TSLP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TSLP
Entrez Gene ID	85480
Full Name	thymic stromal lymphopoietin
General protein information	Preferred Names thymic stromal lymphopoietin Names thymic stromal lymphopoietin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q22.1
Summary	This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012].
Disorder MIM:	607003

mRNA and Protein(s)

mRNA	Protein	Name
NM_138551.5	NP_612561.2	thymic stromal lymphopoietin isoform 2
NM_033035.4	NP_149024.1	thymic stromal lymphopoietin isoform 1 precursor
NM_138551.4	NP_612561.2	thymic stromal lymphopoietin isoform 2
XM_011543698.1	XP_011542000.1	thymic stromal lymphopoietin isoform X1
NM_033035.5	NP_149024.1	thymic stromal lymphopoietin isoform 1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	TSLP	NP_149024.1
Pan troglodytes (chimpanzee)	TSLP	XP_001141816.1
Bos taurus (cattle)	LOC617637	XP_002691117.2
	TSLP	XP_001100503.1
Mus musculus (house mouse)	Tslp	NP_067342.1
Rattus norvegicus (Norway rat)	Tslp	XP_001067649.1

Gene Ontology
Bibliography

Related articles in PubMed

Role of thymic stromal lymphopoietin in the pathogenesis of lumbar disc degeneration.
Wang Y, Yi XD, Li CD
Medicine96(30)e7516(2017 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study provides evidence for the hypothesis that TSLP could reflect the histological severity of lumbar disc degeneration (LDD), and TSLP-siRNA and TSLPR-siRNA could inhibit apoptosis of nucleus pulposus cells. The evident information obtained from the investigation could lead the way for new therapeutic approaches regarding LDD treatment.
Title: Role of thymic stromal lymphopoietin in the pathogenesis of lumbar disc degeneration.

The results suggest that IL-1beta may be an early key mediator for the acquisition of an Atopic dermatitis (AD) phenotype through induction of thymic stromal lymphopoietin (TSLP) and alteration of the epidermal homeostasis.
Title: IL-1? induces thymic stromal lymphopoietin and an atopic dermatitis-like phenotype in reconstructed healthy human epidermis.

House dust mite exposure increases the expression of TSLP through PI3K/Akt signaling pathway in human bronchial epithelial 16HBE cells.
Title: TSLP signaling blocking alleviates E-cadherin dysfunction of airway epithelium in a HDM-induced asthma model.

Study demonstrated that naturally occurring severe infections by the most common respiratory viruses in hospitalized infants induce nasal airway secretion of TSLP, IL-33, and periostin when compared with healthy controls
Title: Thymic stromal lymphopoietin, IL-33, and periostin in hospitalized infants with viral bronchiolitis.

this study shows that TSLP may be involved in the pathogenesis of asthma and rhinitis; dust mite and mugwort allergy could increase it significantly
Title: The significance of the levels of IL-4, IL-31 and TLSP in patients with asthma and/or rhinitis.

