SUCLA2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SUCLA2
Entrez Gene ID	8803
Full Name	succinate-CoA ligase ADP-forming beta subunit
Synonyms	A-BETA,A-SCS,MTDPS5,SCS-betaA
General protein information	Preferred Names succinate-CoA ligase ADP-forming beta subunit Names succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial ATP-specific succinyl-CoA synthetase subunit beta ATP-specific succinyl-CoA synthetase, beta subunit mitochondrial succinyl-CoA ligase [ADP-forming] subunit beta renal carcinoma antigen NY-REN-39 succinate--CoA ligase (ADP-forming) succinate-CoA ligase beta subunit succinyl-CoA synthetase beta-A chain
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 13 Map Location: 13q14.2
Summary	Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq, Jul 2008].
Disorder MIM:	603921
Disorder Html:	Mitochondrial DNA depletion syndrome 5 (encephalomyopathic with or without methylmalonic aciduria), 612073 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_017020807.1	XP_016876296.1	succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial isoform X2
XM_017020809.1	XP_016876298.1	succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial isoform X4
NM_003850.2	NP_003841.1	succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial precursor
XM_017020806.1	XP_016876295.1	succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial isoform X1
XM_017020808.1	XP_016876297.1	succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial isoform X3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SUCLA2	XP_001151014.2
	SUCLA2	XP_001100026.1
Danio rerio (zebrafish)	sucla2	NP_998191.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004744	XP_318074.3
Caenorhabditis elegans (roundworm)	suca-1	NP_509821.1
Saccharomyces cerevisiae (baker's yeast)	LSC2	NP_011760.3
Kluyveromyces lactis	KLLA0A05478g	XP_451242.1
Eremothecium gossypii	AGOS_AEL211W	NP_984650.1
Bos taurus (cattle)	SUCLA2	NP_001068961.1
Gallus gallus (chicken)	SUCLA2	NP_001006271.2
Magnaporthe oryzae (rice blast fungus)	MGG_16230	XP_003709726.1
Arabidopsis thaliana (thale cress)	AT2G20420	NP_179632.1
Oryza sativa (rice)	Os02g0621700	NP_001047463.1
Rattus norvegicus (Norway rat)	Sucla2	NP_001101857.2
Homo sapiens (human)	SUCLA2	NP_003841.1
Canis lupus familiaris (dog)	SUCLA2	XP_542566.4
Mus musculus (house mouse)	Sucla2	NP_035636.1
Drosophila melanogaster (fruit fly)	skap	NP_001097713.1
Schizosaccharomyces pombe (fission yeast)	SPCC1620.08	NP_588466.1
Neurospora crassa	NCU08471	XP_963313.1
Xenopus tropicalis (tropical clawed frog)	sucla2	NP_989233.1

Gene Ontology
Bibliography

Related articles in PubMed

Co-occurring Down syndrome and SUCLA2-related mitochondrial depletion syndrome.
Couser NL, Marchuk DS, Smith LD, Arreola A, Kaiser-Rogers KA, Muenzer J, Pandya A, Gucsavas-Calikoglu M, Powell CM
American journal of medical genetics. Part A173(10)2720-2724(2017 Oct)

Expanding the phenotypic spectrum of Succinyl-CoA ligase deficiency through functional validation of a new SUCLG1 variant.
Donti TR, Masand R, Scott DA, Craigen WJ, Graham BH
Molecular genetics and metabolism119(1-2)68-74(2016 09)

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

Knockdown of Sucla2 decreases the viability of mouse spermatocytes by inducing apoptosis through injury of the mitochondrial function of cells.
Huang S, Wang J, Wang L
Folia histochemica et cytobiologica54(3)134-142(2016)

Influences of XDH genotype by gene-gene interactions with SUCLA2 for thiopurine-induced leukopenia in Korean patients with Crohn's disease.
Park SK, Hong M, Ye BD, Kim KJ, Park SH, Yang DH, Hwang SW, Kwak MS, Lee HS, Song K, Yang SK
Scandinavian journal of gastroenterology51(6)684-91(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The patient's cells lack the SUCLG1 protein, with significantly reduced levels of SUCLA2 and SUCLG2 protein
Title: Expanding the phenotypic spectrum of Succinyl-CoA ligase deficiency through functional validation of a new SUCLG1 variant.

Long survival, to age 20 years or older, was reported in 12% of SUCLA2 and in 10% of SUCLG1 patients.
Title: Succinate-CoA ligase deficiency due to mutations in SUCLA2 and SUCLG1: phenotype and genotype correlations in 71 patients.

Sucla2 is related to the developmental stages of mouse spermatogenesis. Knockdown of Sucla2 decreases the viability of mouse spermatocytes by inducing apoptosis via decreased mitochondrial function of the cells.
Title: Knockdown of Sucla2 decreases the viability of mouse spermatocytes by inducing apoptosis through injury of the mitochondrial function of cells.

XDH and SUCLA2 genes associated with thiopurine-induced leukopenia can act in a complex interactive manner in patients with Crohn's disease.
Title: Influences of XDH genotype by gene-gene interactions with SUCLA2 for thiopurine-induced leukopenia in Korean patients with Crohn's disease.

