YARS1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	YARS1
Entrez Gene ID	8565
Full Name	tyrosyl-tRNA synthetase
Synonyms	CMTDIC,TYRRS,YRS,YTS
General protein information	Preferred Names tyrosyl-tRNA synthetase Names tyrosine--tRNA ligase, cytoplasmic tyrosine tRNA ligase 1, cytoplasmic tyrosyl--tRNA ligase tyrosyl-tRNA synthetase, cytoplasmic
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p35.1
Summary	Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008].
Disorder MIM:	603623
Disorder Html:	Charcot-Marie-Tooth disease, dominant intermediate C, 608323 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011542347.1	XP_011540649.1	tyrosine--tRNA ligase, cytoplasmic isoform X1
XM_017002651.2	XP_016858140.1	tyrosine--tRNA ligase, cytoplasmic isoform X1
XM_011542347.2	XP_011540649.1	tyrosine--tRNA ligase, cytoplasmic isoform X1
XM_011542348.1	XP_011540650.1	tyrosine--tRNA ligase, cytoplasmic isoform X1
XM_017002651.1	XP_016858140.1	tyrosine--tRNA ligase, cytoplasmic isoform X1
NM_003680.3	NP_003671.1	tyrosine--tRNA ligase, cytoplasmic

Pathways from BioSystems

Homologies

Saccharomyces cerevisiae (baker's yeast)	TYS1	NP_011701.3
Kluyveromyces lactis	KLLA0F15389g	XP_455771.1
Oryza sativa (rice)	Os04g0303900	NP_001052413.1
Neurospora crassa	NCU07755	XP_958548.2
Homo sapiens (human)	YARS	NP_003671.1
Pan troglodytes (chimpanzee)	YARS	XP_001164500.1
	YARS	XP_001104797.2
Mus musculus (house mouse)	Yars	NP_598912.4
Rattus norvegicus (Norway rat)	Yars	NP_001020867.2
Gallus gallus (chicken)	YARS	NP_001006314.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003003	XP_311880.3
Schizosaccharomyces pombe (fission yeast)	yrs1	NP_587876.1
Xenopus tropicalis (tropical clawed frog)	yars	NP_001004987.1
Canis lupus familiaris (dog)	YARS	XP_535324.4
Bos taurus (cattle)	YARS	NP_776645.1
Danio rerio (zebrafish)	yars	NP_958473.1
Eremothecium gossypii	AGOS_AAL148W	NP_982394.1
Drosophila melanogaster (fruit fly)	Aats-tyr	NP_648895.1
Magnaporthe oryzae (rice blast fungus)	MGG_02449	XP_003709239.1

Gene Ontology
Bibliography

Related articles in PubMed

Tyrosyl-tRNA synthetase: A potential kyotorphin synthetase in mammals.
Tsukahara T, Yamagishi S, Neyama H, Ueda H
Peptides10160-68(2017 Dec)

Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy.
Blocquel D, Li S, Wei N, Daub H, Sajish M, Erfurth ML, Kooi G, Zhou J, Bai G, Schimmel P, Jordanova A, Yang XL
Nucleic acids research45(13)8091-8104(2017 Jul)

A novel multisystem disease associated with recessive mutations in the tyrosyl-tRNA synthetase (YARS) gene.
Nowaczyk MJ, Huang L, Tarnopolsky M, Schwartzentruber J, Majewski J, Bulman DE, , Hartley T, Boycott KM
American journal of medical genetics. Part A173(1)126-134(2017 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Studied the structural effect of three Charcot-Marie-Tooth disease-causing mutations in tyrosyl-tRNA synthetase. The mutations do not induce changes in protein secondary structures, or shared effects on oligomerization state and stability. However, all mutations provide access to a surface masked in the wild-type enzyme, and that access correlates with protein misinteraction.
Title: Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy.

These YARS variants occur in the catalytic domain and the C-terminal domain, respectively. Mutations in YARS have been previously associated with an autosomal dominant form of Charcot-Marie-Tooth (CMT); our findings suggest the disease spectrum associated with YARS dysregulation is broader than peripheral neuropathy.
Title: A novel multisystem disease associated with recessive mutations in the tyrosyl-tRNA synthetase (YARS) gene.

Data show that the internal deletion of tyrosyl-tRNA synthetase TyrRSDeltaE2-4 splice variants (SVs) gave an alternative, neomorphic dimer interface 'orthogonal' to that of native TyrRS.
Title: Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase.

Computational modeling of molecular dynamics of G41R mutant form of human tyrosyl-tRNA synthetase, assosiated with Charcot-Marie-Tooth neuropathy has been presented.
Title: [COMPUTATIONAL MODELING OF MOLECULAR DYNAMICS OF G41R MUTANT FORM OF HUMAN TYROSYL-tRNA SYNTHETASE, ASSOSIATED WITH CHARCOT-MARIE-TOOTH NEUROPATHY].

Expression of CMT-mutant tyrosyl-tRNA synthetase in Drosophila impairs protein translation.
Title: Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases.

