HYAL2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HYAL2
Entrez Gene ID	8692
Full Name	hyaluronoglucosaminidase 2
Synonyms	LUCA2
General protein information	Preferred Names hyaluronoglucosaminidase 2 Names hyaluronidase-2 PH-20 homolog PH20 homolog hyal-2 lung carcinoma protein 2 lysosomal hyaluronidase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3p21.31
Summary	This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.[provided by RefSeq, Mar 2010].
Disorder MIM:	603551

mRNA and Protein(s)

mRNA	Protein	Name
XM_005265525.2	XP_005265582.1	hyaluronidase-2 isoform X1
NM_003773.4	NP_003764.3	hyaluronidase-2 precursor
NM_033158.4	NP_149348.2	hyaluronidase-2 precursor
XM_005265524.2	XP_005265581.1	hyaluronidase-2 isoform X1
NM_003773.5	NP_003764.3	hyaluronidase-2 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	HYAL2	XP_001168599.1
Danio rerio (zebrafish)	hyal2	XP_687640.2
Rattus norvegicus (Norway rat)	Hyal2	NP_742037.2
Danio rerio (zebrafish)	LOC100330444	XP_002662593.3
Danio rerio (zebrafish)	LOC567869	XP_005166205.1
Homo sapiens (human)	HYAL2	NP_149348.2
	HYAL2	XP_001101134.1
Bos taurus (cattle)	HYAL2	NP_776772.1
Gallus gallus (chicken)	HYAL2	XP_414258.2
Canis lupus familiaris (dog)	HYAL2	XP_005632567.1
Mus musculus (house mouse)	Hyal2	NP_034619.2
Xenopus tropicalis (tropical clawed frog)	hyal2	NP_001119986.1

Gene Ontology
Bibliography

Related articles in PubMed

Nuclear hyaluronidase 2 drives alternative splicing of
Midgley AC, Oltean S, Hascall V, Woods EL, Steadman R, Phillips AO, Meran S
Science signaling10(506)(2017 Nov)

Whole exome sequencing in the Framingham Heart Study identifies rare variation in HYAL2 that influences platelet aggregation.
Eicher JD, Chen MH, Pitsillides AN, Lin H, Veeraraghavan N, Brody JA, Metcalf GA, Muzny DM, Gibbs RA, Becker DM, Becker LC, Faraday N, Mathias RA, Yanek LR, Boerwinkle E, Cupples LA, Johnson AD
Thrombosis and haemostasis117(6)1083-1092(2017 Jun)

Mutations in HYAL2, Encoding Hyaluronidase 2, Cause a Syndrome of Orofacial Clefting and Cor Triatriatum Sinister in Humans and Mice.
Muggenthaler MM, Chowdhury B, Hasan SN, Cross HE, Mark B, Harlalka GV, Patton MA, Ishida M, Behr ER, Sharma S, Zahka K, Faqeih E, Blakley B, Jackson M, Lees M, Dolinsky V, Cross L, Stanier P, Salter C, Baple EL, Alkuraya FS, Crosby AH, Triggs-Raine B, Chioza BA
PLoS genetics13(1)e1006470(2017 Jan)

The role of HYAL2 in LSS-induced glycocalyx impairment and the PKA-mediated decrease in eNOS-Ser-633 phosphorylation and nitric oxide production.
Kong X, Chen L, Ye P, Wang Z, Zhang J, Ye F, Chen S
Molecular biology of the cell27(25)3972-3979(2016 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

HYAL2 mutations identified as a cause of syndromic orofacial clefting and cor triatriatum sinister in amish families.
Title: Mutations in HYAL2, Encoding Hyaluronidase 2, Cause a Syndrome of Orofacial Clefting and Cor Triatriatum Sinister in Humans and Mice.

Knocking down HYAL2 in HUVECs protected against HA degradation in the glycocalyx by inhibiting the expression and activity of HYAL2 and further blocked the dephosphorylation of eNOS-Ser-633 and the decrease in NO production in response to LSS.
Title: The role of HYAL2 in LSS-induced glycocalyx impairment and the PKA-mediated decrease in eNOS-Ser-633 phosphorylation and nitric oxide production.

our data uncover a previously unsuspected mechanism of how hyaluronan and Hyal-2 control platelet generation.
Title: Hyaluronan Depolymerization by Megakaryocyte Hyaluronidase-2 Is Required for Thrombopoiesis.

Data show that DNA methylation at CpG island of hyaluronoglucosaminidase 2 (HYLA2) could be used to identify stage II and III colon cancer patients who are most likely to benefit from 5-flourouracil chemotherapy with respect to progression-free survival.
Title: Methylation status at HYAL2 predicts overall and progression-free survival of colon cancer patients under 5-FU chemotherapy.

High expression of S100P and HYAL2 is significantly associated with advanced disease and shorter survival of triple-negative breast cancer and S100P and HYAL2 could be potential prognostic markers of TNBC.
Title: S100P and HYAL2 as prognostic markers for patients with triple-negative breast cancer.

