FCN3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FCN3
Entrez Gene ID	8547
Full Name	ficolin 3
Synonyms	FCNH,HAKA1
General protein information	Preferred Names ficolin 3 Names ficolin-3 H-ficolin collagen/fibrinogen domain-containing lectin 3 p35 collagen/fibrinogen domain-containing protein 3 ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p36.11
Summary	Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified. [provided by RefSeq, Jul 2008].
Disorder MIM:	604973
Disorder Html:	Immunodeficiency due to ficolin 3 deficiency, 613860 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_173452.1	NP_775628.1	ficolin-3 isoform 2 precursor
NM_003665.3	NP_003656.2	ficolin-3 isoform 1 precursor
NM_003665.2	NP_003656.2	ficolin-3 isoform 1 precursor
NM_173452.2	NP_775628.1	ficolin-3 isoform 2 precursor

Pathways from BioSystems

Homologies

	LOC720154	XP_001115235.2
Caenorhabditis elegans (roundworm)	T15B7.1	NP_504743.3
Pan troglodytes (chimpanzee)	FCN3	XP_001148844.1
Homo sapiens (human)	FCN3	NP_003656.2
Bos taurus (cattle)	FCN3	XP_003585855.1

Gene Ontology
Bibliography

Related articles in PubMed

Serum H-ficolin levels: Clinical association with interstitial lung disease in patients with systemic sclerosis.
Miyagawa T, Asano Y, de Mestier Y, Saigusa R, Taniguchi T, Yamashita T, Nakamura K, Hirabayashi M, Miura S, Ichimura Y, Takahashi T, Yoshizaki A, Miyagaki T, Sugaya M, Sato S
The Journal of dermatology44(10)1168-1171(2017 Oct)

Ficolin-3/adiponectin ratio for the prediction of gestational diabetes mellitus in pregnant women.
Yuan XS, Shi H, Wang HY, Yu B, Jiang J
Journal of diabetes investigation(2017 Apr)

Association of a new FCN3 haplotype with high ficolin-3 levels in leprosy.
Andrade FA, Beltrame MH, Bini VB, Gon?alves LB, Boldt AB, Messias-Reason IJ
PLoS neglected tropical diseases11(2)e0005409(2017 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

in patients with systemic lupus erythematosus, there was no significant association between ficolin-1 and ficolin-3 with lupus nephritis
Title: Plasma ficolin levels and risk of nephritis in Danish patients with systemic lupus erythematosus.

These results suggest that polymorphisms in the FCN3 gene cooperate to increase ficolin-3 concentration and that it might contribute to leprosy susceptibility by favoring Mycobacterium leprae infection.
Title: Association of a new FCN3 haplotype with high ficolin-3 levels in leprosy.

this study shows that H-ficolin may aid clearance of influenza A virus by promoting monocyte uptake of the virus, while reducing viral replication and virus-induced TNF-a responses in these cells
Title: Collectins, H-ficolin and LL-37 reduce influence viral replication in human monocytes and modulate virus-induced cytokine production.

Serum levels of ficolin-2 and ficolin-3 were significantly lower in the cardiac syndrome X patients compared to controls.
Title: Association of Low Ficolin-Lectin Pathway Parameters with Cardiac Syndrome X.

results suggest that anti-ficolin-3 antibodies could be useful for the diagnosis of active nephritis in SLE patients
Title: Association between the Presence of Autoantibodies Targeting Ficolin-3 and Active Nephritis in Patients with Systemic Lupus Erythematosus.

