GALR2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GALR2
Entrez Gene ID	8811
Full Name	galanin receptor 2
Synonyms	GAL2-R,GALNR2,GALR-2
General protein information	Preferred Names galanin receptor 2 Names galanin receptor type 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q25.1
Summary	Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008].
Disorder MIM:	603691

mRNA and Protein(s)

mRNA	Protein	Name
NM_003857.4	NP_003848.1	galanin receptor type 2
XM_011525427.2	XP_011523729.1	galanin receptor type 2 isoform X1
XM_011525427.3	XP_011523729.1	galanin receptor type 2 isoform X1
NM_003857.3	NP_003848.1	galanin receptor type 2

Pathways from BioSystems

Homologies

	GALR2	XP_001103768.1
Mus musculus (house mouse)	Galr2	NP_034384.3
Gallus gallus (chicken)	GALR2	NP_001121535.1
Danio rerio (zebrafish)	si:ch211-250n8.2	XP_002664053.2
Drosophila melanogaster (fruit fly)	AlstR	NP_524700.1
Bos taurus (cattle)	GALR2	NP_001098480.1
Rattus norvegicus (Norway rat)	Galr2	NP_062045.1
Xenopus tropicalis (tropical clawed frog)	galr2	XP_002940025.1
Homo sapiens (human)	GALR2	NP_003848.1
Pan troglodytes (chimpanzee)	GALR2	XP_523721.1
Canis lupus familiaris (dog)	GALR2	XP_540444.3
Rattus norvegicus (Norway rat)	LOC100910349	XP_003751012.1
Anopheles gambiae (African malaria mosquito)	GPRALS2	XP_003435928.1
Caenorhabditis elegans (roundworm)	npr-9	NP_509896.1

Gene Ontology
Bibliography

Related articles in PubMed

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.
Badgandi HB, Hwang SH, Shimada IS, Loriot E, Mukhopadhyay S
The Journal of cell biology216(3)743-760(2017 Mar)

Site-specific methylation patterns of the GAL and GALR1/2 genes in head and neck cancer: Potential utility as biomarkers for prognosis.
Misawa K, Mochizuki D, Endo S, Mima M, Misawa Y, Imai A, Shinmura K, Kanazawa T, Carey TE, Mineta H
Molecular carcinogenesis56(3)1107-1116(2017 Mar)

Epigenetic inactivation of galanin and GALR1/2 is associated with early recurrence in head and neck cancer.
Misawa K, Misawa Y, Kanazawa T, Mochizuki D, Imai A, Endo S, Carey TE, Mineta H
Clinical & experimental metastasis33(2)187-95(2016 Feb)

Galanin pathogenic mutations in temporal lobe epilepsy.
Guipponi M, Chentouf A, Webling KE, Freimann K, Crespel A, Nobile C, Lemke JR, Hansen J, Dorn T, Lesca G, Ryvlin P, Hirsch E, Rudolf G, Rosenberg DS, Weber Y, Becker F, Helbig I, Muhle H, Salzmann A, Chaouch M, Oubaiche ML, Ziglio S, Gehrig C, Santoni F, Pizzato M, Langel ?, Antonarakis SE
Human molecular genetics24(11)3082-91(2015 Jun)

Brain galanin system genes interact with life stresses in depression-related phenotypes.
Juhasz G, Hullam G, Eszlari N, Gonda X, Antal P, Anderson IM, H?kfelt TG, Deakin JF, Bagdy G
Proceedings of the National Academy of Sciences of the United States of America111(16)E1666-73(2014 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study provides evidence that GAL and GALR1/2 genes were identified as aberrantly methylated in head and neck squamous cell carcinoma.
Title: Site-specific methylation patterns of the GAL and GALR1/2 genes in head and neck cancer: Potential utility as biomarkers for prognosis.

GAL and its receptors, GALR1 and GALR2, play a role in head and neck squamous cell carcinoma tumorigenesis
Title: Epigenetic inactivation of galanin and GALR1/2 is associated with early recurrence in head and neck cancer.

The G protein-coupled receptor GALR2 promotes angiogenesis in head and neck cancer
Title: The G protein-coupled receptor GALR2 promotes angiogenesis in head and neck cancer.

Variants in genes for galanin (GAL) and its receptors (GALR1, GALR2, GALR3), despite their disparate genomic loci, conferred increased risk of depression and anxiety in people who experienced childhood adversity or recent negative life events.
Title: Brain galanin system genes interact with life stresses in depression-related phenotypes.

