ADAM7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ADAM7
Entrez Gene ID	8756
Full Name	ADAM metallopeptidase domain 7
Synonyms	ADAM 7,ADAM-7,EAPI,GP-83,GP83
General protein information	Preferred Names ADAM metallopeptidase domain 7 Names disintegrin and metalloproteinase domain-containing protein 7 a disintegrin and metalloproteinase domain 7 epididymal apical protein I sperm maturation-related glycoprotein GP-83
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8p21.2
Summary	This gene encodes a member of the ADAMs family of zinc proteases. These transmembrane proteins play roles in multiple processes including cell signaling, adhesion and migration. The encoded protein lacks protease activity and may play roles in protein-protein interactions and cell adhesion processes including sperm-egg fusion. Mutations in this gene may be involved in the progression of melanoma. [provided by RefSeq, Oct 2011].
Disorder MIM:	607310

mRNA and Protein(s)

mRNA	Protein	Name
XM_017013943.1	XP_016869432.1	disintegrin and metalloproteinase domain-containing protein 7 isoform X1
NM_003817.4	NP_003808.2	disintegrin and metalloproteinase domain-containing protein 7 preproprotein
NM_003817.3	NP_003808.2	disintegrin and metalloproteinase domain-containing protein 7 preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	ADAM7	NP_003808.2
Canis lupus familiaris (dog)	ADAM7	XP_005635753.1
Bos taurus (cattle)	ADAM7	XP_003586462.2
Mus musculus (house mouse)	Adam7	NP_031428.2
Rattus norvegicus (Norway rat)	Adam7	NP_064697.1
Pan troglodytes (chimpanzee)	ADAM7	XP_519664.2
	LOC100427614	XP_002805338.1

Gene Ontology
Bibliography

Related articles in PubMed

White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder.
Sprooten E, Fleming KM, Thomson PA, Bastin ME, Whalley HC, Hall J, Sussmann JE, McKirdy J, Blackwood D, Lawrie SM, McIntosh AM
Psychiatry research206(2-3)223-31(2013 Apr)

Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma.
Wei X, Moncada-Pazos A, Cal S, Soria-Valles C, Gartner J, Rudloff U, Lin JC, , Rosenberg SA, L?pez-Ot?n C, Samuels Y
Human mutation32(6)E2148-75(2011 Jun)

ADAM7 is associated with epididymosomes and integrated into sperm plasma membrane.
Oh JS, Han C, Cho C
Molecules and cells28(5)441-6(2009 Nov)

Molecular, biochemical, and cellular characterization of epididymal ADAMs, ADAM7 and ADAM28.
Oh J, Woo JM, Choi E, Kim T, Cho BN, Park ZY, Kim YC, Kim DH, Cho C
Biochemical and biophysical research communications331(4)1374-83(2005 Jun)

The ADAMs family of metalloproteases: multidomain proteins with multiple functions.
Seals DF, Courtneidge SA
Genes & development17(1)7-30(2003 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

mutated ADAM27 and ADAM7 genes could play a role in melanoma progression.
Title: Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma.

The following ADAM7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ADAM7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12921	NM_003817.4 Latest version!	Homo sapiens ADAM metallopeptidase domain 7 (ADAM7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$531.30 $759.00
OHu98266	XM_017013943.1 Latest version!	Homo sapiens ADAM metallopeptidase domain 7 (ADAM7), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
View Old Accession Versions >>
OHu12921	NM_003817.3	Homo sapiens ADAM metallopeptidase domain 7 (ADAM7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$531.30 $759.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ADAM7 ( NM_003817.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003808.2 Homo sapiens ADAM metallopeptidase domain 7 (ADAM7), mRNA.

Price & Availability↑

CloneID	OHu12921
Clone ID Related Accession (Same CDS sequence)	NM_003817.4 , NM_003817.3
Accession Version	NM_003817.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2265bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	disintegrin and metalloproteinase domain-containing protein 7 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK292492.1 and AC024958.8. On May 17, 2019 this sequence version replaced NM_003817.3. ##Evidence-Data-START## Transcript exon combination :: AF215824.1, GQ891358.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2153427, SAMEA2161674 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000175238.10/ ENSP00000175238.5 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END##