The following FCN3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FCN3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19277	NM_003665.3 Latest version!	Homo sapiens ficolin 3 (FCN3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu29743	NM_173452.2 Latest version!	Homo sapiens ficolin 3 (FCN3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu19277	NM_003665.2	Homo sapiens ficolin (collagen/fibrinogen domain containing) 3 (FCN3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu29743	NM_173452.1	Homo sapiens ficolin (collagen/fibrinogen domain containing) 3 (FCN3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FCN3 ( NM_003665.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003656.2 Homo sapiens ficolin 3 (FCN3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19277
Clone ID Related Accession (Same CDS sequence)	NM_003665.3 , NM_003665.2
Accession Version	NM_003665.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 900bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-04
Organism	Homo sapiens(human)
Product	ficolin-3 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG546674.1, CR456808.1 and AY358081.1. On Jul 2, 2016 this sequence version replaced NM_003665.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279837.8551.1, ERR279835.9805.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGATCTAC TGTGGATCCT GCCCTCCCTG TGGCTTCTCC TGCTTGGGGG GCCTGCCTGC 
CTGAAGACCC AGGAACACCC CAGCTGCCCA GGACCCAGGG AACTGGAAGC CAGCAAAGTT 
GTCCTCCTGC CCAGTTGTCC CGGAGCTCCA GGAAGTCCTG GGGAGAAGGG AGCCCCAGGT 
CCTCAAGGGC CACCTGGACC ACCAGGCAAG ATGGGCCCCA AGGGTGAGCC AGGAGATCCA 
GTGAACCTGC TCCGGTGCCA GGAAGGCCCC AGAAACTGCC GGGAGCTGTT GAGCCAGGGC 
GCCACCTTGA GCGGCTGGTA CCATCTGTGC CTACCTGAGG GCAGGGCCCT CCCAGTCTTT 
TGTGACATGG ACACCGAGGG GGGCGGCTGG CTGGTGTTTC AGAGGCGCCA GGATGGTTCT 
GTGGATTTCT TCCGCTCTTG GTCCTCCTAC AGAGCAGGTT TTGGGAACCA AGAGTCTGAA 
TTCTGGCTGG GAAATGAGAA TTTGCACCAG CTTACTCTCC AGGGTAACTG GGAGCTGCGG 
GTAGAGCTGG AAGACTTTAA TGGTAACCGT ACTTTCGCCC ACTATGCGAC CTTCCGCCTC 
CTCGGTGAGG TAGACCACTA CCAGCTGGCA CTGGGCAAGT TCTCAGAGGG CACTGCAGGG 
GATTCCCTGA GCCTCCACAG TGGGAGGCCC TTTACCACCT ATGACGCTGA CCACGATTCA 
AGCAACAGCA ACTGTGCAGT GATTGTCCAC GGTGCCTGGT GGTATGCATC CTGTTACCGA 
TCAAATCTCA ATGGTCGCTA TGCAGTGTCT GAGGCTGCCG CCCACAAATA TGGCATTGAC 
TGGGCCTCAG GCCGTGGTGT GGGCCACCCC TACCGCAGGG TTCGGATGAT GCTTCGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003656.2
CDS	35..934
Translation	MDLLWILPSLWLLLLGGPACLKTQEHPSCPGPRELEASKVVLLPSCPGAPGSPGEKGAPGPQGPPGPPGKMGPKGEPGDPVNLLRCQEGPRNCRELLSQGATLSGWYHLCLPEGRALPVFCDMDTEGGGWLVFQRRQDGSVDFFRSWSSYRAGFGNQESEFWLGNENLHQLTLQGNWELRVELEDFNGNRTFAHYATFRLLGEVDHYQLALGKFSEGTAGDSLSLHSGRPFTTYDADHDSSNSNCAVIVHGAWWYASCYRSNLNGRYAVSEAAAHKYGIDWASGRGVGHPYRRVRMMLR

Target ORF information:

RefSeq Version	NM_003665.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ficolin 3 (FCN3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003665.3

ORF Insert Sequence:

ATGGATCTAC TGTGGATCCT GCCCTCCCTG TGGCTTCTCC TGCTTGGGGG GCCTGCCTGC 
CTGAAGACCC AGGAACACCC CAGCTGCCCA GGACCCAGGG AACTGGAAGC CAGCAAAGTT 
GTCCTCCTGC CCAGTTGTCC CGGAGCTCCA GGAAGTCCTG GGGAGAAGGG AGCCCCAGGT 
CCTCAAGGGC CACCTGGACC ACCAGGCAAG ATGGGCCCCA AGGGTGAGCC AGGAGATCCA 
GTGAACCTGC TCCGGTGCCA GGAAGGCCCC AGAAACTGCC GGGAGCTGTT GAGCCAGGGC 
GCCACCTTGA GCGGCTGGTA CCATCTGTGC CTACCTGAGG GCAGGGCCCT CCCAGTCTTT 
TGTGACATGG ACACCGAGGG GGGCGGCTGG CTGGTGTTTC AGAGGCGCCA GGATGGTTCT 
GTGGATTTCT TCCGCTCTTG GTCCTCCTAC AGAGCAGGTT TTGGGAACCA AGAGTCTGAA 
TTCTGGCTGG GAAATGAGAA TTTGCACCAG CTTACTCTCC AGGGTAACTG GGAGCTGCGG 
GTAGAGCTGG AAGACTTTAA TGGTAACCGT ACTTTCGCCC ACTATGCGAC CTTCCGCCTC 
CTCGGTGAGG TAGACCACTA CCAGCTGGCA CTGGGCAAGT TCTCAGAGGG CACTGCAGGG 
GATTCCCTGA GCCTCCACAG TGGGAGGCCC TTTACCACCT ATGACGCTGA CCACGATTCA 
AGCAACAGCA ACTGTGCAGT GATTGTCCAC GGTGCCTGGT GGTATGCATC CTGTTACCGA 
TCAAATCTCA ATGGTCGCTA TGCAGTGTCT GAGGCTGCCG CCCACAAATA TGGCATTGAC 
TGGGCCTCAG GCCGTGGTGT GGGCCACCCC TACCGCAGGG TTCGGATGAT GCTTCGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FCN3 ( NM_003665.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003656.2 Homo sapiens ficolin (collagen/fibrinogen domain containing) 3 (FCN3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19277
Clone ID Related Accession (Same CDS sequence)	NM_003665.3 , NM_003665.2
Accession Version	NM_003665.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 900bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	ficolin-3 isoform 1 precursor
Comment

ATGGATCTAC TGTGGATCCT GCCCTCCCTG TGGCTTCTCC TGCTTGGGGG GCCTGCCTGC 
CTGAAGACCC AGGAACACCC CAGCTGCCCA GGACCCAGGG AACTGGAAGC CAGCAAAGTT 
GTCCTCCTGC CCAGTTGTCC CGGAGCTCCA GGAAGTCCTG GGGAGAAGGG AGCCCCAGGT 
CCTCAAGGGC CACCTGGACC ACCAGGCAAG ATGGGCCCCA AGGGTGAGCC AGGAGATCCA 
GTGAACCTGC TCCGGTGCCA GGAAGGCCCC AGAAACTGCC GGGAGCTGTT GAGCCAGGGC 
GCCACCTTGA GCGGCTGGTA CCATCTGTGC CTACCTGAGG GCAGGGCCCT CCCAGTCTTT 
TGTGACATGG ACACCGAGGG GGGCGGCTGG CTGGTGTTTC AGAGGCGCCA GGATGGTTCT 
GTGGATTTCT TCCGCTCTTG GTCCTCCTAC AGAGCAGGTT TTGGGAACCA AGAGTCTGAA 
TTCTGGCTGG GAAATGAGAA TTTGCACCAG CTTACTCTCC AGGGTAACTG GGAGCTGCGG 
GTAGAGCTGG AAGACTTTAA TGGTAACCGT ACTTTCGCCC ACTATGCGAC CTTCCGCCTC 
CTCGGTGAGG TAGACCACTA CCAGCTGGCA CTGGGCAAGT TCTCAGAGGG CACTGCAGGG 
GATTCCCTGA GCCTCCACAG TGGGAGGCCC TTTACCACCT ATGACGCTGA CCACGATTCA 
AGCAACAGCA ACTGTGCAGT GATTGTCCAC GGTGCCTGGT GGTATGCATC CTGTTACCGA 
TCAAATCTCA ATGGTCGCTA TGCAGTGTCT GAGGCTGCCG CCCACAAATA TGGCATTGAC 
TGGGCCTCAG GCCGTGGTGT GGGCCACCCC TACCGCAGGG TTCGGATGAT GCTTCGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003656.2
Translation	MDLLWILPSLWLLLLGGPACLKTQEHPSCPGPRELEASKVVLLPSCPGAPGSPGEKGAPGPQGPPGPPGKMGPKGEPGDPVNLLRCQEGPRNCRELLSQGATLSGWYHLCLPEGRALPVFCDMDTEGGGWLVFQRRQDGSVDFFRSWSSYRAGFGNQESEFWLGNENLHQLTLQGNWELRVELEDFNGNRTFAHYATFRLLGEVDHYQLALGKFSEGTAGDSLSLHSGRPFTTYDADHDSSNSNCAVIVHGAWWYASCYRSNLNGRYAVSEAAAHKYGIDWASGRGVGHPYRRVRMMLR

