TCAP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TCAP
Entrez Gene ID	8557
Full Name	titin-cap
Synonyms	CMD1N,CMH25,LGMD2G,T-cap,TELE,telethonin
General protein information	Preferred Names titin-cap Names telethonin 19 kDa sarcomeric protein limb girdle muscular dystrophy 2G (autosomal recessive) teneurin C-terminal associated peptide titin cap protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q12
Summary	Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. [provided by RefSeq, Jul 2008].
Disorder MIM:	604488
Disorder Html:	Muscular dystrophy, limb-girdle, type 2G, 601954 (3); Cardiomyopathy, hypertrophic, 25, 607487 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_003673.4	NP_003664.1	telethonin
NM_003673.3	NP_003664.1	telethonin

Pathways from BioSystems

Homologies

Bos taurus (cattle)	TCAP	NP_001014915.1
Danio rerio (zebrafish)	tcap	XP_684103.1
Pan troglodytes (chimpanzee)	TCAP	XP_511458.3
Homo sapiens (human)	TCAP	NP_003664.1
	TCAP	XP_001089621.1
Mus musculus (house mouse)	Tcap	NP_035670.2
Xenopus tropicalis (tropical clawed frog)	tcap	XP_002940414.1
Canis lupus familiaris (dog)	TCAP	NP_001128597.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression and purification of a difficult sarcomeric protein: Telethonin.
Tan H, Su W, Wang P, Zhang W, Sattler M, Zou P
Protein expression and purification14074-80(2017 Dec)

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

Muscle lim protein isoform negatively regulates striated muscle actin dynamics and differentiation.
Vafiadaki E, Arvanitis DA, Papalouka V, Terzis G, Roumeliotis TI, Spengos K, Garbis SD, Manta P, Kranias EG, Sanoudou D
The FEBS journal281(14)3261-79(2014 Jul)

Novel TCAP mutation c.32C>A causing limb girdle muscular dystrophy 2G.
Francis A, Sunitha B, Vinodh K, Polavarapu K, Katkam SK, Modi S, Bharath MM, Gayathri N, Nalini A, Thangaraj K
PloS one9(7)e102763(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

based on the crystal structure in which Z1Z2 and telethonin1-90 assemble into a 2:1 complex, a single chain fusion protein was designed, comprising two Z1Z2 modules that are connected by flexible linkers N- and C-terminally of the telethonin1-90. Expression of this fusion protein, named ZTZ, affords high yields of soluble expressed and purified protein
Title: Expression and purification of a difficult sarcomeric protein: Telethonin.

cardiac telethonin is constitutively bis-phosphorylated and suggest that such phosphorylation is critical for normal telethonin function, which may include maintenance of transverse tubule organization and intracellular Ca(2+) transients.
Title: Phosphoregulation of the titin-cap protein telethonin in cardiac myocytes.

Data indicate LGMD2G protein TCAP association with limb girdle muscular dystrophy 2G (LGMD2G).
Title: Novel TCAP mutation c.32C>A causing limb girdle muscular dystrophy 2G.

Report TCAP mutations in dilated cardiomyopathy.
Title: The genetics of dilated cardiomyopathy: a prioritized candidate gene study of LMNA, TNNT2, TCAP, and PLN.

This study identified no pathogenic mutations in BAG3, MATR3, PTRF or TCAP in Australian muscular dystrophy.
Title: A study of FHL1, BAG3, MATR3, PTRF and TCAP in Australian muscular dystrophy patients.

The following TCAP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TCAP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18837	NM_003673.4 Latest version!	Homo sapiens titin-cap (TCAP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu18837	NM_003673.3	Homo sapiens titin-cap (TCAP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TCAP ( NM_003673.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003664.1 Homo sapiens titin-cap (TCAP), mRNA.