The following YARS1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the YARS1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22523	NM_003680.3 Latest version!	Homo sapiens tyrosyl-tRNA synthetase 1 (YARS1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu61984	XM_011542347.2 Latest version!	Homo sapiens tyrosyl-tRNA synthetase 1 (YARS1), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OHu61984	XM_011542348.1 Latest version!	Homo sapiens tyrosyl-tRNA synthetase 1 (YARS1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OHu61984	XM_017002651.2 Latest version!	Homo sapiens tyrosyl-tRNA synthetase 1 (YARS1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
View Old Accession Versions >>
OHu61984	XM_011542347.1	Homo sapiens tyrosyl-tRNA synthetase (YARS), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OHu61984	XM_017002651.1	Homo sapiens tyrosyl-tRNA synthetase (YARS), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

YARS1 ( NM_003680.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003671.1 Homo sapiens tyrosyl-tRNA synthetase 1 (YARS1), mRNA.

Price & Availability↑

CloneID	OHu22523
Clone ID Related Accession (Same CDS sequence)	NM_003680.3
Accession Version	NM_003680.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1587bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-16
Organism	Homo sapiens(human)
Product	tyrosine--tRNA ligase, cytoplasmic
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC114493.3 and AC114489.2. This sequence is a reference standard in the RefSeqGene project. On Aug 16, 2007 this sequence version replaced NM_003680.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.170469.1, AK125213.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGGGACG CTCCCAGCCC TGAAGAGAAA CTGCACCTTA TCACCCGGAA CCTGCAGGAG 
GTTCTGGGGG AAGAGAAGCT GAAGGAGATA CTGAAGGAGC GGGAACTTAA AATTTACTGG 
GGAACGGCAA CCACGGGCAA ACCACATGTG GCTTACTTTG TGCCCATGTC AAAGATTGCA 
GACTTCTTAA AGGCAGGGTG TGAGGTAACA ATTCTGTTTG CGGACCTCCA CGCATACCTG 
GATAACATGA AAGCCCCATG GGAACTTCTA GAACTCCGAG TCAGTTACTA TGAGAATGTG 
ATCAAAGCAA TGCTGGAGAG CATTGGTGTG CCCTTGGAGA AGCTCAAGTT CATCAAAGGC 
ACTGATTACC AGCTCAGCAA AGAGTACACA CTAGATGTGT ACAGACTCTC CTCCGTGGTC 
ACACAGCACG ATTCCAAGAA GGCTGGAGCT GAGGTGGTAA AGCAGGTGGA GCACCCTTTG 
CTGAGTGGCC TCTTATACCC CGGACTGCAG GCTTTGGATG AAGAGTATTT AAAAGTAGAT 
GCCCAATTTG GAGGCATTGA TCAGAGAAAG ATTTTCACCT TTGCAGAGAA GTACCTCCCT 
GCACTTGGCT ATTCAAAACG GGTCCATCTG ATGAATCCTA TGGTTCCAGG ATTAACAGGC 
AGCAAAATGA GCTCTTCAGA AGAGGAGTCC AAGATTGATC TCCTTGATCG GAAGGAGGAT 
GTGAAGAAAA AACTGAAGAA GGCCTTCTGT GAGCCAGGAA ATGTGGAGAA CAATGGGGTT 
CTGTCCTTCA TCAAGCATGT CCTTTTTCCC CTTAAGTCCG AGTTTGTGAT CCTACGAGAT 
GAGAAATGGG GTGGAAACAA AACCTACACA GCTTACGTGG ACCTGGAAAA GGACTTTGCT 
GCTGAGGTTG TACATCCTGG AGACCTGAAG AATTCTGTTG AAGTCGCACT GAACAAGTTG 
CTGGATCCAA TCCGGGAAAA GTTTAATACC CCTGCCCTGA AAAAACTGGC CAGCGCTGCC 
TACCCAGATC CCTCAAAGCA GAAGCCAATG GCCAAAGGCC CTGCCAAGAA TTCAGAACCA 
GAGGAGGTCA TCCCATCCCG GCTGGATATC CGTGTGGGGA AAATCATCAC TGTGGAGAAG 
CACCCAGATG CAGACAGCCT GTATGTAGAG AAGATTGACG TGGGGGAAGC TGAACCACGG 
ACTGTGGTGA GCGGCCTGGT ACAGTTCGTG CCCAAGGAGG AACTGCAGGA CAGGCTGGTA 
GTGGTGCTGT GCAACCTGAA ACCCCAGAAG ATGAGAGGAG TCGAGTCCCA AGGCATGCTT 
CTGTGTGCTT CTATAGAAGG GATAAACCGC CAGGTTGAAC CTCTGGACCC TCCGGCAGGC 
TCTGCTCCTG GTGAGCACGT GTTTGTGAAG GGCTATGAAA AGGGCCAACC AGATGAGGAG 
CTCAAGCCCA AGAAGAAAGT CTTCGAGAAG TTGCAGGCTG ACTTCAAAAT TTCTGAGGAG 
TGCATCGCAC AGTGGAAGCA AACCAACTTC ATGACCAAGC TGGGCTCCAT TTCCTGTAAA 
TCGCTGAAAG GGGGGAACAT TAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003671.1
CDS	789..2375
Translation	MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS

Target ORF information:

RefSeq Version	NM_003680.3
Organism	Homo sapiens(human)
Definition	Homo sapiens tyrosyl-tRNA synthetase 1 (YARS1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003680.3