Target ORF information:

RefSeq Version	NM_003665.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens ficolin (collagen/fibrinogen domain containing) 3 (FCN3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003665.2

ORF Insert Sequence:

ATGGATCTAC TGTGGATCCT GCCCTCCCTG TGGCTTCTCC TGCTTGGGGG GCCTGCCTGC 
CTGAAGACCC AGGAACACCC CAGCTGCCCA GGACCCAGGG AACTGGAAGC CAGCAAAGTT 
GTCCTCCTGC CCAGTTGTCC CGGAGCTCCA GGAAGTCCTG GGGAGAAGGG AGCCCCAGGT 
CCTCAAGGGC CACCTGGACC ACCAGGCAAG ATGGGCCCCA AGGGTGAGCC AGGAGATCCA 
GTGAACCTGC TCCGGTGCCA GGAAGGCCCC AGAAACTGCC GGGAGCTGTT GAGCCAGGGC 
GCCACCTTGA GCGGCTGGTA CCATCTGTGC CTACCTGAGG GCAGGGCCCT CCCAGTCTTT 
TGTGACATGG ACACCGAGGG GGGCGGCTGG CTGGTGTTTC AGAGGCGCCA GGATGGTTCT 
GTGGATTTCT TCCGCTCTTG GTCCTCCTAC AGAGCAGGTT TTGGGAACCA AGAGTCTGAA 
TTCTGGCTGG GAAATGAGAA TTTGCACCAG CTTACTCTCC AGGGTAACTG GGAGCTGCGG 
GTAGAGCTGG AAGACTTTAA TGGTAACCGT ACTTTCGCCC ACTATGCGAC CTTCCGCCTC 
CTCGGTGAGG TAGACCACTA CCAGCTGGCA CTGGGCAAGT TCTCAGAGGG CACTGCAGGG 
GATTCCCTGA GCCTCCACAG TGGGAGGCCC TTTACCACCT ATGACGCTGA CCACGATTCA 
AGCAACAGCA ACTGTGCAGT GATTGTCCAC GGTGCCTGGT GGTATGCATC CTGTTACCGA 
TCAAATCTCA ATGGTCGCTA TGCAGTGTCT GAGGCTGCCG CCCACAAATA TGGCATTGAC 
TGGGCCTCAG GCCGTGGTGT GGGCCACCCC TACCGCAGGG TTCGGATGAT GCTTCGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FCN3 ( NM_173452.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_775628.1 Homo sapiens ficolin (collagen/fibrinogen domain containing) 3 (FCN3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu29743
Clone ID Related Accession (Same CDS sequence)	NM_173452.1 , NM_173452.2
Accession Version	NM_173452.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 867bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	ficolin-3 isoform 2 precursor
Comment

