AKR7A2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	AKR7A2
Entrez Gene ID	8574
Full Name	aldo-keto reductase family 7 member A2
Synonyms	AFAR,AFAR1,AFB1-AR1,AKR7
General protein information	Preferred Names aldo-keto reductase family 7 member A2 Names aflatoxin B1 aldehyde reductase member 2 AFB1 aldehyde reductase 1 AFB1-AR 1 HEL-S-166mP SSA reductase aflatoxin aldehyde reductase aflatoxin beta1 aldehyde reductase aldoketoreductase 7 epididymis secretory sperm binding protein Li 166mP succinic semialdehyde reductase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p36.13
Summary	The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].
Disorder MIM:	603418

mRNA and Protein(s)

mRNA	Protein	Name
NM_001320979.1	NP_001307908.1	aflatoxin B1 aldehyde reductase member 2 isoform 2
NM_003689.3	NP_003680.2	aflatoxin B1 aldehyde reductase member 2 isoform 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	AKR7A2	NP_001095419.1
Mus musculus (house mouse)	Akr7a5	NP_079613.3
Homo sapiens (human)	AKR7A2	NP_003680.2
Pan troglodytes (chimpanzee)	AKR7A2	XP_001163068.2
Danio rerio (zebrafish)	akr7a3	NP_001002369.1
Rattus norvegicus (Norway rat)	Akr7a2	NP_599234.1
Gallus gallus (chicken)	AKR7A2	XP_417628.2
Magnaporthe oryzae (rice blast fungus)	MGG_03827	XP_003720065.1
Xenopus tropicalis (tropical clawed frog)	akr7a2	NP_001034821.1
	AKR7A2	XP_001092177.1
Canis lupus familiaris (dog)	AKR7A2	XP_535385.4

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

The identification of human aldo-keto reductase AKR7A2 as a novel cytoglobin-binding partner.
Li X, Zou S, Li Z, Cai G, Chen B, Wang P, Dong W
Cellular & molecular biology letters2125(2016)

Nrf2-mediated adaptive response to methyl glyoxal in HepG2 cells involves the induction of AKR7A2.
Li D, Ma S, Ellis EM
Chemico-biological interactions234366-71(2015 Jun)

GST-M1 is transcribed moreso than AKR7A2 in AFB?-exposed human monocytes and lymphocytes.
Bahari A, Mehrzad J, Mahmoudi M, Bassami MR, Dehghani H
Journal of immunotoxicology12(2)194-8(2015 Apr-Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

AKR7A2 physically interacts with CYGB.
Title: The identification of human aldo-keto reductase AKR7A2 as a novel cytoglobin-binding partner.

AKR7A2 contributes to protection against MG-induced toxicity.
Title: Nrf2-mediated adaptive response to methyl glyoxal in HepG2 cells involves the induction of AKR7A2.

induced expression in human monocytes following exposure to Aflatoxin B1
Title: GST-M1 is transcribed moreso than AKR7A2 in AFB?-exposed human monocytes and lymphocytes.

Observational study of gene-disease association. (HuGE Navigator)
Title: An integrative method for scoring candidate genes from association studies: application to warfarin dosing.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following AKR7A2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AKR7A2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu09522	NM_003689.3 Latest version!	Homo sapiens aldo-keto reductase family 7 member A2 (AKR7A2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$149.50-$209.30 $299.00
OHu100776	NM_001320979.1 Latest version!	Homo sapiens aldo-keto reductase family 7 member A2 (AKR7A2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