ORF Insert Sequence:

ATGGGGGACG CTCCCAGCCC TGAAGAGAAA CTGCACCTTA TCACCCGGAA CCTGCAGGAG 
GTTCTGGGGG AAGAGAAGCT GAAGGAGATA CTGAAGGAGC GGGAACTTAA AATTTACTGG 
GGAACGGCAA CCACGGGCAA ACCACATGTG GCTTACTTTG TGCCCATGTC AAAGATTGCA 
GACTTCTTAA AGGCAGGGTG TGAGGTAACA ATTCTGTTTG CGGACCTCCA CGCATACCTG 
GATAACATGA AAGCCCCATG GGAACTTCTA GAACTCCGAG TCAGTTACTA TGAGAATGTG 
ATCAAAGCAA TGCTGGAGAG CATTGGTGTG CCCTTGGAGA AGCTCAAGTT CATCAAAGGC 
ACTGATTACC AGCTCAGCAA AGAGTACACA CTAGATGTGT ACAGACTCTC CTCCGTGGTC 
ACACAGCACG ATTCCAAGAA GGCTGGAGCT GAGGTGGTAA AGCAGGTGGA GCACCCTTTG 
CTGAGTGGCC TCTTATACCC CGGACTGCAG GCTTTGGATG AAGAGTATTT AAAAGTAGAT 
GCCCAATTTG GAGGCATTGA TCAGAGAAAG ATTTTCACCT TTGCAGAGAA GTACCTCCCT 
GCACTTGGCT ATTCAAAACG GGTCCATCTG ATGAATCCTA TGGTTCCAGG ATTAACAGGC 
AGCAAAATGA GCTCTTCAGA AGAGGAGTCC AAGATTGATC TCCTTGATCG GAAGGAGGAT 
GTGAAGAAAA AACTGAAGAA GGCCTTCTGT GAGCCAGGAA ATGTGGAGAA CAATGGGGTT 
CTGTCCTTCA TCAAGCATGT CCTTTTTCCC CTTAAGTCCG AGTTTGTGAT CCTACGAGAT 
GAGAAATGGG GTGGAAACAA AACCTACACA GCTTACGTGG ACCTGGAAAA GGACTTTGCT 
GCTGAGGTTG TACATCCTGG AGACCTGAAG AATTCTGTTG AAGTCGCACT GAACAAGTTG 
CTGGATCCAA TCCGGGAAAA GTTTAATACC CCTGCCCTGA AAAAACTGGC CAGCGCTGCC 
TACCCAGATC CCTCAAAGCA GAAGCCAATG GCCAAAGGCC CTGCCAAGAA TTCAGAACCA 
GAGGAGGTCA TCCCATCCCG GCTGGATATC CGTGTGGGGA AAATCATCAC TGTGGAGAAG 
CACCCAGATG CAGACAGCCT GTATGTAGAG AAGATTGACG TGGGGGAAGC TGAACCACGG 
ACTGTGGTGA GCGGCCTGGT ACAGTTCGTG CCCAAGGAGG AACTGCAGGA CAGGCTGGTA 
GTGGTGCTGT GCAACCTGAA ACCCCAGAAG ATGAGAGGAG TCGAGTCCCA AGGCATGCTT 
CTGTGTGCTT CTATAGAAGG GATAAACCGC CAGGTTGAAC CTCTGGACCC TCCGGCAGGC 
TCTGCTCCTG GTGAGCACGT GTTTGTGAAG GGCTATGAAA AGGGCCAACC AGATGAGGAG 
CTCAAGCCCA AGAAGAAAGT CTTCGAGAAG TTGCAGGCTG ACTTCAAAAT TTCTGAGGAG 
TGCATCGCAC AGTGGAAGCA AACCAACTTC ATGACCAAGC TGGGCTCCAT TTCCTGTAAA 
TCGCTGAAAG GGGGGAACAT TAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

