ACAGAGCTCA TCAGAAAGTT GAGAGAGGAG GGAAAAGTAA TAGAACCTCT GAAAGATTTT 
CATAAAGATG AAGTGAGAAT TTTGGGCAGA GAACTTGGAC TTCCAGAAGA GTTAGTTTCC 
AGGCATCCAT TTCCAGGTCC TGGCCTGGCA ATCAGAGTAA TATGTGCTGA AGAACCTTAT 
ATTTGTAAGG ACTTTCCTGA AACCAACAAT ATTTTGAAAA TAGTAGCTGA TTTTTCTGCA 
AGTGTTAAAA AGCCACATAC CCTATTACAG AGAGTCAAAG CCTGCACAAC AGAAGAGGAT 
CAGGAGAAGC TGATGCAAAT TACCAGTCTG CATTCACTGA ATGCCTTCTT GCTGCCAATT 
AAAACTGTAG GTGTGCAGGG TGACTGTCGT TCCTACAGTT ACGTGTGTGG AATCTCCAGT 
AAAGATGAAC CTGACTGGGA ATCACTTATT TTTCTGGCTA GGCTTATACC TCGCATGTGT 
CACAACGTTA ACAGAGTTGT TTATATATTT GGCCCACCAG TTAAAGAACC TCCTACAGAT 
GTTACTCCCA CTTTCTTGAC AACAGGGGTG CTCAGTACTT TACGCCAAGC TGATTTTGAG 
GCCCATAACA TTCTCAGGGA GTCTGGGTAT GCTGGGAAAA TCAGCCAGAT GCCGGTGATT 
TTGACACCAT TACATTTTGA TCGGGACCCA CTTCAAAAGC AGCCTTCATG CCAGAGATCT 
GTGGTTATTC GAACCTTTAT TACTAGTGAC TTCATGACTG GTATACCTGC AACACCTGGC 
AATGAGATCC CTGTAGAGGT GGTATTAAAG ATGGTCACTG AGATTAAGAA GATTCCTGGT 
ATTTCTCGAA TTATGTATGA CTTAACATCA AAGCCCCCAG GAACTACTGA GTGGGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GMPS ( XM_017007422.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016862911.1 Homo sapiens guanine monophosphate synthase (GMPS), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu62228
Clone ID Related Accession (Same CDS sequence)	XM_017007422.1
Accession Version	XM_017007422.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2061bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	GMP synthase [glutamine-hydrolyzing] isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTGCTGG AGAATGCTGG AGGAGACCTT AAGGATGGCC ACCACCACTA TGAAGGAGCT 
GTTGTCATTC TGGATGCTGG TGCTCAGTAC GGGAAAGTCA TAGACCGAAG AGTGAGGGAA 
CTGTTCGTGC AGTCTGAAAT TTTCCCCTTG GAAACACCAG CATTTGCTAT AAAGGAACAA 
GGATTCCGTG CTATTATCAT CTCTGGAGGA CCTAATTCTG TGTATGCTGA AGATGCTCCC 
TGGTTTGATC CAGCAATATT CACTATTGGC AAGCCTGTTC TTGGAATTTG CTATGGTATG 
CAGATGATGA ATAAGGTATT TGGAGGTACT GTGCACAAAA AAAGTGTCAG AGAAGATGGA 
GTTTTCAACA TTAGTGTGGA TAATACATGT TCATTATTCA GGGGCCTTCA GAAGGAAGAA 
