ALG2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ALG2
Entrez Gene ID	85365
Full Name	ALG2, alpha-1,3/1,6-mannosyltransferase
Synonyms	CDG1I,CDGIi,CMS14,CMSTA3,NET38,hALPG2
General protein information	Preferred Names ALG2, alpha-1,3/1,6-mannosyltransferase Names alpha-1,3/1,6-mannosyltransferase ALG2 GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase alpha-1,3-mannosyltransferase ALG2 asparagine-linked glycosylation 2 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase) asparagine-linked glycosylation 2 homolog (yeast, alpha-1,3-mannosyltransferase) asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog asparagine-linked glycosylation protein 2 homolog homolog of yeast ALG2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9q22.33
Summary	This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008].
Disorder MIM:	607905
Disorder Html:	?Congenital disorder of glycosylation, type Ii, 607906 (3); Myasthenic syndrome, congenital, 14, with tubular aggregates, 616228 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_033087.3	NP_149078.1	alpha-1,3/1,6-mannosyltransferase ALG2
NM_033087.4	NP_149078.1	alpha-1,3/1,6-mannosyltransferase ALG2

Pathways from BioSystems

Homologies

	ALG2	XP_001112564.1
Caenorhabditis elegans (roundworm)	F09E5.2	NP_495010.2
Magnaporthe oryzae (rice blast fungus)	MGG_02384	XP_003709160.1
Schizosaccharomyces pombe (fission yeast)	alg2	NP_595621.3
Homo sapiens (human)	ALG2	NP_149078.1
Pan troglodytes (chimpanzee)	ALG2	NP_001233488.1
Canis lupus familiaris (dog)	ALG2	XP_532010.2
Mus musculus (house mouse)	Alg2	NP_064382.3
Gallus gallus (chicken)	ALG2	XP_003640838.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001232	XP_321925.2
Saccharomyces cerevisiae (baker's yeast)	ALG2	NP_011450.1
Neurospora crassa	NCU03503	XP_955840.1
Arabidopsis thaliana (thale cress)	AT1G78800	NP_178001.2
Bos taurus (cattle)	ALG2	NP_001076960.1
Xenopus tropicalis (tropical clawed frog)	alg2	NP_001025660.1
Rattus norvegicus (Norway rat)	Alg2	NP_001094180.1
Danio rerio (zebrafish)	alg2	NP_001098406.2
Drosophila melanogaster (fruit fly)	CG1291	NP_647772.1
Kluyveromyces lactis	KLLA0B02420g	XP_451639.1
Eremothecium gossypii	AGOS_AFL098W	NP_985452.1
Oryza sativa (rice)	Os04g0589600	NP_001053699.1

Gene Ontology
Bibliography

Related articles in PubMed

Structural analysis of the complex between penta-EF-hand ALG-2 protein and Sec31A peptide reveals a novel target recognition mechanism of ALG-2.
Takahashi T, Kojima K, Zhang W, Sasaki K, Ito M, Suzuki H, Kawasaki M, Wakatsuki S, Takahara T, Shibata H, Maki M
International journal of molecular sciences16(2)3677-99(2015 Feb)

Mechanism of Ca??-triggered ESCRT assembly and regulation of cell membrane repair.
Scheffer LL, Sreetama SC, Sharma N, Medikayala S, Brown KJ, Defour A, Jaiswal JK
Nature communications55646(2014 Dec)

Apoptosis-linked gene-2 (ALG-2)/Sec31 interactions regulate endoplasmic reticulum (ER)-to-Golgi transport: a potential effector pathway for luminal calcium.
Helm JR, Bentley M, Thorsen KD, Wang T, Foltz L, Oorschot V, Klumperman J, Hay JC
The Journal of biological chemistry289(34)23609-28(2014 Aug)

ALG-2 attenuates COPII budding in vitro and stabilizes the Sec23/Sec31A complex.
la Cour JM, Schindler AJ, Berchtold MW, Schekman R
PloS one8(9)e75309(2013)

