EIF4EBP3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	EIF4EBP3
Entrez Gene ID	8637
Full Name	eukaryotic translation initiation factor 4E binding protein 3
Synonyms	4E-BP3,4EBP3
General protein information	Preferred Names eukaryotic translation initiation factor 4E binding protein 3 Names eukaryotic translation initiation factor 4E-binding protein 3 eIF4E-binding protein 3 eukaryotic initiation factor 4E-binding protein 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q31.3
Summary	This gene encodes a member of the EIF4EBP family, which consists of proteins that bind to eukaryotic translation initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that recognizes the mRNA cap structure. Read-through transcription from the neighboring upstream gene (MASK or ANKHD1) generates a transcript (MASK-BP3) that encodes a protein comprised of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. [provided by RefSeq, Oct 2010].
Disorder MIM:	603483

mRNA and Protein(s)

mRNA	Protein	Name
NM_003732.3	NP_003723.1	eukaryotic translation initiation factor 4E-binding protein 3
NM_003732.2	NP_003723.1	eukaryotic translation initiation factor 4E-binding protein 3

Pathways from BioSystems

Homologies

Homo sapiens (human)	EIF4EBP3	NP_003723.1
Pan troglodytes (chimpanzee)	EIF4EBP3	NP_001191091.1
Canis lupus familiaris (dog)	EIF4EBP3	NP_001189453.1
Danio rerio (zebrafish)	eif4ebp3	NP_001007355.1
Mus musculus (house mouse)	Eif4ebp3	NP_957708.1
Rattus norvegicus (Norway rat)	Eif4ebp3	NP_001189481.1
Danio rerio (zebrafish)	eif4ebp3l	NP_955977.1

Gene Ontology
Bibliography

Related articles in PubMed

MiR-22-3p Regulates Cell Proliferation and Inhibits Cell Apoptosis through Targeting the eIF4EBP3 Gene in Human Cervical Squamous Carcinoma Cells.
Lv KT, Liu Z, Feng J, Zhao W, Hao T, Ding WY, Chu JP, Gao LJ
International journal of medical sciences15(2)142-152(2018)

Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3.
Tsukumo Y, Alain T, Fonseca BD, Nadon R, Sonenberg N
Nature communications711776(2016 Jun)

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
Corominas R, Yang X, Lin GN, Kang S, Shen Y, Ghamsari L, Broly M, Rodriguez M, Tam S, Trigg SA, Fan C, Yi S, Tasan M, Lemmens I, Kuang X, Zhao N, Malhotra D, Michaelson JJ, Vacic V, Calderwood MA, Roth FP, Tavernier J, Horvath S, Salehi-Ashtiani K, Korkin D, Sebat J, Hill DE, Hao T, Vidal M, Iakoucheva LM
Nature communications53650(2014 Apr)

4E-BP3 regulates eIF4E-mediated nuclear mRNA export and interacts with replication protein A2.
Chen CC, Lee JC, Chang MC
FEBS letters586(16)2260-6(2012 Jul)

Associations between genetic variation in RUNX1, RUNX2, RUNX3, MAPK1 and eIF4E and riskof colon and rectal cancer: additional support for a TGF-?-signaling pathway.
Slattery ML, Lundgreen A, Herrick JS, Caan BJ, Potter JD, Wolff RK
Carcinogenesis32(3)318-26(2011 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

4E-BP3 regulates eIF4E-mediated nuclear mRNA export and interacts with replication protein A2
Title: 4E-BP3 regulates eIF4E-mediated nuclear mRNA export and interacts with replication protein A2.

Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Associations between genetic variation in RUNX1, RUNX2, RUNX3, MAPK1 and eIF4E and riskof colon and rectal cancer: additional support for a TGF-?-signaling pathway.

potential prognostic factor for survival in patients with lung adenocarcinoma
Title: Prognostic significance of expression of eukaryotic initiation factor 4E and 4E binding protein 1 in patients with pathological stage I invasive lung adenocarcinoma.

there are overlapping reading frames in the mouse and human genes for 4E-BP3 and MASK
Title: Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK.

PHAS-II, but not PHAS-III, contributes to the control of protein synthesis by insulin
Title: Ser-64 and Ser-111 in PHAS-I are dispensable for insulin-stimulated dissociation from eIF4E.

The following EIF4EBP3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EIF4EBP3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29508	NM_003732.3 Latest version!	Homo sapiens eukaryotic translation initiation factor 4E binding protein 3 (EIF4EBP3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu29508	NM_003732.2	Homo sapiens eukaryotic translation initiation factor 4E binding protein 3 (EIF4EBP3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

EIF4EBP3 ( NM_003732.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003723.1 Homo sapiens eukaryotic translation initiation factor 4E binding protein 3 (EIF4EBP3), mRNA.

