SSNA1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SSNA1
Entrez Gene ID	8636
Full Name	SS nuclear autoantigen 1
Synonyms	N14,NA-14,NA14
General protein information	Preferred Names SS nuclear autoantigen 1 Names Sjoegren syndrome nuclear autoantigen 1 Sjogren syndrome nuclear autoantigen 1 Sjogren's syndrome nuclear autoantigen 1 nuclear autoantigen of 14 kDa
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9q34.3
Disorder MIM:	610882

mRNA and Protein(s)

mRNA	Protein	Name
NM_003731.2	NP_003722.2	Sjoegren syndrome nuclear autoantigen 1
NM_003731.3	NP_003722.2	Sjoegren syndrome nuclear autoantigen 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SSNA1	XP_001137367.1
Homo sapiens (human)	SSNA1	NP_003722.2
	SSNA1	XP_001090313.1
Canis lupus familiaris (dog)	SSNA1	XP_537785.2
Bos taurus (cattle)	SSNA1	NP_001015539.1
Mus musculus (house mouse)	Ssna1	NP_075953.1
Danio rerio (zebrafish)	ssna1	NP_001138265.1
Xenopus tropicalis (tropical clawed frog)	ssna1	NP_001016957.1
Gallus gallus (chicken)	LOC771190	XP_001234484.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R,
Nature communications711491(2016 May)

Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Yachie N, Petsalaki E, Mellor JC, Weile J, Jacob Y, Verby M, Ozturk SB, Li S, Cote AG, Mosca R, Knapp JJ, Ko M, Yu A, Gebbia M, Sahni N, Yi S, Tyagi T, Sheykhkarimli D, Roth JF, Wong C, Musa L, Snider J, Liu YC, Yu H, Braun P, Stagljar I, Hao T, Calderwood MA, Pelletier L, Aloy P, Hill DE, Vidal M, Roth FP
Molecular systems biology12(4)863(2016 Apr)

Spastin-interacting protein NA14/SSNA1 functions in cytokinesis and axon development.
Goyal U, Renvois? B, Chang J, Blackstone C
PloS one9(11)e112428(2014)

Characterization of the structure and self-recognition of the human centrosomal protein NA14: implications for stability and function.
Rodr?guez-Rodr?guez M, Trevi?o MA, Laurents DV, Arranz R, Valpuesta JM, Rico M, Bruix M, Jim?nez MA
Protein engineering, design & selection : PEDS24(12)883-92(2011 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NA14 may act as an adaptor protein regulating SPG4 localization to centrosomes, temporally and spatially regulating the microtubule-severing activity of SPG4 that is particularly critical during the cell cycle and neuronal development.
Title: Spastin-interacting protein NA14/SSNA1 functions in cytokinesis and axon development.

purification and characterization of NA14 and some variants; NA14 structure may be stabilized by two Glu-COO(-) ||| HO-Tyr H-bonds, highly conserved in NA14-like proteins in other species
Title: Characterization of the structure and self-recognition of the human centrosomal protein NA14: implications for stability and function.

The following SSNA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SSNA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31890	NM_003731.3 Latest version!	Homo sapiens SS nuclear autoantigen 1 (SSNA1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu31890	NM_003731.2	Homo sapiens SS nuclear autoantigen 1 (SSNA1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SSNA1 ( NM_003731.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003722.2 Homo sapiens SS nuclear autoantigen 1 (SSNA1), mRNA.

Price & Availability↑

CloneID	OHu31890
Clone ID Related Accession (Same CDS sequence)	NM_003731.2 , NM_003731.3
Accession Version	NM_003731.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 360bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	Sjoegren syndrome nuclear autoantigen 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB466912.1 and BC000864.1. On Jun 10, 2008 this sequence version replaced NM_003731.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000864.1, ERR279827.4959.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGACCCAGC AGGGCGCGGC GCTGCAGAAC TACAACAACG AGCTGGTCAA GTGCATAGAG 
GAGCTGTGCC AGAAGCGGGA GGAGCTGTGC CGGCAGATCC AGGAGGAGGA GGACGAGAAG 
CAGCGGCTGC AGAATGAGGT GAGGCAGCTG ACAGAGAAGC TGGCCCGCGT CAACGAGAAC 
CTGGCACGCA AGATTGCCTC TCGCAACGAG TTCGACCGGA CCATCGCGGA GACGGAGGCC 
GCCTACCTCA AGATCCTGGA GAGCTCCCAG ACTTTGCTCA GCGTTCTCAA GAGGGAAGCT 
GGGAACCTGA CCAAGGCTAC AGCCCCAGAC CAGAAAAGTA GCGGCGGCAG GGACAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003722.2
CDS	126..485
Translation	MTQQGAALQNYNNELVKCIEELCQKREELCRQIQEEEDEKQRLQNEVRQLTEKLARVNENLARKIASRNEFDRTIAETEAAYLKILESSQTLLSVLKREAGNLTKATAPDQKSSGGRDS

Target ORF information:

RefSeq Version	NM_003731.2
Organism	Homo sapiens(human)
Definition	Homo sapiens SS nuclear autoantigen 1 (SSNA1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003731.2

ORF Insert Sequence:

ATGACCCAGC AGGGCGCGGC GCTGCAGAAC TACAACAACG AGCTGGTCAA GTGCATAGAG 
GAGCTGTGCC AGAAGCGGGA GGAGCTGTGC CGGCAGATCC AGGAGGAGGA GGACGAGAAG 
CAGCGGCTGC AGAATGAGGT GAGGCAGCTG ACAGAGAAGC TGGCCCGCGT CAACGAGAAC 
CTGGCACGCA AGATTGCCTC TCGCAACGAG TTCGACCGGA CCATCGCGGA GACGGAGGCC 
GCCTACCTCA AGATCCTGGA GAGCTCCCAG ACTTTGCTCA GCGTTCTCAA GAGGGAAGCT 
GGGAACCTGA CCAAGGCTAC AGCCCCAGAC CAGAAAAGTA GCGGCGGCAG GGACAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SSNA1 ( NM_003731.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003722.2 Homo sapiens SS nuclear autoantigen 1 (SSNA1), mRNA.