Genetics of callous-unemotional behavior in children.
Viding E, Price TS, Jaffee SR, Trzaskowski M, Davis OS, Meaburn EL, Haworth CM, Plomin R
PloS one8(7)e65789(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results show the crystal structure of the complex between ALG-2 and a peptide of Sec31A and found that the peptide binds to the third hydrophobic pocket (Pocket 3) and that ALG-2 recognizing 2 types of motifs at different hydrophobic surfaces of Sec31A.
Title: Structural analysis of the complex between penta-EF-hand ALG-2 protein and Sec31A peptide reveals a novel target recognition mechanism of ALG-2.

Lack of ALG-2, ALIX or Vps4B each prevents shedding, and repair of the injured cell membrane
Title: Mechanism of Ca??-triggered ESCRT assembly and regulation of cell membrane repair.

ALG-2/Sec31A interactions were not required for the localization of Sec31A to ER exit sites per se but appeared to acutely regulate the stability and trafficking of the cargo receptor p24 and the distribution of the vesicle tether protein p115
Title: Apoptosis-linked gene-2 (ALG-2)/Sec31 interactions regulate endoplasmic reticulum (ER)-to-Golgi transport: a potential effector pathway for luminal calcium.

ALG-2 attenuates COPII budding in vitro and stabilizes the Sec23/Sec31A complex.
Title: ALG-2 attenuates COPII budding in vitro and stabilizes the Sec23/Sec31A complex.

The results of in vitro binding assays using purified recombinant proteins indicated that ALG-2 functions as a Ca(2)-dependent adaptor protein that bridges ALIX and ESCRT-I to form a ternary complex
Title: VPS37 isoforms differentially modulate the ternary complex formation of ALIX, ALG-2, and ESCRT-I.