GTTGTTTTGC TTACACATGG AGATAGTGTA GACAAAGTAG CTGATGGATT CAAGGTTGTG 
GCACGTTCTG GAAACATAGT AGCAGGCATA GCAAATGAAT CTAAAAAGTT ATATGGAGCA 
CAGTTCCACC CTGAAGTTGG CCTTACAGAA AATGGAAAAG TAATACTGAA GAATTTCCTT 
TATGATATAG CTGGATGCAG TGGAACCTTC ACCGTGCAGA ACAGAGAACT TGAGTGTATT 
CGAGAGATCA AAGAGAGAGT AGGCACGTCA AAAGTTTTGG TTTTACTCAG TGGTGGAGTA 
GACTCAACAG TTTGTACAGC TTTGCTAAAT CGTGCTTTGA ACCAAGAACA AGTCATTGCT 
GTGCACATTG ATAATGGCTT TATGAGAAAA CGAGAAAGCC AGTCTGTTGA AGAGGCCCTC 
AAAAAGCTTG GAATTCAGGT CAAAGTGATA AATGCTGCTC ATTCTTTCTA CAATGGAACA 
ACAACCCTAC CAATATCAGA TGAAGATAGA ACCCCACGGA AAAGAATTAG CAAAACGTTA 
AATATGACCA CAAGTCCTGA AGAGAAAAGA AAAATCATTG GGGATACTTT TGTTAAGATT 
GCCAATGAAG TAATTGGAGA AATGAACTTG AAACCAGAGG AGGTTTTCCT TGCCCAAGGT 
ACTTTACGGC CTGATCTAAT TGAAAGTGCA TCCCTTGTTG CAAGTGGCAA AGCTGAACTC 
ATCAAAACCC ATCACAATGA CACAGAGCTC ATCAGAAAGT TGAGAGAGGA GGGAAAAGTA 
ATAGAACCTC TGAAAGATTT TCATAAAGAT GAAGTGAGAA TTTTGGGCAG AGAACTTGGA 
CTTCCAGAAG AGTTAGTTTC CAGGCATCCA TTTCCAGGTC CTGGCCTGGC AATCAGAGTA 
ATATGTGCTG AAGAACCTTA TATTTGTAAG GACTTTCCTG AAACCAACAA TATTTTGAAA 
ATAGTAGCTG ATTTTTCTGC AAGTGTTAAA AAGCCACATA CCCTATTACA GAGAGTCAAA 
GCCTGCACAA CAGAAGAGGA TCAGGAGAAG CTGATGCAAA TTACCAGTCT GCATTCACTG 
AATGCCTTCT TGCTGCCAAT TAAAACTGTA GGTGTGCAGG GTGACTGTCG TTCCTACAGT 
TACGTGTGTG GAATCTCCAG TAAAGATGAA CCTGACTGGG AATCACTTAT TTTTCTGGCT 
AGGCTTATAC CTCGCATGTG TCACAACGTT AACAGAGTTG TTTATATATT TGGCCCACCA 
GTTAAAGAAC CTCCTACAGA TGTTACTCCC ACTTTCTTGA CAACAGGGGT GCTCAGTACT 
TTACGCCAAG CTGATTTTGA GGCCCATAAC ATTCTCAGGG AGTCTGGGTA TGCTGGGAAA 
ATCAGCCAGA TGCCGGTGAT TTTGACACCA TTACATTTTG ATCGGGACCC ACTTCAAAAG 
CAGCCTTCAT GCCAGAGATC TGTGGTTATT CGAACCTTTA TTACTAGTGA CTTCATGACT 
GGTATACCTG CAACACCTGG CAATGAGATC CCTGTAGAGG TGGTATTAAA GATGGTCACT 
GAGATTAAGA AGATTCCTGG TATTTCTCGA ATTATGTATG ACTTAACATC AAAGCCCCCA 
GGAACTACTG AGTGGGAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016862911.1
CDS	542..2602
Translation	MLLENAGGDLKDGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEIKKIPGISRIMYDLTSKPPGTTEWE