ATGCTTCCCG GGTGTATATT CTTGATGATT TTACTCATTC CTCAGGTTAA AGAAAAGTTC 
ATCCTTGGAG TAGAGGGTCA ACAACTGGTT CGTCCTAAAA AGCTTCCTCT GATACAGAAG 
CGAGATACTG GACACACCCA TGATGATGAC ATACTGAAAA CGTATGAAGA AGAATTGTTG 
TATGAAATAA AACTAAATAG AAAAACCTTA GTCCTTCATC TTCTAAGATC CAGGGAGTTC 
CTAGGCTCAA ATTACAGTGA AACATTCTAC TCCATGAAAG GAGAAGCGTT CACCAGGCAT 
CCTCAGATCA TGGATCATTG TTTTTACCAA GGATCCATAG TACACGAATA TGATTCAGCT 
GCCAGTATCA GTACGTGTAA TGGTCTAAGG GGATTCTTCA GAATAAACGA CCAAAGATAC 
CTCATTGAAC CAGTGAAATA CTCAGATGAG GGAGAACATT TGGTGTTCAA ATATAACCTG 
AGGGTGCCGT ATGGTGCCAA TTATTCCTGT ACAGAGCTTA ATTTTACCAG AAAAACTGTT 
CCAGGGGATA ATGAATCTGA AGAAGACTCC AAAATAAAAG GCATCCATGA TGAAAAGTAT 
GTTGAATTGT TCATTGTTGC TGATGATACT GTGTATCGCA GAAATGGTCA TCCTCACAAT 
AAACTAAGGA ACCGAATTTG GGGAATGGTC AATTTTGTCA ACATGATTTA TAAAACCTTA 
AACATCCATG TGACGTTGGT TGGCATTGAA ATATGGACAC ATGAAGATAA AATAGAACTA 
TATTCAAATA TAGAAACTAC CTTATTGCGT TTTTCATTTT GGCAAGAAAA GATCCTTAAA 
ACACGGAAGG ATTTTGATCA TGTTGTATTA CTCAGTGGGA AGTGGCTCTA CTCACATGTG 
CAAGGAATTT CTTATCCAGG GGGTATGTGC CTGCCCTATT ATTCCACCAG TATCATTAAG 
GATCTTTTAC CTGACACAAA CATAATTGCA AACAGAATGG CACATCAACT GGGGCATAAC 
CTTGGGATGC AGCATGACGA GTTCCCATGC ACCTGTCCTT CAGGAAAATG CGTGATGGAC 
AGTGATGGAA GCATTCCTGC ACTGAAATTC AGTAAATGCA GCCAAAACCA ATACCACCAG 
TACTTGAAGG ATTATAAGCC AACATGCATG CTCAACATTC CATTTCCTTA CAATTTTCAT 
GATTTCCAAT TTTGTGGAAA CAAGAAGTTG GATGAGGGTG AAGAGTGTGA CTGTGGCCCT 
GCTCAGGAGT GTACTAATCC TTGCTGTGAT GCACACACAT GTGTACTGAA GCCAGGATTT 
ACTTGTGCAG AAGGAGAATG CTGTGAATCT TGTCAGATAA AAAAAGCAGG GTCCATATGC 
AGACCGGCGA AAGATGAATG TGATTTTCCT GAGATGTGCA CTGGCCACTC GCCTGCCTGT 
CCTAAGGACC AGTTCAGGGT CAATGGATTT CCTTGCAAGA ACTCAGAAGG CTACTGTTTC 
ATGGGGAAAT GTCCAACTCG TGAGGATCAG TGCTCTGAAC TATTTGATGA TGAGGCAATA 
GAGAGTCATG ATATCTGCTA CAAGATGAAT ACAAAAGGAA ATAAATTTGG ATACTGCAAA 
AACAAGGAAA ACAGATTTCT TCCCTGTGAG GAGAAAGATG TCAGATGTGG AAAGATCTAC 
TGCACTGGAG GGGAGCTTTC CTCTCTCCTT GGAGAAGACA AGACTTATCA CCTTAAGGAT 
CCCCAGAAGA ATGCTACTGT CAAATGCAAA ACTATTTTTT TATACCATGA TTCTACAGAC 
ATTGGCCTGG TGGCGTCAGG AACAAAATGT GGAGAGGGAA TGGTGTGCAA CAATGGTGAA 
TGTCTAAACA TGGAAAAGGT CTATATCTCA ACCAATTGCC CCTCTCAGTG CAATGAAAAT 
CCTGTGGATG GCCACGGACT CCAGTGCCAC TGTGAGGAAG GACAGGCACC TGTAGCCTGT 
GAAGAAACCT TACATGTTAC CAATATCACC ATCTTGGTTG TTGTGCTTGT CCTGGTTATT 
GTCGGTATCG GAGTTCTTAT ACTATTAGTT CGTTACCGAA AATGTATCAA GTTGAAGCAA 
GTTCAGAGCC CACCTACAGA AACCCTGGGA GTGGAGAACA AAGGATACTT TGGTGATGAG 
CAGCAGATAA GGACTGAGCC AATCCTGCCA GAAATTCATT TCCTAAATAA ACCTGCAAGT 
AAAGATTCAA GAGGAATCGC AGATCCCAAT CAAAGTGCCA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003808.2
CDS	84..2348
Translation	MLPGCIFLMILLIPQVKEKFILGVEGQQLVRPKKLPLIQKRDTGHTHDDDILKTYEEELLYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDSAASISTCNGLRGFFRINDQRYLIEPVKYSDEGEHLVFKYNLRVPYGANYSCTELNFTRKTVPGDNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGMVNFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVLLSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDEFPCTCPSGKCVMDSDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCGNKKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKDECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDICYKMNTKGNKFGYCKNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQKNATVKCKTIFLYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNENPVDGHGLQCHCEEGQAPVACEETLHVTNITILVVVLVLVIVGIGVLILLVRYRKCIKLKQVQSPPTETLGVENKGYFGDEQQIRTEPILPEIHFLNKPASKDSRGIADPNQSAK

