CDC23 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CDC23
Entrez Gene ID	8697
Full Name	cell division cycle 23
Synonyms	ANAPC8,APC8,CUT23
General protein information	Preferred Names cell division cycle 23 Names cell division cycle protein 23 homolog anaphase-promoting complex subunit 8 cell division cycle 23 homolog cyclosome subunit 8
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q31.2
Summary	The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008].
Disorder MIM:	603462

mRNA and Protein(s)

mRNA	Protein	Name
NM_004661.3	NP_004652.2	cell division cycle protein 23 homolog
NM_004661.4	NP_004652.2	cell division cycle protein 23 homolog

Pathways from BioSystems

Homologies

	CDC23	XP_001112573.1
Rattus norvegicus (Norway rat)	Cdc23	NP_001094129.1
Drosophila melanogaster (fruit fly)	CG31687	NP_001163022.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009880	XP_319000.3
Saccharomyces cerevisiae (baker's yeast)	CDC23	NP_012036.1
Schizosaccharomyces pombe (fission yeast)	cut23	NP_593300.1
Bos taurus (cattle)	CDC23	NP_001073735.1
Gallus gallus (chicken)	CDC23	XP_003642151.1
Danio rerio (zebrafish)	cdc23	NP_957227.1
Kluyveromyces lactis	KLLA0A05258g	XP_451232.1
Magnaporthe oryzae (rice blast fungus)	MGG_08648	XP_003711081.1
Oryza sativa (rice)	Os02g0656300	NP_001047624.1
Homo sapiens (human)	CDC23	NP_004652.2
Neurospora crassa	NCU01174	XP_961540.2
Pan troglodytes (chimpanzee)	CDC23	XP_517953.2
Canis lupus familiaris (dog)	CDC23	XP_538647.2
Mus musculus (house mouse)	Cdc23	NP_848124.1
Drosophila melanogaster (fruit fly)	cdc23	NP_001260629.1
Eremothecium gossypii	AGOS_ABR206W	NP_983155.2
Arabidopsis thaliana (thale cress)	APC8	NP_190398.1
Xenopus tropicalis (tropical clawed frog)	cdc23	NP_001016759.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R,
Nature communications711491(2016 May)

An inter-species protein-protein interaction network across vast evolutionary distance.
Zhong Q, Pevzner SJ, Hao T, Wang Y, Mosca R, Menche J, Taipale M, Ta?an M, Fan C, Yang X, Haley P, Murray RR, Mer F, Gebreab F, Tam S, MacWilliams A, Dricot A, Reichert P, Santhanam B, Ghamsari L, Calderwood MA, Rolland T, Charloteaux B, Lindquist S, Barab?si AL, Hill DE, Aloy P, Cusick ME, Xia Y, Roth FP, Vidal M
Molecular systems biology12(4)865(2016 Apr)

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results identified CDC23 as a miR-34c-regulated target that could be responsible for the miR-34c-induced cell cycle arrest.
Title: Expression of miR-34c induces G2/M cell cycle arrest in breast cancer cells.

Cdc20 requires APC3 and APC8 to bind and activate the APC/C when the spindle assembly checkpoint is satisfied, but only APC8 when active, and APC10 is crucial for the destruction of cyclin B1 and securin, but not cyclin A
Title: How APC/C-Cdc20 changes its substrate specificity in?mitosis.

CDC23 is a critical regulator of cell cycle and cell growth, may be involved in thyroid cancer initiation and progression, and may explain the different tumor biology observed by gender.
Title: CDC23 regulates cancer cell phenotype and is overexpressed in papillary thyroid cancer.

We report gene alterations in several components of this complex in human colon cancer cells, including APC6/CDC16 and APC8/CDC23 which are known to be key function elements.
Title: Alterations of anaphase-promoting complex genes in human colon cancer cells.

The following CDC23 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDC23 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04188	NM_004661.4 Latest version!	Homo sapiens cell division cycle 23 (CDC23), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$349.30 $499.00
View Old Accession Versions >>
OHu04188	NM_004661.3	Homo sapiens cell division cycle 23 (CDC23), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$349.30 $499.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CDC23 ( NM_004661.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004652.2 Homo sapiens cell division cycle 23 (CDC23), mRNA.

