SERPINA6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SERPINA6
Entrez Gene ID	866
Full Name	serpin family A member 6
Synonyms	CBG
General protein information	Preferred Names serpin family A member 6 Names corticosteroid-binding globulin serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 serpin A6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 transcortin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q32.13
Summary	This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008].
Disorder MIM:	122500
Disorder Html:	Corticosteroid-binding globulin deficiency, 611489 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001756.3	NP_001747.2	corticosteroid-binding globulin precursor
NM_001756.4	NP_001747.3	corticosteroid-binding globulin precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Serpina6	NP_031644.1
Canis lupus familiaris (dog)	SERPINA6	XP_005623821.1
Homo sapiens (human)	SERPINA6	NP_001747.2
Pan troglodytes (chimpanzee)	SERPINA6	XP_510143.2
	SERPINA6	XP_002805222.1
Bos taurus (cattle)	SERPINA6	XP_005222338.1
Rattus norvegicus (Norway rat)	Serpina6	NP_001009663.1

Gene Ontology
Bibliography

Related articles in PubMed

Functional Implications of Corticosteroid-binding Globulin N-Glycosylation.
Simard M, Underhill C, Hammond GL
Journal of molecular endocrinology(2017 Dec)

The role of corticosteroid-binding globulin in the evaluation of adrenal insufficiency.
Verbeeten KC, Ahmet AH
Journal of pediatric endocrinology & metabolism : JPEM(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Corticosteroid-binding globulin cleavage may be pathogen-dependent in bloodstream infection
Title: Corticosteroid-binding globulin cleavage may be pathogen-dependent in bloodstream infection.

The results suggest reduced CBG cleavage in central obesity, possibly contributing to the characteristic inflammatory phenotype of the central obesity and metabolic syndrome.
Title: Evidence of Reduced CBG Cleavage in Abdominal Obesity: A Potential Factor in Development of the Metabolic Syndrome.

In conclusion, site-specific CBG N-glycosylation regulates the bioavailability of cortisol in inflamed environments by fine-tuning the RCL proteolysis by endogenous and exogenous elastases.
Title: Asn347 Glycosylation of Corticosteroid-binding Globulin Fine-tunes the Host Immune Response by Modulating Proteolysis by Pseudomonas aeruginosa and Neutrophil Elastase.

Data indicate there was no significant circadian variation in serum cortisol-binding globulin (CBG) concentration in any of the 4 groups.
Title: Circadian variation in serum cortisol during hydrocortisone replacement is not attributable to changes in cortisol-binding globulin concentrations.

The study investigate the half-life of intact and elastase cleaved CBG in the rabbit. The half-lives of intact and cleaved human CBG are 10 h and identical.
Title: The half-lives of intact and elastase cleaved human corticosteroid-binding globulin (CBG) are identical in the rabbit.

The following SERPINA6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SERPINA6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu19181	NM_001756.3 Latest version!	Homo sapiens serpin family A member 6 (SERPINA6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu107593	NM_001756.4 Latest version!	Homo sapiens serpin family A member 6 (SERPINA6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SERPINA6 ( NM_001756.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001747.2 Homo sapiens serpin family A member 6 (SERPINA6), mRNA.