YARS1 ( XM_011542347.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011540649.1 Homo sapiens tyrosyl-tRNA synthetase (YARS), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu61984
Clone ID Related Accession (Same CDS sequence)	XM_011542347.1 , XM_017002651.2 , XM_011542347.2 , XM_011542348.1 , XM_017002651.1
Accession Version	XM_011542347.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 957bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	tyrosine--tRNA ligase, cytoplasmic isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAATCCTA TGGTTCCAGG ATTAACAGGC AGCAAAATGA GCTCTTCAGA AGAGGAGTCC 
AAGATTGATC TCCTTGATCG GAAGGAGGAT GTGAAGAAAA AACTGAAGAA GGCCTTCTGT 
GAGCCAGGAA ATGTGGAGAA CAATGGGGTT CTGTCCTTCA TCAAGCATGT CCTTTTTCCC 
CTTAAGTCCG AGTTTGTGAT CCTACGAGAT GAGAAATGGG GTGGAAACAA AACCTACACA 
GCTTACGTGG ACCTGGAAAA GGACTTTGCT GCTGAGGTTG TACATCCTGG AGACCTGAAG 
AATTCTGTTG AAGTCGCACT GAACAAGTTG CTGGATCCAA TCCGGGAAAA GTTTAATACC 
CCTGCCCTGA AAAAACTGGC CAGCGCTGCC TACCCAGATC CCTCAAAGCA GAAGCCAATG 
GCCAAAGGCC CTGCCAAGAA TTCAGAACCA GAGGAGGTCA TCCCATCCCG GCTGGATATC 
CGTGTGGGGA AAATCATCAC TGTGGAGAAG CACCCAGATG CAGACAGCCT GTATGTAGAG 
AAGATTGACG TGGGGGAAGC TGAACCACGG ACTGTGGTGA GCGGCCTGGT ACAGTTCGTG 
CCCAAGGAGG AACTGCAGGA CAGGCTGGTA GTGGTGCTGT GCAACCTGAA ACCCCAGAAG 
ATGAGAGGAG TCGAGTCCCA AGGCATGCTT CTGTGTGCTT CTATAGAAGG GATAAACCGC 
CAGGTTGAAC CTCTGGACCC TCCGGCAGGC TCTGCTCCTG GTGAGCACGT GTTTGTGAAG 
GGCTATGAAA AGGGCCAACC AGATGAGGAG CTCAAGCCCA AGAAGAAAGT CTTCGAGAAG 
TTGCAGGCTG ACTTCAAAAT TTCTGAGGAG TGCATCGCAC AGTGGAAGCA AACCAACTTC 
ATGACCAAGC TGGGCTCCAT TTCCTGTAAA TCGCTGAAAG GGGGGAACAT TAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011540649.1
CDS	418..1374
Translation	MNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS

Target ORF information:

RefSeq Version	XM_011542347.1
Organism	Homo sapiens(human)
Definition	Homo sapiens tyrosyl-tRNA synthetase (YARS), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011542347.1

ORF Insert Sequence:

ATGAATCCTA TGGTTCCAGG ATTAACAGGC AGCAAAATGA GCTCTTCAGA AGAGGAGTCC 
AAGATTGATC TCCTTGATCG GAAGGAGGAT GTGAAGAAAA AACTGAAGAA GGCCTTCTGT 
GAGCCAGGAA ATGTGGAGAA CAATGGGGTT CTGTCCTTCA TCAAGCATGT CCTTTTTCCC 
CTTAAGTCCG AGTTTGTGAT CCTACGAGAT GAGAAATGGG GTGGAAACAA AACCTACACA 
GCTTACGTGG ACCTGGAAAA GGACTTTGCT GCTGAGGTTG TACATCCTGG AGACCTGAAG 
AATTCTGTTG AAGTCGCACT GAACAAGTTG CTGGATCCAA TCCGGGAAAA GTTTAATACC 
CCTGCCCTGA AAAAACTGGC CAGCGCTGCC TACCCAGATC CCTCAAAGCA GAAGCCAATG 
GCCAAAGGCC CTGCCAAGAA TTCAGAACCA GAGGAGGTCA TCCCATCCCG GCTGGATATC 
CGTGTGGGGA AAATCATCAC TGTGGAGAAG CACCCAGATG CAGACAGCCT GTATGTAGAG 
AAGATTGACG TGGGGGAAGC TGAACCACGG ACTGTGGTGA GCGGCCTGGT ACAGTTCGTG 
CCCAAGGAGG AACTGCAGGA CAGGCTGGTA GTGGTGCTGT GCAACCTGAA ACCCCAGAAG 
ATGAGAGGAG TCGAGTCCCA AGGCATGCTT CTGTGTGCTT CTATAGAAGG GATAAACCGC 
CAGGTTGAAC CTCTGGACCC TCCGGCAGGC TCTGCTCCTG GTGAGCACGT GTTTGTGAAG 
GGCTATGAAA AGGGCCAACC AGATGAGGAG CTCAAGCCCA AGAAGAAAGT CTTCGAGAAG 
TTGCAGGCTG ACTTCAAAAT TTCTGAGGAG TGCATCGCAC AGTGGAAGCA AACCAACTTC 
ATGACCAAGC TGGGCTCCAT TTCCTGTAAA TCGCTGAAAG GGGGGAACAT TAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