Price & Availability↑

CloneID	OHu04188
Clone ID Related Accession (Same CDS sequence)	NM_004661.3 , NM_004661.4
Accession Version	NM_004661.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1794bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-26
Organism	Homo sapiens(human)
Product	cell division cycle protein 23 homolog
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC106752.3 and BC017713.1. On Nov 24, 2006 this sequence version replaced NM_004661.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.262676.1, SRR1660807.1149.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCGA GTACCTCCAT GGTCCCGGTG GCTGTGACGG CGGCAGTGGC GCCTGTCCTG 
TCCATAAACA GCGATTTCTC AGATTTGCGG GAAATTAAAA AGCAACTGCT GCTTATTGCG 
GGCCTTACCC GGGAGCGGGG CCTACTACAC AGTAGCAAAT GGTCGGCGGA GTTGGCTTTC 
TCTCTCCCTG CATTGCCTCT GGCCGAGCTG CAACCGCCTC CGCCTATTAC AGAGGAAGAT 
GCCCAGGATA TGGATGCCTA TACCCTGGCC AAGGCCTACT TTGACGTTAA AGAGTATGAT 
CGGGCAGCAC ATTTCCTGCA TGGCTGCAAT AGCAAGAAAG CCTATTTTCT GTATATGTAT 
TCCAGATATC TGTCTGGAGA AAAAAAGAAG GACGATGAAA CAGTTGATAG CTTAGGCCCC 
CTGGAAAAAG GACAAGTGAA AAATGAGGCG CTTAGAGAAT TGAGAGTGGA GCTCAGCAAA 
AAACACCAAG CTCGAGAACT TGATGGATTT GGACTTTATC TGTATGGTGT GGTGCTTCGA 
AAACTGGACT TGGTTAAAGA GGCCATTGAT GTGTTTGTGG AAGCTACTCA TGTTTTGCCC 
TTGCATTGGG GAGCCTGGTT AGAACTCTGT AACCTGATCA CAGACAAAGA GATGCTGAAG 
TTCCTGTCTT TGCCAGACAC CTGGATGAAA GAGTTTTTTC TGGCTCATAT ATACACAGAG 
TTGCAGTTGA TAGAGGAGGC CCTGCAAAAG TATCAGAATC TCATTGATGT GGGCTTCTCT 
AAGAGCTCGT ATATTGTTTC CCAAATTGCA GTTGCCTATC ACAATATCAG AGATATTGAC 
AAAGCCCTCT CCATTTTTAA TGAGCTAAGG AAACAAGACC CTTACAGGAT TGAAAATATG 
GACACATTCT CCAACCTTCT TTATGTCAGG AGCATGAAAT CGGAGTTGAG TTATCTGGCT 
CATAACCTCT GTGAGATTGA TAAATATCGT GTAGAAACGT GCTGTGTAAT TGGCAATTAT 
TACAGTTTAC GTTCTCAGCA TGAGAAAGCA GCCTTATATT TCCAGAGAGC CCTGAAATTA 
AATCCTCGGT ATCTTGGTGC CTGGACACTA ATGGGACATG AGTACATGGA GATGAAGAAC 
ACGTCTGCTG CTATCCAGGC TTATAGACAT GCCATTGAGG TCAACAAACG GGACTACAGA 
GCTTGGTATG GCCTCGGGCA GACCTATGAA ATCCTTAAGA TGCCATTTTA CTGCCTTTAT 
TATTATAGAC GGGCCCACCA GCTTCGACCC AATGATTCTC GCATGCTGGT TGCTTTAGGA 
GAATGTTACG AGAAACTCAA TCAACTAGTG GAAGCCAAAA AGTGTTATTG GAGAGCTTAC 
GCCGTGGGAG ATGTGGAGAA AATGGCTCTG GTGAAACTGG CAAAGCTTCA TGAACAGTTG 
ACTGAGTCAG AACAGGCTGC CCAGTGTTAC ATCAAATATA TCCAAGATAT CTATTCCTGT 
GGGGAAATAG TAGAACACTT GGAGGAAAGC ACTGCCTTTC GCTATCTGGC CCAGTACTAT 
TTTAAGTGCA AACTGTGGGA TGAAGCTTCA ACTTGTGCAC AAAAGTGTTG TGCATTTAAT 
GATACCCGGG AAGAAGGTAA GGCCTTACTC CGGCAAATCC TACAGCTTCG GAACCAAGGC 
GAGACTCCTA CCACCGAGGT GCCTGCTCCC TTTTTCCTAC CTGCTTCACT CTCTGCTAAC 
AATACCCCCA CACGCAGAGT TTCTCCACTC AACTTGTCTT CTGTCACGCC ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004652.2
CDS	32..1825
Translation	MAASTSMVPVAVTAAVAPVLSINSDFSDLREIKKQLLLIAGLTRERGLLHSSKWSAELAFSLPALPLAELQPPPPITEEDAQDMDAYTLAKAYFDVKEYDRAAHFLHGCNSKKAYFLYMYSRYLSGEKKKDDETVDSLGPLEKGQVKNEALRELRVELSKKHQARELDGFGLYLYGVVLRKLDLVKEAIDVFVEATHVLPLHWGAWLELCNLITDKEMLKFLSLPDTWMKEFFLAHIYTELQLIEEALQKYQNLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQLTESEQAAQCYIKYIQDIYSCGEIVEHLEESTAFRYLAQYYFKCKLWDEASTCAQKCCAFNDTREEGKALLRQILQLRNQGETPTTEVPAPFFLPASLSANNTPTRRVSPLNLSSVTP