The following TSLP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TSLP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27324	NM_033035.5 Latest version!	Homo sapiens thymic stromal lymphopoietin (TSLP), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu27433	NM_138551.5 Latest version!	Homo sapiens thymic stromal lymphopoietin (TSLP), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu27433	XM_011543698.1 Latest version!	Homo sapiens thymic stromal lymphopoietin (TSLP), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu27433	NM_138551.4	Homo sapiens thymic stromal lymphopoietin (TSLP), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu27324	NM_033035.4	Homo sapiens thymic stromal lymphopoietin (TSLP), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TSLP ( NM_033035.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_149024.1 Homo sapiens thymic stromal lymphopoietin (TSLP), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu27324
Clone ID Related Accession (Same CDS sequence)	NM_033035.4 , NM_033035.5
Accession Version	NM_033035.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 480bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	thymic stromal lymphopoietin isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY037115.1 and AL833421.1. On Jun 20, 2008 this sequence version replaced NM_033035.3. Transcript Variant: This variant (1) encodes the longer isoform (1, also known as lfTSLP). This isoform is found in much lower abundance compared to the shorter isoform sfTSLP (PMID:24850429) and is known to stimulate allergic inflammation in diseases such as asthma and COPD. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY037115.1, AF338732.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2146982 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTCCCTT TTGCCTTACT ATATGTTCTG TCAGTTTCTT TCAGGAAAAT CTTCATCTTA 
CAACTTGTAG GGCTGGTGTT AACTTACGAC TTCACTAACT GTGACTTTGA GAAGATTAAA 
GCAGCCTATC TCAGTACTAT TTCTAAAGAC CTGATTACAT ATATGAGTGG GACCAAAAGT 
ACCGAGTTCA ACAACACCGT CTCTTGTAGC AATCGGCCAC ATTGCCTTAC TGAAATCCAG 
AGCCTAACCT TCAATCCCAC CGCCGGCTGC GCGTCGCTCG CCAAAGAAAT GTTCGCCATG 
AAAACTAAGG CTGCCTTAGC TATCTGGTGC CCAGGCTATT CGGAAACTCA GATAAATGCT 
ACTCAGGCAA TGAAGAAGAG GAGAAAAAGG AAAGTCACAA CCAATAAATG TCTGGAACAA 
GTGTCACAAT TACAAGGATT GTGGCGTCGC TTCAATCGAC CTTTACTGAA ACAACAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_149024.1
CDS	200..679
Translation	MFPFALLYVLSVSFRKIFILQLVGLVLTYDFTNCDFEKIKAAYLSTISKDLITYMSGTKSTEFNNTVSCSNRPHCLTEIQSLTFNPTAGCASLAKEMFAMKTKAALAIWCPGYSETQINATQAMKKRRKRKVTTNKCLEQVSQLQGLWRRFNRPLLKQQ

Target ORF information:

RefSeq Version	NM_033035.4
Organism	Homo sapiens(human)
Definition	Homo sapiens thymic stromal lymphopoietin (TSLP), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033035.4

ORF Insert Sequence:

ATGTTCCCTT TTGCCTTACT ATATGTTCTG TCAGTTTCTT TCAGGAAAAT CTTCATCTTA 
CAACTTGTAG GGCTGGTGTT AACTTACGAC TTCACTAACT GTGACTTTGA GAAGATTAAA 
GCAGCCTATC TCAGTACTAT TTCTAAAGAC CTGATTACAT ATATGAGTGG GACCAAAAGT 
ACCGAGTTCA ACAACACCGT CTCTTGTAGC AATCGGCCAC ATTGCCTTAC TGAAATCCAG 
AGCCTAACCT TCAATCCCAC CGCCGGCTGC GCGTCGCTCG CCAAAGAAAT GTTCGCCATG 
AAAACTAAGG CTGCCTTAGC TATCTGGTGC CCAGGCTATT CGGAAACTCA GATAAATGCT 
ACTCAGGCAA TGAAGAAGAG GAGAAAAAGG AAAGTCACAA CCAATAAATG TCTGGAACAA 
GTGTCACAAT TACAAGGATT GTGGCGTCGC TTCAATCGAC CTTTACTGAA ACAACAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TSLP ( NM_033035.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_149024.1 Homo sapiens thymic stromal lymphopoietin (TSLP), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu27324
Clone ID Related Accession (Same CDS sequence)	NM_033035.4 , NM_033035.5
Accession Version	NM_033035.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 480bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-22
Organism	Homo sapiens(human)
Product	thymic stromal lymphopoietin isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY037115.1, AL833421.1 and AC008572.6. On Nov 22, 2018 this sequence version replaced NM_033035.4. Transcript Variant: This variant (1) encodes the longer isoform (1, also known as lfTSLP). This isoform is found in much lower abundance compared to the shorter isoform sfTSLP (PMID:24850429) and is known to stimulate allergic inflammation in diseases such as asthma and COPD. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY037115.1, AF338732.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2146982 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000344895.4/ ENSP00000339804.3 RefSeq Select criteria :: based on expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTCCCTT TTGCCTTACT ATATGTTCTG TCAGTTTCTT TCAGGAAAAT CTTCATCTTA 
CAACTTGTAG GGCTGGTGTT AACTTACGAC TTCACTAACT GTGACTTTGA GAAGATTAAA 
GCAGCCTATC TCAGTACTAT TTCTAAAGAC CTGATTACAT ATATGAGTGG GACCAAAAGT 
ACCGAGTTCA ACAACACCGT CTCTTGTAGC AATCGGCCAC ATTGCCTTAC TGAAATCCAG 
AGCCTAACCT TCAATCCCAC CGCCGGCTGC GCGTCGCTCG CCAAAGAAAT GTTCGCCATG 
AAAACTAAGG CTGCCTTAGC TATCTGGTGC CCAGGCTATT CGGAAACTCA GATAAATGCT 
ACTCAGGCAA TGAAGAAGAG GAGAAAAAGG AAAGTCACAA CCAATAAATG TCTGGAACAA 
GTGTCACAAT TACAAGGATT GTGGCGTCGC TTCAATCGAC CTTTACTGAA ACAACAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_149024.1
CDS	179..658
Translation	MFPFALLYVLSVSFRKIFILQLVGLVLTYDFTNCDFEKIKAAYLSTISKDLITYMSGTKSTEFNNTVSCSNRPHCLTEIQSLTFNPTAGCASLAKEMFAMKTKAALAIWCPGYSETQINATQAMKKRRKRKVTTNKCLEQVSQLQGLWRRFNRPLLKQQ