The following HYAL2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HYAL2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03539	NM_003773.5 Latest version!	Homo sapiens hyaluronidase 2 (HYAL2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu03539	NM_033158.4 Latest version!	Homo sapiens hyaluronidase 2 (HYAL2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu03539	XM_005265525.2 Latest version!	Homo sapiens hyaluronidase 2 (HYAL2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu03539	XM_005265524.2 Latest version!	Homo sapiens hyaluronidase 2 (HYAL2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu03539	NM_003773.4	Homo sapiens hyaluronoglucosaminidase 2 (HYAL2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HYAL2 ( NM_003773.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_003764.3 Homo sapiens hyaluronidase 2 (HYAL2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu03539
Clone ID Related Accession (Same CDS sequence)	XM_005265525.2 , NM_003773.4 , NM_033158.4 , XM_005265524.2 , NM_003773.5
Accession Version	NM_003773.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1422bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Homo sapiens(human)
Product	hyaluronidase-2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC358776.1, U09577.1 and AK127945.1. On Nov 23, 2018 this sequence version replaced NM_003773.4. Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.404612.1, SRR3476690.428957.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2147920 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000357750.9/ ENSP00000350387.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCGGGCAG GCCCAGGCCC CACCGTTACA TTGGCCCTGG TGCTGGCGGT GTCATGGGCC 
ATGGAGCTCA AGCCCACAGC ACCACCCATC TTCACTGGCC GGCCCTTTGT GGTAGCGTGG 
GACGTGCCCA CACAGGACTG TGGCCCACGC CTCAAGGTGC CACTGGACCT GAATGCCTTT 
GATGTGCAGG CCTCACCTAA TGAGGGTTTT GTGAACCAGA ATATTACCAT CTTCTACCGC 
GACCGTCTAG GCCTGTATCC ACGCTTCGAT TCTGCCGGAA GGTCTGTGCA TGGTGGTGTG 
CCACAGAATG TCAGCCTTTG GGCACACCGG AAGATGCTGC AGAAACGTGT GGAGCACTAC 
ATTCGGACAC AGGAGTCTGC GGGGCTGGCG GTCATCGACT GGGAGGACTG GCGACCTGTG 
TGGGTGCGCA ACTGGCAGGA CAAAGATGTG TATCGCCGGT TATCACGCCA GCTAGTGGCC 
AGTCGTCACC CTGACTGGCC TCCAGACCGC ATAGTCAAAC AGGCACAATA TGAGTTTGAG 
TTCGCAGCAC AGCAGTTCAT GCTGGAGACA CTGCGTTATG TCAAGGCAGT GCGGCCCCGG 
CACCTCTGGG GCTTCTACCT CTTTCCTGAC TGCTACAATC ATGATTATGT GCAGAACTGG 
GAGAGCTACA CAGGCCGCTG CCCTGATGTT GAGGTGGCCC GCAATGACCA GCTGGCCTGG 
CTGTGGGCTG AGAGCACGGC CCTCTTCCCG TCTGTCTACC TGGACGAGAC ACTTGCTTCC 
TCCCGCCATG GCCGCAACTT TGTGAGCTTC CGTGTTCAGG AGGCCCTTCG TGTGGCTCGC 
ACCCACCATG CCAACCATGC ACTCCCAGTC TACGTCTTCA CACGACCCAC CTACAGCCGC 
AGGCTCACGG GGCTTAGTGA GATGGACCTC ATCTCTACCA TTGGCGAGAG TGCGGCCCTG 
GGCGCAGCTG GTGTCATCCT CTGGGGTGAC GCGGGGTACA CCACAAGCAC GGAGACCTGC 
CAGTACCTCA AAGATTACCT GACACGGCTG CTGGTCCCCT ACGTGGTCAA TGTGTCCTGG 
GCCACCCAAT ATTGCAGCCG GGCCCAGTGC CATGGCCATG GGCGCTGTGT GCGCCGCAAC 
CCCAGTGCCA GTACCTTCCT GCATCTCAGC ACCAACAGTT TCCGCCTAGT GCCTGGCCAT 
GCACCTGGTG AACCCCAGCT GCGACCTGTG GGGGAGCTCA GTTGGGCCGA CATTGACCAC 
CTGCAGACAC ACTTCCGCTG CCAGTGCTAC TTGGGCTGGA GTGGTGAGCA ATGCCAGTGG 
GACCATAGGC AGGCAGCTGG AGGTGCCAGC GAGGCCTGGG CTGGGTCCCA CCTCACCAGT 
CTGCTGGCTC TGGCAGCCCT GGCCTTTACC TGGACCTTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003764.3
CDS	140..1561
Translation	MRAGPGPTVTLALVLAVSWAMELKPTAPPIFTGRPFVVAWDVPTQDCGPRLKVPLDLNAFDVQASPNEGFVNQNITIFYRDRLGLYPRFDSAGRSVHGGVPQNVSLWAHRKMLQKRVEHYIRTQESAGLAVIDWEDWRPVWVRNWQDKDVYRRLSRQLVASRHPDWPPDRIVKQAQYEFEFAAQQFMLETLRYVKAVRPRHLWGFYLFPDCYNHDYVQNWESYTGRCPDVEVARNDQLAWLWAESTALFPSVYLDETLASSRHGRNFVSFRVQEALRVARTHHANHALPVYVFTRPTYSRRLTGLSEMDLISTIGESAALGAAGVILWGDAGYTTSTETCQYLKDYLTRLLVPYVVNVSWATQYCSRAQCHGHGRCVRRNPSASTFLHLSTNSFRLVPGHAPGEPQLRPVGELSWADIDHLQTHFRCQCYLGWSGEQCQWDHRQAAGGASEAWAGSHLTSLLALAALAFTWTL

Target ORF information:

RefSeq Version	NM_003773.5
Organism	Homo sapiens(human)
Definition	Homo sapiens hyaluronidase 2 (HYAL2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003773.5

ORF Insert Sequence:

ATGCGGGCAG GCCCAGGCCC CACCGTTACA TTGGCCCTGG TGCTGGCGGT GTCATGGGCC 
ATGGAGCTCA AGCCCACAGC ACCACCCATC TTCACTGGCC GGCCCTTTGT GGTAGCGTGG 
GACGTGCCCA CACAGGACTG TGGCCCACGC CTCAAGGTGC CACTGGACCT GAATGCCTTT 
GATGTGCAGG CCTCACCTAA TGAGGGTTTT GTGAACCAGA ATATTACCAT CTTCTACCGC 
GACCGTCTAG GCCTGTATCC ACGCTTCGAT TCTGCCGGAA GGTCTGTGCA TGGTGGTGTG 
CCACAGAATG TCAGCCTTTG GGCACACCGG AAGATGCTGC AGAAACGTGT GGAGCACTAC 
ATTCGGACAC AGGAGTCTGC GGGGCTGGCG GTCATCGACT GGGAGGACTG GCGACCTGTG 
TGGGTGCGCA ACTGGCAGGA CAAAGATGTG TATCGCCGGT TATCACGCCA GCTAGTGGCC 
AGTCGTCACC CTGACTGGCC TCCAGACCGC ATAGTCAAAC AGGCACAATA TGAGTTTGAG 
TTCGCAGCAC AGCAGTTCAT GCTGGAGACA CTGCGTTATG TCAAGGCAGT GCGGCCCCGG 
CACCTCTGGG GCTTCTACCT CTTTCCTGAC TGCTACAATC ATGATTATGT GCAGAACTGG 
GAGAGCTACA CAGGCCGCTG CCCTGATGTT GAGGTGGCCC GCAATGACCA GCTGGCCTGG 
CTGTGGGCTG AGAGCACGGC CCTCTTCCCG TCTGTCTACC TGGACGAGAC ACTTGCTTCC 
TCCCGCCATG GCCGCAACTT TGTGAGCTTC CGTGTTCAGG AGGCCCTTCG TGTGGCTCGC 
ACCCACCATG CCAACCATGC ACTCCCAGTC TACGTCTTCA CACGACCCAC CTACAGCCGC 
AGGCTCACGG GGCTTAGTGA GATGGACCTC ATCTCTACCA TTGGCGAGAG TGCGGCCCTG 
GGCGCAGCTG GTGTCATCCT CTGGGGTGAC GCGGGGTACA CCACAAGCAC GGAGACCTGC 
CAGTACCTCA AAGATTACCT GACACGGCTG CTGGTCCCCT ACGTGGTCAA TGTGTCCTGG 
GCCACCCAAT ATTGCAGCCG GGCCCAGTGC CATGGCCATG GGCGCTGTGT GCGCCGCAAC 
CCCAGTGCCA GTACCTTCCT GCATCTCAGC ACCAACAGTT TCCGCCTAGT GCCTGGCCAT 
GCACCTGGTG AACCCCAGCT GCGACCTGTG GGGGAGCTCA GTTGGGCCGA CATTGACCAC 
CTGCAGACAC ACTTCCGCTG CCAGTGCTAC TTGGGCTGGA GTGGTGAGCA ATGCCAGTGG 
GACCATAGGC AGGCAGCTGG AGGTGCCAGC GAGGCCTGGG CTGGGTCCCA CCTCACCAGT 
CTGCTGGCTC TGGCAGCCCT GGCCTTTACC TGGACCTTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HYAL2 ( NM_003773.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003764.3 Homo sapiens hyaluronoglucosaminidase 2 (HYAL2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu03539
Clone ID Related Accession (Same CDS sequence)	XM_005265525.2 , NM_003773.4 , NM_033158.4 , XM_005265524.2 , NM_003773.5
Accession Version	NM_003773.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1422bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-24
Organism	Homo sapiens(human)
Product	hyaluronidase-2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC358776.1, U09577.1 and AK127945.1. On Mar 2, 2010 this sequence version replaced NM_003773.3. Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.237908.1, SRR1803616.237616.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2147920 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGGGCAG GCCCAGGCCC CACCGTTACA TTGGCCCTGG TGCTGGCGGT GTCATGGGCC 
ATGGAGCTCA AGCCCACAGC ACCACCCATC TTCACTGGCC GGCCCTTTGT GGTAGCGTGG 
GACGTGCCCA CACAGGACTG TGGCCCACGC CTCAAGGTGC CACTGGACCT GAATGCCTTT 
GATGTGCAGG CCTCACCTAA TGAGGGTTTT GTGAACCAGA ATATTACCAT CTTCTACCGC 
GACCGTCTAG GCCTGTATCC ACGCTTCGAT TCTGCCGGAA GGTCTGTGCA TGGTGGTGTG 
CCACAGAATG TCAGCCTTTG GGCACACCGG AAGATGCTGC AGAAACGTGT GGAGCACTAC 
ATTCGGACAC AGGAGTCTGC GGGGCTGGCG GTCATCGACT GGGAGGACTG GCGACCTGTG 
TGGGTGCGCA ACTGGCAGGA CAAAGATGTG TATCGCCGGT TATCACGCCA GCTAGTGGCC 
AGTCGTCACC CTGACTGGCC TCCAGACCGC ATAGTCAAAC AGGCACAATA TGAGTTTGAG 
TTCGCAGCAC AGCAGTTCAT GCTGGAGACA CTGCGTTATG TCAAGGCAGT GCGGCCCCGG 
CACCTCTGGG GCTTCTACCT CTTTCCTGAC TGCTACAATC ATGATTATGT GCAGAACTGG 
GAGAGCTACA CAGGCCGCTG CCCTGATGTT GAGGTGGCCC GCAATGACCA GCTGGCCTGG 
CTGTGGGCTG AGAGCACGGC CCTCTTCCCG TCTGTCTACC TGGACGAGAC ACTTGCTTCC 
TCCCGCCATG GCCGCAACTT TGTGAGCTTC CGTGTTCAGG AGGCCCTTCG TGTGGCTCGC 
ACCCACCATG CCAACCATGC ACTCCCAGTC TACGTCTTCA CACGACCCAC CTACAGCCGC 
AGGCTCACGG GGCTTAGTGA GATGGACCTC ATCTCTACCA TTGGCGAGAG TGCGGCCCTG 
GGCGCAGCTG GTGTCATCCT CTGGGGTGAC GCGGGGTACA CCACAAGCAC GGAGACCTGC 
CAGTACCTCA AAGATTACCT GACACGGCTG CTGGTCCCCT ACGTGGTCAA TGTGTCCTGG 
GCCACCCAAT ATTGCAGCCG GGCCCAGTGC CATGGCCATG GGCGCTGTGT GCGCCGCAAC 
CCCAGTGCCA GTACCTTCCT GCATCTCAGC ACCAACAGTT TCCGCCTAGT GCCTGGCCAT 
GCACCTGGTG AACCCCAGCT GCGACCTGTG GGGGAGCTCA GTTGGGCCGA CATTGACCAC 
CTGCAGACAC ACTTCCGCTG CCAGTGCTAC TTGGGCTGGA GTGGTGAGCA ATGCCAGTGG 
GACCATAGGC AGGCAGCTGG AGGTGCCAGC GAGGCCTGGG CTGGGTCCCA CCTCACCAGT 
CTGCTGGCTC TGGCAGCCCT GGCCTTTACC TGGACCTTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003764.3
CDS	245..1666
Translation	MRAGPGPTVTLALVLAVSWAMELKPTAPPIFTGRPFVVAWDVPTQDCGPRLKVPLDLNAFDVQASPNEGFVNQNITIFYRDRLGLYPRFDSAGRSVHGGVPQNVSLWAHRKMLQKRVEHYIRTQESAGLAVIDWEDWRPVWVRNWQDKDVYRRLSRQLVASRHPDWPPDRIVKQAQYEFEFAAQQFMLETLRYVKAVRPRHLWGFYLFPDCYNHDYVQNWESYTGRCPDVEVARNDQLAWLWAESTALFPSVYLDETLASSRHGRNFVSFRVQEALRVARTHHANHALPVYVFTRPTYSRRLTGLSEMDLISTIGESAALGAAGVILWGDAGYTTSTETCQYLKDYLTRLLVPYVVNVSWATQYCSRAQCHGHGRCVRRNPSASTFLHLSTNSFRLVPGHAPGEPQLRPVGELSWADIDHLQTHFRCQCYLGWSGEQCQWDHRQAAGGASEAWAGSHLTSLLALAALAFTWTL