Price & Availability↑

CloneID	OHu31890
Clone ID Related Accession (Same CDS sequence)	NM_003731.2 , NM_003731.3
Accession Version	NM_003731.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 360bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	Sjoegren syndrome nuclear autoantigen 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC000864.1. On Nov 23, 2018 this sequence version replaced NM_003731.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.254204.1, BC000864.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000322310.10/ ENSP00000313752.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACCCAGC AGGGCGCGGC GCTGCAGAAC TACAACAACG AGCTGGTCAA GTGCATAGAG 
GAGCTGTGCC AGAAGCGGGA GGAGCTGTGC CGGCAGATCC AGGAGGAGGA GGACGAGAAG 
CAGCGGCTGC AGAATGAGGT GAGGCAGCTG ACAGAGAAGC TGGCCCGCGT CAACGAGAAC 
CTGGCACGCA AGATTGCCTC TCGCAACGAG TTCGACCGGA CCATCGCGGA GACGGAGGCC 
GCCTACCTCA AGATCCTGGA GAGCTCCCAG ACTTTGCTCA GCGTTCTCAA GAGGGAAGCT 
GGGAACCTGA CCAAGGCTAC AGCCCCAGAC CAGAAAAGTA GCGGCGGCAG GGACAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003722.2
CDS	52..411
Translation	MTQQGAALQNYNNELVKCIEELCQKREELCRQIQEEEDEKQRLQNEVRQLTEKLARVNENLARKIASRNEFDRTIAETEAAYLKILESSQTLLSVLKREAGNLTKATAPDQKSSGGRDS

Target ORF information:

RefSeq Version	NM_003731.3
Organism	Homo sapiens(human)
Definition	Homo sapiens SS nuclear autoantigen 1 (SSNA1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003731.3

ORF Insert Sequence:

ATGACCCAGC AGGGCGCGGC GCTGCAGAAC TACAACAACG AGCTGGTCAA GTGCATAGAG 
GAGCTGTGCC AGAAGCGGGA GGAGCTGTGC CGGCAGATCC AGGAGGAGGA GGACGAGAAG 
CAGCGGCTGC AGAATGAGGT GAGGCAGCTG ACAGAGAAGC TGGCCCGCGT CAACGAGAAC 
CTGGCACGCA AGATTGCCTC TCGCAACGAG TTCGACCGGA CCATCGCGGA GACGGAGGCC 
GCCTACCTCA AGATCCTGGA GAGCTCCCAG ACTTTGCTCA GCGTTCTCAA GAGGGAAGCT 
GGGAACCTGA CCAAGGCTAC AGCCCCAGAC CAGAAAAGTA GCGGCGGCAG GGACAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Nature communications711491(2016 May)
Boldt K,van Reeuwijk J,Lu Q,Koutroumpas K,Nguyen TM,Texier Y,van Beersum SE,Horn N,Willer JR,Mans DA,Dougherty G,Lamers IJ,Coene KL,Arts HH,Betts MJ,Beyer T,Bolat E,Gloeckner CJ,Haidari K,Hetterschijt L,Iaconis D,Jenkins D,Klose F,Knapp B,Latour B,Letteboer SJ,Marcelis CL,Mitic D,Morleo M,Oud MM,Riemersma M,Rix S,Terhal PA,Toedt G,van Dam TJ,de Vrieze E,Wissinger Y,Wu KM,Apic G,Beales PL,Blacque OE,Gibson TJ,Huynen MA,Katsanis N,Kremer H,Omran H,van Wijk E,Wolfrum U,Kepes F,Davis EE,Franco B,Giles RH,Ueffing M,Russell RB,Roepman R,

Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Molecular systems biology12(4)863(2016 Apr)
Yachie N,Petsalaki E,Mellor JC,Weile J,Jacob Y,Verby M,Ozturk SB,Li S,Cote AG,Mosca R,Knapp JJ,Ko M,Yu A,Gebbia M,Sahni N,Yi S,Tyagi T,Sheykhkarimli D,Roth JF,Wong C,Musa L,Snider J,Liu YC,Yu H,Braun P,Stagljar I,Hao T,Calderwood MA,Pelletier L,Aloy P,Hill DE,Vidal M,Roth FP

Spastin-interacting protein NA14/SSNA1 functions in cytokinesis and axon development.
PloS one9(11)e112428(2014)
Goyal U,Renvois? B,Chang J,Blackstone C

Characterization of the structure and self-recognition of the human centrosomal protein NA14: implications for stability and function.
Protein engineering, design & selection : PEDS24(12)883-92(2011 Dec)
Rodr?guez-Rodr?guez M,Trevi?o MA,Laurents DV,Arranz R,Valpuesta JM,Rico M,Bruix M,Jim?nez MA

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SSNA1 cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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