The absence of SUCLA2 and SUCLG2 in human glia is in compliance with the presence of alternative pathways occurring in these cells, namely the GABA shunt and ketone body metabolism
Title: Localization of SUCLA2 and SUCLG2 subunits of succinyl CoA ligase within the cerebral cortex suggests the absence of matrix substrate-level phosphorylation in glial cells of the human brain.

The following SUCLA2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SUCLA2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19821	NM_003850.2 Latest version!	Homo sapiens succinate-CoA ligase ADP-forming subunit beta (SUCLA2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$194.50-$272.30 $389.00
OHu62198	XM_017020809.1 Latest version!	Homo sapiens succinate-CoA ligase ADP-forming beta subunit (SUCLA2), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OHu62197	XM_017020807.1 Latest version!	Homo sapiens succinate-CoA ligase ADP-forming beta subunit (SUCLA2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu84667	XM_017020806.1 Latest version!	Homo sapiens succinate-CoA ligase ADP-forming beta subunit (SUCLA2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu84668	XM_017020808.1 Latest version!	Homo sapiens succinate-CoA ligase ADP-forming beta subunit (SUCLA2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SUCLA2 ( NM_003850.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003841.1 Homo sapiens succinate-CoA ligase ADP-forming subunit beta (SUCLA2), mRNA.

Price & Availability↑

CloneID	OHu19821
Clone ID Related Accession (Same CDS sequence)	NM_003850.2
Accession Version	NM_003850.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1392bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-26
Organism	Homo sapiens(human)
Product	succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB035863.1 and AL080096.2. This sequence is a reference standard in the RefSeqGene project. On Apr 29, 2008 this sequence version replaced NM_003850.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB035863.1, AK001847.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCCT CCATGTTCTA CGGCAGGCTA GTGGCCGTGG CCACCCTTCG GAACCACCGG 
CCTCGGACGG CCCAGCGGGC TGCTGCTCAG GTTCTGGGAA GTTCTGGATT GTTTAATAAC 
CATGGACTCC AAGTACAGCA GCAACAGCAA AGGAATCTCT CACTACATGA ATACATGAGT 
ATGGAATTAT TGCAAGAAGC TGGTGTCTCC GTTCCCAAAG GATATGTGGC AAAGTCACCA 
GATGAAGCTT ATGCAATTGC CAAAAAATTA GGTTCAAAAG ATGTCGTGAT AAAGGCACAG 
GTTTTAGCTG GTGGTAGAGG AAAAGGAACA TTTGAAAGTG GCCTCAAAGG AGGAGTGAAG 
ATAGTTTTCT CTCCAGAAGA AGCAAAAGCT GTTTCTTCAC AAATGATTGG GAAAAAATTG 
TTTACCAAGC AAACGGGAGA AAAGGGCAGA ATATGCAATC AAGTATTGGT CTGTGAGCGA 
AAATATCCCA GGAGAGAATA CTACTTTGCA ATAACAATGG AAAGGTCATT TCAAGGTCCT 
GTATTAATAG GAAGTTCACA TGGTGGTGTC AACATTGAAG ATGTTGCTGC TGAGTCTCCT 
GAAGCAATAA TTAAAGAACC TATTGATATT GAAGAAGGCA TCAAAAAGGA ACAAGCTCTC 
CAGCTTGCAC AGAAGATGGG ATTTCCACCT AATATTGTGG AATCAGCAGC AGAAAACATG 
GTCAAGCTTT ACAGCCTTTT TCTGAAATAC GATGCAACCA TGATAGAAAT AAATCCAATG 
GTGGAAGATT CAGATGGAGC TGTATTGTGT ATGGATGCAA AGATCAATTT TGACTCTAAT 
TCAGCCTATC GCCAAAAGAA AATCTTTGAT CTACAGGACT GGACCCAGGA AGATGAAAGG 
GACAAAGATG CTGCTAAGGC AAATCTCAAC TACATTGGCC TCGATGGAAA TATAGGCTGC 
CTAGTAAATG GTGCTGGTTT GGCTATGGCC ACAATGGATA TAATAAAACT TCATGGAGGG 
ACTCCAGCCA ACTTCCTTGA TGTTGGTGGT GGTGCTACAG TCCATCAAGT AACAGAAGCA 
TTTAAGCTTA TCACTTCAGA TAAAAAGGTA CTGGCTATTC TGGTCAACAT TTTTGGAGGA 
ATCATGCGCT GTGATGTTAT TGCACAGGGT ATAGTCATGG CAGTAAAAGA CTTGGAAATT 
AAAATACCTG TTGTGGTACG GTTACAAGGT ACACGAGTCG ATGATGCTAA GGCACTGATA 
GCGGACAGTG GACTTAAAAT ACTTGCTTGT GATGACTTGG ATGAAGCTGC TAGAATGGTT 
GTAAAGCTCT CTGAAATAGT GACCTTAGCG AAGCAAGCAC ATGTGGATGT GAAATTTCAG 
TTGCCAATAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003841.1
CDS	58..1449
Translation	MAASMFYGRLVAVATLRNHRPRTAQRAAAQVLGSSGLFNNHGLQVQQQQQRNLSLHEYMSMELLQEAGVSVPKGYVAKSPDEAYAIAKKLGSKDVVIKAQVLAGGRGKGTFESGLKGGVKIVFSPEEAKAVSSQMIGKKLFTKQTGEKGRICNQVLVCERKYPRREYYFAITMERSFQGPVLIGSSHGGVNIEDVAAESPEAIIKEPIDIEEGIKKEQALQLAQKMGFPPNIVESAAENMVKLYSLFLKYDATMIEINPMVEDSDGAVLCMDAKINFDSNSAYRQKKIFDLQDWTQEDERDKDAAKANLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQVTEAFKLITSDKKVLAILVNIFGGIMRCDVIAQGIVMAVKDLEIKIPVVVRLQGTRVDDAKALIADSGLKILACDDLDEAARMVVKLSEIVTLAKQAHVDVKFQLPI