Target ORF information:

RefSeq Version	NM_003817.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ADAM metallopeptidase domain 7 (ADAM7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003817.4

ORF Insert Sequence:

ATGCTTCCCG GGTGTATATT CTTGATGATT TTACTCATTC CTCAGGTTAA AGAAAAGTTC 
ATCCTTGGAG TAGAGGGTCA ACAACTGGTT CGTCCTAAAA AGCTTCCTCT GATACAGAAG 
CGAGATACTG GACACACCCA TGATGATGAC ATACTGAAAA CGTATGAAGA AGAATTGTTG 
TATGAAATAA AACTAAATAG AAAAACCTTA GTCCTTCATC TTCTAAGATC CAGGGAGTTC 
CTAGGCTCAA ATTACAGTGA AACATTCTAC TCCATGAAAG GAGAAGCGTT CACCAGGCAT 
CCTCAGATCA TGGATCATTG TTTTTACCAA GGATCCATAG TACACGAATA TGATTCAGCT 
GCCAGTATCA GTACGTGTAA TGGTCTAAGG GGATTCTTCA GAATAAACGA CCAAAGATAC 
CTCATTGAAC CAGTGAAATA CTCAGATGAG GGAGAACATT TGGTGTTCAA ATATAACCTG 
AGGGTGCCGT ATGGTGCCAA TTATTCCTGT ACAGAGCTTA ATTTTACCAG AAAAACTGTT 
CCAGGGGATA ATGAATCTGA AGAAGACTCC AAAATAAAAG GCATCCATGA TGAAAAGTAT 
GTTGAATTGT TCATTGTTGC TGATGATACT GTGTATCGCA GAAATGGTCA TCCTCACAAT 
AAACTAAGGA ACCGAATTTG GGGAATGGTC AATTTTGTCA ACATGATTTA TAAAACCTTA 
AACATCCATG TGACGTTGGT TGGCATTGAA ATATGGACAC ATGAAGATAA AATAGAACTA 
TATTCAAATA TAGAAACTAC CTTATTGCGT TTTTCATTTT GGCAAGAAAA GATCCTTAAA 
ACACGGAAGG ATTTTGATCA TGTTGTATTA CTCAGTGGGA AGTGGCTCTA CTCACATGTG 
CAAGGAATTT CTTATCCAGG GGGTATGTGC CTGCCCTATT ATTCCACCAG TATCATTAAG 
GATCTTTTAC CTGACACAAA CATAATTGCA AACAGAATGG CACATCAACT GGGGCATAAC 
CTTGGGATGC AGCATGACGA GTTCCCATGC ACCTGTCCTT CAGGAAAATG CGTGATGGAC 
AGTGATGGAA GCATTCCTGC ACTGAAATTC AGTAAATGCA GCCAAAACCA ATACCACCAG 
TACTTGAAGG ATTATAAGCC AACATGCATG CTCAACATTC CATTTCCTTA CAATTTTCAT 
GATTTCCAAT TTTGTGGAAA CAAGAAGTTG GATGAGGGTG AAGAGTGTGA CTGTGGCCCT 
GCTCAGGAGT GTACTAATCC TTGCTGTGAT GCACACACAT GTGTACTGAA GCCAGGATTT 
ACTTGTGCAG AAGGAGAATG CTGTGAATCT TGTCAGATAA AAAAAGCAGG GTCCATATGC 
AGACCGGCGA AAGATGAATG TGATTTTCCT GAGATGTGCA CTGGCCACTC GCCTGCCTGT 
CCTAAGGACC AGTTCAGGGT CAATGGATTT CCTTGCAAGA ACTCAGAAGG CTACTGTTTC 
ATGGGGAAAT GTCCAACTCG TGAGGATCAG TGCTCTGAAC TATTTGATGA TGAGGCAATA 
GAGAGTCATG ATATCTGCTA CAAGATGAAT ACAAAAGGAA ATAAATTTGG ATACTGCAAA 
AACAAGGAAA ACAGATTTCT TCCCTGTGAG GAGAAAGATG TCAGATGTGG AAAGATCTAC 
TGCACTGGAG GGGAGCTTTC CTCTCTCCTT GGAGAAGACA AGACTTATCA CCTTAAGGAT 
CCCCAGAAGA ATGCTACTGT CAAATGCAAA ACTATTTTTT TATACCATGA TTCTACAGAC 
ATTGGCCTGG TGGCGTCAGG AACAAAATGT GGAGAGGGAA TGGTGTGCAA CAATGGTGAA 
TGTCTAAACA TGGAAAAGGT CTATATCTCA ACCAATTGCC CCTCTCAGTG CAATGAAAAT 
CCTGTGGATG GCCACGGACT CCAGTGCCAC TGTGAGGAAG GACAGGCACC TGTAGCCTGT 
GAAGAAACCT TACATGTTAC CAATATCACC ATCTTGGTTG TTGTGCTTGT CCTGGTTATT 
GTCGGTATCG GAGTTCTTAT ACTATTAGTT CGTTACCGAA AATGTATCAA GTTGAAGCAA 
GTTCAGAGCC CACCTACAGA AACCCTGGGA GTGGAGAACA AAGGATACTT TGGTGATGAG 
CAGCAGATAA GGACTGAGCC AATCCTGCCA GAAATTCATT TCCTAAATAA ACCTGCAAGT 
AAAGATTCAA GAGGAATCGC AGATCCCAAT CAAAGTGCCA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ADAM7 ( NM_003817.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003808.2 Homo sapiens ADAM metallopeptidase domain 7 (ADAM7), mRNA.