YARS1 ( XM_017002651.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016858140.1 Homo sapiens tyrosyl-tRNA synthetase 1 (YARS1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu61984
Clone ID Related Accession (Same CDS sequence)	XM_011542347.1 , XM_017002651.2 , XM_011542347.2 , XM_011542348.1 , XM_017002651.1
Accession Version	XM_017002651.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 957bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	tyrosine--tRNA ligase, cytoplasmic isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017002651.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAATCCTA TGGTTCCAGG ATTAACAGGC AGCAAAATGA GCTCTTCAGA AGAGGAGTCC 
AAGATTGATC TCCTTGATCG GAAGGAGGAT GTGAAGAAAA AACTGAAGAA GGCCTTCTGT 
GAGCCAGGAA ATGTGGAGAA CAATGGGGTT CTGTCCTTCA TCAAGCATGT CCTTTTTCCC 
CTTAAGTCCG AGTTTGTGAT CCTACGAGAT GAGAAATGGG GTGGAAACAA AACCTACACA 
GCTTACGTGG ACCTGGAAAA GGACTTTGCT GCTGAGGTTG TACATCCTGG AGACCTGAAG 
AATTCTGTTG AAGTCGCACT GAACAAGTTG CTGGATCCAA TCCGGGAAAA GTTTAATACC 
CCTGCCCTGA AAAAACTGGC CAGCGCTGCC TACCCAGATC CCTCAAAGCA GAAGCCAATG 
GCCAAAGGCC CTGCCAAGAA TTCAGAACCA GAGGAGGTCA TCCCATCCCG GCTGGATATC 
CGTGTGGGGA AAATCATCAC TGTGGAGAAG CACCCAGATG CAGACAGCCT GTATGTAGAG 
AAGATTGACG TGGGGGAAGC TGAACCACGG ACTGTGGTGA GCGGCCTGGT ACAGTTCGTG 
CCCAAGGAGG AACTGCAGGA CAGGCTGGTA GTGGTGCTGT GCAACCTGAA ACCCCAGAAG 
ATGAGAGGAG TCGAGTCCCA AGGCATGCTT CTGTGTGCTT CTATAGAAGG GATAAACCGC 
CAGGTTGAAC CTCTGGACCC TCCGGCAGGC TCTGCTCCTG GTGAGCACGT GTTTGTGAAG 
GGCTATGAAA AGGGCCAACC AGATGAGGAG CTCAAGCCCA AGAAGAAAGT CTTCGAGAAG 
TTGCAGGCTG ACTTCAAAAT TTCTGAGGAG TGCATCGCAC AGTGGAAGCA AACCAACTTC 
ATGACCAAGC TGGGCTCCAT TTCCTGTAAA TCGCTGAAAG GGGGGAACAT TAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016858140.1
CDS	792..1748
Translation	MNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS

Target ORF information:

RefSeq Version	XM_017002651.2
Organism	Homo sapiens(human)
Definition	Homo sapiens tyrosyl-tRNA synthetase 1 (YARS1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017002651.2

ORF Insert Sequence:

ATGAATCCTA TGGTTCCAGG ATTAACAGGC AGCAAAATGA GCTCTTCAGA AGAGGAGTCC 
AAGATTGATC TCCTTGATCG GAAGGAGGAT GTGAAGAAAA AACTGAAGAA GGCCTTCTGT 
GAGCCAGGAA ATGTGGAGAA CAATGGGGTT CTGTCCTTCA TCAAGCATGT CCTTTTTCCC 
CTTAAGTCCG AGTTTGTGAT CCTACGAGAT GAGAAATGGG GTGGAAACAA AACCTACACA 
GCTTACGTGG ACCTGGAAAA GGACTTTGCT GCTGAGGTTG TACATCCTGG AGACCTGAAG 
AATTCTGTTG AAGTCGCACT GAACAAGTTG CTGGATCCAA TCCGGGAAAA GTTTAATACC 
CCTGCCCTGA AAAAACTGGC CAGCGCTGCC TACCCAGATC CCTCAAAGCA GAAGCCAATG 
GCCAAAGGCC CTGCCAAGAA TTCAGAACCA GAGGAGGTCA TCCCATCCCG GCTGGATATC 
CGTGTGGGGA AAATCATCAC TGTGGAGAAG CACCCAGATG CAGACAGCCT GTATGTAGAG 
AAGATTGACG TGGGGGAAGC TGAACCACGG ACTGTGGTGA GCGGCCTGGT ACAGTTCGTG 
CCCAAGGAGG AACTGCAGGA CAGGCTGGTA GTGGTGCTGT GCAACCTGAA ACCCCAGAAG 
ATGAGAGGAG TCGAGTCCCA AGGCATGCTT CTGTGTGCTT CTATAGAAGG GATAAACCGC 
CAGGTTGAAC CTCTGGACCC TCCGGCAGGC TCTGCTCCTG GTGAGCACGT GTTTGTGAAG 
GGCTATGAAA AGGGCCAACC AGATGAGGAG CTCAAGCCCA AGAAGAAAGT CTTCGAGAAG 
TTGCAGGCTG ACTTCAAAAT TTCTGAGGAG TGCATCGCAC AGTGGAAGCA AACCAACTTC 
ATGACCAAGC TGGGCTCCAT TTCCTGTAAA TCGCTGAAAG GGGGGAACAT TAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