Activation of GalR2 leads to elevation of intracellular Ca(2+) due to Ca(2+) efflux from endoplasmic reticulum through IP3R sequentially opening BK alpha channels.
Title: Activation of galanin receptor 2 stimulates large conductance Ca(2+)-dependent K(+) (BK) channels through the IP3 pathway in human embryonic kidney (HEK293) cells.

The following GALR2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GALR2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11374	NM_003857.4 Latest version!	Homo sapiens galanin receptor 2 (GALR2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu62210	XM_011525427.3 Latest version!	Homo sapiens galanin receptor 2 (GALR2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu62210	XM_011525427.2	Homo sapiens galanin receptor 2 (GALR2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu11374	NM_003857.3	Homo sapiens galanin receptor 2 (GALR2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GALR2 ( NM_003857.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003848.1 Homo sapiens galanin receptor 2 (GALR2), mRNA.

Price & Availability↑

CloneID	OHu11374
Clone ID Related Accession (Same CDS sequence)	NM_003857.4 , NM_003857.3
Accession Version	NM_003857.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1164bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	galanin receptor type 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC018665.9, BC069130.1 and BU631750.1. On Nov 23, 2018 this sequence version replaced NM_003857.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279871.164.1, BC069130.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000329003.4/ ENSP00000329684.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAACGTCT CGGGCTGCCC AGGGGCCGGG AACGCGAGCC AGGCGGGCGG CGGGGGAGGC 
TGGCACCCCG AGGCGGTCAT CGTGCCCCTG CTCTTCGCGC TCATCTTCCT CGTGGGCACC 
GTGGGCAACA CGCTGGTGCT GGCGGTGCTG CTGCGCGGCG GCCAGGCGGT CAGCACTACC 
AACCTGTTCA TCCTTAACCT GGGCGTGGCC GACCTGTGTT TCATCCTGTG CTGCGTGCCC 
TTCCAGGCCA CCATCTACAC CCTGGACGGC TGGGTGTTCG GCTCGCTGCT GTGCAAGGCG 
GTGCACTTCC TCATCTTCCT CACCATGCAC GCCAGCAGCT TCACGCTGGC CGCCGTCTCC 
CTGGACAGGT ATCTGGCCAT CCGCTACCCG CTGCACTCCC GCGAGCTGCG CACGCCTCGA 
AACGCGCTGG CAGCCATCGG GCTCATCTGG GGGCTGTCGC TGCTCTTCTC CGGGCCCTAC 
CTGAGCTACT ACCGCCAGTC GCAGCTGGCC AACCTGACCG TGTGCCATCC CGCGTGGAGC 
GCCCCTCGCC GCCGCGCCAT GGACATCTGC ACCTTCGTCT TCAGCTACCT GCTTCCTGTG 
CTGGTTCTCG GCCTGACCTA CGCGCGCACC TTGCGCTACC TCTGGCGCGC CGTCGACCCG 
GTGGCCGCGG GCTCGGGTGC CCGGCGCGCC AAGCGCAAGG TGACACGCAT GATCCTCATC 
GTGGCCGCGC TCTTCTGCCT CTGCTGGATG CCCCACCACG CGCTCATCCT CTGCGTGTGG 
TTCGGCCAGT TCCCGCTCAC GCGCGCCACT TATGCGCTTC GCATCCTCTC GCACCTGGTC 
TCCTACGCCA ACTCCTGCGT CAACCCCATC GTTTACGCGC TGGTCTCCAA GCACTTCCGC 
AAAGGCTTCC GCACGATCTG CGCGGGCCTG CTGGGCCGTG CCCCAGGCCG AGCCTCGGGC 
CGTGTGTGCG CTGCCGCGCG GGGCACCCAC AGTGGCAGCG TGTTGGAGCG CGAGTCCAGC 
GACCTGTTGC ACATGAGCGA GGCGGCGGGG GCCCTTCGTC CCTGCCCCGG CGCTTCCCAG 
CCATGCATCC TCGAGCCCTG TCCTGGCCCG TCCTGGCAGG GCCCAAAGGC AGGCGACAGC 
ATCCTGACGG TTGATGTGGC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003848.1
CDS	104..1267
Translation	MNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA

Target ORF information:

RefSeq Version	NM_003857.4
Organism	Homo sapiens(human)
Definition	Homo sapiens galanin receptor 2 (GALR2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003857.4