Price & Availability↑

CloneID	OHu12921
Clone ID Related Accession (Same CDS sequence)	NM_003817.4 , NM_003817.3
Accession Version	NM_003817.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2265bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	disintegrin and metalloproteinase domain-containing protein 7 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK292492.1 and AC024958.8. On Nov 1, 2011 this sequence version replaced NM_003817.2. ##Evidence-Data-START## Transcript exon combination :: AK292492.1, AF215824.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2153427, SAMEA2161674 [ECO:0000350] ##Evidence-Data-END##

ATGCTTCCCG GGTGTATATT CTTGATGATT TTACTCATTC CTCAGGTTAA AGAAAAGTTC 
ATCCTTGGAG TAGAGGGTCA ACAACTGGTT CGTCCTAAAA AGCTTCCTCT GATACAGAAG 
CGAGATACTG GACACACCCA TGATGATGAC ATACTGAAAA CGTATGAAGA AGAATTGTTG 
TATGAAATAA AACTAAATAG AAAAACCTTA GTCCTTCATC TTCTAAGATC CAGGGAGTTC 
CTAGGCTCAA ATTACAGTGA AACATTCTAC TCCATGAAAG GAGAAGCGTT CACCAGGCAT 
CCTCAGATCA TGGATCATTG TTTTTACCAA GGATCCATAG TACACGAATA TGATTCAGCT 
GCCAGTATCA GTACGTGTAA TGGTCTAAGG GGATTCTTCA GAATAAACGA CCAAAGATAC 
CTCATTGAAC CAGTGAAATA CTCAGATGAG GGAGAACATT TGGTGTTCAA ATATAACCTG 
AGGGTGCCGT ATGGTGCCAA TTATTCCTGT ACAGAGCTTA ATTTTACCAG AAAAACTGTT 
CCAGGGGATA ATGAATCTGA AGAAGACTCC AAAATAAAAG GCATCCATGA TGAAAAGTAT 
GTTGAATTGT TCATTGTTGC TGATGATACT GTGTATCGCA GAAATGGTCA TCCTCACAAT 
AAACTAAGGA ACCGAATTTG GGGAATGGTC AATTTTGTCA ACATGATTTA TAAAACCTTA 
AACATCCATG TGACGTTGGT TGGCATTGAA ATATGGACAC ATGAAGATAA AATAGAACTA 
TATTCAAATA TAGAAACTAC CTTATTGCGT TTTTCATTTT GGCAAGAAAA GATCCTTAAA 
ACACGGAAGG ATTTTGATCA TGTTGTATTA CTCAGTGGGA AGTGGCTCTA CTCACATGTG 
CAAGGAATTT CTTATCCAGG GGGTATGTGC CTGCCCTATT ATTCCACCAG TATCATTAAG 
GATCTTTTAC CTGACACAAA CATAATTGCA AACAGAATGG CACATCAACT GGGGCATAAC 
CTTGGGATGC AGCATGACGA GTTCCCATGC ACCTGTCCTT CAGGAAAATG CGTGATGGAC 
AGTGATGGAA GCATTCCTGC ACTGAAATTC AGTAAATGCA GCCAAAACCA ATACCACCAG 
TACTTGAAGG ATTATAAGCC AACATGCATG CTCAACATTC CATTTCCTTA CAATTTTCAT 
GATTTCCAAT TTTGTGGAAA CAAGAAGTTG GATGAGGGTG AAGAGTGTGA CTGTGGCCCT 
GCTCAGGAGT GTACTAATCC TTGCTGTGAT GCACACACAT GTGTACTGAA GCCAGGATTT 
ACTTGTGCAG AAGGAGAATG CTGTGAATCT TGTCAGATAA AAAAAGCAGG GTCCATATGC 
AGACCGGCGA AAGATGAATG TGATTTTCCT GAGATGTGCA CTGGCCACTC GCCTGCCTGT 
CCTAAGGACC AGTTCAGGGT CAATGGATTT CCTTGCAAGA ACTCAGAAGG CTACTGTTTC 
ATGGGGAAAT GTCCAACTCG TGAGGATCAG TGCTCTGAAC TATTTGATGA TGAGGCAATA 
GAGAGTCATG ATATCTGCTA CAAGATGAAT ACAAAAGGAA ATAAATTTGG ATACTGCAAA 
AACAAGGAAA ACAGATTTCT TCCCTGTGAG GAGAAAGATG TCAGATGTGG AAAGATCTAC 
TGCACTGGAG GGGAGCTTTC CTCTCTCCTT GGAGAAGACA AGACTTATCA CCTTAAGGAT 
CCCCAGAAGA ATGCTACTGT CAAATGCAAA ACTATTTTTT TATACCATGA TTCTACAGAC 
ATTGGCCTGG TGGCGTCAGG AACAAAATGT GGAGAGGGAA TGGTGTGCAA CAATGGTGAA 
TGTCTAAACA TGGAAAAGGT CTATATCTCA ACCAATTGCC CCTCTCAGTG CAATGAAAAT 
CCTGTGGATG GCCACGGACT CCAGTGCCAC TGTGAGGAAG GACAGGCACC TGTAGCCTGT 
GAAGAAACCT TACATGTTAC CAATATCACC ATCTTGGTTG TTGTGCTTGT CCTGGTTATT 
GTCGGTATCG GAGTTCTTAT ACTATTAGTT CGTTACCGAA AATGTATCAA GTTGAAGCAA 
GTTCAGAGCC CACCTACAGA AACCCTGGGA GTGGAGAACA AAGGATACTT TGGTGATGAG 
CAGCAGATAA GGACTGAGCC AATCCTGCCA GAAATTCATT TCCTAAATAA ACCTGCAAGT 
AAAGATTCAA GAGGAATCGC AGATCCCAAT CAAAGTGCCA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003808.2
CDS	114..2378
Translation	MLPGCIFLMILLIPQVKEKFILGVEGQQLVRPKKLPLIQKRDTGHTHDDDILKTYEEELLYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDSAASISTCNGLRGFFRINDQRYLIEPVKYSDEGEHLVFKYNLRVPYGANYSCTELNFTRKTVPGDNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGMVNFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVLLSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDEFPCTCPSGKCVMDSDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCGNKKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKDECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDICYKMNTKGNKFGYCKNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQKNATVKCKTIFLYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNENPVDGHGLQCHCEEGQAPVACEETLHVTNITILVVVLVLVIVGIGVLILLVRYRKCIKLKQVQSPPTETLGVENKGYFGDEQQIRTEPILPEIHFLNKPASKDSRGIADPNQSAK