YARS1 ( XM_011542347.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011540649.1 Homo sapiens tyrosyl-tRNA synthetase 1 (YARS1), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu61984
Clone ID Related Accession (Same CDS sequence)	XM_011542347.1 , XM_017002651.2 , XM_011542347.2 , XM_011542348.1 , XM_017002651.1
Accession Version	XM_011542347.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 957bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	tyrosine--tRNA ligase, cytoplasmic isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011542347.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAATCCTA TGGTTCCAGG ATTAACAGGC AGCAAAATGA GCTCTTCAGA AGAGGAGTCC 
AAGATTGATC TCCTTGATCG GAAGGAGGAT GTGAAGAAAA AACTGAAGAA GGCCTTCTGT 
GAGCCAGGAA ATGTGGAGAA CAATGGGGTT CTGTCCTTCA TCAAGCATGT CCTTTTTCCC 
CTTAAGTCCG AGTTTGTGAT CCTACGAGAT GAGAAATGGG GTGGAAACAA AACCTACACA 
GCTTACGTGG ACCTGGAAAA GGACTTTGCT GCTGAGGTTG TACATCCTGG AGACCTGAAG 
AATTCTGTTG AAGTCGCACT GAACAAGTTG CTGGATCCAA TCCGGGAAAA GTTTAATACC 
CCTGCCCTGA AAAAACTGGC CAGCGCTGCC TACCCAGATC CCTCAAAGCA GAAGCCAATG 
GCCAAAGGCC CTGCCAAGAA TTCAGAACCA GAGGAGGTCA TCCCATCCCG GCTGGATATC 
CGTGTGGGGA AAATCATCAC TGTGGAGAAG CACCCAGATG CAGACAGCCT GTATGTAGAG 
AAGATTGACG TGGGGGAAGC TGAACCACGG ACTGTGGTGA GCGGCCTGGT ACAGTTCGTG 
CCCAAGGAGG AACTGCAGGA CAGGCTGGTA GTGGTGCTGT GCAACCTGAA ACCCCAGAAG 
ATGAGAGGAG TCGAGTCCCA AGGCATGCTT CTGTGTGCTT CTATAGAAGG GATAAACCGC 
CAGGTTGAAC CTCTGGACCC TCCGGCAGGC TCTGCTCCTG GTGAGCACGT GTTTGTGAAG 
GGCTATGAAA AGGGCCAACC AGATGAGGAG CTCAAGCCCA AGAAGAAAGT CTTCGAGAAG 
TTGCAGGCTG ACTTCAAAAT TTCTGAGGAG TGCATCGCAC AGTGGAAGCA AACCAACTTC 
ATGACCAAGC TGGGCTCCAT TTCCTGTAAA TCGCTGAAAG GGGGGAACAT TAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011540649.1
CDS	449..1405
Translation	MNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS

Target ORF information:

RefSeq Version	XM_011542347.2
Organism	Homo sapiens(human)
Definition	Homo sapiens tyrosyl-tRNA synthetase 1 (YARS1), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011542347.2

ORF Insert Sequence:

ATGAATCCTA TGGTTCCAGG ATTAACAGGC AGCAAAATGA GCTCTTCAGA AGAGGAGTCC 
AAGATTGATC TCCTTGATCG GAAGGAGGAT GTGAAGAAAA AACTGAAGAA GGCCTTCTGT 
GAGCCAGGAA ATGTGGAGAA CAATGGGGTT CTGTCCTTCA TCAAGCATGT CCTTTTTCCC 
CTTAAGTCCG AGTTTGTGAT CCTACGAGAT GAGAAATGGG GTGGAAACAA AACCTACACA 
GCTTACGTGG ACCTGGAAAA GGACTTTGCT GCTGAGGTTG TACATCCTGG AGACCTGAAG 
AATTCTGTTG AAGTCGCACT GAACAAGTTG CTGGATCCAA TCCGGGAAAA GTTTAATACC 
CCTGCCCTGA AAAAACTGGC CAGCGCTGCC TACCCAGATC CCTCAAAGCA GAAGCCAATG 
GCCAAAGGCC CTGCCAAGAA TTCAGAACCA GAGGAGGTCA TCCCATCCCG GCTGGATATC 
CGTGTGGGGA AAATCATCAC TGTGGAGAAG CACCCAGATG CAGACAGCCT GTATGTAGAG 
AAGATTGACG TGGGGGAAGC TGAACCACGG ACTGTGGTGA GCGGCCTGGT ACAGTTCGTG 
CCCAAGGAGG AACTGCAGGA CAGGCTGGTA GTGGTGCTGT GCAACCTGAA ACCCCAGAAG 
ATGAGAGGAG TCGAGTCCCA AGGCATGCTT CTGTGTGCTT CTATAGAAGG GATAAACCGC 
CAGGTTGAAC CTCTGGACCC TCCGGCAGGC TCTGCTCCTG GTGAGCACGT GTTTGTGAAG 
GGCTATGAAA AGGGCCAACC AGATGAGGAG CTCAAGCCCA AGAAGAAAGT CTTCGAGAAG 
TTGCAGGCTG ACTTCAAAAT TTCTGAGGAG TGCATCGCAC AGTGGAAGCA AACCAACTTC 
ATGACCAAGC TGGGCTCCAT TTCCTGTAAA TCGCTGAAAG GGGGGAACAT TAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