Target ORF information:

RefSeq Version	NM_004661.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cell division cycle 23 (CDC23), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004661.3

ORF Insert Sequence:

ATGGCTGCGA GTACCTCCAT GGTCCCGGTG GCTGTGACGG CGGCAGTGGC GCCTGTCCTG 
TCCATAAACA GCGATTTCTC AGATTTGCGG GAAATTAAAA AGCAACTGCT GCTTATTGCG 
GGCCTTACCC GGGAGCGGGG CCTACTACAC AGTAGCAAAT GGTCGGCGGA GTTGGCTTTC 
TCTCTCCCTG CATTGCCTCT GGCCGAGCTG CAACCGCCTC CGCCTATTAC AGAGGAAGAT 
GCCCAGGATA TGGATGCCTA TACCCTGGCC AAGGCCTACT TTGACGTTAA AGAGTATGAT 
CGGGCAGCAC ATTTCCTGCA TGGCTGCAAT AGCAAGAAAG CCTATTTTCT GTATATGTAT 
TCCAGATATC TGTCTGGAGA AAAAAAGAAG GACGATGAAA CAGTTGATAG CTTAGGCCCC 
CTGGAAAAAG GACAAGTGAA AAATGAGGCG CTTAGAGAAT TGAGAGTGGA GCTCAGCAAA 
AAACACCAAG CTCGAGAACT TGATGGATTT GGACTTTATC TGTATGGTGT GGTGCTTCGA 
AAACTGGACT TGGTTAAAGA GGCCATTGAT GTGTTTGTGG AAGCTACTCA TGTTTTGCCC 
TTGCATTGGG GAGCCTGGTT AGAACTCTGT AACCTGATCA CAGACAAAGA GATGCTGAAG 
TTCCTGTCTT TGCCAGACAC CTGGATGAAA GAGTTTTTTC TGGCTCATAT ATACACAGAG 
TTGCAGTTGA TAGAGGAGGC CCTGCAAAAG TATCAGAATC TCATTGATGT GGGCTTCTCT 
AAGAGCTCGT ATATTGTTTC CCAAATTGCA GTTGCCTATC ACAATATCAG AGATATTGAC 
AAAGCCCTCT CCATTTTTAA TGAGCTAAGG AAACAAGACC CTTACAGGAT TGAAAATATG 
GACACATTCT CCAACCTTCT TTATGTCAGG AGCATGAAAT CGGAGTTGAG TTATCTGGCT 
CATAACCTCT GTGAGATTGA TAAATATCGT GTAGAAACGT GCTGTGTAAT TGGCAATTAT 
TACAGTTTAC GTTCTCAGCA TGAGAAAGCA GCCTTATATT TCCAGAGAGC CCTGAAATTA 
AATCCTCGGT ATCTTGGTGC CTGGACACTA ATGGGACATG AGTACATGGA GATGAAGAAC 
ACGTCTGCTG CTATCCAGGC TTATAGACAT GCCATTGAGG TCAACAAACG GGACTACAGA 
GCTTGGTATG GCCTCGGGCA GACCTATGAA ATCCTTAAGA TGCCATTTTA CTGCCTTTAT 
TATTATAGAC GGGCCCACCA GCTTCGACCC AATGATTCTC GCATGCTGGT TGCTTTAGGA 
GAATGTTACG AGAAACTCAA TCAACTAGTG GAAGCCAAAA AGTGTTATTG GAGAGCTTAC 
GCCGTGGGAG ATGTGGAGAA AATGGCTCTG GTGAAACTGG CAAAGCTTCA TGAACAGTTG 
ACTGAGTCAG AACAGGCTGC CCAGTGTTAC ATCAAATATA TCCAAGATAT CTATTCCTGT 
GGGGAAATAG TAGAACACTT GGAGGAAAGC ACTGCCTTTC GCTATCTGGC CCAGTACTAT 
TTTAAGTGCA AACTGTGGGA TGAAGCTTCA ACTTGTGCAC AAAAGTGTTG TGCATTTAAT 
GATACCCGGG AAGAAGGTAA GGCCTTACTC CGGCAAATCC TACAGCTTCG GAACCAAGGC 
GAGACTCCTA CCACCGAGGT GCCTGCTCCC TTTTTCCTAC CTGCTTCACT CTCTGCTAAC 
AATACCCCCA CACGCAGAGT TTCTCCACTC AACTTGTCTT CTGTCACGCC ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDC23 ( NM_004661.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004652.2 Homo sapiens cell division cycle 23 (CDC23), mRNA.