ATGGATCTAC TGTGGATCCT GCCCTCCCTG TGGCTTCTCC TGCTTGGGGG GCCTGCCTGC 
CTGAAGACCC AGGAACACCC CAGCTGCCCA GGACCCAGGG AACTGGAAGC CAGCAAAGTT 
GTCCTCCTGC CCAGTTGTCC CGGAGCTCCA GGAAGTCCTG GGGAGAAGGG AGCCCCAGGT 
CCTCAAGGGC CACCTGGACC ACCAGGCAAG ATGGGCCCCA AGGGTGAGCC AGGCCCCAGA 
AACTGCCGGG AGCTGTTGAG CCAGGGCGCC ACCTTGAGCG GCTGGTACCA TCTGTGCCTA 
CCTGAGGGCA GGGCCCTCCC AGTCTTTTGT GACATGGACA CCGAGGGGGG CGGCTGGCTG 
GTGTTTCAGA GGCGCCAGGA TGGTTCTGTG GATTTCTTCC GCTCTTGGTC CTCCTACAGA 
GCAGGTTTTG GGAACCAAGA GTCTGAATTC TGGCTGGGAA ATGAGAATTT GCACCAGCTT 
ACTCTCCAGG GTAACTGGGA GCTGCGGGTA GAGCTGGAAG ACTTTAATGG TAACCGTACT 
TTCGCCCACT ATGCGACCTT CCGCCTCCTC GGTGAGGTAG ACCACTACCA GCTGGCACTG 
GGCAAGTTCT CAGAGGGCAC TGCAGGGGAT TCCCTGAGCC TCCACAGTGG GAGGCCCTTT 
ACCACCTATG ACGCTGACCA CGATTCAAGC AACAGCAACT GTGCAGTGAT TGTCCACGGT 
GCCTGGTGGT ATGCATCCTG TTACCGATCA AATCTCAATG GTCGCTATGC AGTGTCTGAG 
GCTGCCGCCC ACAAATATGG CATTGACTGG GCCTCAGGCC GTGGTGTGGG CCACCCCTAC 
CGCAGGGTTC GGATGATGCT TCGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_775628.1
Translation	MDLLWILPSLWLLLLGGPACLKTQEHPSCPGPRELEASKVVLLPSCPGAPGSPGEKGAPGPQGPPGPPGKMGPKGEPGPRNCRELLSQGATLSGWYHLCLPEGRALPVFCDMDTEGGGWLVFQRRQDGSVDFFRSWSSYRAGFGNQESEFWLGNENLHQLTLQGNWELRVELEDFNGNRTFAHYATFRLLGEVDHYQLALGKFSEGTAGDSLSLHSGRPFTTYDADHDSSNSNCAVIVHGAWWYASCYRSNLNGRYAVSEAAAHKYGIDWASGRGVGHPYRRVRMMLR

Target ORF information:

RefSeq Version	NM_173452.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens ficolin (collagen/fibrinogen domain containing) 3 (FCN3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173452.1

ORF Insert Sequence:

ATGGATCTAC TGTGGATCCT GCCCTCCCTG TGGCTTCTCC TGCTTGGGGG GCCTGCCTGC 
CTGAAGACCC AGGAACACCC CAGCTGCCCA GGACCCAGGG AACTGGAAGC CAGCAAAGTT 
GTCCTCCTGC CCAGTTGTCC CGGAGCTCCA GGAAGTCCTG GGGAGAAGGG AGCCCCAGGT 
CCTCAAGGGC CACCTGGACC ACCAGGCAAG ATGGGCCCCA AGGGTGAGCC AGGCCCCAGA 
AACTGCCGGG AGCTGTTGAG CCAGGGCGCC ACCTTGAGCG GCTGGTACCA TCTGTGCCTA 
CCTGAGGGCA GGGCCCTCCC AGTCTTTTGT GACATGGACA CCGAGGGGGG CGGCTGGCTG 
GTGTTTCAGA GGCGCCAGGA TGGTTCTGTG GATTTCTTCC GCTCTTGGTC CTCCTACAGA 
GCAGGTTTTG GGAACCAAGA GTCTGAATTC TGGCTGGGAA ATGAGAATTT GCACCAGCTT 
ACTCTCCAGG GTAACTGGGA GCTGCGGGTA GAGCTGGAAG ACTTTAATGG TAACCGTACT 
TTCGCCCACT ATGCGACCTT CCGCCTCCTC GGTGAGGTAG ACCACTACCA GCTGGCACTG 
GGCAAGTTCT CAGAGGGCAC TGCAGGGGAT TCCCTGAGCC TCCACAGTGG GAGGCCCTTT 
ACCACCTATG ACGCTGACCA CGATTCAAGC AACAGCAACT GTGCAGTGAT TGTCCACGGT 
GCCTGGTGGT ATGCATCCTG TTACCGATCA AATCTCAATG GTCGCTATGC AGTGTCTGAG 
GCTGCCGCCC ACAAATATGG CATTGACTGG GCCTCAGGCC GTGGTGTGGG CCACCCCTAC 
CGCAGGGTTC GGATGATGCT TCGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FCN3 ( NM_173452.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_775628.1 Homo sapiens ficolin 3 (FCN3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu29743
Clone ID Related Accession (Same CDS sequence)	NM_173452.1 , NM_173452.2
Accession Version	NM_173452.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 867bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	ficolin-3 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG546674.1, BC020731.1 and AY358081.1. On Jul 2, 2016 this sequence version replaced NM_173452.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2) that lacks an internal segment compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY358081.1, BC020731.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATCTAC TGTGGATCCT GCCCTCCCTG TGGCTTCTCC TGCTTGGGGG GCCTGCCTGC 
CTGAAGACCC AGGAACACCC CAGCTGCCCA GGACCCAGGG AACTGGAAGC CAGCAAAGTT 
GTCCTCCTGC CCAGTTGTCC CGGAGCTCCA GGAAGTCCTG GGGAGAAGGG AGCCCCAGGT 
CCTCAAGGGC CACCTGGACC ACCAGGCAAG ATGGGCCCCA AGGGTGAGCC AGGCCCCAGA 
AACTGCCGGG AGCTGTTGAG CCAGGGCGCC ACCTTGAGCG GCTGGTACCA TCTGTGCCTA 
CCTGAGGGCA GGGCCCTCCC AGTCTTTTGT GACATGGACA CCGAGGGGGG CGGCTGGCTG 
GTGTTTCAGA GGCGCCAGGA TGGTTCTGTG GATTTCTTCC GCTCTTGGTC CTCCTACAGA 
GCAGGTTTTG GGAACCAAGA GTCTGAATTC TGGCTGGGAA ATGAGAATTT GCACCAGCTT 
ACTCTCCAGG GTAACTGGGA GCTGCGGGTA GAGCTGGAAG ACTTTAATGG TAACCGTACT 
TTCGCCCACT ATGCGACCTT CCGCCTCCTC GGTGAGGTAG ACCACTACCA GCTGGCACTG 
GGCAAGTTCT CAGAGGGCAC TGCAGGGGAT TCCCTGAGCC TCCACAGTGG GAGGCCCTTT 
ACCACCTATG ACGCTGACCA CGATTCAAGC AACAGCAACT GTGCAGTGAT TGTCCACGGT 
GCCTGGTGGT ATGCATCCTG TTACCGATCA AATCTCAATG GTCGCTATGC AGTGTCTGAG 
GCTGCCGCCC ACAAATATGG CATTGACTGG GCCTCAGGCC GTGGTGTGGG CCACCCCTAC 
CGCAGGGTTC GGATGATGCT TCGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_775628.1
CDS	35..901
Translation	MDLLWILPSLWLLLLGGPACLKTQEHPSCPGPRELEASKVVLLPSCPGAPGSPGEKGAPGPQGPPGPPGKMGPKGEPGPRNCRELLSQGATLSGWYHLCLPEGRALPVFCDMDTEGGGWLVFQRRQDGSVDFFRSWSSYRAGFGNQESEFWLGNENLHQLTLQGNWELRVELEDFNGNRTFAHYATFRLLGEVDHYQLALGKFSEGTAGDSLSLHSGRPFTTYDADHDSSNSNCAVIVHGAWWYASCYRSNLNGRYAVSEAAAHKYGIDWASGRGVGHPYRRVRMMLR

