SOCS1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SOCS1
Entrez Gene ID	8651
Full Name	suppressor of cytokine signaling 1
Synonyms	CIS1,CISH1,JAB,SOCS-1,SSI-1,SSI1,TIP-3,TIP3
General protein information	Preferred Names suppressor of cytokine signaling 1 Names suppressor of cytokine signaling 1 JAK binding protein STAT induced SH3 protein 1 STAT-induced STAT inhibitor 1 Tec-interacting protein 3 cytokine-inducible SH2 protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p13.13
Summary	This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008].
Disorder MIM:	603597

mRNA and Protein(s)

mRNA	Protein	Name
NM_003745.1	NP_003736.1	suppressor of cytokine signaling 1

Pathways from BioSystems

Homologies

	SOCS1	XP_001104595.1
Bos taurus (cattle)	SOCS1	XP_002698010.1
Danio rerio (zebrafish)	socs1a	NP_001003467.1
Mus musculus (house mouse)	Socs1	NP_001258532.1
Homo sapiens (human)	SOCS1	NP_003736.1
Rattus norvegicus (Norway rat)	Socs1	NP_665886.1
Xenopus tropicalis (tropical clawed frog)	socs1	NP_001011327.1
Pan troglodytes (chimpanzee)	SOCS1	XP_001141793.1
Canis lupus familiaris (dog)	SOCS1	XP_005622136.1
Gallus gallus (chicken)	SOCS1	NP_001131120.1

Gene Ontology
Bibliography

Related articles in PubMed

Regulation of SOCS-1 expression by translational repression.
Gregorieff A, Pyronnet S, Sonenberg N, Veillette A
The Journal of biological chemistry275(28)21596-604(2000 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Inhibiting the STAT3-Mcl-1 signaling axis by ectopic SOCS1 improved radiosensitivity by inducing apoptosis and enhancing DNA damage after radiotherapy, offering a mechanistic rationale for a new esophageal squamous cell carcinoma treatment.
Title: SOCS1 Gene Therapy Improves Radiosensitivity and Enhances Irradiation-Induced DNA Damage in Esophageal Squamous Cell Carcinoma.

This study evaluation the roles of SOCS1, the regulator of TLR9, RIG-I, and CD152 in patients with liver fibrosis/cirrhosis; the use of polymorphisms as markers for genetic risk is reported.
Title: SOCS1 and pattern recognition receptors: TLR9 and RIG-I; novel haplotype associations in Egyptian fibrotic/cirrhotic patients with HCV genotype 4.

SOCS1 silencing can inhibit proliferation and induce apoptosis of MV3 and A357 melanoma cells in vivo and in vitro by inhibiting extracellular signal-regulated kinase and janus kinase signal transduction and activators of transcription signaling pathways.
Title: Effect of SOCS1 silencing on proliferation and apoptosis of melanoma cells: An in vivo and in vitro study.

IL-4 signaling plays a crucial role in the regulatory functions of SOCS1 in apoptosis and inflammation in human osteoarthritic chondrocytes. These findings provide a potential therapeutic target for the clinical treatment of osteoarthritis (OA)
Title: SOCS1 Regulates Apoptosis and Inflammation by Inhibiting IL-4 Signaling in IL-1

SOCS1 rs33932899 genotype was significantly related to severe necroinflammatory activity (NIA) grade of chronic hepatitis C patients.
Title: Interferon-related genetic markers of necroinflammatory activity in chronic hepatitis C.

The following SOCS1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SOCS1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu17289	NM_003745.1 Latest version!	Homo sapiens suppressor of cytokine signaling 1 (SOCS1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SOCS1 ( NM_003745.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_003736.1 Homo sapiens suppressor of cytokine signaling 1 (SOCS1), mRNA.