Target ORF information:

RefSeq Version	NM_003773.4
Organism	Homo sapiens(human)
Definition	Homo sapiens hyaluronoglucosaminidase 2 (HYAL2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003773.4

ORF Insert Sequence:

ATGCGGGCAG GCCCAGGCCC CACCGTTACA TTGGCCCTGG TGCTGGCGGT GTCATGGGCC 
ATGGAGCTCA AGCCCACAGC ACCACCCATC TTCACTGGCC GGCCCTTTGT GGTAGCGTGG 
GACGTGCCCA CACAGGACTG TGGCCCACGC CTCAAGGTGC CACTGGACCT GAATGCCTTT 
GATGTGCAGG CCTCACCTAA TGAGGGTTTT GTGAACCAGA ATATTACCAT CTTCTACCGC 
GACCGTCTAG GCCTGTATCC ACGCTTCGAT TCTGCCGGAA GGTCTGTGCA TGGTGGTGTG 
CCACAGAATG TCAGCCTTTG GGCACACCGG AAGATGCTGC AGAAACGTGT GGAGCACTAC 
ATTCGGACAC AGGAGTCTGC GGGGCTGGCG GTCATCGACT GGGAGGACTG GCGACCTGTG 
TGGGTGCGCA ACTGGCAGGA CAAAGATGTG TATCGCCGGT TATCACGCCA GCTAGTGGCC 
AGTCGTCACC CTGACTGGCC TCCAGACCGC ATAGTCAAAC AGGCACAATA TGAGTTTGAG 
TTCGCAGCAC AGCAGTTCAT GCTGGAGACA CTGCGTTATG TCAAGGCAGT GCGGCCCCGG 
CACCTCTGGG GCTTCTACCT CTTTCCTGAC TGCTACAATC ATGATTATGT GCAGAACTGG 
GAGAGCTACA CAGGCCGCTG CCCTGATGTT GAGGTGGCCC GCAATGACCA GCTGGCCTGG 
CTGTGGGCTG AGAGCACGGC CCTCTTCCCG TCTGTCTACC TGGACGAGAC ACTTGCTTCC 
TCCCGCCATG GCCGCAACTT TGTGAGCTTC CGTGTTCAGG AGGCCCTTCG TGTGGCTCGC 
ACCCACCATG CCAACCATGC ACTCCCAGTC TACGTCTTCA CACGACCCAC CTACAGCCGC 
AGGCTCACGG GGCTTAGTGA GATGGACCTC ATCTCTACCA TTGGCGAGAG TGCGGCCCTG 
GGCGCAGCTG GTGTCATCCT CTGGGGTGAC GCGGGGTACA CCACAAGCAC GGAGACCTGC 
CAGTACCTCA AAGATTACCT GACACGGCTG CTGGTCCCCT ACGTGGTCAA TGTGTCCTGG 
GCCACCCAAT ATTGCAGCCG GGCCCAGTGC CATGGCCATG GGCGCTGTGT GCGCCGCAAC 
CCCAGTGCCA GTACCTTCCT GCATCTCAGC ACCAACAGTT TCCGCCTAGT GCCTGGCCAT 
GCACCTGGTG AACCCCAGCT GCGACCTGTG GGGGAGCTCA GTTGGGCCGA CATTGACCAC 
CTGCAGACAC ACTTCCGCTG CCAGTGCTAC TTGGGCTGGA GTGGTGAGCA ATGCCAGTGG 
GACCATAGGC AGGCAGCTGG AGGTGCCAGC GAGGCCTGGG CTGGGTCCCA CCTCACCAGT 
CTGCTGGCTC TGGCAGCCCT GGCCTTTACC TGGACCTTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HYAL2 ( NM_033158.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_149348.2 Homo sapiens hyaluronidase 2 (HYAL2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu03539
Clone ID Related Accession (Same CDS sequence)	XM_005265525.2 , NM_003773.4 , NM_033158.4 , XM_005265524.2 , NM_003773.5
Accession Version	NM_033158.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1422bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Homo sapiens(human)
Product	hyaluronidase-2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC358776.1, AK092449.1, U09577.1 and AK127945.1. On Mar 2, 2010 this sequence version replaced NM_033158.3. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK092449.1, ERR279833.2619.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGGGCAG GCCCAGGCCC CACCGTTACA TTGGCCCTGG TGCTGGCGGT GTCATGGGCC 
ATGGAGCTCA AGCCCACAGC ACCACCCATC TTCACTGGCC GGCCCTTTGT GGTAGCGTGG 
GACGTGCCCA CACAGGACTG TGGCCCACGC CTCAAGGTGC CACTGGACCT GAATGCCTTT 
GATGTGCAGG CCTCACCTAA TGAGGGTTTT GTGAACCAGA ATATTACCAT CTTCTACCGC 
GACCGTCTAG GCCTGTATCC ACGCTTCGAT TCTGCCGGAA GGTCTGTGCA TGGTGGTGTG 
CCACAGAATG TCAGCCTTTG GGCACACCGG AAGATGCTGC AGAAACGTGT GGAGCACTAC 
ATTCGGACAC AGGAGTCTGC GGGGCTGGCG GTCATCGACT GGGAGGACTG GCGACCTGTG 
TGGGTGCGCA ACTGGCAGGA CAAAGATGTG TATCGCCGGT TATCACGCCA GCTAGTGGCC 
AGTCGTCACC CTGACTGGCC TCCAGACCGC ATAGTCAAAC AGGCACAATA TGAGTTTGAG 
TTCGCAGCAC AGCAGTTCAT GCTGGAGACA CTGCGTTATG TCAAGGCAGT GCGGCCCCGG 
CACCTCTGGG GCTTCTACCT CTTTCCTGAC TGCTACAATC ATGATTATGT GCAGAACTGG 
GAGAGCTACA CAGGCCGCTG CCCTGATGTT GAGGTGGCCC GCAATGACCA GCTGGCCTGG 
CTGTGGGCTG AGAGCACGGC CCTCTTCCCG TCTGTCTACC TGGACGAGAC ACTTGCTTCC 
TCCCGCCATG GCCGCAACTT TGTGAGCTTC CGTGTTCAGG AGGCCCTTCG TGTGGCTCGC 
ACCCACCATG CCAACCATGC ACTCCCAGTC TACGTCTTCA CACGACCCAC CTACAGCCGC 
AGGCTCACGG GGCTTAGTGA GATGGACCTC ATCTCTACCA TTGGCGAGAG TGCGGCCCTG 
GGCGCAGCTG GTGTCATCCT CTGGGGTGAC GCGGGGTACA CCACAAGCAC GGAGACCTGC 
CAGTACCTCA AAGATTACCT GACACGGCTG CTGGTCCCCT ACGTGGTCAA TGTGTCCTGG 
GCCACCCAAT ATTGCAGCCG GGCCCAGTGC CATGGCCATG GGCGCTGTGT GCGCCGCAAC 
CCCAGTGCCA GTACCTTCCT GCATCTCAGC ACCAACAGTT TCCGCCTAGT GCCTGGCCAT 
GCACCTGGTG AACCCCAGCT GCGACCTGTG GGGGAGCTCA GTTGGGCCGA CATTGACCAC 
CTGCAGACAC ACTTCCGCTG CCAGTGCTAC TTGGGCTGGA GTGGTGAGCA ATGCCAGTGG 
GACCATAGGC AGGCAGCTGG AGGTGCCAGC GAGGCCTGGG CTGGGTCCCA CCTCACCAGT 
CTGCTGGCTC TGGCAGCCCT GGCCTTTACC TGGACCTTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_149348.2
CDS	653..2074
Translation	MRAGPGPTVTLALVLAVSWAMELKPTAPPIFTGRPFVVAWDVPTQDCGPRLKVPLDLNAFDVQASPNEGFVNQNITIFYRDRLGLYPRFDSAGRSVHGGVPQNVSLWAHRKMLQKRVEHYIRTQESAGLAVIDWEDWRPVWVRNWQDKDVYRRLSRQLVASRHPDWPPDRIVKQAQYEFEFAAQQFMLETLRYVKAVRPRHLWGFYLFPDCYNHDYVQNWESYTGRCPDVEVARNDQLAWLWAESTALFPSVYLDETLASSRHGRNFVSFRVQEALRVARTHHANHALPVYVFTRPTYSRRLTGLSEMDLISTIGESAALGAAGVILWGDAGYTTSTETCQYLKDYLTRLLVPYVVNVSWATQYCSRAQCHGHGRCVRRNPSASTFLHLSTNSFRLVPGHAPGEPQLRPVGELSWADIDHLQTHFRCQCYLGWSGEQCQWDHRQAAGGASEAWAGSHLTSLLALAALAFTWTL