AKR7A2 ( NM_003689.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003680.2 Homo sapiens aldo-keto reductase family 7 member A2 (AKR7A2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09522
Clone ID Related Accession (Same CDS sequence)	NM_003689.3
Accession Version	NM_003689.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	aflatoxin B1 aldehyde reductase member 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL035413.19. On Oct 22, 2011 this sequence version replaced NM_003689.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BK000395.1, SRR1803613.76443.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGAGTG CCGCGTCTCG CGTAGTCTCC CGCGCCGCCG TCCACTGCGC GCTTCGCTCT 
CCGCCGCCCG AGGCCCGCGC GCTCGCCATG TCCCGGCCAC CGCCACCGCG GGTCGCCTCG 
GTGCTGGGCA CCATGGAGAT GGGGCGCCGC ATGGACGCGC CCGCCAGCGC CGCGGCCGTG 
CGCGCCTTTC TGGAGCGCGG CCACACCGAA CTGGACACGG CCTTCATGTA CAGCGACGGC 
CAGTCCGAGA CCATCCTGGG CGGCCTGGGG CTCGGGCTGG GCGGTGGCGA CTGCAGAGTG 
AAAATTGCCA CCAAGGCCAA CCCTTGGGAT GGAAAATCAC TAAAGCCTGA CAGTGTCCGG 
TCCCAGCTGG AGACGTCATT GAAGAGGCTG CAGTGTCCCC AAGTGGACCT CTTCTACCTA 
CACGCACCTG ACCACGGCAC CCCGGTGGAA GAGACGCTGC ATGCCTGCCA GCGGCTGCAC 
CAGGAGGGCA AGTTCGTGGA GCTTGGCCTC TCCAACTATG CTAGCTGGGA AGTGGCCGAG 
ATCTGTACCC TCTGCAAGAG CAATGGCTGG ATCCTGCCCA CTGTGTACCA GGGCATGTAC 
AACGCCACCA CCCGGCAGGT GGAAACGGAG CTCTTCCCCT GCCTCAGGCA CTTTGGACTG 
AGGTTCTATG CCTACAACCC TCTGGCTGGG GGCCTGCTGA CTGGCAAGTA CAAGTATGAG 
GACAAGGACG GGAAACAGCC TGTGGGCCGC TTCTTTGGGA ATAGCTGGGC TGAGACCTAC 
AGGAATCGCT TCTGGAAGGA GCACCACTTC GAGGCCATTG CGTTGGTGGA GAAGGCCCTG 
CAGGCCGCAT ATGGCGCCAG CGCCCCCAGT GTGACCTCGG CTGCCCTCCG GTGGATGTAC 
CACCACTCAC AGCTGCAGGG TGCCCACGGG GACGCGGTCA TCCTGGGCAT GTCCAGCCTG 
GAGCAGCTGG AGCAGAACTT GGCAGCAACA GAGGAAGGGC CCCTGGAGCC GGCTGTCGTG 
GATGCCTTTA ATCAAGCCTG GCATTTGGTT GCTCACGAAT GTCCCAACTA CTTCCGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003680.2
CDS	23..1102
Translation	MLSAASRVVSRAAVHCALRSPPPEARALAMSRPPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAATEEGPLEPAVVDAFNQAWHLVAHECPNYFR

Target ORF information:

RefSeq Version	NM_003689.3
Organism	Homo sapiens(human)
Definition	Homo sapiens aldo-keto reductase family 7 member A2 (AKR7A2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003689.3

ORF Insert Sequence:

ATGCTGAGTG CCGCGTCTCG CGTAGTCTCC CGCGCCGCCG TCCACTGCGC GCTTCGCTCT 
CCGCCGCCCG AGGCCCGCGC GCTCGCCATG TCCCGGCCAC CGCCACCGCG GGTCGCCTCG 
GTGCTGGGCA CCATGGAGAT GGGGCGCCGC ATGGACGCGC CCGCCAGCGC CGCGGCCGTG 
CGCGCCTTTC TGGAGCGCGG CCACACCGAA CTGGACACGG CCTTCATGTA CAGCGACGGC 
CAGTCCGAGA CCATCCTGGG CGGCCTGGGG CTCGGGCTGG GCGGTGGCGA CTGCAGAGTG 
AAAATTGCCA CCAAGGCCAA CCCTTGGGAT GGAAAATCAC TAAAGCCTGA CAGTGTCCGG 
TCCCAGCTGG AGACGTCATT GAAGAGGCTG CAGTGTCCCC AAGTGGACCT CTTCTACCTA 
CACGCACCTG ACCACGGCAC CCCGGTGGAA GAGACGCTGC ATGCCTGCCA GCGGCTGCAC 
CAGGAGGGCA AGTTCGTGGA GCTTGGCCTC TCCAACTATG CTAGCTGGGA AGTGGCCGAG 
ATCTGTACCC TCTGCAAGAG CAATGGCTGG ATCCTGCCCA CTGTGTACCA GGGCATGTAC 
AACGCCACCA CCCGGCAGGT GGAAACGGAG CTCTTCCCCT GCCTCAGGCA CTTTGGACTG 
AGGTTCTATG CCTACAACCC TCTGGCTGGG GGCCTGCTGA CTGGCAAGTA CAAGTATGAG 
GACAAGGACG GGAAACAGCC TGTGGGCCGC TTCTTTGGGA ATAGCTGGGC TGAGACCTAC 
AGGAATCGCT TCTGGAAGGA GCACCACTTC GAGGCCATTG CGTTGGTGGA GAAGGCCCTG 
CAGGCCGCAT ATGGCGCCAG CGCCCCCAGT GTGACCTCGG CTGCCCTCCG GTGGATGTAC 
CACCACTCAC AGCTGCAGGG TGCCCACGGG GACGCGGTCA TCCTGGGCAT GTCCAGCCTG 
GAGCAGCTGG AGCAGAACTT GGCAGCAACA GAGGAAGGGC CCCTGGAGCC GGCTGTCGTG 
GATGCCTTTA ATCAAGCCTG GCATTTGGTT GCTCACGAAT GTCCCAACTA CTTCCGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AKR7A2 ( NM_001320979.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001307908.1 Homo sapiens aldo-keto reductase family 7 member A2 (AKR7A2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu100776
Clone ID Related Accession (Same CDS sequence)	NM_001320979.1
Accession Version	NM_001320979.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 975bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	aflatoxin B1 aldehyde reductase member 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG386786.1, BX401279.2, AK303131.1 and AL035413.19. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.164732.1, BX401278.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGAGTG CCGCGTCTCG CGTAGTCTCC CGCGCCGCCG TCCACTGCGC GCTTCGCTCT 
CCGCCGCCCG AGGCCCGCGC GCTCGCCATG TCCCGGCCAC CGCCACCGCG GGTCGCCTCG 
GTGCTGGGCA CCATGGAGAT GGGGCGCCGC ATGGACGCGC CCGCCAGCGC CGCGGCCGTG 
CGCGCCTTTC TGGAGCGCGG CCACACCGAA CTGGACACGG CCTTCATGTA CAGCGACGGC 
CAGTCCGAGA CCATCCTGGG CGGCCTGGGG CTCGGGCTGG GCGGTGGCGA CTGCAGAGTG 
AAAATTGCCA CCAAGGCCAA CCCTTGGGAT GGAAAATCAC TAAAGCCTGA CAGTGTCCGG 
TCCCAGCTGG AGACGTCATT GAAGAGGCTG CAGTGTCCCC AAGTGGACCT CTTCTACCTA 
CACGCACCTG ACCACGGCAC CCCGGTGGAA GAGACGCTGC ATGCCTGCCA GCGGCTGCAC 
CAGGAGGGCA TGTACAACGC CACCACCCGG CAGGTGGAAA CGGAGCTCTT CCCCTGCCTC 
AGGCACTTTG GACTGAGGTT CTATGCCTAC AACCCTCTGG CTGGGGGCCT GCTGACTGGC 
AAGTACAAGT ATGAGGACAA GGACGGGAAA CAGCCTGTGG GCCGCTTCTT TGGGAATAGC 
TGGGCTGAGA CCTACAGGAA TCGCTTCTGG AAGGAGCACC ACTTCGAGGC CATTGCGTTG 
GTGGAGAAGG CCCTGCAGGC CGCATATGGC GCCAGCGCCC CCAGTGTGAC CTCGGCTGCC 
CTCCGGTGGA TGTACCACCA CTCACAGCTG CAGGGTGCCC ACGGGGACGC GGTCATCCTG 
GGCATGTCCA GCCTGGAGCA GCTGGAGCAG AACTTGGCAG CAACAGAGGA AGGGCCCCTG 
GAGCCGGCTG TCGTGGATGC CTTTAATCAA GCCTGGCATT TGGTTGCTCA CGAATGTCCC 
AACTACTTCC GCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001307908.1
CDS	23..997
Translation	MLSAASRVVSRAAVHCALRSPPPEARALAMSRPPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAATEEGPLEPAVVDAFNQAWHLVAHECPNYFR

