EIF3G cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	EIF3G
Entrez Gene ID	8666
Full Name	eukaryotic translation initiation factor 3 subunit G
Synonyms	EIF3-P42,EIF3S4,eIF3-delta,eIF3-p44
General protein information	Preferred Names eukaryotic translation initiation factor 3 subunit G Names eukaryotic translation initiation factor 3 subunit G eukaryotic translation initiation factor 3 RNA-binding subunit eukaryotic translation initiation factor 3 subunit p42 eukaryotic translation initiation factor 3, subunit 4 delta, 44kDa
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.2
Summary	This gene encodes a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex, which is required for initiation of protein translation. An N-terminal caspase cleavage product of the encoded protein may stimulate degradation of DNA. A mutation in this gene is associated with narcolepsy. [provided by RefSeq, Jul 2016].
Disorder MIM:	603913

mRNA and Protein(s)

mRNA	Protein	Name
NM_003755.3	NP_003746.2	eukaryotic translation initiation factor 3 subunit G
NM_003755.4	NP_003746.2	eukaryotic translation initiation factor 3 subunit G
NM_003755.5	NP_003746.2	eukaryotic translation initiation factor 3 subunit G

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	EIF3G	XP_004950534.1
Danio rerio (zebrafish)	eif3g	NP_957293.1
Caenorhabditis elegans (roundworm)	eif-3.G	NP_495778.1
Eremothecium gossypii	AGOS_ADR189W	NP_984285.1
Neurospora crassa	NCU08046	XP_962716.2
Homo sapiens (human)	EIF3G	NP_003746.2
Mus musculus (house mouse)	Eif3g	NP_058572.2
Oryza sativa (rice)	Os02g0788400	NP_001048347.1
	EIF3G	XP_001104633.2
Drosophila melanogaster (fruit fly)	CG10881	NP_650887.1
Magnaporthe oryzae (rice blast fungus)	MGG_07109	XP_003715298.1
Xenopus tropicalis (tropical clawed frog)	eif3s4	NP_001016749.1
Drosophila melanogaster (fruit fly)	CG8636	NP_570011.1
Anopheles gambiae (African malaria mosquito)	EIF3G_ANOGA	XP_308202.3
Kluyveromyces lactis	KLLA0B00847g	XP_451568.1
Pan troglodytes (chimpanzee)	EIF3G	XP_001162705.1
Canis lupus familiaris (dog)	EIF3G	XP_854113.1
Bos taurus (cattle)	EIF3G	NP_001073091.1
Rattus norvegicus (Norway rat)	Eif3g	NP_001013113.1
Saccharomyces cerevisiae (baker's yeast)	TIF35	NP_010717.1
Schizosaccharomyces pombe (fission yeast)	tif35	NP_595727.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.
Lee AS, Kranzusch PJ, Doudna JA, Cate JH
Nature536(7614)96-9(2016 08)

eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition.
Simonetti A, Brito Querido J, Myasnikov AG, Mancera-Martinez E, Renaud A, Kuhn L, Hashem Y
Molecular cell63(2)206-217(2016 Jul)

An inter-species protein-protein interaction network across vast evolutionary distance.
Zhong Q, Pevzner SJ, Hao T, Wang Y, Mosca R, Menche J, Taipale M, Ta?an M, Fan C, Yang X, Haley P, Murray RR, Mer F, Gebreab F, Tam S, MacWilliams A, Dricot A, Reichert P, Santhanam B, Ghamsari L, Calderwood MA, Rolland T, Charloteaux B, Lindquist S, Barab?si AL, Hill DE, Aloy P, Cusick ME, Xia Y, Roth FP, Vidal M
Molecular systems biology12(4)865(2016 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The disease-associated allele increases EIF3G mRNA expression. EIF3G is located in the narcolepsy risk locus and EIF3G expression correlates with PPAN and P2RY11 expression.
Title: EIF3G is associated with narcolepsy across ethnicities.