Target ORF information:

RefSeq Version	NM_003850.2
Organism	Homo sapiens(human)
Definition	Homo sapiens succinate-CoA ligase ADP-forming subunit beta (SUCLA2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003850.2

ORF Insert Sequence:

ATGGCGGCCT CCATGTTCTA CGGCAGGCTA GTGGCCGTGG CCACCCTTCG GAACCACCGG 
CCTCGGACGG CCCAGCGGGC TGCTGCTCAG GTTCTGGGAA GTTCTGGATT GTTTAATAAC 
CATGGACTCC AAGTACAGCA GCAACAGCAA AGGAATCTCT CACTACATGA ATACATGAGT 
ATGGAATTAT TGCAAGAAGC TGGTGTCTCC GTTCCCAAAG GATATGTGGC AAAGTCACCA 
GATGAAGCTT ATGCAATTGC CAAAAAATTA GGTTCAAAAG ATGTCGTGAT AAAGGCACAG 
GTTTTAGCTG GTGGTAGAGG AAAAGGAACA TTTGAAAGTG GCCTCAAAGG AGGAGTGAAG 
ATAGTTTTCT CTCCAGAAGA AGCAAAAGCT GTTTCTTCAC AAATGATTGG GAAAAAATTG 
TTTACCAAGC AAACGGGAGA AAAGGGCAGA ATATGCAATC AAGTATTGGT CTGTGAGCGA 
AAATATCCCA GGAGAGAATA CTACTTTGCA ATAACAATGG AAAGGTCATT TCAAGGTCCT 
GTATTAATAG GAAGTTCACA TGGTGGTGTC AACATTGAAG ATGTTGCTGC TGAGTCTCCT 
GAAGCAATAA TTAAAGAACC TATTGATATT GAAGAAGGCA TCAAAAAGGA ACAAGCTCTC 
CAGCTTGCAC AGAAGATGGG ATTTCCACCT AATATTGTGG AATCAGCAGC AGAAAACATG 
GTCAAGCTTT ACAGCCTTTT TCTGAAATAC GATGCAACCA TGATAGAAAT AAATCCAATG 
GTGGAAGATT CAGATGGAGC TGTATTGTGT ATGGATGCAA AGATCAATTT TGACTCTAAT 
TCAGCCTATC GCCAAAAGAA AATCTTTGAT CTACAGGACT GGACCCAGGA AGATGAAAGG 
GACAAAGATG CTGCTAAGGC AAATCTCAAC TACATTGGCC TCGATGGAAA TATAGGCTGC 
CTAGTAAATG GTGCTGGTTT GGCTATGGCC ACAATGGATA TAATAAAACT TCATGGAGGG 
ACTCCAGCCA ACTTCCTTGA TGTTGGTGGT GGTGCTACAG TCCATCAAGT AACAGAAGCA 
TTTAAGCTTA TCACTTCAGA TAAAAAGGTA CTGGCTATTC TGGTCAACAT TTTTGGAGGA 
ATCATGCGCT GTGATGTTAT TGCACAGGGT ATAGTCATGG CAGTAAAAGA CTTGGAAATT 
AAAATACCTG TTGTGGTACG GTTACAAGGT ACACGAGTCG ATGATGCTAA GGCACTGATA 
GCGGACAGTG GACTTAAAAT ACTTGCTTGT GATGACTTGG ATGAAGCTGC TAGAATGGTT 
GTAAAGCTCT CTGAAATAGT GACCTTAGCG AAGCAAGCAC ATGTGGATGT GAAATTTCAG 
TTGCCAATAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SUCLA2 ( XM_017020809.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016876298.1 Homo sapiens succinate-CoA ligase ADP-forming beta subunit (SUCLA2), transcript variant X4, mRNA.