Target ORF information:

RefSeq Version	NM_001320979.1
Organism	Homo sapiens(human)
Definition	Homo sapiens aldo-keto reductase family 7 member A2 (AKR7A2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001320979.1

ORF Insert Sequence:

ATGCTGAGTG CCGCGTCTCG CGTAGTCTCC CGCGCCGCCG TCCACTGCGC GCTTCGCTCT 
CCGCCGCCCG AGGCCCGCGC GCTCGCCATG TCCCGGCCAC CGCCACCGCG GGTCGCCTCG 
GTGCTGGGCA CCATGGAGAT GGGGCGCCGC ATGGACGCGC CCGCCAGCGC CGCGGCCGTG 
CGCGCCTTTC TGGAGCGCGG CCACACCGAA CTGGACACGG CCTTCATGTA CAGCGACGGC 
CAGTCCGAGA CCATCCTGGG CGGCCTGGGG CTCGGGCTGG GCGGTGGCGA CTGCAGAGTG 
AAAATTGCCA CCAAGGCCAA CCCTTGGGAT GGAAAATCAC TAAAGCCTGA CAGTGTCCGG 
TCCCAGCTGG AGACGTCATT GAAGAGGCTG CAGTGTCCCC AAGTGGACCT CTTCTACCTA 
CACGCACCTG ACCACGGCAC CCCGGTGGAA GAGACGCTGC ATGCCTGCCA GCGGCTGCAC 
CAGGAGGGCA TGTACAACGC CACCACCCGG CAGGTGGAAA CGGAGCTCTT CCCCTGCCTC 
AGGCACTTTG GACTGAGGTT CTATGCCTAC AACCCTCTGG CTGGGGGCCT GCTGACTGGC 
AAGTACAAGT ATGAGGACAA GGACGGGAAA CAGCCTGTGG GCCGCTTCTT TGGGAATAGC 
TGGGCTGAGA CCTACAGGAA TCGCTTCTGG AAGGAGCACC ACTTCGAGGC CATTGCGTTG 
GTGGAGAAGG CCCTGCAGGC CGCATATGGC GCCAGCGCCC CCAGTGTGAC CTCGGCTGCC 
CTCCGGTGGA TGTACCACCA CTCACAGCTG CAGGGTGCCC ACGGGGACGC GGTCATCCTG 
GGCATGTCCA GCCTGGAGCA GCTGGAGCAG AACTTGGCAG CAACAGAGGA AGGGCCCCTG 
GAGCCGGCTG TCGTGGATGC CTTTAATCAA GCCTGGCATT TGGTTGCTCA CGAATGTCCC 
AACTACTTCC GCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

The identification of human aldo-keto reductase AKR7A2 as a novel cytoglobin-binding partner.
Cellular & molecular biology letters2125(2016)
Li X,Zou S,Li Z,Cai G,Chen B,Wang P,Dong W

Nrf2-mediated adaptive response to methyl glyoxal in HepG2 cells involves the induction of AKR7A2.
Chemico-biological interactions234366-71(2015 Jun)
Li D,Ma S,Ellis EM

GST-M1 is transcribed moreso than AKR7A2 in AFB?-exposed human monocytes and lymphocytes.
Journal of immunotoxicology12(2)194-8(2015 Apr-Jun)
Bahari A,Mehrzad J,Mahmoudi M,Bassami MR,Dehghani H

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AKR7A2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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