H2AC12 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	H2AC12
Entrez Gene ID	85235
Full Name	histone cluster 1 H2A family member h
Synonyms	H2A/S,H2AFALii,H2AH,dJ86C11.1
General protein information	Preferred Names histone cluster 1 H2A family member h Names histone H2A type 1-H H2A histone family member histone H2A/s histone cluster 1, H2ah
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p22.1
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015].
Disorder MIM:	615013

mRNA and Protein(s)

mRNA	Protein	Name
NM_080596.2	NP_542163.1	histone H2A type 1-H
NM_080596.3	NP_542163.1	histone H2A type 1-H

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LOC488291	XP_545413.1
Mus musculus (house mouse)	Hist1h2ah	NP_783590.1
	LOC701826	XP_001093153.1
Bos taurus (cattle)	HIST1H2AH	XP_005223846.1
Rattus norvegicus (Norway rat)	LOC680322	XP_006254181.1
Homo sapiens (human)	HIST1H2AH	NP_542163.1

Gene Ontology
Bibliography

Related articles in PubMed

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W
Immunology and cell biology88(8)851-6(2010 Nov-Dec)

A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B.
Kimura H, Takizawa N, Allemand E, Hori T, Iborra FJ, Nozaki N, Muraki M, Hagiwara M, Krainer AR, Fukagawa T, Okawa K
The Journal of cell biology175(3)389-400(2006 Nov)

DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A.
Bergink S, Salomons FA, Hoogstraten D, Groothuis TA, de Waard H, Wu J, Yuan L, Citterio E, Houtsmuller AB, Neefjes J, Hoeijmakers JH, Vermeulen W, Dantuma NP
Genes & development20(10)1343-52(2006 May)

Characterization of histone H2A and H2B variants and their post-translational modifications by mass spectrometry.
Bonenfant D, Coulot M, Towbin H, Schindler P, van Oostrum J
Molecular & cellular proteomics : MCP5(3)541-52(2006 Mar)

Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing.
Cao R, Tsukada Y, Zhang Y
Molecular cell20(6)845-54(2005 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Protein phosphatase 2C gamma binds to/dephosphorylates H2A to affect chromatin function.
Title: A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B.

The following H2AC12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H2AC12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu14152	NM_080596.3 Latest version!	Homo sapiens H2A clustered histone 12 (H2AC12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu14152	NM_080596.2	Homo sapiens histone cluster 1 H2A family member h (HIST1H2AH), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H2AC12 ( NM_080596.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_542163.1 Homo sapiens histone cluster 1 H2A family member h (HIST1H2AH), mRNA.

Price & Availability↑

CloneID	OHu14152
Clone ID Related Accession (Same CDS sequence)	NM_080596.2 , NM_080596.3
Accession Version	NM_080596.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	histone H2A type 1-H
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC093849.1 and BC134366.1. On Jan 30, 2013 this sequence version replaced NM_080596.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTGGAC GTGGCAAGCA AGGCGGTAAA GCTCGCGCCA AGGCCAAGAC CCGCTCTTCT 
CGGGCTGGGC TTCAGTTCCC CGTGGGCCGA GTGCACCGCC TGCTCCGCAA GGGTAATTAT 
GCCGAGCGGG TTGGAGCCGG CGCGCCAGTG TACCTGGCTG CGGTGCTGGA GTACCTGACC 
GCTGAGATCC TGGAGCTGGC TGGCAATGCG GCCCGCGACA ACAAGAAGAC CCGTATCATC 
CCGCGTCACC TCCAACTGGC CATCCGCAAC GACGAGGAGC TCAACAAGCT GCTGGGCAAA 
GTCACCATCG CGCAGGGTGG TGTCTTGCCC AATATCCAGG CCGTGCTGCT GCCTAAGAAG 
ACTGAGAGCC ACCATAAGGC CAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_542163.1
CDS	48..434
Translation	MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHHKAK

Target ORF information:

RefSeq Version	NM_080596.2
Organism	Homo sapiens(human)
Definition	Homo sapiens histone cluster 1 H2A family member h (HIST1H2AH), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080596.2

ORF Insert Sequence:

ATGTCTGGAC GTGGCAAGCA AGGCGGTAAA GCTCGCGCCA AGGCCAAGAC CCGCTCTTCT 
CGGGCTGGGC TTCAGTTCCC CGTGGGCCGA GTGCACCGCC TGCTCCGCAA GGGTAATTAT 
GCCGAGCGGG TTGGAGCCGG CGCGCCAGTG TACCTGGCTG CGGTGCTGGA GTACCTGACC 
GCTGAGATCC TGGAGCTGGC TGGCAATGCG GCCCGCGACA ACAAGAAGAC CCGTATCATC 
CCGCGTCACC TCCAACTGGC CATCCGCAAC GACGAGGAGC TCAACAAGCT GCTGGGCAAA 
GTCACCATCG CGCAGGGTGG TGTCTTGCCC AATATCCAGG CCGTGCTGCT GCCTAAGAAG 
ACTGAGAGCC ACCATAAGGC CAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H2AC12 ( NM_080596.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_542163.1 Homo sapiens H2A clustered histone 12 (H2AC12), mRNA.

Price & Availability↑

CloneID	OHu14152
Clone ID Related Accession (Same CDS sequence)	NM_080596.2 , NM_080596.3
Accession Version	NM_080596.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	histone H2A type 1-H
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL021807.2. On Dec 3, 2019 this sequence version replaced NM_080596.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BX955192.1, AK312232.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTGGAC GTGGCAAGCA AGGCGGTAAA GCTCGCGCCA AGGCCAAGAC CCGCTCTTCT 
CGGGCTGGGC TTCAGTTCCC CGTGGGCCGA GTGCACCGCC TGCTCCGCAA GGGTAATTAT 
GCCGAGCGGG TTGGAGCCGG CGCGCCAGTG TACCTGGCTG CGGTGCTGGA GTACCTGACC 
GCTGAGATCC TGGAGCTGGC TGGCAATGCG GCCCGCGACA ACAAGAAGAC CCGTATCATC 
CCGCGTCACC TCCAACTGGC CATCCGCAAC GACGAGGAGC TCAACAAGCT GCTGGGCAAA 
GTCACCATCG CGCAGGGTGG TGTCTTGCCC AATATCCAGG CCGTGCTGCT GCCTAAGAAG 
ACTGAGAGCC ACCATAAGGC CAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_542163.1
CDS	24..410
Translation	MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHHKAK

Target ORF information:

RefSeq Version	NM_080596.3
Organism	Homo sapiens(human)
Definition	Homo sapiens H2A clustered histone 12 (H2AC12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080596.3

ORF Insert Sequence:

ATGTCTGGAC GTGGCAAGCA AGGCGGTAAA GCTCGCGCCA AGGCCAAGAC CCGCTCTTCT 
CGGGCTGGGC TTCAGTTCCC CGTGGGCCGA GTGCACCGCC TGCTCCGCAA GGGTAATTAT 
GCCGAGCGGG TTGGAGCCGG CGCGCCAGTG TACCTGGCTG CGGTGCTGGA GTACCTGACC 
GCTGAGATCC TGGAGCTGGC TGGCAATGCG GCCCGCGACA ACAAGAAGAC CCGTATCATC 
CCGCGTCACC TCCAACTGGC CATCCGCAAC GACGAGGAGC TCAACAAGCT GCTGGGCAAA 
GTCACCATCG CGCAGGGTGG TGTCTTGCCC AATATCCAGG CCGTGCTGCT GCCTAAGAAG 
ACTGAGAGCC ACCATAAGGC CAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Immunology and cell biology88(8)851-6(2010 Nov-Dec)
Buschow SI,van Balkom BW,Aalberts M,Heck AJ,Wauben M,Stoorvogel W

A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B.
The Journal of cell biology175(3)389-400(2006 Nov)
Kimura H,Takizawa N,Allemand E,Hori T,Iborra FJ,Nozaki N,Muraki M,Hagiwara M,Krainer AR,Fukagawa T,Okawa K

DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A.
Genes & development20(10)1343-52(2006 May)
Bergink S,Salomons FA,Hoogstraten D,Groothuis TA,de Waard H,Wu J,Yuan L,Citterio E,Houtsmuller AB,Neefjes J,Hoeijmakers JH,Vermeulen W,Dantuma NP

Characterization of histone H2A and H2B variants and their post-translational modifications by mass spectrometry.
Molecular & cellular proteomics : MCP5(3)541-52(2006 Mar)
Bonenfant D,Coulot M,Towbin H,Schindler P,van Oostrum J

Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing.
Molecular cell20(6)845-54(2005 Dec)
Cao R,Tsukada Y,Zhang Y

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H2AC12 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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