Price & Availability↑

CloneID	OHu19181
Clone ID Related Accession (Same CDS sequence)	NM_001756.3
Accession Version	NM_001756.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1218bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	corticosteroid-binding globulin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AV689566.2, BC058021.1 and BC017462.1. This sequence is a reference standard in the RefSeqGene project. On Aug 29, 2005 this sequence version replaced NM_001756.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC017462.1, BC058021.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCCACTCC TCCTGTACAC CTGTCTTCTC TGGCTGCCCA CCAGCGGCCT CTGGACCGTC 
CAGGCCATGG ATCCTAACGC TGCTTATGTG AACATGAGTA ACCATCACCG GGGCCTGGCT 
TCAGCCAACG TTGACTTTGC CTTCAGCCTG TATAAGCACC TAGTGGCCTT GAGTCCCAAA 
AAGAACATTT TCATCTCCCC TGTGAGCATC TCCATGGCCT TAGCTATGCT GTCCCTGGGC 
ACCTGTGGCC ACACACGGGC CCAGCTTCTC CAGGGCCTGG GTTTCAACCT CACTGAGAGG 
TCTGAGACTG AGATCCACCA GGGTTTCCAG CACCTGCACC AACTCTTTGC AAAGTCAGAC 
ACCAGCTTAG AAATGACCAT GGGCAATGCC TTGTTTCTTG ATGGCAGCCT GGAGTTGCTG 
GAGTCATTCT CAGCAGACAT CAAGCACTAC TATGAGTCAG AGGTCTTGGC TATGAATTTC 
CAGGACTGGG CAACAGCCAG CAGACAGATC AACAGCTATG TCAAGAATAA GACACAGGGG 
AAAATTGTCG ACTTGTTTTC AGGGCTGGAT AGCCCAGCCA TCCTCGTCCT GGTCAACTAT 
ATCTTCTTCA AAGGCACATG GACACAGCCC TTTGACCTGG CAAGCACCAG GGAGGAGAAC 
TTCTATGTGG ACGAGACAAC TGTGGTGAAG GTGCCCATGA TGTTGCAGTC GAGCACCATC 
AGTTACCTTC ATGACGCGGA GCTCCCCTGC CAGCTGGTGC AGATGAACTA CGTGGGCAAT 
GGGACTGTCT TCTTCATCCT TCCGGACAAG GGGAAGATGA ACACAGTCAT CGCTGCACTG 
AGCCGGGACA CGATTAACAG GTGGTCCGCA GGCCTGACCA GCAGCCAGGT GGACCTGTAC 
ATTCCAAAGG TCACCATCTC TGGAGTCTAT GACCTCGGAG ATGTGCTGGA GGAAATGGGC 
ATTGCAGACT TGTTCACCAA CCAGGCAAAT TTCTCACGCA TCACCCAGGA CGCCCAGCTG 
AAGTCATCAA AGGTGGTCCA TAAAGCTGTG CTGCAACTCA ATGAGGAGGG TGTGGACACA 
GCTGGCTCCA CTGGGGTCAC CCTAAACCTG ACGTCCAAGC CTATCATCTT GCGTTTCAAC 
CAGCCCTTCA TCATCATGAT CTTCGACCAC TTCACCTGGA GCAGCCTTTT CCTGGCGAGG 
GTTATGAACC CAGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001747.2
CDS	105..1322
Translation	MPLLLYTCLLWLPTSGLWTVQAMDPNAAYVNMSNHHRGLASANVDFAFSLYKHLVALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLTERSETEIHQGFQHLHQLFAKSDTSLEMTMGNALFLDGSLELLESFSADIKHYYESEVLAMNFQDWATASRQINSYVKNKTQGKIVDLFSGLDSPAILVLVNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTISYLHDAELPCQLVQMNYVGNGTVFFILPDKGKMNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLFTNQANFSRITQDAQLKSSKVVHKAVLQLNEEGVDTAGSTGVTLNLTSKPIILRFNQPFIIMIFDHFTWSSLFLARVMNPV

Target ORF information:

RefSeq Version	NM_001756.3
Organism	Homo sapiens(human)
Definition	Homo sapiens serpin family A member 6 (SERPINA6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001756.3

ORF Insert Sequence:

ATGCCACTCC TCCTGTACAC CTGTCTTCTC TGGCTGCCCA CCAGCGGCCT CTGGACCGTC 
CAGGCCATGG ATCCTAACGC TGCTTATGTG AACATGAGTA ACCATCACCG GGGCCTGGCT 
TCAGCCAACG TTGACTTTGC CTTCAGCCTG TATAAGCACC TAGTGGCCTT GAGTCCCAAA 
AAGAACATTT TCATCTCCCC TGTGAGCATC TCCATGGCCT TAGCTATGCT GTCCCTGGGC 
ACCTGTGGCC ACACACGGGC CCAGCTTCTC CAGGGCCTGG GTTTCAACCT CACTGAGAGG 
TCTGAGACTG AGATCCACCA GGGTTTCCAG CACCTGCACC AACTCTTTGC AAAGTCAGAC 
ACCAGCTTAG AAATGACCAT GGGCAATGCC TTGTTTCTTG ATGGCAGCCT GGAGTTGCTG 
GAGTCATTCT CAGCAGACAT CAAGCACTAC TATGAGTCAG AGGTCTTGGC TATGAATTTC 
CAGGACTGGG CAACAGCCAG CAGACAGATC AACAGCTATG TCAAGAATAA GACACAGGGG 
AAAATTGTCG ACTTGTTTTC AGGGCTGGAT AGCCCAGCCA TCCTCGTCCT GGTCAACTAT 
ATCTTCTTCA AAGGCACATG GACACAGCCC TTTGACCTGG CAAGCACCAG GGAGGAGAAC 
TTCTATGTGG ACGAGACAAC TGTGGTGAAG GTGCCCATGA TGTTGCAGTC GAGCACCATC 
AGTTACCTTC ATGACGCGGA GCTCCCCTGC CAGCTGGTGC AGATGAACTA CGTGGGCAAT 
GGGACTGTCT TCTTCATCCT TCCGGACAAG GGGAAGATGA ACACAGTCAT CGCTGCACTG 
AGCCGGGACA CGATTAACAG GTGGTCCGCA GGCCTGACCA GCAGCCAGGT GGACCTGTAC 
ATTCCAAAGG TCACCATCTC TGGAGTCTAT GACCTCGGAG ATGTGCTGGA GGAAATGGGC 
ATTGCAGACT TGTTCACCAA CCAGGCAAAT TTCTCACGCA TCACCCAGGA CGCCCAGCTG 
AAGTCATCAA AGGTGGTCCA TAAAGCTGTG CTGCAACTCA ATGAGGAGGG TGTGGACACA 
GCTGGCTCCA CTGGGGTCAC CCTAAACCTG ACGTCCAAGC CTATCATCTT GCGTTTCAAC 
CAGCCCTTCA TCATCATGAT CTTCGACCAC TTCACCTGGA GCAGCCTTTT CCTGGCGAGG 
GTTATGAACC CAGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SERPINA6 ( NM_001756.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001747.3 Homo sapiens serpin family A member 6 (SERPINA6), mRNA.