Price & Availability↑

CloneID	OHu18837
Clone ID Related Accession (Same CDS sequence)	NM_003673.4 , NM_003673.3
Accession Version	NM_003673.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-27
Organism	Homo sapiens(human)
Product	telethonin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA899335.1 and AJ000491.1. On Aug 31, 2019 this sequence version replaced NM_003673.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC012628.1, AJ000491.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTACCT CAGAGCTGAG CTGCGAGGTG TCGGAGGAGA ACTGTGAGCG CCGGGAGGCC 
TTCTGGGCAG AATGGAAGGA TCTGACACTG TCCACACGGC CCGAGGAGGG CTGCTCCCTG 
CATGAGGAGG ACACCCAGAG ACATGAGACC TACCACCAGC AGGGGCAGTG CCAGGTGCTG 
GTGCAGCGCT CGCCCTGGCT GATGATGCGG ATGGGCATCC TCGGCCGTGG GCTGCAGGAG 
TACCAGCTGC CCTACCAGCG GGTACTGCCG CTGCCCATCT TCACCCCTGC CAAGATGGGC 
GCCACCAAGG AGGAGCGTGA GGACACCCCC ATCCAGCTTC AGGAGCTGCT GGCGCTGGAG 
ACAGCCCTGG GTGGCCAGTG TGTGGACCGC CAGGAGGTGG CTGAGATCAC AAAGCAGCTG 
CCCCCTGTGG TGCCTGTCAG CAAGCCCGGT GCACTTCGTC GCTCCCTGTC CCGCTCCATG 
TCCCAGGAAG CACAGAGAGG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003664.1
CDS	12..515
Translation	MATSELSCEVSEENCERREAFWAEWKDLTLSTRPEEGCSLHEEDTQRHETYHQQGQCQVLVQRSPWLMMRMGILGRGLQEYQLPYQRVLPLPIFTPAKMGATKEEREDTPIQLQELLALETALGGQCVDRQEVAEITKQLPPVVPVSKPGALRRSLSRSMSQEAQRG

Target ORF information:

RefSeq Version	NM_003673.4
Organism	Homo sapiens(human)
Definition	Homo sapiens titin-cap (TCAP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003673.4

ORF Insert Sequence:

ATGGCTACCT CAGAGCTGAG CTGCGAGGTG TCGGAGGAGA ACTGTGAGCG CCGGGAGGCC 
TTCTGGGCAG AATGGAAGGA TCTGACACTG TCCACACGGC CCGAGGAGGG CTGCTCCCTG 
CATGAGGAGG ACACCCAGAG ACATGAGACC TACCACCAGC AGGGGCAGTG CCAGGTGCTG 
GTGCAGCGCT CGCCCTGGCT GATGATGCGG ATGGGCATCC TCGGCCGTGG GCTGCAGGAG 
TACCAGCTGC CCTACCAGCG GGTACTGCCG CTGCCCATCT TCACCCCTGC CAAGATGGGC 
GCCACCAAGG AGGAGCGTGA GGACACCCCC ATCCAGCTTC AGGAGCTGCT GGCGCTGGAG 
ACAGCCCTGG GTGGCCAGTG TGTGGACCGC CAGGAGGTGG CTGAGATCAC AAAGCAGCTG 
CCCCCTGTGG TGCCTGTCAG CAAGCCCGGT GCACTTCGTC GCTCCCTGTC CCGCTCCATG 
TCCCAGGAAG CACAGAGAGG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TCAP ( NM_003673.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003664.1 Homo sapiens titin-cap (TCAP), mRNA.