YARS1 ( XM_011542348.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011540650.1 Homo sapiens tyrosyl-tRNA synthetase 1 (YARS1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu61984
Clone ID Related Accession (Same CDS sequence)	XM_011542347.1 , XM_017002651.2 , XM_011542347.2 , XM_011542348.1 , XM_017002651.1
Accession Version	XM_011542348.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 957bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	tyrosine--tRNA ligase, cytoplasmic isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAATCCTA TGGTTCCAGG ATTAACAGGC AGCAAAATGA GCTCTTCAGA AGAGGAGTCC 
AAGATTGATC TCCTTGATCG GAAGGAGGAT GTGAAGAAAA AACTGAAGAA GGCCTTCTGT 
GAGCCAGGAA ATGTGGAGAA CAATGGGGTT CTGTCCTTCA TCAAGCATGT CCTTTTTCCC 
CTTAAGTCCG AGTTTGTGAT CCTACGAGAT GAGAAATGGG GTGGAAACAA AACCTACACA 
GCTTACGTGG ACCTGGAAAA GGACTTTGCT GCTGAGGTTG TACATCCTGG AGACCTGAAG 
AATTCTGTTG AAGTCGCACT GAACAAGTTG CTGGATCCAA TCCGGGAAAA GTTTAATACC 
CCTGCCCTGA AAAAACTGGC CAGCGCTGCC TACCCAGATC CCTCAAAGCA GAAGCCAATG 
GCCAAAGGCC CTGCCAAGAA TTCAGAACCA GAGGAGGTCA TCCCATCCCG GCTGGATATC 
CGTGTGGGGA AAATCATCAC TGTGGAGAAG CACCCAGATG CAGACAGCCT GTATGTAGAG 
AAGATTGACG TGGGGGAAGC TGAACCACGG ACTGTGGTGA GCGGCCTGGT ACAGTTCGTG 
CCCAAGGAGG AACTGCAGGA CAGGCTGGTA GTGGTGCTGT GCAACCTGAA ACCCCAGAAG 
ATGAGAGGAG TCGAGTCCCA AGGCATGCTT CTGTGTGCTT CTATAGAAGG GATAAACCGC 
CAGGTTGAAC CTCTGGACCC TCCGGCAGGC TCTGCTCCTG GTGAGCACGT GTTTGTGAAG 
GGCTATGAAA AGGGCCAACC AGATGAGGAG CTCAAGCCCA AGAAGAAAGT CTTCGAGAAG 
TTGCAGGCTG ACTTCAAAAT TTCTGAGGAG TGCATCGCAC AGTGGAAGCA AACCAACTTC 
ATGACCAAGC TGGGCTCCAT TTCCTGTAAA TCGCTGAAAG GGGGGAACAT TAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011540650.1
CDS	486..1442
Translation	MNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS

Target ORF information:

RefSeq Version	XM_011542348.1
Organism	Homo sapiens(human)
Definition	Homo sapiens tyrosyl-tRNA synthetase 1 (YARS1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011542348.1

ORF Insert Sequence:

ATGAATCCTA TGGTTCCAGG ATTAACAGGC AGCAAAATGA GCTCTTCAGA AGAGGAGTCC 
AAGATTGATC TCCTTGATCG GAAGGAGGAT GTGAAGAAAA AACTGAAGAA GGCCTTCTGT 
GAGCCAGGAA ATGTGGAGAA CAATGGGGTT CTGTCCTTCA TCAAGCATGT CCTTTTTCCC 
CTTAAGTCCG AGTTTGTGAT CCTACGAGAT GAGAAATGGG GTGGAAACAA AACCTACACA 
GCTTACGTGG ACCTGGAAAA GGACTTTGCT GCTGAGGTTG TACATCCTGG AGACCTGAAG 
AATTCTGTTG AAGTCGCACT GAACAAGTTG CTGGATCCAA TCCGGGAAAA GTTTAATACC 
CCTGCCCTGA AAAAACTGGC CAGCGCTGCC TACCCAGATC CCTCAAAGCA GAAGCCAATG 
GCCAAAGGCC CTGCCAAGAA TTCAGAACCA GAGGAGGTCA TCCCATCCCG GCTGGATATC 
CGTGTGGGGA AAATCATCAC TGTGGAGAAG CACCCAGATG CAGACAGCCT GTATGTAGAG 
AAGATTGACG TGGGGGAAGC TGAACCACGG ACTGTGGTGA GCGGCCTGGT ACAGTTCGTG 
CCCAAGGAGG AACTGCAGGA CAGGCTGGTA GTGGTGCTGT GCAACCTGAA ACCCCAGAAG 
ATGAGAGGAG TCGAGTCCCA AGGCATGCTT CTGTGTGCTT CTATAGAAGG GATAAACCGC 
CAGGTTGAAC CTCTGGACCC TCCGGCAGGC TCTGCTCCTG GTGAGCACGT GTTTGTGAAG 
GGCTATGAAA AGGGCCAACC AGATGAGGAG CTCAAGCCCA AGAAGAAAGT CTTCGAGAAG 
TTGCAGGCTG ACTTCAAAAT TTCTGAGGAG TGCATCGCAC AGTGGAAGCA AACCAACTTC 
ATGACCAAGC TGGGCTCCAT TTCCTGTAAA TCGCTGAAAG GGGGGAACAT TAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