Important roles for eIF3g in the translation initiation machinery and in DNA degradation during apoptosis.
Title: Caspase-mediated cleavage and DNase activity of the translation initiation factor 3, subunit G (eIF3g).

down-regulation of eIF3g inhibits the efficiency of nonsense-mediated mRNA decay, which is tightly coupled to CT but not to ET
Title: Translation initiation on mRNAs bound by nuclear cap-binding protein complex CBP80/20 requires interaction between CBP80/20-dependent translation initiation factor and eukaryotic translation initiation factor 3g.

PELO is subcellularly localized at the actin cytoskeleton, interacts with HAX1, EIF3G and SRPX proteins and that this interaction occurs at the cytoskeleton; this interaction may facilitate PELO to detect and degrade aberrant mRNAs.
Title: Pelota interacts with HAX1, EIF3G and SRPX and the resulting protein complexes are associated with the actin cytoskeleton.

AIF overexpression specifically resulted in the activation of caspase-7, thereby amplifying the inhibition of protein
Title: Apoptosis-inducing factor (AIF) inhibits protein synthesis by interacting with the eukaryotic translation initiation factor 3 subunit p44 (eIF3g).

The following EIF3G gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EIF3G cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03521	NM_003755.5 Latest version!	Homo sapiens eukaryotic translation initiation factor 3 subunit G (EIF3G), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu03521	NM_003755.3	Homo sapiens eukaryotic translation initiation factor 3, subunit G (EIF3G), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu03521	NM_003755.4	Homo sapiens eukaryotic translation initiation factor 3 subunit G (EIF3G), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

EIF3G ( NM_003755.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003746.2 Homo sapiens eukaryotic translation initiation factor 3, subunit G (EIF3G), mRNA.

Price & Availability↑

CloneID	OHu03521
Clone ID Related Accession (Same CDS sequence)	NM_003755.3 , NM_003755.4 , NM_003755.5
Accession Version	NM_003755.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 963bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	eukaryotic translation initiation factor 3 subunit G
Comment

ATGCCTACTG GAGACTTTGA TTCGAAGCCC AGTTGGGCCG ACCAGGTGGA GGAGGAGGGG 
GAGGACGACA AATGTGTCAC CAGCGAGCTC CTCAAGGGGA TCCCTCTGGC CACAGGTGAC 
ACCAGCCCAG AGCCAGAGCT ACTGCCGGGA GCTCCACTGC CGCCTCCCAA GGAGGTCATC 
AACGGAAACA TAAAGACAGT GACAGAGTAC AAGATAGATG AGGATGGCAA GAAGTTCAAG 
ATTGTCCGCA CCTTCAGGAT TGAGACCCGG AAGGCTTCAA AGGCTGTCGC AAGGAGGAAG 
AACTGGAAGA AGTTCGGGAA CTCAGAGTTT GACCCCCCCG GACCCAATGT GGCCACCACC 
ACTGTCAGTG ACGATGTCTC TATGACGTTC ATCACCAGCA AAGAGGACCT GAACTGCCAG 
GAGGAGGAGG ACCCTATGAA CAAACTCAAG GGCCAGAAGA TCGTGTCCTG CCGCATCTGC 
AAGGGCGACC ACTGGACCAC CCGCTGCCCC TACAAGGATA CGCTGGGGCC CATGCAGAAG 
GAGCTGGCCG AGCAGCTGGG CCTGTCTACT GGCGAGAAGG AGAAGCTGCC GGGAGAGCTA 
GAGCCGGTGC AGGCCACGCA GAACAAGACA GGGAAGTATG TGCCGCCGAG CCTGCGCGAC 
GGGGCCAGCC GCCGCGGGGA GTCCATGCAG CCCAACCGCA GAGCCGACGA CAACGCCACC 
ATCCGTGTCA CCAACTTGTC AGAGGACACG CGTGAGACCG ACCTGCAGGA GCTCTTCCGG 
CCTTTCGGCT CCATCTCCCG CATCTACCTG GCTAAGGACA AGACCACTGG CCAATCCAAG 
GGCTTTGCCT TCATCAGCTT CCACCGCCGC GAGGATGCTG CGCGTGCCAT TGCCGGGGTG 
TCCGGCTTTG GCTACGACCA CCTCATCCTC AACGTCGAGT GGGCCAAGCC GTCCACCAAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003746.2
Translation	MPTGDFDSKPSWADQVEEEGEDDKCVTSELLKGIPLATGDTSPEPELLPGAPLPPPKEVINGNIKTVTEYKIDEDGKKFKIVRTFRIETRKASKAVARRKNWKKFGNSEFDPPGPNVATTTVSDDVSMTFITSKEDLNCQEEEDPMNKLKGQKIVSCRICKGDHWTTRCPYKDTLGPMQKELAEQLGLSTGEKEKLPGELEPVQATQNKTGKYVPPSLRDGASRRGESMQPNRRADDNATIRVTNLSEDTRETDLQELFRPFGSISRIYLAKDKTTGQSKGFAFISFHRREDAARAIAGVSGFGYDHLILNVEWAKPSTN

