NIPSNAP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NIPSNAP1
Entrez Gene ID	8508
Full Name	nipsnap homolog 1
General protein information	Preferred Names nipsnap homolog 1 Names protein NipSnap homolog 1 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q12.2
Summary	This gene encodes a member of the NipSnap family of proteins that may be involved in vesicular transport. A similar protein in mice inhibits the calcium channel TRPV6, and is also localized to the inner mitochondrial membrane where it may play a role in mitochondrial DNA maintenance. A pseudogene of this gene is located on the short arm of chromosome 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011].
Disorder MIM:	603249

mRNA and Protein(s)

mRNA	Protein	Name
NM_003634.4	NP_003625.2	protein NipSnap homolog 1 isoform 1
NM_003634.3	NP_003625.2	protein NipSnap homolog 1 isoform 1
NM_001202502.1	NP_001189431.1	protein NipSnap homolog 1 isoform 2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Nipsnap1	NP_001094200.1
Gallus gallus (chicken)	NIPSNAP1	NP_001264444.1
Magnaporthe oryzae (rice blast fungus)	MGG_02605	XP_003721191.1
Homo sapiens (human)	NIPSNAP1	NP_003625.2
Pan troglodytes (chimpanzee)	NIPSNAP1	XP_515060.3
Neurospora crassa	NCU08092	XP_965223.2
Xenopus tropicalis (tropical clawed frog)	nipsnap1	NP_001016032.1
Canis lupus familiaris (dog)	NIPSNAP1	XP_854687.1
Danio rerio (zebrafish)	nipsnap1	NP_571108.1
Bos taurus (cattle)	NIPSNAP1	NP_001069824.1
Mus musculus (house mouse)	Nipsnap1	NP_032724.1

Gene Ontology
Bibliography

Related articles in PubMed

Mitochondrial proteins NIP-SNAP-1 and -2 are a target for the immunomodulatory activity of clarithromycin, which involves NF-?B-mediated cytokine production.
Yamamoto S, Ogasawara N, Yamamoto K, Uemura C, Takaya Y, Shiraishi T, Sato T, Hashimoto S, Tsutsumi H, Takano K, Himi T, Yokota SI
Biochemical and biophysical research communications483(3)911-916(2017 02)

NIP-SNAP-1 and -2 mitochondrial proteins are maintained by heat shock protein 60.
Yamamoto S, Okamoto T, Ogasawara N, Hashimoto S, Shiraishi T, Sato T, Yamamoto K, Tsutsumi H, Takano K, Himi T, Itoh H, Yokota SI
Biochemical and biophysical research communications483(3)917-922(2017 02)

Involvement of NIPSNAP1, a neuropeptide nocistatin-interacting protein, in inflammatory pain.
Okamoto K, Ohashi M, Ohno K, Takeuchi A, Matsuoka E, Fujisato K, Minami T, Ito S, Okuda-Ashitaka E
Molecular pain12(2016)

FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation.
Dunlop EA, Seifan S, Claessens T, Behrends C, Kamps MA, Rozycka E, Kemp AJ, Nookala RK, Blenis J, Coull BJ, Murray JT, van Steensel MA, Wilkinson S, Tee AR
Autophagy10(10)1749-60(2014 Oct)

Sequence variants in four candidate genes (NIPSNAP1, GBAS, CHCHD1 and METT11D1) in patients with combined oxidative phosphorylation system deficiencies.
Smits P, Rodenburg RJ, Smeitink JA, van den Heuvel LP
Journal of inherited metabolic disease33 Suppl 3S13-9(2010 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

identified mitochondrial proteins 4-nitrophenylphosphatase domain and non-neuronal synaptosomal associated protein 25-like protein homolog (NIP-SNAP)-1 and -2 as clarithromycin-binding proteins. Production of proinflammatory cytokines induced by lipopolysaccharides and Pam3-CSK4 in epithelial cell lines BEAS-2B and T24 were suppressed by knockdown of NIP-SNAP-1 or -2
Title: Mitochondrial proteins NIP-SNAP-1 and -2 are a target for the immunomodulatory activity of clarithromycin, which involves NF-?B-mediated cytokine production.