YARS1 ( XM_017002651.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016858140.1 Homo sapiens tyrosyl-tRNA synthetase (YARS), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu61984
Clone ID Related Accession (Same CDS sequence)	XM_011542347.1 , XM_017002651.2 , XM_011542347.2 , XM_011542348.1 , XM_017002651.1
Accession Version	XM_017002651.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 957bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	tyrosine--tRNA ligase, cytoplasmic isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAATCCTA TGGTTCCAGG ATTAACAGGC AGCAAAATGA GCTCTTCAGA AGAGGAGTCC 
AAGATTGATC TCCTTGATCG GAAGGAGGAT GTGAAGAAAA AACTGAAGAA GGCCTTCTGT 
GAGCCAGGAA ATGTGGAGAA CAATGGGGTT CTGTCCTTCA TCAAGCATGT CCTTTTTCCC 
CTTAAGTCCG AGTTTGTGAT CCTACGAGAT GAGAAATGGG GTGGAAACAA AACCTACACA 
GCTTACGTGG ACCTGGAAAA GGACTTTGCT GCTGAGGTTG TACATCCTGG AGACCTGAAG 
AATTCTGTTG AAGTCGCACT GAACAAGTTG CTGGATCCAA TCCGGGAAAA GTTTAATACC 
CCTGCCCTGA AAAAACTGGC CAGCGCTGCC TACCCAGATC CCTCAAAGCA GAAGCCAATG 
GCCAAAGGCC CTGCCAAGAA TTCAGAACCA GAGGAGGTCA TCCCATCCCG GCTGGATATC 
CGTGTGGGGA AAATCATCAC TGTGGAGAAG CACCCAGATG CAGACAGCCT GTATGTAGAG 
AAGATTGACG TGGGGGAAGC TGAACCACGG ACTGTGGTGA GCGGCCTGGT ACAGTTCGTG 
CCCAAGGAGG AACTGCAGGA CAGGCTGGTA GTGGTGCTGT GCAACCTGAA ACCCCAGAAG 
ATGAGAGGAG TCGAGTCCCA AGGCATGCTT CTGTGTGCTT CTATAGAAGG GATAAACCGC 
CAGGTTGAAC CTCTGGACCC TCCGGCAGGC TCTGCTCCTG GTGAGCACGT GTTTGTGAAG 
GGCTATGAAA AGGGCCAACC AGATGAGGAG CTCAAGCCCA AGAAGAAAGT CTTCGAGAAG 
TTGCAGGCTG ACTTCAAAAT TTCTGAGGAG TGCATCGCAC AGTGGAAGCA AACCAACTTC 
ATGACCAAGC TGGGCTCCAT TTCCTGTAAA TCGCTGAAAG GGGGGAACAT TAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016858140.1
CDS	792..1748
Translation	MNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS

Target ORF information:

RefSeq Version	XM_017002651.1
Organism	Homo sapiens(human)
Definition	Homo sapiens tyrosyl-tRNA synthetase (YARS), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017002651.1

ORF Insert Sequence:

ATGAATCCTA TGGTTCCAGG ATTAACAGGC AGCAAAATGA GCTCTTCAGA AGAGGAGTCC 
AAGATTGATC TCCTTGATCG GAAGGAGGAT GTGAAGAAAA AACTGAAGAA GGCCTTCTGT 
GAGCCAGGAA ATGTGGAGAA CAATGGGGTT CTGTCCTTCA TCAAGCATGT CCTTTTTCCC 
CTTAAGTCCG AGTTTGTGAT CCTACGAGAT GAGAAATGGG GTGGAAACAA AACCTACACA 
GCTTACGTGG ACCTGGAAAA GGACTTTGCT GCTGAGGTTG TACATCCTGG AGACCTGAAG 
AATTCTGTTG AAGTCGCACT GAACAAGTTG CTGGATCCAA TCCGGGAAAA GTTTAATACC 
CCTGCCCTGA AAAAACTGGC CAGCGCTGCC TACCCAGATC CCTCAAAGCA GAAGCCAATG 
GCCAAAGGCC CTGCCAAGAA TTCAGAACCA GAGGAGGTCA TCCCATCCCG GCTGGATATC 
CGTGTGGGGA AAATCATCAC TGTGGAGAAG CACCCAGATG CAGACAGCCT GTATGTAGAG 
AAGATTGACG TGGGGGAAGC TGAACCACGG ACTGTGGTGA GCGGCCTGGT ACAGTTCGTG 
CCCAAGGAGG AACTGCAGGA CAGGCTGGTA GTGGTGCTGT GCAACCTGAA ACCCCAGAAG 
ATGAGAGGAG TCGAGTCCCA AGGCATGCTT CTGTGTGCTT CTATAGAAGG GATAAACCGC 
CAGGTTGAAC CTCTGGACCC TCCGGCAGGC TCTGCTCCTG GTGAGCACGT GTTTGTGAAG 
GGCTATGAAA AGGGCCAACC AGATGAGGAG CTCAAGCCCA AGAAGAAAGT CTTCGAGAAG 
TTGCAGGCTG ACTTCAAAAT TTCTGAGGAG TGCATCGCAC AGTGGAAGCA AACCAACTTC 
ATGACCAAGC TGGGCTCCAT TTCCTGTAAA TCGCTGAAAG GGGGGAACAT TAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tyrosyl-tRNA synthetase: A potential kyotorphin synthetase in mammals.
Peptides10160-68(2017 Dec)
Tsukahara T,Yamagishi S,Neyama H,Ueda H

Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy.
Nucleic acids research45(13)8091-8104(2017 Jul)
Blocquel D,Li S,Wei N,Daub H,Sajish M,Erfurth ML,Kooi G,Zhou J,Bai G,Schimmel P,Jordanova A,Yang XL

A novel multisystem disease associated with recessive mutations in the tyrosyl-tRNA synthetase (YARS) gene.
American journal of medical genetics. Part A173(1)126-134(2017 Jan)
Nowaczyk MJ,Huang L,Tarnopolsky M,Schwartzentruber J,Majewski J,Bulman DE,,Hartley T,Boycott KM

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YARS1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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