Target ORF information:

RefSeq Version	NM_003817.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ADAM metallopeptidase domain 7 (ADAM7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003817.3

ORF Insert Sequence:

ATGCTTCCCG GGTGTATATT CTTGATGATT TTACTCATTC CTCAGGTTAA AGAAAAGTTC 
ATCCTTGGAG TAGAGGGTCA ACAACTGGTT CGTCCTAAAA AGCTTCCTCT GATACAGAAG 
CGAGATACTG GACACACCCA TGATGATGAC ATACTGAAAA CGTATGAAGA AGAATTGTTG 
TATGAAATAA AACTAAATAG AAAAACCTTA GTCCTTCATC TTCTAAGATC CAGGGAGTTC 
CTAGGCTCAA ATTACAGTGA AACATTCTAC TCCATGAAAG GAGAAGCGTT CACCAGGCAT 
CCTCAGATCA TGGATCATTG TTTTTACCAA GGATCCATAG TACACGAATA TGATTCAGCT 
GCCAGTATCA GTACGTGTAA TGGTCTAAGG GGATTCTTCA GAATAAACGA CCAAAGATAC 
CTCATTGAAC CAGTGAAATA CTCAGATGAG GGAGAACATT TGGTGTTCAA ATATAACCTG 
AGGGTGCCGT ATGGTGCCAA TTATTCCTGT ACAGAGCTTA ATTTTACCAG AAAAACTGTT 
CCAGGGGATA ATGAATCTGA AGAAGACTCC AAAATAAAAG GCATCCATGA TGAAAAGTAT 
GTTGAATTGT TCATTGTTGC TGATGATACT GTGTATCGCA GAAATGGTCA TCCTCACAAT 
AAACTAAGGA ACCGAATTTG GGGAATGGTC AATTTTGTCA ACATGATTTA TAAAACCTTA 
AACATCCATG TGACGTTGGT TGGCATTGAA ATATGGACAC ATGAAGATAA AATAGAACTA 
TATTCAAATA TAGAAACTAC CTTATTGCGT TTTTCATTTT GGCAAGAAAA GATCCTTAAA 
ACACGGAAGG ATTTTGATCA TGTTGTATTA CTCAGTGGGA AGTGGCTCTA CTCACATGTG 
CAAGGAATTT CTTATCCAGG GGGTATGTGC CTGCCCTATT ATTCCACCAG TATCATTAAG 
GATCTTTTAC CTGACACAAA CATAATTGCA AACAGAATGG CACATCAACT GGGGCATAAC 
CTTGGGATGC AGCATGACGA GTTCCCATGC ACCTGTCCTT CAGGAAAATG CGTGATGGAC 
AGTGATGGAA GCATTCCTGC ACTGAAATTC AGTAAATGCA GCCAAAACCA ATACCACCAG 
TACTTGAAGG ATTATAAGCC AACATGCATG CTCAACATTC CATTTCCTTA CAATTTTCAT 
GATTTCCAAT TTTGTGGAAA CAAGAAGTTG GATGAGGGTG AAGAGTGTGA CTGTGGCCCT 
GCTCAGGAGT GTACTAATCC TTGCTGTGAT GCACACACAT GTGTACTGAA GCCAGGATTT 
ACTTGTGCAG AAGGAGAATG CTGTGAATCT TGTCAGATAA AAAAAGCAGG GTCCATATGC 
AGACCGGCGA AAGATGAATG TGATTTTCCT GAGATGTGCA CTGGCCACTC GCCTGCCTGT 
CCTAAGGACC AGTTCAGGGT CAATGGATTT CCTTGCAAGA ACTCAGAAGG CTACTGTTTC 
ATGGGGAAAT GTCCAACTCG TGAGGATCAG TGCTCTGAAC TATTTGATGA TGAGGCAATA 
GAGAGTCATG ATATCTGCTA CAAGATGAAT ACAAAAGGAA ATAAATTTGG ATACTGCAAA 
AACAAGGAAA ACAGATTTCT TCCCTGTGAG GAGAAAGATG TCAGATGTGG AAAGATCTAC 
TGCACTGGAG GGGAGCTTTC CTCTCTCCTT GGAGAAGACA AGACTTATCA CCTTAAGGAT 
CCCCAGAAGA ATGCTACTGT CAAATGCAAA ACTATTTTTT TATACCATGA TTCTACAGAC 
ATTGGCCTGG TGGCGTCAGG AACAAAATGT GGAGAGGGAA TGGTGTGCAA CAATGGTGAA 
TGTCTAAACA TGGAAAAGGT CTATATCTCA ACCAATTGCC CCTCTCAGTG CAATGAAAAT 
CCTGTGGATG GCCACGGACT CCAGTGCCAC TGTGAGGAAG GACAGGCACC TGTAGCCTGT 
GAAGAAACCT TACATGTTAC CAATATCACC ATCTTGGTTG TTGTGCTTGT CCTGGTTATT 
GTCGGTATCG GAGTTCTTAT ACTATTAGTT CGTTACCGAA AATGTATCAA GTTGAAGCAA 
GTTCAGAGCC CACCTACAGA AACCCTGGGA GTGGAGAACA AAGGATACTT TGGTGATGAG 
CAGCAGATAA GGACTGAGCC AATCCTGCCA GAAATTCATT TCCTAAATAA ACCTGCAAGT 
AAAGATTCAA GAGGAATCGC AGATCCCAAT CAAAGTGCCA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ADAM7 ( XM_017013943.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016869432.1 Homo sapiens ADAM metallopeptidase domain 7 (ADAM7), transcript variant X1, mRNA.