NIP-SNAP-1 and -2 localized in the mitochondrial inner membrane space, whereas HSP60 localized in the matrix. Expression levels of NIP-SNAP-1 and -2 in cells were decreased by knockdown of HSP60, but not HSP10. The findings indicate that HSP60 promotes folding and maintains the stability of NIP-SNAP-1 and -2.
Title: NIP-SNAP-1 and -2 mitochondrial proteins are maintained by heat shock protein 60.

These results suggest that changes in NIPSNAP1 expression may contribute to the pathogenesis of inflammatory pain.
Title: Involvement of NIPSNAP1, a neuropeptide nocistatin-interacting protein, in inflammatory pain.

Structural variants unique to the malignant cell line inactivated: gene NIPSNAP1, putative tumor suppressor that inhibits TRPV6, an anti-apoptotic oncogene implicated in prostate cancer progression.
Title: Chromosomal structural variations during progression of a prostate epithelial cell line to a malignant metastatic state inactivate the NF2, NIPSNAP1, UGT2B17, and LPIN2 genes.

NIPSNAP1 mutations could not explain phenotype of patients with combined oxidative phosphorylation system deficiencies.
Title: Sequence variants in four candidate genes (NIPSNAP1, GBAS, CHCHD1 and METT11D1) in patients with combined oxidative phosphorylation system deficiencies.

The following NIPSNAP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NIPSNAP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16019	NM_003634.4 Latest version!	Homo sapiens nipsnap homolog 1 (NIPSNAP1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu15885	NM_001202502.1 Latest version!	Homo sapiens nipsnap homolog 1 (NIPSNAP1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu16019	NM_003634.3	Homo sapiens nipsnap homolog 1 (NIPSNAP1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NIPSNAP1 ( NM_003634.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003625.2 Homo sapiens nipsnap homolog 1 (NIPSNAP1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu16019
Clone ID Related Accession (Same CDS sequence)	NM_003634.4 , NM_003634.3
Accession Version	NM_003634.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	protein NipSnap homolog 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC005529.7 and BC006473.1. On May 17, 2019 this sequence version replaced NM_003634.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002371.2, SRR1803611.228575.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000216121.12/ ENSP00000216121.7 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTCCGC GGCTGTGCAG CATCTCTGTG ACGGCGCGGC GGCTGCTGGG GGGCCCGGGG 
CCTCGCGCTG GGGACGTTGC GTCTGCAGCT GCGGCGCGTT TCTATTCCAA GGACAATGAA 
GGCAGCTGGT TCCGCTCCCT CTTTGTTCAC AAAGTGGATC CCCGGAAGGA TGCCCACTCC 
ACCCTGCTGT CCAAGAAGGA AACCAGCAAC CTCTATAAGA TCCAGTTTCA CAATGTAAAG 
CCTGAATACC TGGATGCCTA CAACAGCCTC ACGGAGGCTG TGCTGCCCAA GCTTCACCTG 
GATGAGGACT ACCCATGCTC ACTCGTGGGC AACTGGAACA CGTGGTATGG GGAGCAGGAC 
CAGGCAGTGC ACCTGTGGCG ATTCTCAGGT GGCTACCCAG CCCTCATGGA CTGCATGAAC 
AAGCTCAAAA ACAATAAGGA GTACCTGGAG TTCCGAAGGG AGCGGAGCCA GATGCTGCTG 
TCCAGGAGAA ACCAGCTGCT CCTCGAGTTC AGCTTCTGGA ATGAGCCACA GCCCAGAATG 
GGTCCCAACA TCTATGAGCT GAGGACATAC AAGCTCAAGC CAGGAACCAT GATCGAGTGG 
GGGAACAACT GGGCTCGGGC CATCAAGTAC CGGCAGGAGA ACCAGGAGGC AGTGGGCGGC 
TTCTTCTCAC AGATAGGAGA GCTCTACGTG GTGCACCATC TCTGGGCCTA TAAAGACCTG 
CAGTCTCGGG AGGAGACTCG AAACGCTGCC TGGAGGAAGA GAGGCTGGGA TGAAAATGTC 
TACTATACAG TCCCCCTGGT GCGACACATG GAGTCTAGGA TCATGATCCC CTTGAAGATC 
TCGCCTCTGC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003625.2
CDS	32..886
Translation	MAPRLCSISVTARRLLGGPGPRAGDVASAAAARFYSKDNEGSWFRSLFVHKVDPRKDAHSTLLSKKETSNLYKIQFHNVKPEYLDAYNSLTEAVLPKLHLDEDYPCSLVGNWNTWYGEQDQAVHLWRFSGGYPALMDCMNKLKNNKEYLEFRRERSQMLLSRRNQLLLEFSFWNEPQPRMGPNIYELRTYKLKPGTMIEWGNNWARAIKYRQENQEAVGGFFSQIGELYVVHHLWAYKDLQSREETRNAAWRKRGWDENVYYTVPLVRHMESRIMIPLKISPLQ