Target ORF information:

RefSeq Version	NM_003755.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens eukaryotic translation initiation factor 3, subunit G (EIF3G), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003755.3

ORF Insert Sequence:

ATGCCTACTG GAGACTTTGA TTCGAAGCCC AGTTGGGCCG ACCAGGTGGA GGAGGAGGGG 
GAGGACGACA AATGTGTCAC CAGCGAGCTC CTCAAGGGGA TCCCTCTGGC CACAGGTGAC 
ACCAGCCCAG AGCCAGAGCT ACTGCCGGGA GCTCCACTGC CGCCTCCCAA GGAGGTCATC 
AACGGAAACA TAAAGACAGT GACAGAGTAC AAGATAGATG AGGATGGCAA GAAGTTCAAG 
ATTGTCCGCA CCTTCAGGAT TGAGACCCGG AAGGCTTCAA AGGCTGTCGC AAGGAGGAAG 
AACTGGAAGA AGTTCGGGAA CTCAGAGTTT GACCCCCCCG GACCCAATGT GGCCACCACC 
ACTGTCAGTG ACGATGTCTC TATGACGTTC ATCACCAGCA AAGAGGACCT GAACTGCCAG 
GAGGAGGAGG ACCCTATGAA CAAACTCAAG GGCCAGAAGA TCGTGTCCTG CCGCATCTGC 
AAGGGCGACC ACTGGACCAC CCGCTGCCCC TACAAGGATA CGCTGGGGCC CATGCAGAAG 
GAGCTGGCCG AGCAGCTGGG CCTGTCTACT GGCGAGAAGG AGAAGCTGCC GGGAGAGCTA 
GAGCCGGTGC AGGCCACGCA GAACAAGACA GGGAAGTATG TGCCGCCGAG CCTGCGCGAC 
GGGGCCAGCC GCCGCGGGGA GTCCATGCAG CCCAACCGCA GAGCCGACGA CAACGCCACC 
ATCCGTGTCA CCAACTTGTC AGAGGACACG CGTGAGACCG ACCTGCAGGA GCTCTTCCGG 
CCTTTCGGCT CCATCTCCCG CATCTACCTG GCTAAGGACA AGACCACTGG CCAATCCAAG 
GGCTTTGCCT TCATCAGCTT CCACCGCCGC GAGGATGCTG CGCGTGCCAT TGCCGGGGTG 
TCCGGCTTTG GCTACGACCA CCTCATCCTC AACGTCGAGT GGGCCAAGCC GTCCACCAAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF3G ( NM_003755.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003746.2 Homo sapiens eukaryotic translation initiation factor 3 subunit G (EIF3G), mRNA.