Target ORF information:

RefSeq Version	NM_033035.5
Organism	Homo sapiens(human)
Definition	Homo sapiens thymic stromal lymphopoietin (TSLP), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033035.5

ORF Insert Sequence:

ATGTTCCCTT TTGCCTTACT ATATGTTCTG TCAGTTTCTT TCAGGAAAAT CTTCATCTTA 
CAACTTGTAG GGCTGGTGTT AACTTACGAC TTCACTAACT GTGACTTTGA GAAGATTAAA 
GCAGCCTATC TCAGTACTAT TTCTAAAGAC CTGATTACAT ATATGAGTGG GACCAAAAGT 
ACCGAGTTCA ACAACACCGT CTCTTGTAGC AATCGGCCAC ATTGCCTTAC TGAAATCCAG 
AGCCTAACCT TCAATCCCAC CGCCGGCTGC GCGTCGCTCG CCAAAGAAAT GTTCGCCATG 
AAAACTAAGG CTGCCTTAGC TATCTGGTGC CCAGGCTATT CGGAAACTCA GATAAATGCT 
ACTCAGGCAA TGAAGAAGAG GAGAAAAAGG AAAGTCACAA CCAATAAATG TCTGGAACAA 
GTGTCACAAT TACAAGGATT GTGGCGTCGC TTCAATCGAC CTTTACTGAA ACAACAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TSLP ( NM_138551.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_612561.2 Homo sapiens thymic stromal lymphopoietin (TSLP), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu27433
Clone ID Related Accession (Same CDS sequence)	NM_138551.5 , NM_138551.4 , XM_011543698.1
Accession Version	NM_138551.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 192bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	thymic stromal lymphopoietin isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU571002.1, AL833421.1 and AC008572.6. On May 31, 2019 this sequence version replaced NM_138551.4. Transcript Variant: This variant (2, also known as sfTSLP) lacks two 5' exons but contains an alternate 5' exon, differs in the 5' UTR, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1. This is the predominant isoform, and it exhibits a much stronger antimicrobial activity compared to the longer isoform lfTSLP (PMID:24850429). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL833421.1, SRR5189658.78255.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTCGCCA TGAAAACTAA GGCTGCCTTA GCTATCTGGT GCCCAGGCTA TTCGGAAACT 
CAGATAAATG CTACTCAGGC AATGAAGAAG AGGAGAAAAA GGAAAGTCAC AACCAATAAA 
TGTCTGGAAC AAGTGTCACA ATTACAAGGA TTGTGGCGTC GCTTCAATCG ACCTTTACTG 
AAACAACAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_612561.2
CDS	210..401
Translation	MFAMKTKAALAIWCPGYSETQINATQAMKKRRKRKVTTNKCLEQVSQLQGLWRRFNRPLLKQQ

Target ORF information:

RefSeq Version	NM_138551.5
Organism	Homo sapiens(human)
Definition	Homo sapiens thymic stromal lymphopoietin (TSLP), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138551.5

ORF Insert Sequence:

ATGTTCGCCA TGAAAACTAA GGCTGCCTTA GCTATCTGGT GCCCAGGCTA TTCGGAAACT 
CAGATAAATG CTACTCAGGC AATGAAGAAG AGGAGAAAAA GGAAAGTCAC AACCAATAAA 
TGTCTGGAAC AAGTGTCACA ATTACAAGGA TTGTGGCGTC GCTTCAATCG ACCTTTACTG 
AAACAACAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TSLP ( NM_138551.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_612561.2 Homo sapiens thymic stromal lymphopoietin (TSLP), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu27433
Clone ID Related Accession (Same CDS sequence)	NM_138551.5 , NM_138551.4 , XM_011543698.1
Accession Version	NM_138551.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 192bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-26
Organism	Homo sapiens(human)
Product	thymic stromal lymphopoietin isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU571002.1 and AL833421.1. On or before Jan 18, 2012 this sequence version replaced NR_033425.1, NM_138551.3. Transcript Variant: This variant (2, also known as sfTSLP) lacks two 5' exons but contains an alternate 5' exon, differs in the 5' UTR, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1. This is the predominant isoform, and it exhibits a much stronger antimicrobial activity compared to the longer isoform lfTSLP (PMID:24850429). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL833421.1, BC022894.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTCGCCA TGAAAACTAA GGCTGCCTTA GCTATCTGGT GCCCAGGCTA TTCGGAAACT 
CAGATAAATG CTACTCAGGC AATGAAGAAG AGGAGAAAAA GGAAAGTCAC AACCAATAAA 
TGTCTGGAAC AAGTGTCACA ATTACAAGGA TTGTGGCGTC GCTTCAATCG ACCTTTACTG 
AAACAACAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_612561.2
CDS	270..461
Translation	MFAMKTKAALAIWCPGYSETQINATQAMKKRRKRKVTTNKCLEQVSQLQGLWRRFNRPLLKQQ

Target ORF information:

RefSeq Version	NM_138551.4
Organism	Homo sapiens(human)
Definition	Homo sapiens thymic stromal lymphopoietin (TSLP), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138551.4

ORF Insert Sequence:

ATGTTCGCCA TGAAAACTAA GGCTGCCTTA GCTATCTGGT GCCCAGGCTA TTCGGAAACT 
CAGATAAATG CTACTCAGGC AATGAAGAAG AGGAGAAAAA GGAAAGTCAC AACCAATAAA 
TGTCTGGAAC AAGTGTCACA ATTACAAGGA TTGTGGCGTC GCTTCAATCG ACCTTTACTG 
AAACAACAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TSLP ( XM_011543698.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011542000.1 Homo sapiens thymic stromal lymphopoietin (TSLP), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu27433
Clone ID Related Accession (Same CDS sequence)	NM_138551.5 , NM_138551.4 , XM_011543698.1
Accession Version	XM_011543698.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 192bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	thymic stromal lymphopoietin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTCGCCA TGAAAACTAA GGCTGCCTTA GCTATCTGGT GCCCAGGCTA TTCGGAAACT 
CAGATAAATG CTACTCAGGC AATGAAGAAG AGGAGAAAAA GGAAAGTCAC AACCAATAAA 
TGTCTGGAAC AAGTGTCACA ATTACAAGGA TTGTGGCGTC GCTTCAATCG ACCTTTACTG 
AAACAACAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011542000.1
CDS	92..283
Translation	MFAMKTKAALAIWCPGYSETQINATQAMKKRRKRKVTTNKCLEQVSQLQGLWRRFNRPLLKQQ

Target ORF information:

RefSeq Version	XM_011543698.1
Organism	Homo sapiens(human)
Definition	Homo sapiens thymic stromal lymphopoietin (TSLP), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011543698.1

ORF Insert Sequence:

ATGTTCGCCA TGAAAACTAA GGCTGCCTTA GCTATCTGGT GCCCAGGCTA TTCGGAAACT 
CAGATAAATG CTACTCAGGC AATGAAGAAG AGGAGAAAAA GGAAAGTCAC AACCAATAAA 
TGTCTGGAAC AAGTGTCACA ATTACAAGGA TTGTGGCGTC GCTTCAATCG ACCTTTACTG 
AAACAACAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Role of thymic stromal lymphopoietin in the pathogenesis of lumbar disc degeneration.
Medicine96(30)e7516(2017 Jul)
Wang Y,Yi XD,Li CD

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TSLP cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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