Price & Availability↑

CloneID	OHu62198
Clone ID Related Accession (Same CDS sequence)	XM_017020809.1
Accession Version	XM_017020809.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 990bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial isoform X4
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATTGGGA AAAAATTGTT TACCAAGCAA ACGGGAGAAA AGGGCAGAAT ATGCAATCAA 
GTATTGGTCT GTGAGCGAAA ATATCCCAGG AGAGAATACT ACTTTGCAAT AACAATGGAA 
AGGTCATTTC AAGGTCCTGT ATTAATAGGA AGTTCACATG GTGGTGTCAA CATTGAAGAT 
GTTGCTGCTG AGTCTCCTGA AGCAATAATT AAAGAACCTA TTGATATTGA AGAAGGCATC 
AAAAAGGAAC AAGCTCTCCA GCTTGCACAG AAGATGGGAT TTCCACCTAA TATTGTGGAA 
TCAGCAGCAG AAAACATGGT CAAGCTTTAC AGCCTTTTTC TGAAATACGA TGCAACCATG 
ATAGAAATAA ATCCAATGGT GGAAGATTCA GATGGAGCTG TATTGTGTAT GGATGCAAAG 
ATCAATTTTG ACTCTAATTC AGCCTATCGC CAAAAGAAAA TCTTTGATCT ACAGGACTGG 
ACCCAGGAAG ATGAAAGGGA CAAAGATGCT GCTAAGGCAA ATCTCAACTA CATTGGCCTC 
GATGGAAATA TAGGCTGCCT AGTAAATGGT GCTGGTTTGG CTATGGCCAC AATGGATATA 
ATAAAACTTC ATGGAGGGAC TCCAGCCAAC TTCCTTGATG TTGGTGGTGG TGCTACAGTC 
CATCAAGTAA CAGAAGCATT TAAGCTTATC ACTTCAGATA AAAAGGTACT GGCTATTCTG 
GTCAACATTT TTGGAGGAAT CATGCGCTGT GATGTTATTG CACAGGGTAT AGTCATGGCA 
GTAAAAGACT TGGAAATTAA AATACCTGTT GTGGTACGGT TACAAGGTAC ACGAGTCGAT 
GATGCTAAGG CACTGATAGC GGACAGTGGA CTTAAAATAC TTGCTTGTGA TGACTTGGAT 
GAAGCTGCTA GAATGGTTGT AAAGCTCTCT GAAATAGTGA CCTTAGCGAA GCAAGCACAT 
GTGGATGTGA AATTTCAGTT GCCAATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016876298.1
CDS	544..1533
Translation	MIGKKLFTKQTGEKGRICNQVLVCERKYPRREYYFAITMERSFQGPVLIGSSHGGVNIEDVAAESPEAIIKEPIDIEEGIKKEQALQLAQKMGFPPNIVESAAENMVKLYSLFLKYDATMIEINPMVEDSDGAVLCMDAKINFDSNSAYRQKKIFDLQDWTQEDERDKDAAKANLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQVTEAFKLITSDKKVLAILVNIFGGIMRCDVIAQGIVMAVKDLEIKIPVVVRLQGTRVDDAKALIADSGLKILACDDLDEAARMVVKLSEIVTLAKQAHVDVKFQLPI

Target ORF information:

RefSeq Version	XM_017020809.1
Organism	Homo sapiens(human)
Definition	Homo sapiens succinate-CoA ligase ADP-forming beta subunit (SUCLA2), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017020809.1

ORF Insert Sequence:

ATGATTGGGA AAAAATTGTT TACCAAGCAA ACGGGAGAAA AGGGCAGAAT ATGCAATCAA 
GTATTGGTCT GTGAGCGAAA ATATCCCAGG AGAGAATACT ACTTTGCAAT AACAATGGAA 
AGGTCATTTC AAGGTCCTGT ATTAATAGGA AGTTCACATG GTGGTGTCAA CATTGAAGAT 
GTTGCTGCTG AGTCTCCTGA AGCAATAATT AAAGAACCTA TTGATATTGA AGAAGGCATC 
AAAAAGGAAC AAGCTCTCCA GCTTGCACAG AAGATGGGAT TTCCACCTAA TATTGTGGAA 
TCAGCAGCAG AAAACATGGT CAAGCTTTAC AGCCTTTTTC TGAAATACGA TGCAACCATG 
ATAGAAATAA ATCCAATGGT GGAAGATTCA GATGGAGCTG TATTGTGTAT GGATGCAAAG 
ATCAATTTTG ACTCTAATTC AGCCTATCGC CAAAAGAAAA TCTTTGATCT ACAGGACTGG 
ACCCAGGAAG ATGAAAGGGA CAAAGATGCT GCTAAGGCAA ATCTCAACTA CATTGGCCTC 
GATGGAAATA TAGGCTGCCT AGTAAATGGT GCTGGTTTGG CTATGGCCAC AATGGATATA 
ATAAAACTTC ATGGAGGGAC TCCAGCCAAC TTCCTTGATG TTGGTGGTGG TGCTACAGTC 
CATCAAGTAA CAGAAGCATT TAAGCTTATC ACTTCAGATA AAAAGGTACT GGCTATTCTG 
GTCAACATTT TTGGAGGAAT CATGCGCTGT GATGTTATTG CACAGGGTAT AGTCATGGCA 
GTAAAAGACT TGGAAATTAA AATACCTGTT GTGGTACGGT TACAAGGTAC ACGAGTCGAT 
GATGCTAAGG CACTGATAGC GGACAGTGGA CTTAAAATAC TTGCTTGTGA TGACTTGGAT 
GAAGCTGCTA GAATGGTTGT AAAGCTCTCT GAAATAGTGA CCTTAGCGAA GCAAGCACAT 
GTGGATGTGA AATTTCAGTT GCCAATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SUCLA2 ( XM_017020807.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016876296.1 Homo sapiens succinate-CoA ligase ADP-forming beta subunit (SUCLA2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu62197
Clone ID Related Accession (Same CDS sequence)	XM_017020807.1
Accession Version	XM_017020807.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1155bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATGAATT CTATGGCGGA AAGAAGTGTA GTAGGTTCAA AAGATGTCGT GATAAAGGCA 
CAGGTTTTAG CTGGTGGTAG AGGAAAAGGA ACATTTGAAA GTGGCCTCAA AGGAGGAGTG 
AAGATAGTTT TCTCTCCAGA AGAAGCAAAA GCTGTTTCTT CACAAATGAT TGGGAAAAAA 
TTGTTTACCA AGCAAACGGG AGAAAAGGGC AGAATATGCA ATCAAGTATT GGTCTGTGAG 
CGAAAATATC CCAGGAGAGA ATACTACTTT GCAATAACAA TGGAAAGGTC ATTTCAAGGT 
CCTGTATTAA TAGGAAGTTC ACATGGTGGT GTCAACATTG AAGATGTTGC TGCTGAGTCT 
CCTGAAGCAA TAATTAAAGA ACCTATTGAT ATTGAAGAAG GCATCAAAAA GGAACAAGCT 
CTCCAGCTTG CACAGAAGAT GGGATTTCCA CCTAATATTG TGGAATCAGC AGCAGAAAAC 
ATGGTCAAGC TTTACAGCCT TTTTCTGAAA TACGATGCAA CCATGATAGA AATAAATCCA 
ATGGTGGAAG ATTCAGATGG AGCTGTATTG TGTATGGATG CAAAGATCAA TTTTGACTCT 
AATTCAGCCT ATCGCCAAAA GAAAATCTTT GATCTACAGG ACTGGACCCA GGAAGATGAA 
AGGGACAAAG ATGCTGCTAA GGCAAATCTC AACTACATTG GCCTCGATGG AAATATAGGC 
TGCCTAGTAA ATGGTGCTGG TTTGGCTATG GCCACAATGG ATATAATAAA ACTTCATGGA 
GGGACTCCAG CCAACTTCCT TGATGTTGGT GGTGGTGCTA CAGTCCATCA AGTAACAGAA 
GCATTTAAGC TTATCACTTC AGATAAAAAG GTACTGGCTA TTCTGGTCAA CATTTTTGGA 
GGAATCATGC GCTGTGATGT TATTGCACAG GGTATAGTCA TGGCAGTAAA AGACTTGGAA 
ATTAAAATAC CTGTTGTGGT ACGGTTACAA GGTACACGAG TCGATGATGC TAAGGCACTG 
ATAGCGGACA GTGGACTTAA AATACTTGCT TGTGATGACT TGGATGAAGC TGCTAGAATG 
GTTGTAAAGC TCTCTGAAAT AGTGACCTTA GCGAAGCAAG CACATGTGGA TGTGAAATTT 
CAGTTGCCAA TATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016876296.1
CDS	530..1684
Translation	MMNSMAERSVVGSKDVVIKAQVLAGGRGKGTFESGLKGGVKIVFSPEEAKAVSSQMIGKKLFTKQTGEKGRICNQVLVCERKYPRREYYFAITMERSFQGPVLIGSSHGGVNIEDVAAESPEAIIKEPIDIEEGIKKEQALQLAQKMGFPPNIVESAAENMVKLYSLFLKYDATMIEINPMVEDSDGAVLCMDAKINFDSNSAYRQKKIFDLQDWTQEDERDKDAAKANLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQVTEAFKLITSDKKVLAILVNIFGGIMRCDVIAQGIVMAVKDLEIKIPVVVRLQGTRVDDAKALIADSGLKILACDDLDEAARMVVKLSEIVTLAKQAHVDVKFQLPI

Target ORF information:

RefSeq Version	XM_017020807.1
Organism	Homo sapiens(human)
Definition	Homo sapiens succinate-CoA ligase ADP-forming beta subunit (SUCLA2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017020807.1

ORF Insert Sequence:

ATGATGAATT CTATGGCGGA AAGAAGTGTA GTAGGTTCAA AAGATGTCGT GATAAAGGCA 
CAGGTTTTAG CTGGTGGTAG AGGAAAAGGA ACATTTGAAA GTGGCCTCAA AGGAGGAGTG 
AAGATAGTTT TCTCTCCAGA AGAAGCAAAA GCTGTTTCTT CACAAATGAT TGGGAAAAAA 
TTGTTTACCA AGCAAACGGG AGAAAAGGGC AGAATATGCA ATCAAGTATT GGTCTGTGAG 
CGAAAATATC CCAGGAGAGA ATACTACTTT GCAATAACAA TGGAAAGGTC ATTTCAAGGT 
CCTGTATTAA TAGGAAGTTC ACATGGTGGT GTCAACATTG AAGATGTTGC TGCTGAGTCT 
CCTGAAGCAA TAATTAAAGA ACCTATTGAT ATTGAAGAAG GCATCAAAAA GGAACAAGCT 
CTCCAGCTTG CACAGAAGAT GGGATTTCCA CCTAATATTG TGGAATCAGC AGCAGAAAAC 
ATGGTCAAGC TTTACAGCCT TTTTCTGAAA TACGATGCAA CCATGATAGA AATAAATCCA 
ATGGTGGAAG ATTCAGATGG AGCTGTATTG TGTATGGATG CAAAGATCAA TTTTGACTCT 
AATTCAGCCT ATCGCCAAAA GAAAATCTTT GATCTACAGG ACTGGACCCA GGAAGATGAA 
AGGGACAAAG ATGCTGCTAA GGCAAATCTC AACTACATTG GCCTCGATGG AAATATAGGC 
TGCCTAGTAA ATGGTGCTGG TTTGGCTATG GCCACAATGG ATATAATAAA ACTTCATGGA 
GGGACTCCAG CCAACTTCCT TGATGTTGGT GGTGGTGCTA CAGTCCATCA AGTAACAGAA 
GCATTTAAGC TTATCACTTC AGATAAAAAG GTACTGGCTA TTCTGGTCAA CATTTTTGGA 
GGAATCATGC GCTGTGATGT TATTGCACAG GGTATAGTCA TGGCAGTAAA AGACTTGGAA 
ATTAAAATAC CTGTTGTGGT ACGGTTACAA GGTACACGAG TCGATGATGC TAAGGCACTG 
ATAGCGGACA GTGGACTTAA AATACTTGCT TGTGATGACT TGGATGAAGC TGCTAGAATG 
GTTGTAAAGC TCTCTGAAAT AGTGACCTTA GCGAAGCAAG CACATGTGGA TGTGAAATTT 
CAGTTGCCAA TATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SUCLA2 ( XM_017020806.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016876295.1 Homo sapiens succinate-CoA ligase ADP-forming beta subunit (SUCLA2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu84667
Clone ID Related Accession (Same CDS sequence)	XM_017020806.1
Accession Version	XM_017020806.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1218bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTATGG AATTATTGCA AGAAGCTGGT GTCTCCGTTC CCAAAGGATA TGTGGCAAAG 
TCACCAGATG AAGCTTATGC AATTGCCAAA AAATTAGGTT CAAAAGATGT CGTGATAAAG 
GCACAGGTTT TAGCTGGTGG TAGAGGAAAA GGAACATTTG AAAGTGGCCT CAAAGGAGGA 
GTGAAGATAG TTTTCTCTCC AGAAGAAGCA AAAGCTGTTT CTTCACAAAT GATTGGGAAA 
AAATTGTTTA CCAAGCAAAC GGGAGAAAAG GGCAGAATAT GCAATCAAGT ATTGGTCTGT 
GAGCGAAAAT ATCCCAGGAG AGAATACTAC TTTGCAATAA CAATGGAAAG GTCATTTCAA 
GGTCCTGTAT TAATAGGAAG TTCACATGGT GGTGTCAACA TTGAAGATGT TGCTGCTGAG 
TCTCCTGAAG CAATAATTAA AGAACCTATT GATATTGAAG AAGGCATCAA AAAGGAACAA 
GCTCTCCAGC TTGCACAGAA GATGGGATTT CCACCTAATA TTGTGGAATC AGCAGCAGAA 
AACATGGTCA AGCTTTACAG CCTTTTTCTG AAATACGATG CAACCATGAT AGAAATAAAT 
CCAATGGTGG AAGATTCAGA TGGAGCTGTA TTGTGTATGG ATGCAAAGAT CAATTTTGAC 
TCTAATTCAG CCTATCGCCA AAAGAAAATC TTTGATCTAC AGGACTGGAC CCAGGAAGAT 
GAAAGGGACA AAGATGCTGC TAAGGCAAAT CTCAACTACA TTGGCCTCGA TGGAAATATA 
GGCTGCCTAG TAAATGGTGC TGGTTTGGCT ATGGCCACAA TGGATATAAT AAAACTTCAT 
GGAGGGACTC CAGCCAACTT CCTTGATGTT GGTGGTGGTG CTACAGTCCA TCAAGTAACA 
GAAGCATTTA AGCTTATCAC TTCAGATAAA AAGGTACTGG CTATTCTGGT CAACATTTTT 
GGAGGAATCA TGCGCTGTGA TGTTATTGCA CAGGGTATAG TCATGGCAGT AAAAGACTTG 
GAAATTAAAA TACCTGTTGT GGTACGGTTA CAAGGTACAC GAGTCGATGA TGCTAAGGCA 
CTGATAGCGG ACAGTGGACT TAAAATACTT GCTTGTGATG ACTTGGATGA AGCTGCTAGA 
ATGGTTGTAA AGCTCTCTGA AATAGTGACC TTAGCGAAGC AAGCACATGT GGATGTGAAA 
TTTCAGTTGC CAATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016876295.1
CDS	452..1669
Translation	MSMELLQEAGVSVPKGYVAKSPDEAYAIAKKLGSKDVVIKAQVLAGGRGKGTFESGLKGGVKIVFSPEEAKAVSSQMIGKKLFTKQTGEKGRICNQVLVCERKYPRREYYFAITMERSFQGPVLIGSSHGGVNIEDVAAESPEAIIKEPIDIEEGIKKEQALQLAQKMGFPPNIVESAAENMVKLYSLFLKYDATMIEINPMVEDSDGAVLCMDAKINFDSNSAYRQKKIFDLQDWTQEDERDKDAAKANLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQVTEAFKLITSDKKVLAILVNIFGGIMRCDVIAQGIVMAVKDLEIKIPVVVRLQGTRVDDAKALIADSGLKILACDDLDEAARMVVKLSEIVTLAKQAHVDVKFQLPI

Target ORF information:

RefSeq Version	XM_017020806.1
Organism	Homo sapiens(human)
Definition	Homo sapiens succinate-CoA ligase ADP-forming beta subunit (SUCLA2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017020806.1