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CloneID	OHu98266
Clone ID Related Accession (Same CDS sequence)	XM_017013943.1
Accession Version	XM_017013943.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2268bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	disintegrin and metalloproteinase domain-containing protein 7 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTTCCCG GGTGTATATT CTTGATGATT TTACTCATTC CTCAGGTTAA AGAAAAGTTC 
ATCCTTGGAG TAGAGGGTCA ACAACTGGTT CGTCCTAAAA AGCTTCCTCT GATACAGAAG 
CGAGATACTG GACACACCCA TGATGATGAC ATACTGAAAA CGTATGAAGA AGAATTGTTG 
TATGAAATAA AACTAAATAG AAAAACCTTA GTCCTTCATC TTCTAAGATC CAGGGAGTTC 
CTAGGCTCAA ATTACAGTGA AACATTCTAC TCCATGAAAG GAGAAGCGTT CACCAGGCAT 
CCTCAGATCA TGGATCATTG TTTTTACCAA GGATCCATAG TACACGAATA TGATTCAGCT 
GCCAGTATCA GTACGTGTAA TGGTCTAAGG GGATTCTTCA GAATAAACGA CCAAAGATAC 
CTCATTGAAC CAGTGAAATA CTCAGATGAG GGAGAACATT TGGTGTTCAA ATATAACCTG 
AGGGTGCCGT ATGGTGCCAA TTATTCCTGT ACAGAGCTTA ATTTTACCAG AAAAACTGTT 
CCAGGGGATA ATGAATCTGA AGAAGACTCC AAAATAAAAG GCATCCATGA TGAAAAGTAT 
GTTGAATTGT TCATTGTTGC TGATGATACT GTGTATCGCA GAAATGGTCA TCCTCACAAT 
AAACTAAGGA ACCGAATTTG GGGAATGGTC AATTTTGTCA ACATGATTTA TAAAACCTTA 
AACATCCATG TGACGTTGGT TGGCATTGAA ATATGGACAC ATGAAGATAA AATAGAACTA 
TATTCAAATA TAGAAACTAC CTTATTGCGT TTTTCATTTT GGCAAGAAAA GATCCTTAAA 
ACACGGAAGG ATTTTGATCA TGTTGTATTA CTCAGTGGGA AGTGGCTCTA CTCACATGTG 
CAAGGAATTT CTTATCCAGG GGGTATGTGC CTGCCCTATT ATTCCACCAG TATCATTAAG 
GATCTTTTAC CTGACACAAA CATAATTGCA AACAGAATGG CACATCAACT GGGGCATAAC 
CTTGGGATGC AGCATGACGA GTTCCCATGC ACCTGTCCTT CAGGAAAATG CGTGATGGAC 
AGTGATGGAA GCATTCCTGC ACTGAAATTC AGTAAATGCA GCCAAAACCA ATACCACCAG 
TACTTGAAGG ATTATAAGCC AACATGCATG CTCAACATTC CATTTCCTTA CAATTTTCAT 
GATTTCCAAT TTTGTGGAAA CAAGAAGTTG GATGAGGGTG AAGAGTGTGA CTGTGGCCCT 
GCTCAGGAGT GTACTAATCC TTGCTGTGAT GCACACACAT GTGTACTGAA GCCAGGATTT 
ACTTGTGCAG AAGGAGAATG CTGTGAATCT TGTCAGATAA AAAAAGCAGG GTCCATATGC 
AGACCGGCGA AAGATGAATG TGATTTTCCT GAGATGTGCA CTGGCCACTC GCCTGCCTGT 
CCTAAGGACC AGTTCAGGGT CAATGGATTT CCTTGCAAGA ACTCAGAAGG CTACTGTTTC 
ATGGGGAAAT GTCCAACTCG TGAGGATCAG TGCTCTGAAC TATTTGATGA TGAGGCAATA 
GAGAGTCATG ATATCTGCTA CAAGATGAAT ACAAAAGGAA ATAAATTTGG ATACTGCAAA 
AACAAGGAAA ACAGATTTCT TCCCTGTGAG GAGAAAGATG TCAGATGTGG AAAGATCTAC 
TGCACTGGAG GGGAGCTTTC CTCTCTCCTT GGAGAAGACA AGACTTATCA CCTTAAGGAT 
CCCCAGAAGA ATGCTACTGT CAAATGCAAA ACTATTTTTT TATACCATGA TTCTACAGAC 
ATTGGCCTGG TGGCGTCAGG AACAAAATGT GGAGAGGGAA TGGTGTGCAA CAATGGTGAA 
TGTCTAAACA TGGAAAAGGT CTATATCTCA ACCAATTGCC CCTCTCAGTG CAATGAAAAT 
CCTGTGGATG GCCACGGACT CCAGTGCCAC TGTGAGGAAG GACAGGCACC TGTAGCCTGT 
GAAGAAACCT TACATGTTAC CAATATCACC ATCTTGGTTG TTGTGCTTGT CCTGGTTATT 
GTCGGTATCG GAGTTCTTAT ACTATTAGTT CGTTACCGAA AATGTATCAA GTTGAAGCAA 
GTTCAGAGCC CACCTACAGA AACCCTGGGA GTGGAGAACA AAGGATACTT TGGTGATGAG 
CAGCAGATAA GGACTGAGCC AATCCTGCCA GAAATTCATT TCCTAAATAA ACCTGCAAGT 
AAAGATTCAA GAGGAATCGC AGATCCCAAT CAAAGTGCCA AGTGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016869432.1
CDS	1..2268
Translation	MLPGCIFLMILLIPQVKEKFILGVEGQQLVRPKKLPLIQKRDTGHTHDDDILKTYEEELLYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDSAASISTCNGLRGFFRINDQRYLIEPVKYSDEGEHLVFKYNLRVPYGANYSCTELNFTRKTVPGDNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGMVNFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVLLSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDEFPCTCPSGKCVMDSDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCGNKKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKDECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDICYKMNTKGNKFGYCKNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQKNATVKCKTIFLYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNENPVDGHGLQCHCEEGQAPVACEETLHVTNITILVVVLVLVIVGIGVLILLVRYRKCIKLKQVQSPPTETLGVENKGYFGDEQQIRTEPILPEIHFLNKPASKDSRGIADPNQSAKW