Price & Availability↑

CloneID	OHu107593
Clone ID Related Accession (Same CDS sequence)	NM_001756.4
Accession Version	NM_001756.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1218bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-27
Organism	Homo sapiens(human)
Product	corticosteroid-binding globulin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL117259.6. On Nov 22, 2018 this sequence version replaced NM_001756.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189664.100985.1, SRR5189664.110076.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000341584.4/ ENSP00000342850.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCACTCC TCCTGTACAC CTGTCTTCTC TGGCTGCCCA CCAGCGGCCT CTGGACCGTC 
CAGGCCATGG ATCCTAACGC TGCTTATGTG AACATGAGTA ACCATCACCG GGGCCTGGCT 
TCAGCCAACG TTGACTTTGC CTTCAGCCTG TATAAGCACC TAGTGGCCTT GAGTCCCAAA 
AAGAACATTT TCATCTCCCC TGTGAGCATC TCCATGGCCT TAGCTATGCT GTCCCTGGGC 
ACCTGTGGCC ACACACGGGC CCAGCTTCTC CAGGGCCTGG GTTTCAACCT CACTGAGAGG 
TCTGAGACTG AGATCCACCA GGGTTTCCAG CACCTGCACC AACTCTTTGC AAAGTCAGAC 
ACCAGCTTAG AAATGACCAT GGGCAATGCC TTGTTTCTTG ATGGCAGCCT GGAGTTGCTG 
GAGTCATTCT CAGCAGACAT CAAGCACTAC TATGAGTCAG AGGTCTTGGC TATGAATTTC 
CAGGACTGGG CAACAGCCAG CAGACAGATC AACAGCTATG TCAAGAATAA GACACAGGGG 
AAAATTGTCG ACTTGTTTTC AGGGCTGGAT AGCCCAGCCA TCCTCGTCCT GGTCAACTAT 
ATCTTCTTCA AAGGCACATG GACACAGCCC TTTGACCTGG CAAGCACCAG GGAGGAGAAC 
TTCTATGTGG ACGAGACAAC TGTGGTGAAG GTGCCCATGA TGTTGCAGTC GAGCACCATC 
AGTTACCTTC ATGACTCGGA GCTCCCCTGC CAGCTGGTGC AGATGAACTA CGTGGGCAAT 
GGGACTGTCT TCTTCATCCT TCCGGACAAG GGGAAGATGA ACACAGTCAT CGCTGCACTG 
AGCCGGGACA CGATTAACAG GTGGTCCGCA GGCCTGACCA GCAGCCAGGT GGACCTGTAC 
ATTCCAAAGG TCACCATCTC TGGAGTCTAT GACCTCGGAG ATGTGCTGGA GGAAATGGGC 
ATTGCAGACT TGTTCACCAA CCAGGCAAAT TTCTCACGCA TCACCCAGGA CGCCCAGCTG 
AAGTCATCAA AGGTGGTCCA TAAAGCTGTG CTGCAACTCA ATGAGGAGGG TGTGGACACA 
GCTGGCTCCA CTGGGGTCAC CCTAAACCTG ACGTCCAAGC CTATCATCTT GCGTTTCAAC 
CAGCCCTTCA TCATCATGAT CTTCGACCAC TTCACCTGGA GCAGCCTTTT CCTGGCGAGG 
GTTATGAACC CAGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001747.3
CDS	90..1307
Translation	MPLLLYTCLLWLPTSGLWTVQAMDPNAAYVNMSNHHRGLASANVDFAFSLYKHLVALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLTERSETEIHQGFQHLHQLFAKSDTSLEMTMGNALFLDGSLELLESFSADIKHYYESEVLAMNFQDWATASRQINSYVKNKTQGKIVDLFSGLDSPAILVLVNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTISYLHDSELPCQLVQMNYVGNGTVFFILPDKGKMNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLFTNQANFSRITQDAQLKSSKVVHKAVLQLNEEGVDTAGSTGVTLNLTSKPIILRFNQPFIIMIFDHFTWSSLFLARVMNPV