Price & Availability↑

CloneID	OHu29508
Clone ID Related Accession (Same CDS sequence)	NM_003732.3 , NM_003732.2
Accession Version	NM_003732.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 303bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	eukaryotic translation initiation factor 4E-binding protein 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC011399.6, AF038869.1 and BC010881.1. On Nov 23, 2018 this sequence version replaced NM_003732.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF038869.1, SRR1163657.37210.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000310331.3/ ENSP00000308472.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCAACGT CCACTAGCTG CCCGATTCCC GGGGGCCGGG ACCAGCTGCC CGACTGCTAC 
AGCACCACGC CGGGGGGCAC GCTATACGCC ACTACCCCCG GAGGCACCAG GATCATCTAC 
GACCGAAAGT TCCTGCTGGA GTGCAAGAAC TCACCCATTG CCCGGACACC CCCCTGCTGC 
CTCCCTCAGA TTCCCGGGGT CACAACTCCT CCAACAGCCC CTCTCTCCAA GCTGGAGGAG 
CTGAAGGAGC AGGAGACAGA GGAAGAGATA CCCGATGACG CACAATTTGA AATGGACATC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003723.1
CDS	77..379
Translation	MSTSTSCPIPGGRDQLPDCYSTTPGGTLYATTPGGTRIIYDRKFLLECKNSPIARTPPCCLPQIPGVTTPPTAPLSKLEELKEQETEEEIPDDAQFEMDI

Target ORF information:

RefSeq Version	NM_003732.3
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 4E binding protein 3 (EIF4EBP3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003732.3

ORF Insert Sequence:

ATGTCAACGT CCACTAGCTG CCCGATTCCC GGGGGCCGGG ACCAGCTGCC CGACTGCTAC 
AGCACCACGC CGGGGGGCAC GCTATACGCC ACTACCCCCG GAGGCACCAG GATCATCTAC 
GACCGAAAGT TCCTGCTGGA GTGCAAGAAC TCACCCATTG CCCGGACACC CCCCTGCTGC 
CTCCCTCAGA TTCCCGGGGT CACAACTCCT CCAACAGCCC CTCTCTCCAA GCTGGAGGAG 
CTGAAGGAGC AGGAGACAGA GGAAGAGATA CCCGATGACG CACAATTTGA AATGGACATC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF4EBP3 ( NM_003732.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003723.1 Homo sapiens eukaryotic translation initiation factor 4E binding protein 3 (EIF4EBP3), mRNA.

Price & Availability↑

CloneID	OHu29508
Clone ID Related Accession (Same CDS sequence)	NM_003732.3 , NM_003732.2
Accession Version	NM_003732.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 303bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	eukaryotic translation initiation factor 4E-binding protein 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF038869.1 and BC010881.1. On Apr 23, 2004 this sequence version replaced NM_003732.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC010881.1, ERR279875.5959.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCAACGT CCACTAGCTG CCCGATTCCC GGGGGCCGGG ACCAGCTGCC CGACTGCTAC 
AGCACCACGC CGGGGGGCAC GCTATACGCC ACTACCCCCG GAGGCACCAG GATCATCTAC 
GACCGAAAGT TCCTGCTGGA GTGCAAGAAC TCACCCATTG CCCGGACACC CCCCTGCTGC 
CTCCCTCAGA TTCCCGGGGT CACAACTCCT CCAACAGCCC CTCTCTCCAA GCTGGAGGAG 
CTGAAGGAGC AGGAGACAGA GGAAGAGATA CCCGATGACG CACAATTTGA AATGGACATC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003723.1
CDS	73..375
Translation	MSTSTSCPIPGGRDQLPDCYSTTPGGTLYATTPGGTRIIYDRKFLLECKNSPIARTPPCCLPQIPGVTTPPTAPLSKLEELKEQETEEEIPDDAQFEMDI

Target ORF information:

RefSeq Version	NM_003732.2
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 4E binding protein 3 (EIF4EBP3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003732.2

ORF Insert Sequence:

ATGTCAACGT CCACTAGCTG CCCGATTCCC GGGGGCCGGG ACCAGCTGCC CGACTGCTAC 
AGCACCACGC CGGGGGGCAC GCTATACGCC ACTACCCCCG GAGGCACCAG GATCATCTAC 
GACCGAAAGT TCCTGCTGGA GTGCAAGAAC TCACCCATTG CCCGGACACC CCCCTGCTGC 
CTCCCTCAGA TTCCCGGGGT CACAACTCCT CCAACAGCCC CTCTCTCCAA GCTGGAGGAG 
CTGAAGGAGC AGGAGACAGA GGAAGAGATA CCCGATGACG CACAATTTGA AATGGACATC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MiR-22-3p Regulates Cell Proliferation and Inhibits Cell Apoptosis through Targeting the eIF4EBP3 Gene in Human Cervical Squamous Carcinoma Cells.
International journal of medical sciences15(2)142-152(2018)
Lv KT,Liu Z,Feng J,Zhao W,Hao T,Ding WY,Chu JP,Gao LJ

Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3.
Nature communications711776(2016 Jun)
Tsukumo Y,Alain T,Fonseca BD,Nadon R,Sonenberg N

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
Nature communications53650(2014 Apr)
Corominas R,Yang X,Lin GN,Kang S,Shen Y,Ghamsari L,Broly M,Rodriguez M,Tam S,Trigg SA,Fan C,Yi S,Tasan M,Lemmens I,Kuang X,Zhao N,Malhotra D,Michaelson JJ,Vacic V,Calderwood MA,Roth FP,Tavernier J,Horvath S,Salehi-Ashtiani K,Korkin D,Sebat J,Hill DE,Hao T,Vidal M,Iakoucheva LM

4E-BP3 regulates eIF4E-mediated nuclear mRNA export and interacts with replication protein A2.
FEBS letters586(16)2260-6(2012 Jul)
Chen CC,Lee JC,Chang MC

Associations between genetic variation in RUNX1, RUNX2, RUNX3, MAPK1 and eIF4E and riskof colon and rectal cancer: additional support for a TGF-?-signaling pathway.
Carcinogenesis32(3)318-26(2011 Mar)
Slattery ML,Lundgreen A,Herrick JS,Caan BJ,Potter JD,Wolff RK

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

EIF4EBP3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報