Target ORF information:

RefSeq Version	XM_017013943.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ADAM metallopeptidase domain 7 (ADAM7), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017013943.1

ORF Insert Sequence:

ATGCTTCCCG GGTGTATATT CTTGATGATT TTACTCATTC CTCAGGTTAA AGAAAAGTTC 
ATCCTTGGAG TAGAGGGTCA ACAACTGGTT CGTCCTAAAA AGCTTCCTCT GATACAGAAG 
CGAGATACTG GACACACCCA TGATGATGAC ATACTGAAAA CGTATGAAGA AGAATTGTTG 
TATGAAATAA AACTAAATAG AAAAACCTTA GTCCTTCATC TTCTAAGATC CAGGGAGTTC 
CTAGGCTCAA ATTACAGTGA AACATTCTAC TCCATGAAAG GAGAAGCGTT CACCAGGCAT 
CCTCAGATCA TGGATCATTG TTTTTACCAA GGATCCATAG TACACGAATA TGATTCAGCT 
GCCAGTATCA GTACGTGTAA TGGTCTAAGG GGATTCTTCA GAATAAACGA CCAAAGATAC 
CTCATTGAAC CAGTGAAATA CTCAGATGAG GGAGAACATT TGGTGTTCAA ATATAACCTG 
AGGGTGCCGT ATGGTGCCAA TTATTCCTGT ACAGAGCTTA ATTTTACCAG AAAAACTGTT 
CCAGGGGATA ATGAATCTGA AGAAGACTCC AAAATAAAAG GCATCCATGA TGAAAAGTAT 
GTTGAATTGT TCATTGTTGC TGATGATACT GTGTATCGCA GAAATGGTCA TCCTCACAAT 
AAACTAAGGA ACCGAATTTG GGGAATGGTC AATTTTGTCA ACATGATTTA TAAAACCTTA 
AACATCCATG TGACGTTGGT TGGCATTGAA ATATGGACAC ATGAAGATAA AATAGAACTA 
TATTCAAATA TAGAAACTAC CTTATTGCGT TTTTCATTTT GGCAAGAAAA GATCCTTAAA 
ACACGGAAGG ATTTTGATCA TGTTGTATTA CTCAGTGGGA AGTGGCTCTA CTCACATGTG 
CAAGGAATTT CTTATCCAGG GGGTATGTGC CTGCCCTATT ATTCCACCAG TATCATTAAG 
GATCTTTTAC CTGACACAAA CATAATTGCA AACAGAATGG CACATCAACT GGGGCATAAC 
CTTGGGATGC AGCATGACGA GTTCCCATGC ACCTGTCCTT CAGGAAAATG CGTGATGGAC 
AGTGATGGAA GCATTCCTGC ACTGAAATTC AGTAAATGCA GCCAAAACCA ATACCACCAG 
TACTTGAAGG ATTATAAGCC AACATGCATG CTCAACATTC CATTTCCTTA CAATTTTCAT 
GATTTCCAAT TTTGTGGAAA CAAGAAGTTG GATGAGGGTG AAGAGTGTGA CTGTGGCCCT 
GCTCAGGAGT GTACTAATCC TTGCTGTGAT GCACACACAT GTGTACTGAA GCCAGGATTT 
ACTTGTGCAG AAGGAGAATG CTGTGAATCT TGTCAGATAA AAAAAGCAGG GTCCATATGC 
AGACCGGCGA AAGATGAATG TGATTTTCCT GAGATGTGCA CTGGCCACTC GCCTGCCTGT 
CCTAAGGACC AGTTCAGGGT CAATGGATTT CCTTGCAAGA ACTCAGAAGG CTACTGTTTC 