Price & Availability↑

CloneID	OHu03521
Clone ID Related Accession (Same CDS sequence)	NM_003755.3 , NM_003755.4 , NM_003755.5
Accession Version	NM_003755.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 963bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-03
Organism	Homo sapiens(human)
Product	eukaryotic translation initiation factor 3 subunit G
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from DC356593.1, BC000733.2 and AA588881.1. This sequence is a reference standard in the RefSeqGene project. On Jul 14, 2016 this sequence version replaced NM_003755.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.189429.1, BC008469.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467144 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCCTACTG GAGACTTTGA TTCGAAGCCC AGTTGGGCCG ACCAGGTGGA GGAGGAGGGG 
GAGGACGACA AATGTGTCAC CAGCGAGCTC CTCAAGGGGA TCCCTCTGGC CACAGGTGAC 
ACCAGCCCAG AGCCAGAGCT ACTGCCGGGA GCTCCACTGC CGCCTCCCAA GGAGGTCATC 
AACGGAAACA TAAAGACAGT GACAGAGTAC AAGATAGATG AGGATGGCAA GAAGTTCAAG 
ATTGTCCGCA CCTTCAGGAT TGAGACCCGG AAGGCTTCAA AGGCTGTCGC AAGGAGGAAG 
AACTGGAAGA AGTTCGGGAA CTCAGAGTTT GACCCCCCCG GACCCAATGT GGCCACCACC 
ACTGTCAGTG ACGATGTCTC TATGACGTTC ATCACCAGCA AAGAGGACCT GAACTGCCAG 
GAGGAGGAGG ACCCTATGAA CAAACTCAAG GGCCAGAAGA TCGTGTCCTG CCGCATCTGC 
AAGGGCGACC ACTGGACCAC CCGCTGCCCC TACAAGGATA CGCTGGGGCC CATGCAGAAG 
GAGCTGGCCG AGCAGCTGGG CCTGTCTACT GGCGAGAAGG AGAAGCTGCC GGGAGAGCTA 
GAGCCGGTGC AGGCCACGCA GAACAAGACA GGGAAGTATG TGCCGCCGAG CCTGCGCGAC 
GGGGCCAGCC GCCGCGGGGA GTCCATGCAG CCCAACCGCA GAGCCGACGA CAACGCCACC 
ATCCGTGTCA CCAACTTGTC AGAGGACACG CGTGAGACCG ACCTGCAGGA GCTCTTCCGG 
CCTTTCGGCT CCATCTCCCG CATCTACCTG GCTAAGGACA AGACCACTGG CCAATCCAAG 
GGCTTTGCCT TCATCAGCTT CCACCGCCGC GAGGATGCTG CGCGTGCCAT TGCCGGGGTG 
TCCGGCTTTG GCTACGACCA CCTCATCCTC AACGTCGAGT GGGCCAAGCC GTCCACCAAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003746.2
CDS	66..1028
Translation	MPTGDFDSKPSWADQVEEEGEDDKCVTSELLKGIPLATGDTSPEPELLPGAPLPPPKEVINGNIKTVTEYKIDEDGKKFKIVRTFRIETRKASKAVARRKNWKKFGNSEFDPPGPNVATTTVSDDVSMTFITSKEDLNCQEEEDPMNKLKGQKIVSCRICKGDHWTTRCPYKDTLGPMQKELAEQLGLSTGEKEKLPGELEPVQATQNKTGKYVPPSLRDGASRRGESMQPNRRADDNATIRVTNLSEDTRETDLQELFRPFGSISRIYLAKDKTTGQSKGFAFISFHRREDAARAIAGVSGFGYDHLILNVEWAKPSTN

Target ORF information:

RefSeq Version	NM_003755.4
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 3 subunit G (EIF3G), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003755.4

ORF Insert Sequence:

ATGCCTACTG GAGACTTTGA TTCGAAGCCC AGTTGGGCCG ACCAGGTGGA GGAGGAGGGG 
GAGGACGACA AATGTGTCAC CAGCGAGCTC CTCAAGGGGA TCCCTCTGGC CACAGGTGAC 
ACCAGCCCAG AGCCAGAGCT ACTGCCGGGA GCTCCACTGC CGCCTCCCAA GGAGGTCATC 
AACGGAAACA TAAAGACAGT GACAGAGTAC AAGATAGATG AGGATGGCAA GAAGTTCAAG 
ATTGTCCGCA CCTTCAGGAT TGAGACCCGG AAGGCTTCAA AGGCTGTCGC AAGGAGGAAG 
AACTGGAAGA AGTTCGGGAA CTCAGAGTTT GACCCCCCCG GACCCAATGT GGCCACCACC 
ACTGTCAGTG ACGATGTCTC TATGACGTTC ATCACCAGCA AAGAGGACCT GAACTGCCAG 
GAGGAGGAGG ACCCTATGAA CAAACTCAAG GGCCAGAAGA TCGTGTCCTG CCGCATCTGC 
AAGGGCGACC ACTGGACCAC CCGCTGCCCC TACAAGGATA CGCTGGGGCC CATGCAGAAG 
GAGCTGGCCG AGCAGCTGGG CCTGTCTACT GGCGAGAAGG AGAAGCTGCC GGGAGAGCTA 
GAGCCGGTGC AGGCCACGCA GAACAAGACA GGGAAGTATG TGCCGCCGAG CCTGCGCGAC 
GGGGCCAGCC GCCGCGGGGA GTCCATGCAG CCCAACCGCA GAGCCGACGA CAACGCCACC 
ATCCGTGTCA CCAACTTGTC AGAGGACACG CGTGAGACCG ACCTGCAGGA GCTCTTCCGG 
CCTTTCGGCT CCATCTCCCG CATCTACCTG GCTAAGGACA AGACCACTGG CCAATCCAAG 
GGCTTTGCCT TCATCAGCTT CCACCGCCGC GAGGATGCTG CGCGTGCCAT TGCCGGGGTG 
TCCGGCTTTG GCTACGACCA CCTCATCCTC AACGTCGAGT GGGCCAAGCC GTCCACCAAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF3G ( NM_003755.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_003746.2 Homo sapiens eukaryotic translation initiation factor 3 subunit G (EIF3G), mRNA.

Price & Availability↑

CloneID	OHu03521
Clone ID Related Accession (Same CDS sequence)	NM_003755.3 , NM_003755.4 , NM_003755.5
Accession Version	NM_003755.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 963bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	eukaryotic translation initiation factor 3 subunit G
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from BC000733.2 and AA588881.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_003755.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.189429.1, AF094850.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467144 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000253108.9/ ENSP00000253108.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCTACTG GAGACTTTGA TTCGAAGCCC AGTTGGGCCG ACCAGGTGGA GGAGGAGGGG 
GAGGACGACA AATGTGTCAC CAGCGAGCTC CTCAAGGGGA TCCCTCTGGC CACAGGTGAC 
ACCAGCCCAG AGCCAGAGCT ACTGCCGGGA GCTCCACTGC CGCCTCCCAA GGAGGTCATC 
AACGGAAACA TAAAGACAGT GACAGAGTAC AAGATAGATG AGGATGGCAA GAAGTTCAAG 
ATTGTCCGCA CCTTCAGGAT TGAGACCCGG AAGGCTTCAA AGGCTGTCGC AAGGAGGAAG 
AACTGGAAGA AGTTCGGGAA CTCAGAGTTT GACCCCCCCG GACCCAATGT GGCCACCACC 
ACTGTCAGTG ACGATGTCTC TATGACGTTC ATCACCAGCA AAGAGGACCT GAACTGCCAG 
GAGGAGGAGG ACCCTATGAA CAAACTCAAG GGCCAGAAGA TCGTGTCCTG CCGCATCTGC 
AAGGGCGACC ACTGGACCAC CCGCTGCCCC TACAAGGATA CGCTGGGGCC CATGCAGAAG 
GAGCTGGCCG AGCAGCTGGG CCTGTCTACT GGCGAGAAGG AGAAGCTGCC GGGAGAGCTA 
GAGCCGGTGC AGGCCACGCA GAACAAGACA GGGAAGTATG TGCCGCCGAG CCTGCGCGAC 
GGGGCCAGCC GCCGCGGGGA GTCCATGCAG CCCAACCGCA GAGCCGACGA CAACGCCACC 
ATCCGTGTCA CCAACTTGTC AGAGGACACG CGTGAGACCG ACCTGCAGGA GCTCTTCCGG 
CCTTTCGGCT CCATCTCCCG CATCTACCTG GCTAAGGACA AGACCACTGG CCAATCCAAG 
GGCTTTGCCT TCATCAGCTT CCACCGCCGC GAGGATGCTG CGCGTGCCAT TGCCGGGGTG 
TCCGGCTTTG GCTACGACCA CCTCATCCTC AACGTCGAGT GGGCCAAGCC GTCCACCAAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003746.2
CDS	41..1003
Translation	MPTGDFDSKPSWADQVEEEGEDDKCVTSELLKGIPLATGDTSPEPELLPGAPLPPPKEVINGNIKTVTEYKIDEDGKKFKIVRTFRIETRKASKAVARRKNWKKFGNSEFDPPGPNVATTTVSDDVSMTFITSKEDLNCQEEEDPMNKLKGQKIVSCRICKGDHWTTRCPYKDTLGPMQKELAEQLGLSTGEKEKLPGELEPVQATQNKTGKYVPPSLRDGASRRGESMQPNRRADDNATIRVTNLSEDTRETDLQELFRPFGSISRIYLAKDKTTGQSKGFAFISFHRREDAARAIAGVSGFGYDHLILNVEWAKPSTN