Price & Availability↑

CloneID	OHu17289
Clone ID Related Accession (Same CDS sequence)	NM_003745.1
Accession Version	NM_003745.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 636bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Homo sapiens(human)
Product	suppressor of cytokine signaling 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB000734.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB000734.1, DR006685.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript regulatory uORF :: PMID: 10679190 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTAGCAC ACAACCAGGT GGCAGCCGAC AATGCAGTCT CCACAGCAGC AGAGCCCCGA 
CGGCGGCCAG AACCTTCCTC CTCTTCCTCC TCCTCGCCCG CGGCCCCCGC GCGCCCGCGG 
CCGTGCCCCG CGGTCCCGGC CCCGGCCCCC GGCGACACGC ACTTCCGCAC ATTCCGTTCG 
CACGCCGATT ACCGGCGCAT CACGCGCGCC AGCGCGCTCC TGGACGCCTG CGGATTCTAC 
TGGGGGCCCC TGAGCGTGCA CGGGGCGCAC GAGCGGCTGC GCGCCGAGCC CGTGGGCACC 
TTCCTGGTGC GCGACAGCCG CCAGCGGAAC TGCTTTTTCG CCCTTAGCGT GAAGATGGCC 
TCGGGACCCA CGAGCATCCG CGTGCACTTT CAGGCCGGCC GCTTTCACCT GGATGGCAGC 
CGCGAGAGCT TCGACTGCCT CTTCGAGCTG CTGGAGCACT ACGTGGCGGC GCCGCGCCGC 
ATGCTGGGGG CCCCGCTGCG CCAGCGCCGC GTGCGGCCGC TGCAGGAGCT GTGCCGCCAG 
CGCATCGTGG CCACCGTGGG CCGCGAGAAC CTGGCTCGCA TCCCCCTCAA CCCCGTCCTC 
CGCGACTACC TGAGCTCCTT CCCCTTCCAG ATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003736.1
CDS	155..790
Translation	MVAHNQVAADNAVSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRESFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVATVGRENLARIPLNPVLRDYLSSFPFQI

Target ORF information:

RefSeq Version	NM_003745.1
Organism	Homo sapiens(human)
Definition	Homo sapiens suppressor of cytokine signaling 1 (SOCS1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003745.1

ORF Insert Sequence:

ATGGTAGCAC ACAACCAGGT GGCAGCCGAC AATGCAGTCT CCACAGCAGC AGAGCCCCGA 
CGGCGGCCAG AACCTTCCTC CTCTTCCTCC TCCTCGCCCG CGGCCCCCGC GCGCCCGCGG 
CCGTGCCCCG CGGTCCCGGC CCCGGCCCCC GGCGACACGC ACTTCCGCAC ATTCCGTTCG 
CACGCCGATT ACCGGCGCAT CACGCGCGCC AGCGCGCTCC TGGACGCCTG CGGATTCTAC 
TGGGGGCCCC TGAGCGTGCA CGGGGCGCAC GAGCGGCTGC GCGCCGAGCC CGTGGGCACC 
TTCCTGGTGC GCGACAGCCG CCAGCGGAAC TGCTTTTTCG CCCTTAGCGT GAAGATGGCC 
TCGGGACCCA CGAGCATCCG CGTGCACTTT CAGGCCGGCC GCTTTCACCT GGATGGCAGC 
CGCGAGAGCT TCGACTGCCT CTTCGAGCTG CTGGAGCACT ACGTGGCGGC GCCGCGCCGC 
ATGCTGGGGG CCCCGCTGCG CCAGCGCCGC GTGCGGCCGC TGCAGGAGCT GTGCCGCCAG 
CGCATCGTGG CCACCGTGGG CCGCGAGAAC CTGGCTCGCA TCCCCCTCAA CCCCGTCCTC 
CGCGACTACC TGAGCTCCTT CCCCTTCCAG ATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Regulation of SOCS-1 expression by translational repression.
The Journal of biological chemistry275(28)21596-604(2000 Jul)
Gregorieff A,Pyronnet S,Sonenberg N,Veillette A

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SOCS1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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