Price & Availability↑

CloneID	OHu04188
Clone ID Related Accession (Same CDS sequence)	NM_004661.3 , NM_004661.4
Accession Version	NM_004661.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1794bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	cell division cycle protein 23 homolog
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC106752.3 and BC017713.1. On Nov 23, 2018 this sequence version replaced NM_004661.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.212236.1, SRR1660805.62674.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000394886.7/ ENSP00000378350.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTGCGA GTACCTCCAT GGTCCCGGTG GCTGTGACGG CGGCAGTGGC GCCTGTCCTG 
TCCATAAACA GCGATTTCTC AGATTTGCGG GAAATTAAAA AGCAACTGCT GCTTATTGCG 
GGCCTTACCC GGGAGCGGGG CCTACTACAC AGTAGCAAAT GGTCGGCGGA GTTGGCTTTC 
TCTCTCCCTG CATTGCCTCT GGCCGAGCTG CAACCGCCTC CGCCTATTAC AGAGGAAGAT 
GCCCAGGATA TGGATGCCTA TACCCTGGCC AAGGCCTACT TTGACGTTAA AGAGTATGAT 
CGGGCAGCAC ATTTCCTGCA TGGCTGCAAT AGCAAGAAAG CCTATTTTCT GTATATGTAT 
TCCAGATATC TGTCTGGAGA AAAAAAGAAG GACGATGAAA CAGTTGATAG CTTAGGCCCC 
CTGGAAAAAG GACAAGTGAA AAATGAGGCG CTTAGAGAAT TGAGAGTGGA GCTCAGCAAA 
AAACACCAAG CTCGAGAACT TGATGGATTT GGACTTTATC TGTATGGTGT GGTGCTTCGA 
AAACTGGACT TGGTTAAAGA GGCCATTGAT GTGTTTGTGG AAGCTACTCA TGTTTTGCCC 
TTGCATTGGG GAGCCTGGTT AGAACTCTGT AACCTGATCA CAGACAAAGA GATGCTGAAG 
TTCCTGTCTT TGCCAGACAC CTGGATGAAA GAGTTTTTTC TGGCTCATAT ATACACAGAG 
TTGCAGTTGA TAGAGGAGGC CCTGCAAAAG TATCAGAATC TCATTGATGT GGGCTTCTCT 
AAGAGCTCGT ATATTGTTTC CCAAATTGCA GTTGCCTATC ACAATATCAG AGATATTGAC 
AAAGCCCTCT CCATTTTTAA TGAGCTAAGG AAACAAGACC CTTACAGGAT TGAAAATATG 
GACACATTCT CCAACCTTCT TTATGTCAGG AGCATGAAAT CGGAGTTGAG TTATCTGGCT 
CATAACCTCT GTGAGATTGA TAAATATCGT GTAGAAACGT GCTGTGTAAT TGGCAATTAT 
TACAGTTTAC GTTCTCAGCA TGAGAAAGCA GCCTTATATT TCCAGAGAGC CCTGAAATTA 
AATCCTCGGT ATCTTGGTGC CTGGACACTA ATGGGACATG AGTACATGGA GATGAAGAAC 
ACGTCTGCTG CTATCCAGGC TTATAGACAT GCCATTGAGG TCAACAAACG GGACTACAGA 
GCTTGGTATG GCCTCGGGCA GACCTATGAA ATCCTTAAGA TGCCATTTTA CTGCCTTTAT 
TATTATAGAC GGGCCCACCA GCTTCGACCC AATGATTCTC GCATGCTGGT TGCTTTAGGA 
GAATGTTACG AGAAACTCAA TCAACTAGTG GAAGCCAAAA AGTGTTATTG GAGAGCTTAC 
GCCGTGGGAG ATGTGGAGAA AATGGCTCTG GTGAAACTGG CAAAGCTTCA TGAACAGTTG 
ACTGAGTCAG AACAGGCTGC CCAGTGTTAC ATCAAATATA TCCAAGATAT CTATTCCTGT 
GGGGAAATAG TAGAACACTT GGAGGAAAGC ACTGCCTTTC GCTATCTGGC CCAGTACTAT 
TTTAAGTGCA AACTGTGGGA TGAAGCTTCA ACTTGTGCAC AAAAGTGTTG TGCATTTAAT 
GATACCCGGG AAGAAGGTAA GGCCTTACTC CGGCAAATCC TACAGCTTCG GAACCAAGGC 
GAGACTCCTA CCACCGAGGT GCCTGCTCCC TTTTTCCTAC CTGCTTCACT CTCTGCTAAC 
AATACCCCCA CACGCAGAGT TTCTCCACTC AACTTGTCTT CTGTCACGCC ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004652.2
CDS	12..1805
Translation	MAASTSMVPVAVTAAVAPVLSINSDFSDLREIKKQLLLIAGLTRERGLLHSSKWSAELAFSLPALPLAELQPPPPITEEDAQDMDAYTLAKAYFDVKEYDRAAHFLHGCNSKKAYFLYMYSRYLSGEKKKDDETVDSLGPLEKGQVKNEALRELRVELSKKHQARELDGFGLYLYGVVLRKLDLVKEAIDVFVEATHVLPLHWGAWLELCNLITDKEMLKFLSLPDTWMKEFFLAHIYTELQLIEEALQKYQNLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQLTESEQAAQCYIKYIQDIYSCGEIVEHLEESTAFRYLAQYYFKCKLWDEASTCAQKCCAFNDTREEGKALLRQILQLRNQGETPTTEVPAPFFLPASLSANNTPTRRVSPLNLSSVTP