Target ORF information:

RefSeq Version	NM_003755.5
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 3 subunit G (EIF3G), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003755.5

ORF Insert Sequence:

ATGCCTACTG GAGACTTTGA TTCGAAGCCC AGTTGGGCCG ACCAGGTGGA GGAGGAGGGG 
GAGGACGACA AATGTGTCAC CAGCGAGCTC CTCAAGGGGA TCCCTCTGGC CACAGGTGAC 
ACCAGCCCAG AGCCAGAGCT ACTGCCGGGA GCTCCACTGC CGCCTCCCAA GGAGGTCATC 
AACGGAAACA TAAAGACAGT GACAGAGTAC AAGATAGATG AGGATGGCAA GAAGTTCAAG 
ATTGTCCGCA CCTTCAGGAT TGAGACCCGG AAGGCTTCAA AGGCTGTCGC AAGGAGGAAG 
AACTGGAAGA AGTTCGGGAA CTCAGAGTTT GACCCCCCCG GACCCAATGT GGCCACCACC 
ACTGTCAGTG ACGATGTCTC TATGACGTTC ATCACCAGCA AAGAGGACCT GAACTGCCAG 
GAGGAGGAGG ACCCTATGAA CAAACTCAAG GGCCAGAAGA TCGTGTCCTG CCGCATCTGC 
AAGGGCGACC ACTGGACCAC CCGCTGCCCC TACAAGGATA CGCTGGGGCC CATGCAGAAG 
GAGCTGGCCG AGCAGCTGGG CCTGTCTACT GGCGAGAAGG AGAAGCTGCC GGGAGAGCTA 
GAGCCGGTGC AGGCCACGCA GAACAAGACA GGGAAGTATG TGCCGCCGAG CCTGCGCGAC 
GGGGCCAGCC GCCGCGGGGA GTCCATGCAG CCCAACCGCA GAGCCGACGA CAACGCCACC 
ATCCGTGTCA CCAACTTGTC AGAGGACACG CGTGAGACCG ACCTGCAGGA GCTCTTCCGG 
CCTTTCGGCT CCATCTCCCG CATCTACCTG GCTAAGGACA AGACCACTGG CCAATCCAAG 
GGCTTTGCCT TCATCAGCTT CCACCGCCGC GAGGATGCTG CGCGTGCCAT TGCCGGGGTG 
TCCGGCTTTG GCTACGACCA CCTCATCCTC AACGTCGAGT GGGCCAAGCC GTCCACCAAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.
Nature536(7614)96-9(2016 08)
Lee AS,Kranzusch PJ,Doudna JA,Cate JH

eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition.
Molecular cell63(2)206-217(2016 Jul)
Simonetti A,Brito Querido J,Myasnikov AG,Mancera-Martinez E,Renaud A,Kuhn L,Hashem Y

An inter-species protein-protein interaction network across vast evolutionary distance.
Molecular systems biology12(4)865(2016 Apr)
Zhong Q,Pevzner SJ,Hao T,Wang Y,Mosca R,Menche J,Taipale M,Ta?an M,Fan C,Yang X,Haley P,Murray RR,Mer F,Gebreab F,Tam S,MacWilliams A,Dricot A,Reichert P,Santhanam B,Ghamsari L,Calderwood MA,Rolland T,Charloteaux B,Lindquist S,Barab?si AL,Hill DE,Aloy P,Cusick ME,Xia Y,Roth FP,Vidal M

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EIF3G cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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