Target ORF information:

RefSeq Version	NM_173452.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ficolin 3 (FCN3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173452.2

ORF Insert Sequence:

ATGGATCTAC TGTGGATCCT GCCCTCCCTG TGGCTTCTCC TGCTTGGGGG GCCTGCCTGC 
CTGAAGACCC AGGAACACCC CAGCTGCCCA GGACCCAGGG AACTGGAAGC CAGCAAAGTT 
GTCCTCCTGC CCAGTTGTCC CGGAGCTCCA GGAAGTCCTG GGGAGAAGGG AGCCCCAGGT 
CCTCAAGGGC CACCTGGACC ACCAGGCAAG ATGGGCCCCA AGGGTGAGCC AGGCCCCAGA 
AACTGCCGGG AGCTGTTGAG CCAGGGCGCC ACCTTGAGCG GCTGGTACCA TCTGTGCCTA 
CCTGAGGGCA GGGCCCTCCC AGTCTTTTGT GACATGGACA CCGAGGGGGG CGGCTGGCTG 
GTGTTTCAGA GGCGCCAGGA TGGTTCTGTG GATTTCTTCC GCTCTTGGTC CTCCTACAGA 
GCAGGTTTTG GGAACCAAGA GTCTGAATTC TGGCTGGGAA ATGAGAATTT GCACCAGCTT 
ACTCTCCAGG GTAACTGGGA GCTGCGGGTA GAGCTGGAAG ACTTTAATGG TAACCGTACT 
TTCGCCCACT ATGCGACCTT CCGCCTCCTC GGTGAGGTAG ACCACTACCA GCTGGCACTG 
GGCAAGTTCT CAGAGGGCAC TGCAGGGGAT TCCCTGAGCC TCCACAGTGG GAGGCCCTTT 
ACCACCTATG ACGCTGACCA CGATTCAAGC AACAGCAACT GTGCAGTGAT TGTCCACGGT 
GCCTGGTGGT ATGCATCCTG TTACCGATCA AATCTCAATG GTCGCTATGC AGTGTCTGAG 
GCTGCCGCCC ACAAATATGG CATTGACTGG GCCTCAGGCC GTGGTGTGGG CCACCCCTAC 
CGCAGGGTTC GGATGATGCT TCGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Serum H-ficolin levels: Clinical association with interstitial lung disease in patients with systemic sclerosis.
The Journal of dermatology44(10)1168-1171(2017 Oct)
Miyagawa T,Asano Y,de Mestier Y,Saigusa R,Taniguchi T,Yamashita T,Nakamura K,Hirabayashi M,Miura S,Ichimura Y,Takahashi T,Yoshizaki A,Miyagaki T,Sugaya M,Sato S

Ficolin-3/adiponectin ratio for the prediction of gestational diabetes mellitus in pregnant women.
Journal of diabetes investigation(2017 Apr)
Yuan XS,Shi H,Wang HY,Yu B,Jiang J

Association of a new FCN3 haplotype with high ficolin-3 levels in leprosy.
PLoS neglected tropical diseases11(2)e0005409(2017 Feb)
Andrade FA,Beltrame MH,Bini VB,Gon?alves LB,Boldt AB,Messias-Reason IJ

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FCN3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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