Target ORF information:

RefSeq Version	NM_001756.4
Organism	Homo sapiens(human)
Definition	Homo sapiens serpin family A member 6 (SERPINA6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001756.4

ORF Insert Sequence:

ATGCCACTCC TCCTGTACAC CTGTCTTCTC TGGCTGCCCA CCAGCGGCCT CTGGACCGTC 
CAGGCCATGG ATCCTAACGC TGCTTATGTG AACATGAGTA ACCATCACCG GGGCCTGGCT 
TCAGCCAACG TTGACTTTGC CTTCAGCCTG TATAAGCACC TAGTGGCCTT GAGTCCCAAA 
AAGAACATTT TCATCTCCCC TGTGAGCATC TCCATGGCCT TAGCTATGCT GTCCCTGGGC 
ACCTGTGGCC ACACACGGGC CCAGCTTCTC CAGGGCCTGG GTTTCAACCT CACTGAGAGG 
TCTGAGACTG AGATCCACCA GGGTTTCCAG CACCTGCACC AACTCTTTGC AAAGTCAGAC 
ACCAGCTTAG AAATGACCAT GGGCAATGCC TTGTTTCTTG ATGGCAGCCT GGAGTTGCTG 
GAGTCATTCT CAGCAGACAT CAAGCACTAC TATGAGTCAG AGGTCTTGGC TATGAATTTC 
CAGGACTGGG CAACAGCCAG CAGACAGATC AACAGCTATG TCAAGAATAA GACACAGGGG 
AAAATTGTCG ACTTGTTTTC AGGGCTGGAT AGCCCAGCCA TCCTCGTCCT GGTCAACTAT 
ATCTTCTTCA AAGGCACATG GACACAGCCC TTTGACCTGG CAAGCACCAG GGAGGAGAAC 
TTCTATGTGG ACGAGACAAC TGTGGTGAAG GTGCCCATGA TGTTGCAGTC GAGCACCATC 
AGTTACCTTC ATGACTCGGA GCTCCCCTGC CAGCTGGTGC AGATGAACTA CGTGGGCAAT 
GGGACTGTCT TCTTCATCCT TCCGGACAAG GGGAAGATGA ACACAGTCAT CGCTGCACTG 
AGCCGGGACA CGATTAACAG GTGGTCCGCA GGCCTGACCA GCAGCCAGGT GGACCTGTAC 
ATTCCAAAGG TCACCATCTC TGGAGTCTAT GACCTCGGAG ATGTGCTGGA GGAAATGGGC 
ATTGCAGACT TGTTCACCAA CCAGGCAAAT TTCTCACGCA TCACCCAGGA CGCCCAGCTG 
AAGTCATCAA AGGTGGTCCA TAAAGCTGTG CTGCAACTCA ATGAGGAGGG TGTGGACACA 
GCTGGCTCCA CTGGGGTCAC CCTAAACCTG ACGTCCAAGC CTATCATCTT GCGTTTCAAC 
CAGCCCTTCA TCATCATGAT CTTCGACCAC TTCACCTGGA GCAGCCTTTT CCTGGCGAGG 
GTTATGAACC CAGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Functional Implications of Corticosteroid-binding Globulin N-Glycosylation.
Journal of molecular endocrinology(2017 Dec)
Simard M,Underhill C,Hammond GL

The role of corticosteroid-binding globulin in the evaluation of adrenal insufficiency.
Journal of pediatric endocrinology & metabolism : JPEM(2017 Dec)
Verbeeten KC,Ahmet AH

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SERPINA6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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