Target ORF information:

RefSeq Version	NM_004661.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cell division cycle 23 (CDC23), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004661.4

ORF Insert Sequence:

ATGGCTGCGA GTACCTCCAT GGTCCCGGTG GCTGTGACGG CGGCAGTGGC GCCTGTCCTG 
TCCATAAACA GCGATTTCTC AGATTTGCGG GAAATTAAAA AGCAACTGCT GCTTATTGCG 
GGCCTTACCC GGGAGCGGGG CCTACTACAC AGTAGCAAAT GGTCGGCGGA GTTGGCTTTC 
TCTCTCCCTG CATTGCCTCT GGCCGAGCTG CAACCGCCTC CGCCTATTAC AGAGGAAGAT 
GCCCAGGATA TGGATGCCTA TACCCTGGCC AAGGCCTACT TTGACGTTAA AGAGTATGAT 
CGGGCAGCAC ATTTCCTGCA TGGCTGCAAT AGCAAGAAAG CCTATTTTCT GTATATGTAT 
TCCAGATATC TGTCTGGAGA AAAAAAGAAG GACGATGAAA CAGTTGATAG CTTAGGCCCC 
CTGGAAAAAG GACAAGTGAA AAATGAGGCG CTTAGAGAAT TGAGAGTGGA GCTCAGCAAA 
AAACACCAAG CTCGAGAACT TGATGGATTT GGACTTTATC TGTATGGTGT GGTGCTTCGA 
AAACTGGACT TGGTTAAAGA GGCCATTGAT GTGTTTGTGG AAGCTACTCA TGTTTTGCCC 
TTGCATTGGG GAGCCTGGTT AGAACTCTGT AACCTGATCA CAGACAAAGA GATGCTGAAG 
TTCCTGTCTT TGCCAGACAC CTGGATGAAA GAGTTTTTTC TGGCTCATAT ATACACAGAG 
TTGCAGTTGA TAGAGGAGGC CCTGCAAAAG TATCAGAATC TCATTGATGT GGGCTTCTCT 
AAGAGCTCGT ATATTGTTTC CCAAATTGCA GTTGCCTATC ACAATATCAG AGATATTGAC 
AAAGCCCTCT CCATTTTTAA TGAGCTAAGG AAACAAGACC CTTACAGGAT TGAAAATATG 
GACACATTCT CCAACCTTCT TTATGTCAGG AGCATGAAAT CGGAGTTGAG TTATCTGGCT 
CATAACCTCT GTGAGATTGA TAAATATCGT GTAGAAACGT GCTGTGTAAT TGGCAATTAT 
TACAGTTTAC GTTCTCAGCA TGAGAAAGCA GCCTTATATT TCCAGAGAGC CCTGAAATTA 
AATCCTCGGT ATCTTGGTGC CTGGACACTA ATGGGACATG AGTACATGGA GATGAAGAAC 
ACGTCTGCTG CTATCCAGGC TTATAGACAT GCCATTGAGG TCAACAAACG GGACTACAGA 
GCTTGGTATG GCCTCGGGCA GACCTATGAA ATCCTTAAGA TGCCATTTTA CTGCCTTTAT 
TATTATAGAC GGGCCCACCA GCTTCGACCC AATGATTCTC GCATGCTGGT TGCTTTAGGA 
GAATGTTACG AGAAACTCAA TCAACTAGTG GAAGCCAAAA AGTGTTATTG GAGAGCTTAC 