ORF Insert Sequence:

ATGAGTATGG AATTATTGCA AGAAGCTGGT GTCTCCGTTC CCAAAGGATA TGTGGCAAAG 
TCACCAGATG AAGCTTATGC AATTGCCAAA AAATTAGGTT CAAAAGATGT CGTGATAAAG 
GCACAGGTTT TAGCTGGTGG TAGAGGAAAA GGAACATTTG AAAGTGGCCT CAAAGGAGGA 
GTGAAGATAG TTTTCTCTCC AGAAGAAGCA AAAGCTGTTT CTTCACAAAT GATTGGGAAA 
AAATTGTTTA CCAAGCAAAC GGGAGAAAAG GGCAGAATAT GCAATCAAGT ATTGGTCTGT 
GAGCGAAAAT ATCCCAGGAG AGAATACTAC TTTGCAATAA CAATGGAAAG GTCATTTCAA 
GGTCCTGTAT TAATAGGAAG TTCACATGGT GGTGTCAACA TTGAAGATGT TGCTGCTGAG 
TCTCCTGAAG CAATAATTAA AGAACCTATT GATATTGAAG AAGGCATCAA AAAGGAACAA 
GCTCTCCAGC TTGCACAGAA GATGGGATTT CCACCTAATA TTGTGGAATC AGCAGCAGAA 
AACATGGTCA AGCTTTACAG CCTTTTTCTG AAATACGATG CAACCATGAT AGAAATAAAT 
CCAATGGTGG AAGATTCAGA TGGAGCTGTA TTGTGTATGG ATGCAAAGAT CAATTTTGAC 
TCTAATTCAG CCTATCGCCA AAAGAAAATC TTTGATCTAC AGGACTGGAC CCAGGAAGAT 
GAAAGGGACA AAGATGCTGC TAAGGCAAAT CTCAACTACA TTGGCCTCGA TGGAAATATA 
GGCTGCCTAG TAAATGGTGC TGGTTTGGCT ATGGCCACAA TGGATATAAT AAAACTTCAT 
GGAGGGACTC CAGCCAACTT CCTTGATGTT GGTGGTGGTG CTACAGTCCA TCAAGTAACA 
GAAGCATTTA AGCTTATCAC TTCAGATAAA AAGGTACTGG CTATTCTGGT CAACATTTTT 
GGAGGAATCA TGCGCTGTGA TGTTATTGCA CAGGGTATAG TCATGGCAGT AAAAGACTTG 
GAAATTAAAA TACCTGTTGT GGTACGGTTA CAAGGTACAC GAGTCGATGA TGCTAAGGCA 
CTGATAGCGG ACAGTGGACT TAAAATACTT GCTTGTGATG ACTTGGATGA AGCTGCTAGA 
ATGGTTGTAA AGCTCTCTGA AATAGTGACC TTAGCGAAGC AAGCACATGT GGATGTGAAA 
TTTCAGTTGC CAATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SUCLA2 ( XM_017020808.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016876297.1 Homo sapiens succinate-CoA ligase ADP-forming beta subunit (SUCLA2), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu84668
Clone ID Related Accession (Same CDS sequence)	XM_017020808.1
Accession Version	XM_017020808.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1035bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGCCT CCATGTTCTA CGGCAGGCTA GTGGCCGTGG CCACCCTTCG GAACCACCGG 
CCTCGGACGG CCCAGCGGGC TGCTGCTCAG GTTCTGGGAA GTTCTGGATT GTTTAATAAC 
CATGGACTCC AAGTACAGCA GCAACAGCAA AGGAATCTCT CACTACATGA ATACATGAGT 
ATGGAATTAT TGCAAGAAGC TGGTGTCTCC GTTCCCAAAG GATATGTGGC AAAGTCACCA 
GATGAAGCTT ATGCAATTGC CAAAAAATTA GGTTCAAAAG ATGTCGTGAT AAAGGCACAG 
GTTTTAGCTG GTGGTAGAGG AAAAGGAACA TTTGAAAGTG GCCTCAAAGG AGGAGTGAAG 
ATAGTTTTCT CTCCAGAAGA AGCAAAAGCT GTTTCTTCAC AAATGATTGG GAAAAAATTG 
TTTACCAAGC AAACGGGAGA AAAGGGCAGA ATATGCAATC AAGTATTGGT CTGTGAGCGA 
AAATATCCCA GGAGAGAATA CTACTTTGCA ATAACAATGG AAAGGTCATT TCAAGGTCCT 
GTATTAATAG GAAGTTCACA TGGTGGTGTC AACATTGAAG ATGTTGCTGC TGAGTCTCCT 
GAAGCAATAA TTAAAGAACC TATTGATATT GAAGAAGGCA TCAAAAAGGA ACAAGCTCTC 
CAGCTTGCAC AGAAGATGGG ATTTCCACCT AATATTGTGG AATCAGCAGC AGAAAACATG 
GTCAAGCTTT ACAGCCTTTT TCTGAAATAC GATGCAACCA TGATAGAAAT AAATCCAATG 
GTGGAAGATT CAGATGGAGC TGGACCACCA GGATCACACA TTGAATTGAG TTGTCACATC 
CATTTGACCT GGAACAGATC TGGAAGTTTG ATTTATTTCT TGACCTTATT TTTTGTTGTT 
CCTGTTTTTC TTTGTTTTTT TTTTTTGTTT GTTTGTTTTT TTTTTTTTAA AGAAGGGGTC 
ATTTATTTCA TAGAATGCCC TTCAGTTTGT GTTTCTCTGT TTGATGTTCC CTCATGGTTT 
TTTTTTCCTT CATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016876297.1
CDS	45..1079
Translation	MAASMFYGRLVAVATLRNHRPRTAQRAAAQVLGSSGLFNNHGLQVQQQQQRNLSLHEYMSMELLQEAGVSVPKGYVAKSPDEAYAIAKKLGSKDVVIKAQVLAGGRGKGTFESGLKGGVKIVFSPEEAKAVSSQMIGKKLFTKQTGEKGRICNQVLVCERKYPRREYYFAITMERSFQGPVLIGSSHGGVNIEDVAAESPEAIIKEPIDIEEGIKKEQALQLAQKMGFPPNIVESAAENMVKLYSLFLKYDATMIEINPMVEDSDGAGPPGSHIELSCHIHLTWNRSGSLIYFLTLFFVVPVFLCFFFLFVCFFFFKEGVIYFIECPSVCVSLFDVPSWFFFPS