ATGGGGAAAT GTCCAACTCG TGAGGATCAG TGCTCTGAAC TATTTGATGA TGAGGCAATA 
GAGAGTCATG ATATCTGCTA CAAGATGAAT ACAAAAGGAA ATAAATTTGG ATACTGCAAA 
AACAAGGAAA ACAGATTTCT TCCCTGTGAG GAGAAAGATG TCAGATGTGG AAAGATCTAC 
TGCACTGGAG GGGAGCTTTC CTCTCTCCTT GGAGAAGACA AGACTTATCA CCTTAAGGAT 
CCCCAGAAGA ATGCTACTGT CAAATGCAAA ACTATTTTTT TATACCATGA TTCTACAGAC 
ATTGGCCTGG TGGCGTCAGG AACAAAATGT GGAGAGGGAA TGGTGTGCAA CAATGGTGAA 
TGTCTAAACA TGGAAAAGGT CTATATCTCA ACCAATTGCC CCTCTCAGTG CAATGAAAAT 
CCTGTGGATG GCCACGGACT CCAGTGCCAC TGTGAGGAAG GACAGGCACC TGTAGCCTGT 
GAAGAAACCT TACATGTTAC CAATATCACC ATCTTGGTTG TTGTGCTTGT CCTGGTTATT 
GTCGGTATCG GAGTTCTTAT ACTATTAGTT CGTTACCGAA AATGTATCAA GTTGAAGCAA 
GTTCAGAGCC CACCTACAGA AACCCTGGGA GTGGAGAACA AAGGATACTT TGGTGATGAG 
CAGCAGATAA GGACTGAGCC AATCCTGCCA GAAATTCATT TCCTAAATAA ACCTGCAAGT 
AAAGATTCAA GAGGAATCGC AGATCCCAAT CAAAGTGCCA AGTGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder.
Psychiatry research206(2-3)223-31(2013 Apr)
Sprooten E,Fleming KM,Thomson PA,Bastin ME,Whalley HC,Hall J,Sussmann JE,McKirdy J,Blackwood D,Lawrie SM,McIntosh AM

Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma.
Human mutation32(6)E2148-75(2011 Jun)
Wei X,Moncada-Pazos A,Cal S,Soria-Valles C,Gartner J,Rudloff U,Lin JC,,Rosenberg SA,L?pez-Ot?n C,Samuels Y

ADAM7 is associated with epididymosomes and integrated into sperm plasma membrane.
Molecules and cells28(5)441-6(2009 Nov)
Oh JS,Han C,Cho C

Molecular, biochemical, and cellular characterization of epididymal ADAMs, ADAM7 and ADAM28.
Biochemical and biophysical research communications331(4)1374-83(2005 Jun)
Oh J,Woo JM,Choi E,Kim T,Cho BN,Park ZY,Kim YC,Kim DH,Cho C

The ADAMs family of metalloproteases: multidomain proteins with multiple functions.
Genes & development17(1)7-30(2003 Jan)
Seals DF,Courtneidge SA

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ADAM7 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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