The following ALG2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ALG2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19266	NM_033087.4 Latest version!	Homo sapiens ALG2 alpha-1,3/1,6-mannosyltransferase (ALG2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu19266	NM_033087.3	Homo sapiens ALG2, alpha-1,3/1,6-mannosyltransferase (ALG2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ALG2 ( NM_033087.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_149078.1 Homo sapiens ALG2, alpha-1,3/1,6-mannosyltransferase (ALG2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19266
Clone ID Related Accession (Same CDS sequence)	NM_033087.3 , NM_033087.4
Accession Version	NM_033087.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1251bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	alpha-1,3/1,6-mannosyltransferase ALG2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB019023.1, AB161356.1, AK075189.1 and AA017454.1. This sequence is a reference standard in the RefSeqGene project. On Apr 11, 2006 this sequence version replaced NM_033087.2. Transcript Variant: This variant (1) represents the shorter transcript. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA076693.1, SRR1660809.22964.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGAGG AGCAGGGCCG GGAACGGGAC TCGGTTCCCA AGCCGTCGGT GCTGTTCCTC 
CACCCAGACC TGGGCGTGGG CGGCGCTGAG CGGCTGGTGT TGGACGCGGC GCTGGCGCTG 
CAGGCGCGCG GGTGTAGCGT GAAGATCTGG ACAGCGCACT ACGACCCGGG CCACTGTTTC 
GCCGAGAGCC GCGAGCTACC GGTGCGCTGT GCCGGGGACT GGCTGCCGCG AGGCCTGGGC 
TGGGGCGGCC GCGGCGCCGC CGTCTGCGCC TACGTGCGCA TGGTTTTCCT GGCGCTCTAC 
GTGCTGTTCC TCGCCGACGA GGAGTTCGAC GTGGTAGTGT GCGACCAGGT GTCTGCCTGT 
ATCCCAGTGT TCAGGCTGGC TAGACGGCGG AAGAAGATCC TATTTTACTG TCACTTCCCA 
GATCTGCTTC TCACCAAGAG AGATTCTTTT CTTAAACGAC TATACAGGGC CCCAATTGAC 
TGGATAGAGG AATACACCAC AGGCATGGCA GACTGCATCT TAGTCAACAG CCAGTTCACA 
GCTGCTGTTT TTAAGGAAAC ATTCAAGTCC CTGTCTCACA TAGACCCTGA TGTCCTCTAT 
CCATCTCTAA ATGTCACCAG CTTTGACTCA GTTGTTCCTG AAAAGCTGGA TGACCTAGTC 
CCCAAGGGGA AAAAATTCCT GCTGCTCTCC ATCAACAGAT ACGAAAGGAA GAAAAATCTG 
ACTTTGGCAC TGGAAGCCCT AGTACAGCTG CGTGGAAGAT TGACATCCCA AGATTGGGAG 
AGGGTTCATC TGATCGTGGC AGGTGGTTAT GACGAGAGAG TCCTGGAGAA TGTGGAACAT 
TATCAGGAAT TGAAGAAAAT GGTCCAACAG TCCGACCTTG GCCAGTATGT GACCTTCTTG 
AGGTCTTTCT CAGACAAACA GAAAATCTCC CTCCTCCACA GCTGCACGTG TGTGCTTTAC 
ACACCAAGCA ATGAGCACTT TGGCATTGTC CCTCTGGAAG CCATGTACAT GCAGTGCCCA 
GTCATTGCTG TTAATTCGGG TGGACCCTTG GAGTCCATTG ACCACAGTGT CACAGGGTTT 
CTGTGTGAGC CTGACCCGGT GCACTTCTCA GAAGCAATAG AAAAGTTCAT CCGTGAACCT 
TCCTTAAAAG CCACCATGGG CCTGGCTGGA AGAGCCAGAG TGAAGGAAAA ATTTTCCCCT 
GAAGCATTTA CAGAACAGCT CTACCGATAT GTTACCAAAC TGCTGGTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_149078.1
CDS	71..1321
Translation	MAEEQGRERDSVPKPSVLFLHPDLGVGGAERLVLDAALALQARGCSVKIWTAHYDPGHCFAESRELPVRCAGDWLPRGLGWGGRGAAVCAYVRMVFLALYVLFLADEEFDVVVCDQVSACIPVFRLARRRKKILFYCHFPDLLLTKRDSFLKRLYRAPIDWIEEYTTGMADCILVNSQFTAAVFKETFKSLSHIDPDVLYPSLNVTSFDSVVPEKLDDLVPKGKKFLLLSINRYERKKNLTLALEALVQLRGRLTSQDWERVHLIVAGGYDERVLENVEHYQELKKMVQQSDLGQYVTFLRSFSDKQKISLLHSCTCVLYTPSNEHFGIVPLEAMYMQCPVIAVNSGGPLESIDHSVTGFLCEPDPVHFSEAIEKFIREPSLKATMGLAGRARVKEKFSPEAFTEQLYRYVTKLLV

Target ORF information:

RefSeq Version	NM_033087.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ALG2, alpha-1,3/1,6-mannosyltransferase (ALG2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033087.3

ORF Insert Sequence:

ATGGCGGAGG AGCAGGGCCG GGAACGGGAC TCGGTTCCCA AGCCGTCGGT GCTGTTCCTC 
CACCCAGACC TGGGCGTGGG CGGCGCTGAG CGGCTGGTGT TGGACGCGGC GCTGGCGCTG 
CAGGCGCGCG GGTGTAGCGT GAAGATCTGG ACAGCGCACT ACGACCCGGG CCACTGTTTC 
GCCGAGAGCC GCGAGCTACC GGTGCGCTGT GCCGGGGACT GGCTGCCGCG AGGCCTGGGC 
TGGGGCGGCC GCGGCGCCGC CGTCTGCGCC TACGTGCGCA TGGTTTTCCT GGCGCTCTAC 
GTGCTGTTCC TCGCCGACGA GGAGTTCGAC GTGGTAGTGT GCGACCAGGT GTCTGCCTGT 
ATCCCAGTGT TCAGGCTGGC TAGACGGCGG AAGAAGATCC TATTTTACTG TCACTTCCCA 
GATCTGCTTC TCACCAAGAG AGATTCTTTT CTTAAACGAC TATACAGGGC CCCAATTGAC 
TGGATAGAGG AATACACCAC AGGCATGGCA GACTGCATCT TAGTCAACAG CCAGTTCACA 
GCTGCTGTTT TTAAGGAAAC ATTCAAGTCC CTGTCTCACA TAGACCCTGA TGTCCTCTAT 
CCATCTCTAA ATGTCACCAG CTTTGACTCA GTTGTTCCTG AAAAGCTGGA TGACCTAGTC 
CCCAAGGGGA AAAAATTCCT GCTGCTCTCC ATCAACAGAT ACGAAAGGAA GAAAAATCTG 
ACTTTGGCAC TGGAAGCCCT AGTACAGCTG CGTGGAAGAT TGACATCCCA AGATTGGGAG 
AGGGTTCATC TGATCGTGGC AGGTGGTTAT GACGAGAGAG TCCTGGAGAA TGTGGAACAT 
TATCAGGAAT TGAAGAAAAT GGTCCAACAG TCCGACCTTG GCCAGTATGT GACCTTCTTG 
AGGTCTTTCT CAGACAAACA GAAAATCTCC CTCCTCCACA GCTGCACGTG TGTGCTTTAC 
ACACCAAGCA ATGAGCACTT TGGCATTGTC CCTCTGGAAG CCATGTACAT GCAGTGCCCA 
GTCATTGCTG TTAATTCGGG TGGACCCTTG GAGTCCATTG ACCACAGTGT CACAGGGTTT 
CTGTGTGAGC CTGACCCGGT GCACTTCTCA GAAGCAATAG AAAAGTTCAT CCGTGAACCT 
TCCTTAAAAG CCACCATGGG CCTGGCTGGA AGAGCCAGAG TGAAGGAAAA ATTTTCCCCT 
GAAGCATTTA CAGAACAGCT CTACCGATAT GTTACCAAAC TGCTGGTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ALG2 ( NM_033087.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_149078.1 Homo sapiens ALG2 alpha-1,3/1,6-mannosyltransferase (ALG2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19266
Clone ID Related Accession (Same CDS sequence)	NM_033087.3 , NM_033087.4
Accession Version	NM_033087.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1251bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	alpha-1,3/1,6-mannosyltransferase ALG2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB019023.1, AB161356.1, AK075189.1 and AA017454.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_033087.3. Transcript Variant: This variant (1) represents the shorter transcript. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.257063.1, SRR1660809.22964.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000476832.2/ ENSP00000417764.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGAGG AGCAGGGCCG GGAACGGGAC TCGGTTCCCA AGCCGTCGGT GCTGTTCCTC 