Target ORF information:

RefSeq Version	XM_017020808.1
Organism	Homo sapiens(human)
Definition	Homo sapiens succinate-CoA ligase ADP-forming beta subunit (SUCLA2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017020808.1

ORF Insert Sequence:

ATGGCGGCCT CCATGTTCTA CGGCAGGCTA GTGGCCGTGG CCACCCTTCG GAACCACCGG 
CCTCGGACGG CCCAGCGGGC TGCTGCTCAG GTTCTGGGAA GTTCTGGATT GTTTAATAAC 
CATGGACTCC AAGTACAGCA GCAACAGCAA AGGAATCTCT CACTACATGA ATACATGAGT 
ATGGAATTAT TGCAAGAAGC TGGTGTCTCC GTTCCCAAAG GATATGTGGC AAAGTCACCA 
GATGAAGCTT ATGCAATTGC CAAAAAATTA GGTTCAAAAG ATGTCGTGAT AAAGGCACAG 
GTTTTAGCTG GTGGTAGAGG AAAAGGAACA TTTGAAAGTG GCCTCAAAGG AGGAGTGAAG 
ATAGTTTTCT CTCCAGAAGA AGCAAAAGCT GTTTCTTCAC AAATGATTGG GAAAAAATTG 
TTTACCAAGC AAACGGGAGA AAAGGGCAGA ATATGCAATC AAGTATTGGT CTGTGAGCGA 
AAATATCCCA GGAGAGAATA CTACTTTGCA ATAACAATGG AAAGGTCATT TCAAGGTCCT 
GTATTAATAG GAAGTTCACA TGGTGGTGTC AACATTGAAG ATGTTGCTGC TGAGTCTCCT 
GAAGCAATAA TTAAAGAACC TATTGATATT GAAGAAGGCA TCAAAAAGGA ACAAGCTCTC 
CAGCTTGCAC AGAAGATGGG ATTTCCACCT AATATTGTGG AATCAGCAGC AGAAAACATG 
GTCAAGCTTT ACAGCCTTTT TCTGAAATAC GATGCAACCA TGATAGAAAT AAATCCAATG 
GTGGAAGATT CAGATGGAGC TGGACCACCA GGATCACACA TTGAATTGAG TTGTCACATC 
CATTTGACCT GGAACAGATC TGGAAGTTTG ATTTATTTCT TGACCTTATT TTTTGTTGTT 
CCTGTTTTTC TTTGTTTTTT TTTTTTGTTT GTTTGTTTTT TTTTTTTTAA AGAAGGGGTC 
ATTTATTTCA TAGAATGCCC TTCAGTTTGT GTTTCTCTGT TTGATGTTCC CTCATGGTTT 
TTTTTTCCTT CATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Co-occurring Down syndrome and SUCLA2-related mitochondrial depletion syndrome.
American journal of medical genetics. Part A173(10)2720-2724(2017 Oct)
Couser NL,Marchuk DS,Smith LD,Arreola A,Kaiser-Rogers KA,Muenzer J,Pandya A,Gucsavas-Calikoglu M,Powell CM

Expanding the phenotypic spectrum of Succinyl-CoA ligase deficiency through functional validation of a new SUCLG1 variant.
Molecular genetics and metabolism119(1-2)68-74(2016 09)
Donti TR,Masand R,Scott DA,Craigen WJ,Graham BH

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M

Knockdown of Sucla2 decreases the viability of mouse spermatocytes by inducing apoptosis through injury of the mitochondrial function of cells.
Folia histochemica et cytobiologica54(3)134-142(2016)
Huang S,Wang J,Wang L

Influences of XDH genotype by gene-gene interactions with SUCLA2 for thiopurine-induced leukopenia in Korean patients with Crohn's disease.
Scandinavian journal of gastroenterology51(6)684-91(2016)
Park SK,Hong M,Ye BD,Kim KJ,Park SH,Yang DH,Hwang SW,Kwak MS,Lee HS,Song K,Yang SK

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SUCLA2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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