Target ORF information:

RefSeq Version	NM_003634.4
Organism	Homo sapiens(human)
Definition	Homo sapiens nipsnap homolog 1 (NIPSNAP1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003634.4

ORF Insert Sequence:

ATGGCTCCGC GGCTGTGCAG CATCTCTGTG ACGGCGCGGC GGCTGCTGGG GGGCCCGGGG 
CCTCGCGCTG GGGACGTTGC GTCTGCAGCT GCGGCGCGTT TCTATTCCAA GGACAATGAA 
GGCAGCTGGT TCCGCTCCCT CTTTGTTCAC AAAGTGGATC CCCGGAAGGA TGCCCACTCC 
ACCCTGCTGT CCAAGAAGGA AACCAGCAAC CTCTATAAGA TCCAGTTTCA CAATGTAAAG 
CCTGAATACC TGGATGCCTA CAACAGCCTC ACGGAGGCTG TGCTGCCCAA GCTTCACCTG 
GATGAGGACT ACCCATGCTC ACTCGTGGGC AACTGGAACA CGTGGTATGG GGAGCAGGAC 
CAGGCAGTGC ACCTGTGGCG ATTCTCAGGT GGCTACCCAG CCCTCATGGA CTGCATGAAC 
AAGCTCAAAA ACAATAAGGA GTACCTGGAG TTCCGAAGGG AGCGGAGCCA GATGCTGCTG 
TCCAGGAGAA ACCAGCTGCT CCTCGAGTTC AGCTTCTGGA ATGAGCCACA GCCCAGAATG 
GGTCCCAACA TCTATGAGCT GAGGACATAC AAGCTCAAGC CAGGAACCAT GATCGAGTGG 
GGGAACAACT GGGCTCGGGC CATCAAGTAC CGGCAGGAGA ACCAGGAGGC AGTGGGCGGC 
TTCTTCTCAC AGATAGGAGA GCTCTACGTG GTGCACCATC TCTGGGCCTA TAAAGACCTG 
CAGTCTCGGG AGGAGACTCG AAACGCTGCC TGGAGGAAGA GAGGCTGGGA TGAAAATGTC 
TACTATACAG TCCCCCTGGT GCGACACATG GAGTCTAGGA TCATGATCCC CTTGAAGATC 
TCGCCTCTGC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NIPSNAP1 ( NM_003634.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003625.2 Homo sapiens nipsnap homolog 1 (NIPSNAP1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu16019
Clone ID Related Accession (Same CDS sequence)	NM_003634.4 , NM_003634.3