Target ORF information:

RefSeq Version	NM_033158.4
Organism	Homo sapiens(human)
Definition	Homo sapiens hyaluronidase 2 (HYAL2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033158.4

ORF Insert Sequence:

ATGCGGGCAG GCCCAGGCCC CACCGTTACA TTGGCCCTGG TGCTGGCGGT GTCATGGGCC 
ATGGAGCTCA AGCCCACAGC ACCACCCATC TTCACTGGCC GGCCCTTTGT GGTAGCGTGG 
GACGTGCCCA CACAGGACTG TGGCCCACGC CTCAAGGTGC CACTGGACCT GAATGCCTTT 
GATGTGCAGG CCTCACCTAA TGAGGGTTTT GTGAACCAGA ATATTACCAT CTTCTACCGC 
GACCGTCTAG GCCTGTATCC ACGCTTCGAT TCTGCCGGAA GGTCTGTGCA TGGTGGTGTG 
CCACAGAATG TCAGCCTTTG GGCACACCGG AAGATGCTGC AGAAACGTGT GGAGCACTAC 
ATTCGGACAC AGGAGTCTGC GGGGCTGGCG GTCATCGACT GGGAGGACTG GCGACCTGTG 
TGGGTGCGCA ACTGGCAGGA CAAAGATGTG TATCGCCGGT TATCACGCCA GCTAGTGGCC 
AGTCGTCACC CTGACTGGCC TCCAGACCGC ATAGTCAAAC AGGCACAATA TGAGTTTGAG 
TTCGCAGCAC AGCAGTTCAT GCTGGAGACA CTGCGTTATG TCAAGGCAGT GCGGCCCCGG 
CACCTCTGGG GCTTCTACCT CTTTCCTGAC TGCTACAATC ATGATTATGT GCAGAACTGG 
GAGAGCTACA CAGGCCGCTG CCCTGATGTT GAGGTGGCCC GCAATGACCA GCTGGCCTGG 
CTGTGGGCTG AGAGCACGGC CCTCTTCCCG TCTGTCTACC TGGACGAGAC ACTTGCTTCC 
TCCCGCCATG GCCGCAACTT TGTGAGCTTC CGTGTTCAGG AGGCCCTTCG TGTGGCTCGC 
ACCCACCATG CCAACCATGC ACTCCCAGTC TACGTCTTCA CACGACCCAC CTACAGCCGC 
AGGCTCACGG GGCTTAGTGA GATGGACCTC ATCTCTACCA TTGGCGAGAG TGCGGCCCTG 
GGCGCAGCTG GTGTCATCCT CTGGGGTGAC GCGGGGTACA CCACAAGCAC GGAGACCTGC 
CAGTACCTCA AAGATTACCT GACACGGCTG CTGGTCCCCT ACGTGGTCAA TGTGTCCTGG 
GCCACCCAAT ATTGCAGCCG GGCCCAGTGC CATGGCCATG GGCGCTGTGT GCGCCGCAAC 
CCCAGTGCCA GTACCTTCCT GCATCTCAGC ACCAACAGTT TCCGCCTAGT GCCTGGCCAT 
GCACCTGGTG AACCCCAGCT GCGACCTGTG GGGGAGCTCA GTTGGGCCGA CATTGACCAC 
CTGCAGACAC ACTTCCGCTG CCAGTGCTAC TTGGGCTGGA GTGGTGAGCA ATGCCAGTGG 
GACCATAGGC AGGCAGCTGG AGGTGCCAGC GAGGCCTGGG CTGGGTCCCA CCTCACCAGT 
CTGCTGGCTC TGGCAGCCCT GGCCTTTACC TGGACCTTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HYAL2 ( XM_005265525.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005265582.1 Homo sapiens hyaluronidase 2 (HYAL2), transcript variant X2, mRNA.