CACCCAGACC TGGGCGTGGG CGGCGCTGAG CGGCTGGTGT TGGACGCGGC GCTGGCGCTG 
CAGGCGCGCG GGTGTAGCGT GAAGATCTGG ACAGCGCACT ACGACCCGGG CCACTGTTTC 
GCCGAGAGCC GCGAGCTACC GGTGCGCTGT GCCGGGGACT GGCTGCCGCG AGGCCTGGGC 
TGGGGCGGCC GCGGCGCCGC CGTCTGCGCC TACGTGCGCA TGGTTTTCCT GGCGCTCTAC 
GTGCTGTTCC TCGCCGACGA GGAGTTCGAC GTGGTAGTGT GCGACCAGGT GTCTGCCTGT 
ATCCCAGTGT TCAGGCTGGC TAGACGGCGG AAGAAGATCC TATTTTACTG TCACTTCCCA 
GATCTGCTTC TCACCAAGAG AGATTCTTTT CTTAAACGAC TATACAGGGC CCCAATTGAC 
TGGATAGAGG AATACACCAC AGGCATGGCA GACTGCATCT TAGTCAACAG CCAGTTCACA 
GCTGCTGTTT TTAAGGAAAC ATTCAAGTCC CTGTCTCACA TAGACCCTGA TGTCCTCTAT 
CCATCTCTAA ATGTCACCAG CTTTGACTCA GTTGTTCCTG AAAAGCTGGA TGACCTAGTC 
CCCAAGGGGA AAAAATTCCT GCTGCTCTCC ATCAACAGAT ACGAAAGGAA GAAAAATCTG 
ACTTTGGCAC TGGAAGCCCT AGTACAGCTG CGTGGAAGAT TGACATCCCA AGATTGGGAG 
AGGGTTCATC TGATCGTGGC AGGTGGTTAT GACGAGAGAG TCCTGGAGAA TGTGGAACAT 
TATCAGGAAT TGAAGAAAAT GGTCCAACAG TCCGACCTTG GCCAGTATGT GACCTTCTTG 
AGGTCTTTCT CAGACAAACA GAAAATCTCC CTCCTCCACA GCTGCACGTG TGTGCTTTAC 
ACACCAAGCA ATGAGCACTT TGGCATTGTC CCTCTGGAAG CCATGTACAT GCAGTGCCCA 
GTCATTGCTG TTAATTCGGG TGGACCCTTG GAGTCCATTG ACCACAGTGT CACAGGGTTT 
CTGTGTGAGC CTGACCCGGT GCACTTCTCA GAAGCAATAG AAAAGTTCAT CCGTGAACCT 
TCCTTAAAAG CCACCATGGG CCTGGCTGGA AGAGCCAGAG TGAAGGAAAA ATTTTCCCCT 
GAAGCATTTA CAGAACAGCT CTACCGATAT GTTACCAAAC TGCTGGTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_149078.1
CDS	49..1299
Translation	MAEEQGRERDSVPKPSVLFLHPDLGVGGAERLVLDAALALQARGCSVKIWTAHYDPGHCFAESRELPVRCAGDWLPRGLGWGGRGAAVCAYVRMVFLALYVLFLADEEFDVVVCDQVSACIPVFRLARRRKKILFYCHFPDLLLTKRDSFLKRLYRAPIDWIEEYTTGMADCILVNSQFTAAVFKETFKSLSHIDPDVLYPSLNVTSFDSVVPEKLDDLVPKGKKFLLLSINRYERKKNLTLALEALVQLRGRLTSQDWERVHLIVAGGYDERVLENVEHYQELKKMVQQSDLGQYVTFLRSFSDKQKISLLHSCTCVLYTPSNEHFGIVPLEAMYMQCPVIAVNSGGPLESIDHSVTGFLCEPDPVHFSEAIEKFIREPSLKATMGLAGRARVKEKFSPEAFTEQLYRYVTKLLV