Accession Version	NM_003634.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	protein NipSnap homolog 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC005529.7 and BC006473.1. On Feb 3, 2011 this sequence version replaced NM_003634.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002371.2, AJ001258.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCCGC GGCTGTGCAG CATCTCTGTG ACGGCGCGGC GGCTGCTGGG GGGCCCGGGG 
CCTCGCGCTG GGGACGTTGC GTCTGCAGCT GCGGCGCGTT TCTATTCCAA GGACAATGAA 
GGCAGCTGGT TCCGCTCCCT CTTTGTTCAC AAAGTGGATC CCCGGAAGGA TGCCCACTCC 
ACCCTGCTGT CCAAGAAGGA AACCAGCAAC CTCTATAAGA TCCAGTTTCA CAATGTAAAG 
CCTGAATACC TGGATGCCTA CAACAGCCTC ACGGAGGCTG TGCTGCCCAA GCTTCACCTG 
GATGAGGACT ACCCATGCTC ACTCGTGGGC AACTGGAACA CGTGGTATGG GGAGCAGGAC 
CAGGCAGTGC ACCTGTGGCG ATTCTCAGGT GGCTACCCAG CCCTCATGGA CTGCATGAAC 
AAGCTCAAAA ACAATAAGGA GTACCTGGAG TTCCGAAGGG AGCGGAGCCA GATGCTGCTG 
TCCAGGAGAA ACCAGCTGCT CCTCGAGTTC AGCTTCTGGA ATGAGCCACA GCCCAGAATG 
GGTCCCAACA TCTATGAGCT GAGGACATAC AAGCTCAAGC CAGGAACCAT GATCGAGTGG 
GGGAACAACT GGGCTCGGGC CATCAAGTAC CGGCAGGAGA ACCAGGAGGC AGTGGGCGGC 
TTCTTCTCAC AGATAGGAGA GCTCTACGTG GTGCACCATC TCTGGGCCTA TAAAGACCTG 
CAGTCTCGGG AGGAGACTCG AAACGCTGCC TGGAGGAAGA GAGGCTGGGA TGAAAATGTC 
TACTATACAG TCCCCCTGGT GCGACACATG GAGTCTAGGA TCATGATCCC CTTGAAGATC 
TCGCCTCTGC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003625.2
CDS	256..1110
Translation	MAPRLCSISVTARRLLGGPGPRAGDVASAAAARFYSKDNEGSWFRSLFVHKVDPRKDAHSTLLSKKETSNLYKIQFHNVKPEYLDAYNSLTEAVLPKLHLDEDYPCSLVGNWNTWYGEQDQAVHLWRFSGGYPALMDCMNKLKNNKEYLEFRRERSQMLLSRRNQLLLEFSFWNEPQPRMGPNIYELRTYKLKPGTMIEWGNNWARAIKYRQENQEAVGGFFSQIGELYVVHHLWAYKDLQSREETRNAAWRKRGWDENVYYTVPLVRHMESRIMIPLKISPLQ

Target ORF information:

RefSeq Version	NM_003634.3
Organism	Homo sapiens(human)
Definition	Homo sapiens nipsnap homolog 1 (NIPSNAP1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003634.3

ORF Insert Sequence:

ATGGCTCCGC GGCTGTGCAG CATCTCTGTG ACGGCGCGGC GGCTGCTGGG GGGCCCGGGG 
CCTCGCGCTG GGGACGTTGC GTCTGCAGCT GCGGCGCGTT TCTATTCCAA GGACAATGAA 
GGCAGCTGGT TCCGCTCCCT CTTTGTTCAC AAAGTGGATC CCCGGAAGGA TGCCCACTCC 
ACCCTGCTGT CCAAGAAGGA AACCAGCAAC CTCTATAAGA TCCAGTTTCA CAATGTAAAG 
CCTGAATACC TGGATGCCTA CAACAGCCTC ACGGAGGCTG TGCTGCCCAA GCTTCACCTG 
GATGAGGACT ACCCATGCTC ACTCGTGGGC AACTGGAACA CGTGGTATGG GGAGCAGGAC 
CAGGCAGTGC ACCTGTGGCG ATTCTCAGGT GGCTACCCAG CCCTCATGGA CTGCATGAAC 
AAGCTCAAAA ACAATAAGGA GTACCTGGAG TTCCGAAGGG AGCGGAGCCA GATGCTGCTG 
TCCAGGAGAA ACCAGCTGCT CCTCGAGTTC AGCTTCTGGA ATGAGCCACA GCCCAGAATG 
GGTCCCAACA TCTATGAGCT GAGGACATAC AAGCTCAAGC CAGGAACCAT GATCGAGTGG 
GGGAACAACT GGGCTCGGGC CATCAAGTAC CGGCAGGAGA ACCAGGAGGC AGTGGGCGGC 
TTCTTCTCAC AGATAGGAGA GCTCTACGTG GTGCACCATC TCTGGGCCTA TAAAGACCTG 
CAGTCTCGGG AGGAGACTCG AAACGCTGCC TGGAGGAAGA GAGGCTGGGA TGAAAATGTC 
TACTATACAG TCCCCCTGGT GCGACACATG GAGTCTAGGA TCATGATCCC CTTGAAGATC 
TCGCCTCTGC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NIPSNAP1 ( NM_001202502.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001189431.1 Homo sapiens nipsnap homolog 1 (NIPSNAP1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu15885
Clone ID Related Accession (Same CDS sequence)	NM_001202502.1
Accession Version	NM_001202502.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 795bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	protein NipSnap homolog 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK298816.1 and BC006473.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.382690.1, AK298816.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCCGC GGCTGTGCAG CATCTCTGTG ACGGCGCGTT TCTATTCCAA GGACAATGAA 
GGCAGCTGGT TCCGCTCCCT CTTTGTTCAC AAAGTGGATC CCCGGAAGGA TGCCCACTCC 
ACCCTGCTGT CCAAGAAGGA AACCAGCAAC CTCTATAAGA TCCAGTTTCA CAATGTAAAG 
CCTGAATACC TGGATGCCTA CAACAGCCTC ACGGAGGCTG TGCTGCCCAA GCTTCACCTG 
GATGAGGACT ACCCATGCTC ACTCGTGGGC AACTGGAACA CGTGGTATGG GGAGCAGGAC 
CAGGCAGTGC ACCTGTGGCG ATTCTCAGGT GGCTACCCAG CCCTCATGGA CTGCATGAAC 
AAGCTCAAAA ACAATAAGGA GTACCTGGAG TTCCGAAGGG AGCGGAGCCA GATGCTGCTG 
TCCAGGAGAA ACCAGCTGCT CCTCGAGTTC AGCTTCTGGA ATGAGCCACA GCCCAGAATG 
GGTCCCAACA TCTATGAGCT GAGGACATAC AAGCTCAAGC CAGGAACCAT GATCGAGTGG 
GGGAACAACT GGGCTCGGGC CATCAAGTAC CGGCAGGAGA ACCAGGAGGC AGTGGGCGGC 
TTCTTCTCAC AGATAGGAGA GCTCTACGTG GTGCACCATC TCTGGGCCTA TAAAGACCTG 
CAGTCTCGGG AGGAGACTCG AAACGCTGCC TGGAGGAAGA GAGGCTGGGA TGAAAATGTC 
TACTATACAG TCCCCCTGGT GCGACACATG GAGTCTAGGA TCATGATCCC CTTGAAGATC 
TCGCCTCTGC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001189431.1
CDS	15..809
Translation	MAPRLCSISVTARFYSKDNEGSWFRSLFVHKVDPRKDAHSTLLSKKETSNLYKIQFHNVKPEYLDAYNSLTEAVLPKLHLDEDYPCSLVGNWNTWYGEQDQAVHLWRFSGGYPALMDCMNKLKNNKEYLEFRRERSQMLLSRRNQLLLEFSFWNEPQPRMGPNIYELRTYKLKPGTMIEWGNNWARAIKYRQENQEAVGGFFSQIGELYVVHHLWAYKDLQSREETRNAAWRKRGWDENVYYTVPLVRHMESRIMIPLKISPLQ