GCCGTGGGAG ATGTGGAGAA AATGGCTCTG GTGAAACTGG CAAAGCTTCA TGAACAGTTG 
ACTGAGTCAG AACAGGCTGC CCAGTGTTAC ATCAAATATA TCCAAGATAT CTATTCCTGT 
GGGGAAATAG TAGAACACTT GGAGGAAAGC ACTGCCTTTC GCTATCTGGC CCAGTACTAT 
TTTAAGTGCA AACTGTGGGA TGAAGCTTCA ACTTGTGCAC AAAAGTGTTG TGCATTTAAT 
GATACCCGGG AAGAAGGTAA GGCCTTACTC CGGCAAATCC TACAGCTTCG GAACCAAGGC 
GAGACTCCTA CCACCGAGGT GCCTGCTCCC TTTTTCCTAC CTGCTTCACT CTCTGCTAAC 
AATACCCCCA CACGCAGAGT TTCTCCACTC AACTTGTCTT CTGTCACGCC ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Nature communications711491(2016 May)
Boldt K,van Reeuwijk J,Lu Q,Koutroumpas K,Nguyen TM,Texier Y,van Beersum SE,Horn N,Willer JR,Mans DA,Dougherty G,Lamers IJ,Coene KL,Arts HH,Betts MJ,Beyer T,Bolat E,Gloeckner CJ,Haidari K,Hetterschijt L,Iaconis D,Jenkins D,Klose F,Knapp B,Latour B,Letteboer SJ,Marcelis CL,Mitic D,Morleo M,Oud MM,Riemersma M,Rix S,Terhal PA,Toedt G,van Dam TJ,de Vrieze E,Wissinger Y,Wu KM,Apic G,Beales PL,Blacque OE,Gibson TJ,Huynen MA,Katsanis N,Kremer H,Omran H,van Wijk E,Wolfrum U,Kepes F,Davis EE,Franco B,Giles RH,Ueffing M,Russell RB,Roepman R,

An inter-species protein-protein interaction network across vast evolutionary distance.
Molecular systems biology12(4)865(2016 Apr)
Zhong Q,Pevzner SJ,Hao T,Wang Y,Mosca R,Menche J,Taipale M,Ta?an M,Fan C,Yang X,Haley P,Murray RR,Mer F,Gebreab F,Tam S,MacWilliams A,Dricot A,Reichert P,Santhanam B,Ghamsari L,Calderwood MA,Rolland T,Charloteaux B,Lindquist S,Barab?si AL,Hill DE,Aloy P,Cusick ME,Xia Y,Roth FP,Vidal M

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M

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CDC23 cDNA ORF clone, Homo sapiens(human)

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ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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