Price & Availability↑

CloneID	OHu18837
Clone ID Related Accession (Same CDS sequence)	NM_003673.4 , NM_003673.3
Accession Version	NM_003673.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-04
Organism	Homo sapiens(human)
Product	telethonin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA899335.1 and AJ000491.1. This sequence is a reference standard in the RefSeqGene project. On Oct 21, 2008 this sequence version replaced NM_003673.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ000491.1, BC012628.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTACCT CAGAGCTGAG CTGCGAGGTG TCGGAGGAGA ACTGTGAGCG CCGGGAGGCC 
TTCTGGGCAG AATGGAAGGA TCTGACACTG TCCACACGGC CCGAGGAGGG CTGCTCCCTG 
CATGAGGAGG ACACCCAGAG ACATGAGACC TACCACCAGC AGGGGCAGTG CCAGGTGCTG 
GTGCAGCGCT CGCCCTGGCT GATGATGCGG ATGGGCATCC TCGGCCGTGG GCTGCAGGAG 
TACCAGCTGC CCTACCAGCG GGTACTGCCG CTGCCCATCT TCACCCCTGC CAAGATGGGC 
GCCACCAAGG AGGAGCGTGA GGACACCCCC ATCCAGCTTC AGGAGCTGCT GGCGCTGGAG 
ACAGCCCTGG GTGGCCAGTG TGTGGACCGC CAGGAGGTGG CTGAGATCAC AAAGCAGCTG 
CCCCCTGTGG TGCCTGTCAG CAAGCCCGGT GCACTTCGTC GCTCCCTGTC CCGCTCCATG 
TCCCAGGAAG CACAGAGAGG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003664.1
CDS	15..518
Translation	MATSELSCEVSEENCERREAFWAEWKDLTLSTRPEEGCSLHEEDTQRHETYHQQGQCQVLVQRSPWLMMRMGILGRGLQEYQLPYQRVLPLPIFTPAKMGATKEEREDTPIQLQELLALETALGGQCVDRQEVAEITKQLPPVVPVSKPGALRRSLSRSMSQEAQRG

Target ORF information:

RefSeq Version	NM_003673.3
Organism	Homo sapiens(human)
Definition	Homo sapiens titin-cap (TCAP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003673.3

ORF Insert Sequence:

ATGGCTACCT CAGAGCTGAG CTGCGAGGTG TCGGAGGAGA ACTGTGAGCG CCGGGAGGCC 
TTCTGGGCAG AATGGAAGGA TCTGACACTG TCCACACGGC CCGAGGAGGG CTGCTCCCTG 
CATGAGGAGG ACACCCAGAG ACATGAGACC TACCACCAGC AGGGGCAGTG CCAGGTGCTG 
GTGCAGCGCT CGCCCTGGCT GATGATGCGG ATGGGCATCC TCGGCCGTGG GCTGCAGGAG 
TACCAGCTGC CCTACCAGCG GGTACTGCCG CTGCCCATCT TCACCCCTGC CAAGATGGGC 
GCCACCAAGG AGGAGCGTGA GGACACCCCC ATCCAGCTTC AGGAGCTGCT GGCGCTGGAG 
ACAGCCCTGG GTGGCCAGTG TGTGGACCGC CAGGAGGTGG CTGAGATCAC AAAGCAGCTG 
CCCCCTGTGG TGCCTGTCAG CAAGCCCGGT GCACTTCGTC GCTCCCTGTC CCGCTCCATG 
TCCCAGGAAG CACAGAGAGG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression and purification of a difficult sarcomeric protein: Telethonin.
Protein expression and purification14074-80(2017 Dec)
Tan H,Su W,Wang P,Zhang W,Sattler M,Zou P

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M

Muscle lim protein isoform negatively regulates striated muscle actin dynamics and differentiation.
The FEBS journal281(14)3261-79(2014 Jul)
Vafiadaki E,Arvanitis DA,Papalouka V,Terzis G,Roumeliotis TI,Spengos K,Garbis SD,Manta P,Kranias EG,Sanoudou D

Novel TCAP mutation c.32C>A causing limb girdle muscular dystrophy 2G.
PloS one9(7)e102763(2014)
Francis A,Sunitha B,Vinodh K,Polavarapu K,Katkam SK,Modi S,Bharath MM,Gayathri N,Nalini A,Thangaraj K

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TCAP cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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