Target ORF information:

RefSeq Version	NM_001202502.1
Organism	Homo sapiens(human)
Definition	Homo sapiens nipsnap homolog 1 (NIPSNAP1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001202502.1

ORF Insert Sequence:

ATGGCTCCGC GGCTGTGCAG CATCTCTGTG ACGGCGCGTT TCTATTCCAA GGACAATGAA 
GGCAGCTGGT TCCGCTCCCT CTTTGTTCAC AAAGTGGATC CCCGGAAGGA TGCCCACTCC 
ACCCTGCTGT CCAAGAAGGA AACCAGCAAC CTCTATAAGA TCCAGTTTCA CAATGTAAAG 
CCTGAATACC TGGATGCCTA CAACAGCCTC ACGGAGGCTG TGCTGCCCAA GCTTCACCTG 
GATGAGGACT ACCCATGCTC ACTCGTGGGC AACTGGAACA CGTGGTATGG GGAGCAGGAC 
CAGGCAGTGC ACCTGTGGCG ATTCTCAGGT GGCTACCCAG CCCTCATGGA CTGCATGAAC 
AAGCTCAAAA ACAATAAGGA GTACCTGGAG TTCCGAAGGG AGCGGAGCCA GATGCTGCTG 
TCCAGGAGAA ACCAGCTGCT CCTCGAGTTC AGCTTCTGGA ATGAGCCACA GCCCAGAATG 
GGTCCCAACA TCTATGAGCT GAGGACATAC AAGCTCAAGC CAGGAACCAT GATCGAGTGG 
GGGAACAACT GGGCTCGGGC CATCAAGTAC CGGCAGGAGA ACCAGGAGGC AGTGGGCGGC 
TTCTTCTCAC AGATAGGAGA GCTCTACGTG GTGCACCATC TCTGGGCCTA TAAAGACCTG 
CAGTCTCGGG AGGAGACTCG AAACGCTGCC TGGAGGAAGA GAGGCTGGGA TGAAAATGTC 
TACTATACAG TCCCCCTGGT GCGACACATG GAGTCTAGGA TCATGATCCC CTTGAAGATC 
TCGCCTCTGC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mitochondrial proteins NIP-SNAP-1 and -2 are a target for the immunomodulatory activity of clarithromycin, which involves NF-?B-mediated cytokine production.
Biochemical and biophysical research communications483(3)911-916(2017 02)
Yamamoto S,Ogasawara N,Yamamoto K,Uemura C,Takaya Y,Shiraishi T,Sato T,Hashimoto S,Tsutsumi H,Takano K,Himi T,Yokota SI

NIP-SNAP-1 and -2 mitochondrial proteins are maintained by heat shock protein 60.
Biochemical and biophysical research communications483(3)917-922(2017 02)
Yamamoto S,Okamoto T,Ogasawara N,Hashimoto S,Shiraishi T,Sato T,Yamamoto K,Tsutsumi H,Takano K,Himi T,Itoh H,Yokota SI

Involvement of NIPSNAP1, a neuropeptide nocistatin-interacting protein, in inflammatory pain.
Molecular pain12(2016)
Okamoto K,Ohashi M,Ohno K,Takeuchi A,Matsuoka E,Fujisato K,Minami T,Ito S,Okuda-Ashitaka E

FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation.
Autophagy10(10)1749-60(2014 Oct)
Dunlop EA,Seifan S,Claessens T,Behrends C,Kamps MA,Rozycka E,Kemp AJ,Nookala RK,Blenis J,Coull BJ,Murray JT,van Steensel MA,Wilkinson S,Tee AR

Sequence variants in four candidate genes (NIPSNAP1, GBAS, CHCHD1 and METT11D1) in patients with combined oxidative phosphorylation system deficiencies.
Journal of inherited metabolic disease33 Suppl 3S13-9(2010 Dec)
Smits P,Rodenburg RJ,Smeitink JA,van den Heuvel LP

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NIPSNAP1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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