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CloneID	OHu03539
Clone ID Related Accession (Same CDS sequence)	XM_005265525.2 , NM_003773.4 , NM_033158.4 , XM_005265524.2 , NM_003773.5
Accession Version	XM_005265525.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1422bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	hyaluronidase-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005265525.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGGGCAG GCCCAGGCCC CACCGTTACA TTGGCCCTGG TGCTGGCGGT GTCATGGGCC 
ATGGAGCTCA AGCCCACAGC ACCACCCATC TTCACTGGCC GGCCCTTTGT GGTAGCGTGG 
GACGTGCCCA CACAGGACTG TGGCCCACGC CTCAAGGTGC CACTGGACCT GAATGCCTTT 
GATGTGCAGG CCTCACCTAA TGAGGGTTTT GTGAACCAGA ATATTACCAT CTTCTACCGC 
GACCGTCTAG GCCTGTATCC ACGCTTCGAT TCTGCCGGAA GGTCTGTGCA TGGTGGTGTG 
CCACAGAATG TCAGCCTTTG GGCACACCGG AAGATGCTGC AGAAACGTGT GGAGCACTAC 
ATTCGGACAC AGGAGTCTGC GGGGCTGGCG GTCATCGACT GGGAGGACTG GCGACCTGTG 
TGGGTGCGCA ACTGGCAGGA CAAAGATGTG TATCGCCGGT TATCACGCCA GCTAGTGGCC 
AGTCGTCACC CTGACTGGCC TCCAGACCGC ATAGTCAAAC AGGCACAATA TGAGTTTGAG 
TTCGCAGCAC AGCAGTTCAT GCTGGAGACA CTGCGTTATG TCAAGGCAGT GCGGCCCCGG 
CACCTCTGGG GCTTCTACCT CTTTCCTGAC TGCTACAATC ATGATTATGT GCAGAACTGG 
GAGAGCTACA CAGGCCGCTG CCCTGATGTT GAGGTGGCCC GCAATGACCA GCTGGCCTGG 
CTGTGGGCTG AGAGCACGGC CCTCTTCCCG TCTGTCTACC TGGACGAGAC ACTTGCTTCC 
TCCCGCCATG GCCGCAACTT TGTGAGCTTC CGTGTTCAGG AGGCCCTTCG TGTGGCTCGC 
ACCCACCATG CCAACCATGC ACTCCCAGTC TACGTCTTCA CACGACCCAC CTACAGCCGC 
AGGCTCACGG GGCTTAGTGA GATGGACCTC ATCTCTACCA TTGGCGAGAG TGCGGCCCTG 
GGCGCAGCTG GTGTCATCCT CTGGGGTGAC GCGGGGTACA CCACAAGCAC GGAGACCTGC 
CAGTACCTCA AAGATTACCT GACACGGCTG CTGGTCCCCT ACGTGGTCAA TGTGTCCTGG 
GCCACCCAAT ATTGCAGCCG GGCCCAGTGC CATGGCCATG GGCGCTGTGT GCGCCGCAAC 
CCCAGTGCCA GTACCTTCCT GCATCTCAGC ACCAACAGTT TCCGCCTAGT GCCTGGCCAT 
GCACCTGGTG AACCCCAGCT GCGACCTGTG GGGGAGCTCA GTTGGGCCGA CATTGACCAC 
CTGCAGACAC ACTTCCGCTG CCAGTGCTAC TTGGGCTGGA GTGGTGAGCA ATGCCAGTGG 
GACCATAGGC AGGCAGCTGG AGGTGCCAGC GAGGCCTGGG CTGGGTCCCA CCTCACCAGT 
CTGCTGGCTC TGGCAGCCCT GGCCTTTACC TGGACCTTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005265582.1
CDS	383..1804
Translation	MRAGPGPTVTLALVLAVSWAMELKPTAPPIFTGRPFVVAWDVPTQDCGPRLKVPLDLNAFDVQASPNEGFVNQNITIFYRDRLGLYPRFDSAGRSVHGGVPQNVSLWAHRKMLQKRVEHYIRTQESAGLAVIDWEDWRPVWVRNWQDKDVYRRLSRQLVASRHPDWPPDRIVKQAQYEFEFAAQQFMLETLRYVKAVRPRHLWGFYLFPDCYNHDYVQNWESYTGRCPDVEVARNDQLAWLWAESTALFPSVYLDETLASSRHGRNFVSFRVQEALRVARTHHANHALPVYVFTRPTYSRRLTGLSEMDLISTIGESAALGAAGVILWGDAGYTTSTETCQYLKDYLTRLLVPYVVNVSWATQYCSRAQCHGHGRCVRRNPSASTFLHLSTNSFRLVPGHAPGEPQLRPVGELSWADIDHLQTHFRCQCYLGWSGEQCQWDHRQAAGGASEAWAGSHLTSLLALAALAFTWTL

Target ORF information:

RefSeq Version	XM_005265525.2
Organism	Homo sapiens(human)
Definition	Homo sapiens hyaluronidase 2 (HYAL2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005265525.2

ORF Insert Sequence:

ATGCGGGCAG GCCCAGGCCC CACCGTTACA TTGGCCCTGG TGCTGGCGGT GTCATGGGCC 
ATGGAGCTCA AGCCCACAGC ACCACCCATC TTCACTGGCC GGCCCTTTGT GGTAGCGTGG 
GACGTGCCCA CACAGGACTG TGGCCCACGC CTCAAGGTGC CACTGGACCT GAATGCCTTT 
GATGTGCAGG CCTCACCTAA TGAGGGTTTT GTGAACCAGA ATATTACCAT CTTCTACCGC 
GACCGTCTAG GCCTGTATCC ACGCTTCGAT TCTGCCGGAA GGTCTGTGCA TGGTGGTGTG 
CCACAGAATG TCAGCCTTTG GGCACACCGG AAGATGCTGC AGAAACGTGT GGAGCACTAC 
ATTCGGACAC AGGAGTCTGC GGGGCTGGCG GTCATCGACT GGGAGGACTG GCGACCTGTG 
TGGGTGCGCA ACTGGCAGGA CAAAGATGTG TATCGCCGGT TATCACGCCA GCTAGTGGCC 
AGTCGTCACC CTGACTGGCC TCCAGACCGC ATAGTCAAAC AGGCACAATA TGAGTTTGAG 
TTCGCAGCAC AGCAGTTCAT GCTGGAGACA CTGCGTTATG TCAAGGCAGT GCGGCCCCGG 
CACCTCTGGG GCTTCTACCT CTTTCCTGAC TGCTACAATC ATGATTATGT GCAGAACTGG 
GAGAGCTACA CAGGCCGCTG CCCTGATGTT GAGGTGGCCC GCAATGACCA GCTGGCCTGG 
CTGTGGGCTG AGAGCACGGC CCTCTTCCCG TCTGTCTACC TGGACGAGAC ACTTGCTTCC 
TCCCGCCATG GCCGCAACTT TGTGAGCTTC CGTGTTCAGG AGGCCCTTCG TGTGGCTCGC 
ACCCACCATG CCAACCATGC ACTCCCAGTC TACGTCTTCA CACGACCCAC CTACAGCCGC 
AGGCTCACGG GGCTTAGTGA GATGGACCTC ATCTCTACCA TTGGCGAGAG TGCGGCCCTG 
GGCGCAGCTG GTGTCATCCT CTGGGGTGAC GCGGGGTACA CCACAAGCAC GGAGACCTGC 
CAGTACCTCA AAGATTACCT GACACGGCTG CTGGTCCCCT ACGTGGTCAA TGTGTCCTGG 
GCCACCCAAT ATTGCAGCCG GGCCCAGTGC CATGGCCATG GGCGCTGTGT GCGCCGCAAC 
CCCAGTGCCA GTACCTTCCT GCATCTCAGC ACCAACAGTT TCCGCCTAGT GCCTGGCCAT 
GCACCTGGTG AACCCCAGCT GCGACCTGTG GGGGAGCTCA GTTGGGCCGA CATTGACCAC 
CTGCAGACAC ACTTCCGCTG CCAGTGCTAC TTGGGCTGGA GTGGTGAGCA ATGCCAGTGG 
GACCATAGGC AGGCAGCTGG AGGTGCCAGC GAGGCCTGGG CTGGGTCCCA CCTCACCAGT 
CTGCTGGCTC TGGCAGCCCT GGCCTTTACC TGGACCTTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HYAL2 ( XM_005265524.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005265581.1 Homo sapiens hyaluronidase 2 (HYAL2), transcript variant X1, mRNA.

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CloneID	OHu03539
Clone ID Related Accession (Same CDS sequence)	XM_005265525.2 , NM_003773.4 , NM_033158.4 , XM_005265524.2 , NM_003773.5
Accession Version	XM_005265524.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1422bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	hyaluronidase-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005265524.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGGGCAG GCCCAGGCCC CACCGTTACA TTGGCCCTGG TGCTGGCGGT GTCATGGGCC 
ATGGAGCTCA AGCCCACAGC ACCACCCATC TTCACTGGCC GGCCCTTTGT GGTAGCGTGG 
GACGTGCCCA CACAGGACTG TGGCCCACGC CTCAAGGTGC CACTGGACCT GAATGCCTTT 
GATGTGCAGG CCTCACCTAA TGAGGGTTTT GTGAACCAGA ATATTACCAT CTTCTACCGC 
GACCGTCTAG GCCTGTATCC ACGCTTCGAT TCTGCCGGAA GGTCTGTGCA TGGTGGTGTG 
CCACAGAATG TCAGCCTTTG GGCACACCGG AAGATGCTGC AGAAACGTGT GGAGCACTAC 
ATTCGGACAC AGGAGTCTGC GGGGCTGGCG GTCATCGACT GGGAGGACTG GCGACCTGTG 
TGGGTGCGCA ACTGGCAGGA CAAAGATGTG TATCGCCGGT TATCACGCCA GCTAGTGGCC 
AGTCGTCACC CTGACTGGCC TCCAGACCGC ATAGTCAAAC AGGCACAATA TGAGTTTGAG 
TTCGCAGCAC AGCAGTTCAT GCTGGAGACA CTGCGTTATG TCAAGGCAGT GCGGCCCCGG 
CACCTCTGGG GCTTCTACCT CTTTCCTGAC TGCTACAATC ATGATTATGT GCAGAACTGG 
GAGAGCTACA CAGGCCGCTG CCCTGATGTT GAGGTGGCCC GCAATGACCA GCTGGCCTGG 
CTGTGGGCTG AGAGCACGGC CCTCTTCCCG TCTGTCTACC TGGACGAGAC ACTTGCTTCC 
TCCCGCCATG GCCGCAACTT TGTGAGCTTC CGTGTTCAGG AGGCCCTTCG TGTGGCTCGC 
ACCCACCATG CCAACCATGC ACTCCCAGTC TACGTCTTCA CACGACCCAC CTACAGCCGC 
AGGCTCACGG GGCTTAGTGA GATGGACCTC ATCTCTACCA TTGGCGAGAG TGCGGCCCTG 
GGCGCAGCTG GTGTCATCCT CTGGGGTGAC GCGGGGTACA CCACAAGCAC GGAGACCTGC 
CAGTACCTCA AAGATTACCT GACACGGCTG CTGGTCCCCT ACGTGGTCAA TGTGTCCTGG 
GCCACCCAAT ATTGCAGCCG GGCCCAGTGC CATGGCCATG GGCGCTGTGT GCGCCGCAAC 
CCCAGTGCCA GTACCTTCCT GCATCTCAGC ACCAACAGTT TCCGCCTAGT GCCTGGCCAT 
GCACCTGGTG AACCCCAGCT GCGACCTGTG GGGGAGCTCA GTTGGGCCGA CATTGACCAC 
CTGCAGACAC ACTTCCGCTG CCAGTGCTAC TTGGGCTGGA GTGGTGAGCA ATGCCAGTGG 
GACCATAGGC AGGCAGCTGG AGGTGCCAGC GAGGCCTGGG CTGGGTCCCA CCTCACCAGT 
CTGCTGGCTC TGGCAGCCCT GGCCTTTACC TGGACCTTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005265581.1
CDS	369..1790
Translation	MRAGPGPTVTLALVLAVSWAMELKPTAPPIFTGRPFVVAWDVPTQDCGPRLKVPLDLNAFDVQASPNEGFVNQNITIFYRDRLGLYPRFDSAGRSVHGGVPQNVSLWAHRKMLQKRVEHYIRTQESAGLAVIDWEDWRPVWVRNWQDKDVYRRLSRQLVASRHPDWPPDRIVKQAQYEFEFAAQQFMLETLRYVKAVRPRHLWGFYLFPDCYNHDYVQNWESYTGRCPDVEVARNDQLAWLWAESTALFPSVYLDETLASSRHGRNFVSFRVQEALRVARTHHANHALPVYVFTRPTYSRRLTGLSEMDLISTIGESAALGAAGVILWGDAGYTTSTETCQYLKDYLTRLLVPYVVNVSWATQYCSRAQCHGHGRCVRRNPSASTFLHLSTNSFRLVPGHAPGEPQLRPVGELSWADIDHLQTHFRCQCYLGWSGEQCQWDHRQAAGGASEAWAGSHLTSLLALAALAFTWTL