Target ORF information:

RefSeq Version	NM_033087.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ALG2 alpha-1,3/1,6-mannosyltransferase (ALG2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033087.4

ORF Insert Sequence:

ATGGCGGAGG AGCAGGGCCG GGAACGGGAC TCGGTTCCCA AGCCGTCGGT GCTGTTCCTC 
CACCCAGACC TGGGCGTGGG CGGCGCTGAG CGGCTGGTGT TGGACGCGGC GCTGGCGCTG 
CAGGCGCGCG GGTGTAGCGT GAAGATCTGG ACAGCGCACT ACGACCCGGG CCACTGTTTC 
GCCGAGAGCC GCGAGCTACC GGTGCGCTGT GCCGGGGACT GGCTGCCGCG AGGCCTGGGC 
TGGGGCGGCC GCGGCGCCGC CGTCTGCGCC TACGTGCGCA TGGTTTTCCT GGCGCTCTAC 
GTGCTGTTCC TCGCCGACGA GGAGTTCGAC GTGGTAGTGT GCGACCAGGT GTCTGCCTGT 
ATCCCAGTGT TCAGGCTGGC TAGACGGCGG AAGAAGATCC TATTTTACTG TCACTTCCCA 
GATCTGCTTC TCACCAAGAG AGATTCTTTT CTTAAACGAC TATACAGGGC CCCAATTGAC 
TGGATAGAGG AATACACCAC AGGCATGGCA GACTGCATCT TAGTCAACAG CCAGTTCACA 
GCTGCTGTTT TTAAGGAAAC ATTCAAGTCC CTGTCTCACA TAGACCCTGA TGTCCTCTAT 
CCATCTCTAA ATGTCACCAG CTTTGACTCA GTTGTTCCTG AAAAGCTGGA TGACCTAGTC 
CCCAAGGGGA AAAAATTCCT GCTGCTCTCC ATCAACAGAT ACGAAAGGAA GAAAAATCTG 
ACTTTGGCAC TGGAAGCCCT AGTACAGCTG CGTGGAAGAT TGACATCCCA AGATTGGGAG 
AGGGTTCATC TGATCGTGGC AGGTGGTTAT GACGAGAGAG TCCTGGAGAA TGTGGAACAT 
TATCAGGAAT TGAAGAAAAT GGTCCAACAG TCCGACCTTG GCCAGTATGT GACCTTCTTG 
AGGTCTTTCT CAGACAAACA GAAAATCTCC CTCCTCCACA GCTGCACGTG TGTGCTTTAC 
ACACCAAGCA ATGAGCACTT TGGCATTGTC CCTCTGGAAG CCATGTACAT GCAGTGCCCA 
GTCATTGCTG TTAATTCGGG TGGACCCTTG GAGTCCATTG ACCACAGTGT CACAGGGTTT 
CTGTGTGAGC CTGACCCGGT GCACTTCTCA GAAGCAATAG AAAAGTTCAT CCGTGAACCT 
TCCTTAAAAG CCACCATGGG CCTGGCTGGA AGAGCCAGAG TGAAGGAAAA ATTTTCCCCT 
GAAGCATTTA CAGAACAGCT CTACCGATAT GTTACCAAAC TGCTGGTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structural analysis of the complex between penta-EF-hand ALG-2 protein and Sec31A peptide reveals a novel target recognition mechanism of ALG-2.
International journal of molecular sciences16(2)3677-99(2015 Feb)
Takahashi T,Kojima K,Zhang W,Sasaki K,Ito M,Suzuki H,Kawasaki M,Wakatsuki S,Takahara T,Shibata H,Maki M

Mechanism of Ca??-triggered ESCRT assembly and regulation of cell membrane repair.
Nature communications55646(2014 Dec)
Scheffer LL,Sreetama SC,Sharma N,Medikayala S,Brown KJ,Defour A,Jaiswal JK

Apoptosis-linked gene-2 (ALG-2)/Sec31 interactions regulate endoplasmic reticulum (ER)-to-Golgi transport: a potential effector pathway for luminal calcium.
The Journal of biological chemistry289(34)23609-28(2014 Aug)
Helm JR,Bentley M,Thorsen KD,Wang T,Foltz L,Oorschot V,Klumperman J,Hay JC

ALG-2 attenuates COPII budding in vitro and stabilizes the Sec23/Sec31A complex.
PloS one8(9)e75309(2013)
la Cour JM,Schindler AJ,Berchtold MW,Schekman R

Genetics of callous-unemotional behavior in children.
PloS one8(7)e65789(2013)
Viding E,Price TS,Jaffee SR,Trzaskowski M,Davis OS,Meaburn EL,Haworth CM,Plomin R

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ALG2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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