Target ORF information:

RefSeq Version	XM_017007422.1
Organism	Homo sapiens(human)
Definition	Homo sapiens guanine monophosphate synthase (GMPS), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017007422.1

ORF Insert Sequence:

ATGTTGCTGG AGAATGCTGG AGGAGACCTT AAGGATGGCC ACCACCACTA TGAAGGAGCT 
GTTGTCATTC TGGATGCTGG TGCTCAGTAC GGGAAAGTCA TAGACCGAAG AGTGAGGGAA 
CTGTTCGTGC AGTCTGAAAT TTTCCCCTTG GAAACACCAG CATTTGCTAT AAAGGAACAA 
GGATTCCGTG CTATTATCAT CTCTGGAGGA CCTAATTCTG TGTATGCTGA AGATGCTCCC 
TGGTTTGATC CAGCAATATT CACTATTGGC AAGCCTGTTC TTGGAATTTG CTATGGTATG 
CAGATGATGA ATAAGGTATT TGGAGGTACT GTGCACAAAA AAAGTGTCAG AGAAGATGGA 
GTTTTCAACA TTAGTGTGGA TAATACATGT TCATTATTCA GGGGCCTTCA GAAGGAAGAA 
GTTGTTTTGC TTACACATGG AGATAGTGTA GACAAAGTAG CTGATGGATT CAAGGTTGTG 
GCACGTTCTG GAAACATAGT AGCAGGCATA GCAAATGAAT CTAAAAAGTT ATATGGAGCA 
CAGTTCCACC CTGAAGTTGG CCTTACAGAA AATGGAAAAG TAATACTGAA GAATTTCCTT 
TATGATATAG CTGGATGCAG TGGAACCTTC ACCGTGCAGA ACAGAGAACT TGAGTGTATT 
CGAGAGATCA AAGAGAGAGT AGGCACGTCA AAAGTTTTGG TTTTACTCAG TGGTGGAGTA 
GACTCAACAG TTTGTACAGC TTTGCTAAAT CGTGCTTTGA ACCAAGAACA AGTCATTGCT 
GTGCACATTG ATAATGGCTT TATGAGAAAA CGAGAAAGCC AGTCTGTTGA AGAGGCCCTC 
AAAAAGCTTG GAATTCAGGT CAAAGTGATA AATGCTGCTC ATTCTTTCTA CAATGGAACA 
ACAACCCTAC CAATATCAGA TGAAGATAGA ACCCCACGGA AAAGAATTAG CAAAACGTTA 
AATATGACCA CAAGTCCTGA AGAGAAAAGA AAAATCATTG GGGATACTTT TGTTAAGATT 
GCCAATGAAG TAATTGGAGA AATGAACTTG AAACCAGAGG AGGTTTTCCT TGCCCAAGGT 
ACTTTACGGC CTGATCTAAT TGAAAGTGCA TCCCTTGTTG CAAGTGGCAA AGCTGAACTC 
ATCAAAACCC ATCACAATGA CACAGAGCTC ATCAGAAAGT TGAGAGAGGA GGGAAAAGTA 
ATAGAACCTC TGAAAGATTT TCATAAAGAT GAAGTGAGAA TTTTGGGCAG AGAACTTGGA 
CTTCCAGAAG AGTTAGTTTC CAGGCATCCA TTTCCAGGTC CTGGCCTGGC AATCAGAGTA 
ATATGTGCTG AAGAACCTTA TATTTGTAAG GACTTTCCTG AAACCAACAA TATTTTGAAA 
ATAGTAGCTG ATTTTTCTGC AAGTGTTAAA AAGCCACATA CCCTATTACA GAGAGTCAAA 
GCCTGCACAA CAGAAGAGGA TCAGGAGAAG CTGATGCAAA TTACCAGTCT GCATTCACTG 
AATGCCTTCT TGCTGCCAAT TAAAACTGTA GGTGTGCAGG GTGACTGTCG TTCCTACAGT 
TACGTGTGTG GAATCTCCAG TAAAGATGAA CCTGACTGGG AATCACTTAT TTTTCTGGCT 
AGGCTTATAC CTCGCATGTG TCACAACGTT AACAGAGTTG TTTATATATT TGGCCCACCA 
GTTAAAGAAC CTCCTACAGA TGTTACTCCC ACTTTCTTGA CAACAGGGGT GCTCAGTACT 
TTACGCCAAG CTGATTTTGA GGCCCATAAC ATTCTCAGGG AGTCTGGGTA TGCTGGGAAA 
ATCAGCCAGA TGCCGGTGAT TTTGACACCA TTACATTTTG ATCGGGACCC ACTTCAAAAG 
CAGCCTTCAT GCCAGAGATC TGTGGTTATT CGAACCTTTA TTACTAGTGA CTTCATGACT 
GGTATACCTG CAACACCTGG CAATGAGATC CCTGTAGAGG TGGTATTAAA GATGGTCACT 
GAGATTAAGA AGATTCCTGG TATTTCTCGA ATTATGTATG ACTTAACATC AAAGCCCCCA 
GGAACTACTG AGTGGGAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Methylation and expression analyses of Pallister-Killian syndrome reveal partial dosage compensation of tetrasomy 12p and hypomethylation of gene-poor regions on 12p.
Epigenetics11(3)194-204(2016 03)
Davidsson J,Johansson B

Nucleotide biosynthetic enzyme GMP synthase is a TRIM21-controlled relay of p53 stabilization.
Molecular cell53(3)458-70(2014 Feb)
Reddy BA,van der Knaap JA,Bot AG,Mohd-Sarip A,Dekkers DH,Timmermans MA,Martens JW,Demmers JA,Verrijzer CP

Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase.
Molecular cell44(1)147-59(2011 Oct)
Faesen AC,Dirac AM,Shanmugham A,Ovaa H,Perrakis A,Sixma TK

Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data.
Schizophrenia research122(1-3)38-42(2010 Sep)
Jia P,Wang L,Meltzer HY,Zhao Z

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GMPS cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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