Target ORF information:

RefSeq Version	XM_005265524.2
Organism	Homo sapiens(human)
Definition	Homo sapiens hyaluronidase 2 (HYAL2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005265524.2

ORF Insert Sequence:

ATGCGGGCAG GCCCAGGCCC CACCGTTACA TTGGCCCTGG TGCTGGCGGT GTCATGGGCC 
ATGGAGCTCA AGCCCACAGC ACCACCCATC TTCACTGGCC GGCCCTTTGT GGTAGCGTGG 
GACGTGCCCA CACAGGACTG TGGCCCACGC CTCAAGGTGC CACTGGACCT GAATGCCTTT 
GATGTGCAGG CCTCACCTAA TGAGGGTTTT GTGAACCAGA ATATTACCAT CTTCTACCGC 
GACCGTCTAG GCCTGTATCC ACGCTTCGAT TCTGCCGGAA GGTCTGTGCA TGGTGGTGTG 
CCACAGAATG TCAGCCTTTG GGCACACCGG AAGATGCTGC AGAAACGTGT GGAGCACTAC 
ATTCGGACAC AGGAGTCTGC GGGGCTGGCG GTCATCGACT GGGAGGACTG GCGACCTGTG 
TGGGTGCGCA ACTGGCAGGA CAAAGATGTG TATCGCCGGT TATCACGCCA GCTAGTGGCC 
AGTCGTCACC CTGACTGGCC TCCAGACCGC ATAGTCAAAC AGGCACAATA TGAGTTTGAG 
TTCGCAGCAC AGCAGTTCAT GCTGGAGACA CTGCGTTATG TCAAGGCAGT GCGGCCCCGG 
CACCTCTGGG GCTTCTACCT CTTTCCTGAC TGCTACAATC ATGATTATGT GCAGAACTGG 
GAGAGCTACA CAGGCCGCTG CCCTGATGTT GAGGTGGCCC GCAATGACCA GCTGGCCTGG 
CTGTGGGCTG AGAGCACGGC CCTCTTCCCG TCTGTCTACC TGGACGAGAC ACTTGCTTCC 
TCCCGCCATG GCCGCAACTT TGTGAGCTTC CGTGTTCAGG AGGCCCTTCG TGTGGCTCGC 
ACCCACCATG CCAACCATGC ACTCCCAGTC TACGTCTTCA CACGACCCAC CTACAGCCGC 
AGGCTCACGG GGCTTAGTGA GATGGACCTC ATCTCTACCA TTGGCGAGAG TGCGGCCCTG 
GGCGCAGCTG GTGTCATCCT CTGGGGTGAC GCGGGGTACA CCACAAGCAC GGAGACCTGC 
CAGTACCTCA AAGATTACCT GACACGGCTG CTGGTCCCCT ACGTGGTCAA TGTGTCCTGG 
GCCACCCAAT ATTGCAGCCG GGCCCAGTGC CATGGCCATG GGCGCTGTGT GCGCCGCAAC 
CCCAGTGCCA GTACCTTCCT GCATCTCAGC ACCAACAGTT TCCGCCTAGT GCCTGGCCAT 
GCACCTGGTG AACCCCAGCT GCGACCTGTG GGGGAGCTCA GTTGGGCCGA CATTGACCAC 
CTGCAGACAC ACTTCCGCTG CCAGTGCTAC TTGGGCTGGA GTGGTGAGCA ATGCCAGTGG 
GACCATAGGC AGGCAGCTGG AGGTGCCAGC GAGGCCTGGG CTGGGTCCCA CCTCACCAGT 
CTGCTGGCTC TGGCAGCCCT GGCCTTTACC TGGACCTTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nuclear hyaluronidase 2 drives alternative splicing of
Science signaling10(506)(2017 Nov)
Midgley AC,Oltean S,Hascall V,Woods EL,Steadman R,Phillips AO,Meran S

Whole exome sequencing in the Framingham Heart Study identifies rare variation in HYAL2 that influences platelet aggregation.
Thrombosis and haemostasis117(6)1083-1092(2017 Jun)
Eicher JD,Chen MH,Pitsillides AN,Lin H,Veeraraghavan N,Brody JA,Metcalf GA,Muzny DM,Gibbs RA,Becker DM,Becker LC,Faraday N,Mathias RA,Yanek LR,Boerwinkle E,Cupples LA,Johnson AD

Mutations in HYAL2, Encoding Hyaluronidase 2, Cause a Syndrome of Orofacial Clefting and Cor Triatriatum Sinister in Humans and Mice.
PLoS genetics13(1)e1006470(2017 Jan)
Muggenthaler MM,Chowdhury B,Hasan SN,Cross HE,Mark B,Harlalka GV,Patton MA,Ishida M,Behr ER,Sharma S,Zahka K,Faqeih E,Blakley B,Jackson M,Lees M,Dolinsky V,Cross L,Stanier P,Salter C,Baple EL,Alkuraya FS,Crosby AH,Triggs-Raine B,Chioza BA

The role of HYAL2 in LSS-induced glycocalyx impairment and the PKA-mediated decrease in eNOS-Ser-633 phosphorylation and nitric oxide production.
Molecular biology of the cell27(25)3972-3979(2016 Dec)
Kong X,Chen L,Ye P,Wang Z,Zhang J,Ye F,Chen S

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HYAL2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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