ORF Insert Sequence:

ATGAACGTCT CGGGCTGCCC AGGGGCCGGG AACGCGAGCC AGGCGGGCGG CGGGGGAGGC 
TGGCACCCCG AGGCGGTCAT CGTGCCCCTG CTCTTCGCGC TCATCTTCCT CGTGGGCACC 
GTGGGCAACA CGCTGGTGCT GGCGGTGCTG CTGCGCGGCG GCCAGGCGGT CAGCACTACC 
AACCTGTTCA TCCTTAACCT GGGCGTGGCC GACCTGTGTT TCATCCTGTG CTGCGTGCCC 
TTCCAGGCCA CCATCTACAC CCTGGACGGC TGGGTGTTCG GCTCGCTGCT GTGCAAGGCG 
GTGCACTTCC TCATCTTCCT CACCATGCAC GCCAGCAGCT TCACGCTGGC CGCCGTCTCC 
CTGGACAGGT ATCTGGCCAT CCGCTACCCG CTGCACTCCC GCGAGCTGCG CACGCCTCGA 
AACGCGCTGG CAGCCATCGG GCTCATCTGG GGGCTGTCGC TGCTCTTCTC CGGGCCCTAC 
CTGAGCTACT ACCGCCAGTC GCAGCTGGCC AACCTGACCG TGTGCCATCC CGCGTGGAGC 
GCCCCTCGCC GCCGCGCCAT GGACATCTGC ACCTTCGTCT TCAGCTACCT GCTTCCTGTG 
CTGGTTCTCG GCCTGACCTA CGCGCGCACC TTGCGCTACC TCTGGCGCGC CGTCGACCCG 
GTGGCCGCGG GCTCGGGTGC CCGGCGCGCC AAGCGCAAGG TGACACGCAT GATCCTCATC 
GTGGCCGCGC TCTTCTGCCT CTGCTGGATG CCCCACCACG CGCTCATCCT CTGCGTGTGG 
TTCGGCCAGT TCCCGCTCAC GCGCGCCACT TATGCGCTTC GCATCCTCTC GCACCTGGTC 
TCCTACGCCA ACTCCTGCGT CAACCCCATC GTTTACGCGC TGGTCTCCAA GCACTTCCGC 
AAAGGCTTCC GCACGATCTG CGCGGGCCTG CTGGGCCGTG CCCCAGGCCG AGCCTCGGGC 
CGTGTGTGCG CTGCCGCGCG GGGCACCCAC AGTGGCAGCG TGTTGGAGCG CGAGTCCAGC 
GACCTGTTGC ACATGAGCGA GGCGGCGGGG GCCCTTCGTC CCTGCCCCGG CGCTTCCCAG 
CCATGCATCC TCGAGCCCTG TCCTGGCCCG TCCTGGCAGG GCCCAAAGGC AGGCGACAGC 
ATCCTGACGG TTGATGTGGC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GALR2 ( NM_003857.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003848.1 Homo sapiens galanin receptor 2 (GALR2), mRNA.

