LAMTOR3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LAMTOR3
Entrez Gene ID	8649
Full Name	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
Synonyms	MAP2K1IP1,MAPBP,MAPKSP1,MP1,PRO0633,Ragulator3
General protein information	Preferred Names late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 Names ragulator complex protein LAMTOR3 MAPK scaffold protein 1 MEK binding partner 1 late endosomal/lysosomal adaptor and MAPK and MTOR activator 3 mitogen-activated protein kinase kinase 1 interacting protein 1 mitogen-activated protein kinase scaffold protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q23
Summary	This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011].
Disorder MIM:	603296

mRNA and Protein(s)

mRNA	Protein	Name
NM_021970.3	NP_068805.1	ragulator complex protein LAMTOR3 isoform 1
NM_001243736.1	NP_001230665.1	ragulator complex protein LAMTOR3 isoform 2
NM_021970.4	NP_068805.1	ragulator complex protein LAMTOR3 isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	LAMTOR3	NP_068805.1
Canis lupus familiaris (dog)	LAMTOR3	XP_862361.1
Rattus norvegicus (Norway rat)	Lamtor3	NP_001008376.1
Xenopus tropicalis (tropical clawed frog)	lamtor3	NP_001135566.1
Pan troglodytes (chimpanzee)	LAMTOR3	XP_517362.2
Bos taurus (cattle)	LAMTOR3	NP_001069450.1
Mus musculus (house mouse)	Lamtor3	NP_064304.1
Danio rerio (zebrafish)	lamtor3	NP_001018410.1
	MAPKSP1	XP_001107957.1
Gallus gallus (chicken)	LAMTOR3	NP_001006559.1
Drosophila melanogaster (fruit fly)	CG5110	NP_001246062.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000997	XP_309192.2

Gene Ontology
Bibliography

Related articles in PubMed

BCL2 induced by LAMTOR3/MAPK is a druggable target of chemoradioresistance in mesenchymal lung cancer.
Kwon OS, Hong SK, Kwon SJ, Go YH, Oh E, Cha HJ
Cancer letters40348-58(2017 Sep)

Role of MEK partner-1 in cancer stemness through MEK/ERK pathway in cancerous neural stem cells, expressing EGFRviii.
Kwon SJ, Kwon OS, Kim KT, Go YH, Yu SI, Lee BH, Miyoshi H, Oh E, Cho SJ, Cha HJ
Molecular cancer16(1)140(2017 Aug)

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.
Rebsamen M, Pochini L, Stasyk T, de Ara?jo ME, Galluccio M, Kandasamy RK, Snijder B, Fauster A, Rudashevskaya EL, Bruckner M, Scorzoni S, Filipek PA, Huber KV, Bigenzahn JW, Heinz LX, Kraft C, Bennett KL, Indiveri C, Huber LA, Superti-Furga G
Nature519(7544)477-81(2015 Mar)

A miR-29c binding site genetic variant in the 3'-untranslated region of LAMTOR3 gene is associated with gastric cancer risk.
Song P, Wang W, Tao G, Chu H, Wang M, Wu D, Tong N, Gong W, Zhou J, Zhang Z, Wang B, Zhu H, Zhao Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie6970-5(2015 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

BCL2 expression in mesennchymal lung cancer cells was induced by ERK1 activity through the upregulation of the MEK1/ERK1 scaffold protein MEK partner-1. Interfering with the MEK1/MP1/ERK1 axis using a MEK1 inhibitor or MP1 depletion repressed BCL2 expression and sensitized MLCCs to chemoradiotherapy.
Title: BCL2 induced by LAMTOR3/MAPK is a druggable target of chemoradioresistance in mesenchymal lung cancer.

The present study was aimed at investigating whether the miR-29c binding site single nucleotide polymorphisms within the 3'-UTRs of LAMTOR3 gene affected the gastric cancer risk.
Title: A miR-29c binding site genetic variant in the 3'-untranslated region of LAMTOR3 gene is associated with gastric cancer risk.

we demonstrate that the MAPK scaffold protein MEK partner 1 (MP1) is important for gastrin-induced phosphorylation of ERK1 and ERK2 and that MP1 promotes gastrin-induced proliferation of AGS-GR cells
Title: Gastrin-induced proliferation involves MEK partner 1 (MP1).

identified polymorphisms in LAMTOR2 and LAMTOR3 do not seem to play a relevant role in breast cancer
Title: Polymorphisms in the gene regions of the adaptor complex LAMTOR2/LAMTOR3 and their association with breast cancer risk.

A complex encoded by the MAPKSP1, ROBLD3, and c11orf59 genes interacts with the Rag GTPases, recruits them to lysosomes, and is essential for mTORC1 activation
Title: Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

The following LAMTOR3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LAMTOR3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09175	NM_021970.4 Latest version!	Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 (LAMTOR3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu10811	NM_001243736.1 Latest version!	Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 (LAMTOR3), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu09175	NM_021970.3	Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 (LAMTOR3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LAMTOR3 ( NM_021970.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_068805.1 Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 (LAMTOR3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09175
Clone ID Related Accession (Same CDS sequence)	NM_021970.3 , NM_021970.4
Accession Version	NM_021970.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 375bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	ragulator complex protein LAMTOR3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI562630.1, BC026245.1, AF201947.1, AK022313.1 and DA300823.1. On or before Mar 17, 2009 this sequence version replaced XM_001723365.1, XM_001723301.1, XM_001724550.1, NM_021970.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.15828.1, SRR1803614.113245.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGATG ACCTAAAGCG ATTCTTGTAT AAAAAGTTAC CAAGTGTTGA AGGGCTCCAT 
GCCATTGTTG TGTCAGATAG AGATGGAGTA CCTGTTATTA AAGTGGCAAA TGACAATGCT 
CCAGAGCATG CTTTGCGACC TGGTTTCTTA TCCACTTTTG CCCTTGCAAC AGACCAAGGA 
AGCAAACTTG GACTTTCCAA AAATAAAAGT ATCATCTGTT ACTATAACAC CTACCAGGTG 
GTTCAATTTA ATCGTTTACC TTTGGTGGTG AGTTTCATAG CCAGCAGCAG TGCCAATACA 
GGACTAATTG TCAGCCTAGA AAAGGAACTT GCTCCATTGT TTGAAGAACT GAGACAAGTT 
GTGGAAGTTT CTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_068805.1
CDS	250..624
Translation	MADDLKRFLYKKLPSVEGLHAIVVSDRDGVPVIKVANDNAPEHALRPGFLSTFALATDQGSKLGLSKNKSIICYYNTYQVVQFNRLPLVVSFIASSSANTGLIVSLEKELAPLFEELRQVVEVS

Target ORF information:

RefSeq Version	NM_021970.3
Organism	Homo sapiens(human)
Definition	Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 (LAMTOR3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021970.3

ORF Insert Sequence:

ATGGCGGATG ACCTAAAGCG ATTCTTGTAT AAAAAGTTAC CAAGTGTTGA AGGGCTCCAT 
GCCATTGTTG TGTCAGATAG AGATGGAGTA CCTGTTATTA AAGTGGCAAA TGACAATGCT 
CCAGAGCATG CTTTGCGACC TGGTTTCTTA TCCACTTTTG CCCTTGCAAC AGACCAAGGA 
AGCAAACTTG GACTTTCCAA AAATAAAAGT ATCATCTGTT ACTATAACAC CTACCAGGTG 
GTTCAATTTA ATCGTTTACC TTTGGTGGTG AGTTTCATAG CCAGCAGCAG TGCCAATACA 
GGACTAATTG TCAGCCTAGA AAAGGAACTT GCTCCATTGT TTGAAGAACT GAGACAAGTT 
GTGGAAGTTT CTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LAMTOR3 ( NM_021970.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_068805.1 Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 (LAMTOR3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09175
Clone ID Related Accession (Same CDS sequence)	NM_021970.3 , NM_021970.4
Accession Version	NM_021970.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 375bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	ragulator complex protein LAMTOR3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC026245.1, AF201947.1, AK022313.1, DA300823.1 and AP001962.2. On Nov 22, 2018 this sequence version replaced NM_021970.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.47431.1, SRR1660807.249589.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000499666.7/ ENSP00000424183.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGATG ACCTAAAGCG ATTCTTGTAT AAAAAGTTAC CAAGTGTTGA AGGGCTCCAT 
GCCATTGTTG TGTCAGATAG AGATGGAGTA CCTGTTATTA AAGTGGCAAA TGACAATGCT 
CCAGAGCATG CTTTGCGACC TGGTTTCTTA TCCACTTTTG CCCTTGCAAC AGACCAAGGA 
AGCAAACTTG GACTTTCCAA AAATAAAAGT ATCATCTGTT ACTATAACAC CTACCAGGTG 
GTTCAATTTA ATCGTTTACC TTTGGTGGTG AGTTTCATAG CCAGCAGCAG TGCCAATACA 
GGACTAATTG TCAGCCTAGA AAAGGAACTT GCTCCATTGT TTGAAGAACT GAGACAAGTT 
GTGGAAGTTT CTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_068805.1
CDS	131..505
Translation	MADDLKRFLYKKLPSVEGLHAIVVSDRDGVPVIKVANDNAPEHALRPGFLSTFALATDQGSKLGLSKNKSIICYYNTYQVVQFNRLPLVVSFIASSSANTGLIVSLEKELAPLFEELRQVVEVS

Target ORF information:

RefSeq Version	NM_021970.4
Organism	Homo sapiens(human)
Definition	Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 (LAMTOR3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021970.4

ORF Insert Sequence:

ATGGCGGATG ACCTAAAGCG ATTCTTGTAT AAAAAGTTAC CAAGTGTTGA AGGGCTCCAT 
GCCATTGTTG TGTCAGATAG AGATGGAGTA CCTGTTATTA AAGTGGCAAA TGACAATGCT 
CCAGAGCATG CTTTGCGACC TGGTTTCTTA TCCACTTTTG CCCTTGCAAC AGACCAAGGA 
AGCAAACTTG GACTTTCCAA AAATAAAAGT ATCATCTGTT ACTATAACAC CTACCAGGTG 
GTTCAATTTA ATCGTTTACC TTTGGTGGTG AGTTTCATAG CCAGCAGCAG TGCCAATACA 
GGACTAATTG TCAGCCTAGA AAAGGAACTT GCTCCATTGT TTGAAGAACT GAGACAAGTT 
GTGGAAGTTT CTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LAMTOR3 ( NM_001243736.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001230665.1 Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 (LAMTOR3), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu10811
Clone ID Related Accession (Same CDS sequence)	NM_001243736.1
Accession Version	NM_001243736.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 354bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-25
Organism	Homo sapiens(human)
Product	ragulator complex protein LAMTOR3 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI562630.1, AL544981.3 and AP001962.2. Transcript Variant: This variant (3) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL544981.3 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGATG ACCTAAAGCG ATTCTTGTAT AAAAAGTTAC CAAGTGTTGA AGGGCTCCAT 
GCCATTGTTG TGTCAGATAG AGATGGAGTA CCTGTTATTA AAGAGCATGC TTTGCGACCT 
GGTTTCTTAT CCACTTTTGC CCTTGCAACA GACCAAGGAA GCAAACTTGG ACTTTCCAAA 
AATAAAAGTA TCATCTGTTA CTATAACACC TACCAGGTGG TTCAATTTAA TCGTTTACCT 
TTGGTGGTGA GTTTCATAGC CAGCAGCAGT GCCAATACAG GACTAATTGT CAGCCTAGAA 
AAGGAACTTG CTCCATTGTT TGAAGAACTG AGACAAGTTG TGGAAGTTTC TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001230665.1
CDS	250..603
Translation	MADDLKRFLYKKLPSVEGLHAIVVSDRDGVPVIKEHALRPGFLSTFALATDQGSKLGLSKNKSIICYYNTYQVVQFNRLPLVVSFIASSSANTGLIVSLEKELAPLFEELRQVVEVS

Target ORF information:

RefSeq Version	NM_001243736.1
Organism	Homo sapiens(human)
Definition	Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 (LAMTOR3), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001243736.1

ORF Insert Sequence:

ATGGCGGATG ACCTAAAGCG ATTCTTGTAT AAAAAGTTAC CAAGTGTTGA AGGGCTCCAT 
GCCATTGTTG TGTCAGATAG AGATGGAGTA CCTGTTATTA AAGAGCATGC TTTGCGACCT 
GGTTTCTTAT CCACTTTTGC CCTTGCAACA GACCAAGGAA GCAAACTTGG ACTTTCCAAA 
AATAAAAGTA TCATCTGTTA CTATAACACC TACCAGGTGG TTCAATTTAA TCGTTTACCT 
TTGGTGGTGA GTTTCATAGC CAGCAGCAGT GCCAATACAG GACTAATTGT CAGCCTAGAA 
AAGGAACTTG CTCCATTGTT TGAAGAACTG AGACAAGTTG TGGAAGTTTC TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

BCL2 induced by LAMTOR3/MAPK is a druggable target of chemoradioresistance in mesenchymal lung cancer.
Cancer letters40348-58(2017 Sep)
Kwon OS,Hong SK,Kwon SJ,Go YH,Oh E,Cha HJ

Role of MEK partner-1 in cancer stemness through MEK/ERK pathway in cancerous neural stem cells, expressing EGFRviii.
Molecular cancer16(1)140(2017 Aug)
Kwon SJ,Kwon OS,Kim KT,Go YH,Yu SI,Lee BH,Miyoshi H,Oh E,Cho SJ,Cha HJ

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.
Nature519(7544)477-81(2015 Mar)
Rebsamen M,Pochini L,Stasyk T,de Ara?jo ME,Galluccio M,Kandasamy RK,Snijder B,Fauster A,Rudashevskaya EL,Bruckner M,Scorzoni S,Filipek PA,Huber KV,Bigenzahn JW,Heinz LX,Kraft C,Bennett KL,Indiveri C,Huber LA,Superti-Furga G

A miR-29c binding site genetic variant in the 3'-untranslated region of LAMTOR3 gene is associated with gastric cancer risk.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie6970-5(2015 Feb)
Song P,Wang W,Tao G,Chu H,Wang M,Wu D,Tong N,Gong W,Zhou J,Zhang Z,Wang B,Zhu H,Zhao Q

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LAMTOR3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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