Price & Availability↑

CloneID	OHu11374
Clone ID Related Accession (Same CDS sequence)	NM_003857.4 , NM_003857.3
Accession Version	NM_003857.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1164bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-10
Organism	Homo sapiens(human)
Product	galanin receptor type 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC018665.9, BC069130.1 and BU631750.1. On Sep 12, 2013 this sequence version replaced NM_003857.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279871.164.1, BC069130.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACGTCT CGGGCTGCCC AGGGGCCGGG AACGCGAGCC AGGCGGGCGG CGGGGGAGGC 
TGGCACCCCG AGGCGGTCAT CGTGCCCCTG CTCTTCGCGC TCATCTTCCT CGTGGGCACC 
GTGGGCAACA CGCTGGTGCT GGCGGTGCTG CTGCGCGGCG GCCAGGCGGT CAGCACTACC 
AACCTGTTCA TCCTTAACCT GGGCGTGGCC GACCTGTGTT TCATCCTGTG CTGCGTGCCC 
TTCCAGGCCA CCATCTACAC CCTGGACGGC TGGGTGTTCG GCTCGCTGCT GTGCAAGGCG 
GTGCACTTCC TCATCTTCCT CACCATGCAC GCCAGCAGCT TCACGCTGGC CGCCGTCTCC 
CTGGACAGGT ATCTGGCCAT CCGCTACCCG CTGCACTCCC GCGAGCTGCG CACGCCTCGA 
AACGCGCTGG CAGCCATCGG GCTCATCTGG GGGCTGTCGC TGCTCTTCTC CGGGCCCTAC 
CTGAGCTACT ACCGCCAGTC GCAGCTGGCC AACCTGACCG TGTGCCATCC CGCGTGGAGC 
GCCCCTCGCC GCCGCGCCAT GGACATCTGC ACCTTCGTCT TCAGCTACCT GCTTCCTGTG 
CTGGTTCTCG GCCTGACCTA CGCGCGCACC TTGCGCTACC TCTGGCGCGC CGTCGACCCG 
GTGGCCGCGG GCTCGGGTGC CCGGCGCGCC AAGCGCAAGG TGACACGCAT GATCCTCATC 
GTGGCCGCGC TCTTCTGCCT CTGCTGGATG CCCCACCACG CGCTCATCCT CTGCGTGTGG 
TTCGGCCAGT TCCCGCTCAC GCGCGCCACT TATGCGCTTC GCATCCTCTC GCACCTGGTC 
TCCTACGCCA ACTCCTGCGT CAACCCCATC GTTTACGCGC TGGTCTCCAA GCACTTCCGC 
AAAGGCTTCC GCACGATCTG CGCGGGCCTG CTGGGCCGTG CCCCAGGCCG AGCCTCGGGC 
CGTGTGTGCG CTGCCGCGCG GGGCACCCAC AGTGGCAGCG TGTTGGAGCG CGAGTCCAGC 
GACCTGTTGC ACATGAGCGA GGCGGCGGGG GCCCTTCGTC CCTGCCCCGG CGCTTCCCAG 
CCATGCATCC TCGAGCCCTG TCCTGGCCCG TCCTGGCAGG GCCCAAAGGC AGGCGACAGC 
ATCCTGACGG TTGATGTGGC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003848.1
CDS	84..1247
Translation	MNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA

Target ORF information:

RefSeq Version	NM_003857.3
Organism	Homo sapiens(human)
Definition	Homo sapiens galanin receptor 2 (GALR2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003857.3

ORF Insert Sequence:

ATGAACGTCT CGGGCTGCCC AGGGGCCGGG AACGCGAGCC AGGCGGGCGG CGGGGGAGGC 
TGGCACCCCG AGGCGGTCAT CGTGCCCCTG CTCTTCGCGC TCATCTTCCT CGTGGGCACC 
GTGGGCAACA CGCTGGTGCT GGCGGTGCTG CTGCGCGGCG GCCAGGCGGT CAGCACTACC 
AACCTGTTCA TCCTTAACCT GGGCGTGGCC GACCTGTGTT TCATCCTGTG CTGCGTGCCC 
TTCCAGGCCA CCATCTACAC CCTGGACGGC TGGGTGTTCG GCTCGCTGCT GTGCAAGGCG 
GTGCACTTCC TCATCTTCCT CACCATGCAC GCCAGCAGCT TCACGCTGGC CGCCGTCTCC 
CTGGACAGGT ATCTGGCCAT CCGCTACCCG CTGCACTCCC GCGAGCTGCG CACGCCTCGA 
AACGCGCTGG CAGCCATCGG GCTCATCTGG GGGCTGTCGC TGCTCTTCTC CGGGCCCTAC 
CTGAGCTACT ACCGCCAGTC GCAGCTGGCC AACCTGACCG TGTGCCATCC CGCGTGGAGC 
GCCCCTCGCC GCCGCGCCAT GGACATCTGC ACCTTCGTCT TCAGCTACCT GCTTCCTGTG 
CTGGTTCTCG GCCTGACCTA CGCGCGCACC TTGCGCTACC TCTGGCGCGC CGTCGACCCG 
GTGGCCGCGG GCTCGGGTGC CCGGCGCGCC AAGCGCAAGG TGACACGCAT GATCCTCATC 
GTGGCCGCGC TCTTCTGCCT CTGCTGGATG CCCCACCACG CGCTCATCCT CTGCGTGTGG 
TTCGGCCAGT TCCCGCTCAC GCGCGCCACT TATGCGCTTC GCATCCTCTC GCACCTGGTC 
TCCTACGCCA ACTCCTGCGT CAACCCCATC GTTTACGCGC TGGTCTCCAA GCACTTCCGC 
AAAGGCTTCC GCACGATCTG CGCGGGCCTG CTGGGCCGTG CCCCAGGCCG AGCCTCGGGC 
CGTGTGTGCG CTGCCGCGCG GGGCACCCAC AGTGGCAGCG TGTTGGAGCG CGAGTCCAGC 
GACCTGTTGC ACATGAGCGA GGCGGCGGGG GCCCTTCGTC CCTGCCCCGG CGCTTCCCAG 
CCATGCATCC TCGAGCCCTG TCCTGGCCCG TCCTGGCAGG GCCCAAAGGC AGGCGACAGC 
ATCCTGACGG TTGATGTGGC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GALR2 ( XM_011525427.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011523729.1 Homo sapiens galanin receptor 2 (GALR2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu62210
Clone ID Related Accession (Same CDS sequence)	XM_011525427.2 , XM_011525427.3
Accession Version	XM_011525427.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	galanin receptor type 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011525427.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCCAA AGACAGAGCC TGACACAATA GATGCTCAGT ATATTGGATT GAATTGGAGG 
GAAAACGTTC AATGGGCCAC CATCTACACC CTGGACGGCT GGGTGTTCGG CTCGCTGCTG 
TGCAAGGCGG TGCACTTCCT CATCTTCCTC ACCATGCACG CCAGCAGCTT CACGCTGGCC 
GCCGTCTCCC TGGACAGGTA TCTGGCCATC CGCTACCCGC TGCACTCCCG CGAGCTGCGC 
ACGCCTCGAA ACGCGCTGGC AGCCATCGGG CTCATCTGGG GGCTGTCGCT GCTCTTCTCC 
GGGCCCTACC TGAGCTACTA CCGCCAGTCG CAGCTGGCCA ACCTGACCGT GTGCCATCCC 
GCGTGGAGCG CCCCTCGCCG CCGCGCCATG GACATCTGCA CCTTCGTCTT CAGCTACCTG 
CTTCCTGTGC TGGTTCTCGG CCTGACCTAC GCGCGCACCT TGCGCTACCT CTGGCGCGCC 
GTCGACCCGG TGGCCGCGGG CTCGGGTGCC CGGCGCGCCA AGCGCAAGGT GACACGCATG 
ATCCTCATCG TGGCCGCGCT CTTCTGCCTC TGCTGGATGC CCCACCACGC GCTCATCCTC 
TGCGTGTGGT TCGGCCAGTT CCCGCTCACG CGCGCCACTT ATGCGCTTCG CATCCTCTCG 
CACCTGGTCT CCTACGCCAA CTCCTGCGTC AACCCCATCG TTTACGCGCT GGTCTCCAAG 
CACTTCCGCA AAGGCTTCCG CACGATCTGC GCGGGCCTGC TGGGCCGTGC CCCAGGCCGA 
GCCTCGGGCC GTGTGTGCGC TGCCGCGCGG GGCACCCACA GTGGCAGCGT GTTGGAGCGC 
GAGTCCAGCG ACCTGTTGCA CATGAGCGAG GCGGCGGGGG CCCTTCGTCC CTGCCCCGGC 
GCTTCCCAGC CATGCATCCT CGAGCCCTGT CCTGGCCCGT CCTGGCAGGG CCCAAAGGCA 
GGCGACAGCA TCCTGACGGT TGATGTGGCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011523729.1
CDS	1412..2404
Translation	MEPKTEPDTIDAQYIGLNWRENVQWATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA

Target ORF information:

RefSeq Version	XM_011525427.2
Organism	Homo sapiens(human)
Definition	Homo sapiens galanin receptor 2 (GALR2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011525427.2

ORF Insert Sequence:

ATGGAGCCAA AGACAGAGCC TGACACAATA GATGCTCAGT ATATTGGATT GAATTGGAGG 
GAAAACGTTC AATGGGCCAC CATCTACACC CTGGACGGCT GGGTGTTCGG CTCGCTGCTG 
TGCAAGGCGG TGCACTTCCT CATCTTCCTC ACCATGCACG CCAGCAGCTT CACGCTGGCC 
GCCGTCTCCC TGGACAGGTA TCTGGCCATC CGCTACCCGC TGCACTCCCG CGAGCTGCGC 
ACGCCTCGAA ACGCGCTGGC AGCCATCGGG CTCATCTGGG GGCTGTCGCT GCTCTTCTCC 
GGGCCCTACC TGAGCTACTA CCGCCAGTCG CAGCTGGCCA ACCTGACCGT GTGCCATCCC 
GCGTGGAGCG CCCCTCGCCG CCGCGCCATG GACATCTGCA CCTTCGTCTT CAGCTACCTG 
CTTCCTGTGC TGGTTCTCGG CCTGACCTAC GCGCGCACCT TGCGCTACCT CTGGCGCGCC 
GTCGACCCGG TGGCCGCGGG CTCGGGTGCC CGGCGCGCCA AGCGCAAGGT GACACGCATG 
ATCCTCATCG TGGCCGCGCT CTTCTGCCTC TGCTGGATGC CCCACCACGC GCTCATCCTC 
TGCGTGTGGT TCGGCCAGTT CCCGCTCACG CGCGCCACTT ATGCGCTTCG CATCCTCTCG 
CACCTGGTCT CCTACGCCAA CTCCTGCGTC AACCCCATCG TTTACGCGCT GGTCTCCAAG 
CACTTCCGCA AAGGCTTCCG CACGATCTGC GCGGGCCTGC TGGGCCGTGC CCCAGGCCGA 
GCCTCGGGCC GTGTGTGCGC TGCCGCGCGG GGCACCCACA GTGGCAGCGT GTTGGAGCGC 
GAGTCCAGCG ACCTGTTGCA CATGAGCGAG GCGGCGGGGG CCCTTCGTCC CTGCCCCGGC 
GCTTCCCAGC CATGCATCCT CGAGCCCTGT CCTGGCCCGT CCTGGCAGGG CCCAAAGGCA 
GGCGACAGCA TCCTGACGGT TGATGTGGCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GALR2 ( XM_011525427.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011523729.1 Homo sapiens galanin receptor 2 (GALR2), transcript variant X1, mRNA.

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CloneID	OHu62210
Clone ID Related Accession (Same CDS sequence)	XM_011525427.2 , XM_011525427.3
Accession Version	XM_011525427.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	galanin receptor type 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011525427.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCCAA AGACAGAGCC TGACACAATA GATGCTCAGT ATATTGGATT GAATTGGAGG 
GAAAACGTTC AATGGGCCAC CATCTACACC CTGGACGGCT GGGTGTTCGG CTCGCTGCTG 
TGCAAGGCGG TGCACTTCCT CATCTTCCTC ACCATGCACG CCAGCAGCTT CACGCTGGCC 
GCCGTCTCCC TGGACAGGTA TCTGGCCATC CGCTACCCGC TGCACTCCCG CGAGCTGCGC 
ACGCCTCGAA ACGCGCTGGC AGCCATCGGG CTCATCTGGG GGCTGTCGCT GCTCTTCTCC 
GGGCCCTACC TGAGCTACTA CCGCCAGTCG CAGCTGGCCA ACCTGACCGT GTGCCATCCC 
GCGTGGAGCG CCCCTCGCCG CCGCGCCATG GACATCTGCA CCTTCGTCTT CAGCTACCTG 
CTTCCTGTGC TGGTTCTCGG CCTGACCTAC GCGCGCACCT TGCGCTACCT CTGGCGCGCC 
GTCGACCCGG TGGCCGCGGG CTCGGGTGCC CGGCGCGCCA AGCGCAAGGT GACACGCATG 
ATCCTCATCG TGGCCGCGCT CTTCTGCCTC TGCTGGATGC CCCACCACGC GCTCATCCTC 
TGCGTGTGGT TCGGCCAGTT CCCGCTCACG CGCGCCACTT ATGCGCTTCG CATCCTCTCG 
CACCTGGTCT CCTACGCCAA CTCCTGCGTC AACCCCATCG TTTACGCGCT GGTCTCCAAG 
CACTTCCGCA AAGGCTTCCG CACGATCTGC GCGGGCCTGC TGGGCCGTGC CCCAGGCCGA 
GCCTCGGGCC GTGTGTGCGC TGCCGCGCGG GGCACCCACA GTGGCAGCGT GTTGGAGCGC 
GAGTCCAGCG ACCTGTTGCA CATGAGCGAG GCGGCGGGGG CCCTTCGTCC CTGCCCCGGC 
GCTTCCCAGC CATGCATCCT CGAGCCCTGT CCTGGCCCGT CCTGGCAGGG CCCAAAGGCA 
GGCGACAGCA TCCTGACGGT TGATGTGGCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011523729.1
CDS	1410..2402
Translation	MEPKTEPDTIDAQYIGLNWRENVQWATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA

Target ORF information:

RefSeq Version	XM_011525427.3
Organism	Homo sapiens(human)
Definition	Homo sapiens galanin receptor 2 (GALR2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011525427.3

ORF Insert Sequence:

ATGGAGCCAA AGACAGAGCC TGACACAATA GATGCTCAGT ATATTGGATT GAATTGGAGG 
GAAAACGTTC AATGGGCCAC CATCTACACC CTGGACGGCT GGGTGTTCGG CTCGCTGCTG 
TGCAAGGCGG TGCACTTCCT CATCTTCCTC ACCATGCACG CCAGCAGCTT CACGCTGGCC 
GCCGTCTCCC TGGACAGGTA TCTGGCCATC CGCTACCCGC TGCACTCCCG CGAGCTGCGC 
ACGCCTCGAA ACGCGCTGGC AGCCATCGGG CTCATCTGGG GGCTGTCGCT GCTCTTCTCC 
GGGCCCTACC TGAGCTACTA CCGCCAGTCG CAGCTGGCCA ACCTGACCGT GTGCCATCCC 
GCGTGGAGCG CCCCTCGCCG CCGCGCCATG GACATCTGCA CCTTCGTCTT CAGCTACCTG 
CTTCCTGTGC TGGTTCTCGG CCTGACCTAC GCGCGCACCT TGCGCTACCT CTGGCGCGCC 
GTCGACCCGG TGGCCGCGGG CTCGGGTGCC CGGCGCGCCA AGCGCAAGGT GACACGCATG 
ATCCTCATCG TGGCCGCGCT CTTCTGCCTC TGCTGGATGC CCCACCACGC GCTCATCCTC 
TGCGTGTGGT TCGGCCAGTT CCCGCTCACG CGCGCCACTT ATGCGCTTCG CATCCTCTCG 
CACCTGGTCT CCTACGCCAA CTCCTGCGTC AACCCCATCG TTTACGCGCT GGTCTCCAAG 
CACTTCCGCA AAGGCTTCCG CACGATCTGC GCGGGCCTGC TGGGCCGTGC CCCAGGCCGA 
GCCTCGGGCC GTGTGTGCGC TGCCGCGCGG GGCACCCACA GTGGCAGCGT GTTGGAGCGC 
GAGTCCAGCG ACCTGTTGCA CATGAGCGAG GCGGCGGGGG CCCTTCGTCC CTGCCCCGGC 
GCTTCCCAGC CATGCATCCT CGAGCCCTGT CCTGGCCCGT CCTGGCAGGG CCCAAAGGCA 
GGCGACAGCA TCCTGACGGT TGATGTGGCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.
The Journal of cell biology216(3)743-760(2017 Mar)
Badgandi HB,Hwang SH,Shimada IS,Loriot E,Mukhopadhyay S

Site-specific methylation patterns of the GAL and GALR1/2 genes in head and neck cancer: Potential utility as biomarkers for prognosis.
Molecular carcinogenesis56(3)1107-1116(2017 Mar)
Misawa K,Mochizuki D,Endo S,Mima M,Misawa Y,Imai A,Shinmura K,Kanazawa T,Carey TE,Mineta H

Epigenetic inactivation of galanin and GALR1/2 is associated with early recurrence in head and neck cancer.
Clinical & experimental metastasis33(2)187-95(2016 Feb)
Misawa K,Misawa Y,Kanazawa T,Mochizuki D,Imai A,Endo S,Carey TE,Mineta H

Galanin pathogenic mutations in temporal lobe epilepsy.
Human molecular genetics24(11)3082-91(2015 Jun)
Guipponi M,Chentouf A,Webling KE,Freimann K,Crespel A,Nobile C,Lemke JR,Hansen J,Dorn T,Lesca G,Ryvlin P,Hirsch E,Rudolf G,Rosenberg DS,Weber Y,Becker F,Helbig I,Muhle H,Salzmann A,Chaouch M,Oubaiche ML,Ziglio S,Gehrig C,Santoni F,Pizzato M,Langel ?,Antonarakis SE

Brain galanin system genes interact with life stresses in depression-related phenotypes.
Proceedings of the National Academy of Sciences of the United States of America111(16)E1666-73(2014 Apr)
Juhasz G,Hullam G,Eszlari N,Gonda X,Antal P,Anderson IM,H?kfelt TG,Deakin JF,Bagdy G

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GALR2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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