PEX3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PEX3
Entrez Gene ID	8504
Full Name	peroxisomal biogenesis factor 3
Synonyms	PBD10A,PBD10B,TRG18
General protein information	Preferred Names peroxisomal biogenesis factor 3 Names peroxisomal biogenesis factor 3 peroxin-3 peroxisomal assembly protein PEX3 transformation-related protein 18
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q24.2
Summary	The product of this gene is involved in peroxisome biosynthesis and integrity. It assembles membrane vesicles before the matrix proteins are translocated. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause Zellweger syndrome (ZWS). [provided by RefSeq, Oct 2008].
Disorder MIM:	603164
Disorder Html:	Peroxisome biogenesis disorder 10A (Zellweger), 614882 (3); ?Peroxisome biogenesis disorder 10B, 617370 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_003630.2	NP_003621.1	peroxisomal biogenesis factor 3
NM_003630.3	NP_003621.1	peroxisomal biogenesis factor 3

Pathways from BioSystems

Homologies

Homo sapiens (human)	PEX3	NP_003621.1
Gallus gallus (chicken)	PEX3	XP_419708.1
Danio rerio (zebrafish)	pex3	NP_956522.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002507	XP_312432.3
Kluyveromyces lactis	KLLA0E16963g	XP_454714.1
Eremothecium gossypii	AGOS_ADR296C	NP_984393.1
Magnaporthe oryzae (rice blast fungus)	MGG_06424	XP_003717143.1
Rattus norvegicus (Norway rat)	Pex3	NP_112640.1
Drosophila melanogaster (fruit fly)	Pex3	NP_648753.1
Neurospora crassa	NCU06175	XP_962987.1
Xenopus tropicalis (tropical clawed frog)	pex3	NP_001039031.1
Bos taurus (cattle)	PEX3	NP_001092457.1
Saccharomyces cerevisiae (baker's yeast)	PEX3	NP_010616.3
Pan troglodytes (chimpanzee)	PEX3	XP_518776.1
	PEX3	XP_001091411.1
Canis lupus familiaris (dog)	PEX3	XP_541132.3
Mus musculus (house mouse)	Pex3	NP_064345.1
Arabidopsis thaliana (thale cress)	PEX3-1	NP_566598.1
Arabidopsis thaliana (thale cress)	PEX3	NP_683410.1
Oryza sativa (rice)	Os09g0314300	NP_001062839.1

Gene Ontology
Bibliography

Related articles in PubMed

Peroxin-dependent targeting of a lipid-droplet-destined membrane protein to ER subdomains.
Schrul B, Kopito RR
Nature cell biology18(7)740-51(2016 07)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

that newly synthesized UBXD8 is post-translationally inserted into discrete ER subdomains by a mechanism requiring cytosolic PEX19 and membrane-integrated PEX3, proteins hitherto exclusively implicated in peroxisome biogenesis
Title: Peroxin-dependent targeting of a lipid-droplet-destined membrane protein to ER subdomains.

This insertion of PEX3 into the ER is physiologically relevant.
Title: Human Peroxin PEX3 Is Co-translationally Integrated into the ER and Exits the ER in?Budding Vesicles.

PEX16 mediates the peroxisomal trafficking of two distinct peroxisomal membrane proteins, PEX3 and PMP34, via the endoplasmic reticulum
Title: PEX16 contributes to peroxisome maintenance by constantly trafficking PEX3 via the ER.

Thus within the cell, PEX3 is stabilized by PEX19 preventing PEX3 aggregation.
Title: Association between the intrinsically disordered protein PEX19 and PEX3.

Mutations in the PEX19-binding domain of PEX3 reduce the affinity for PEX19 and destabilize PEX3.
Title: The role of conserved PEX3 regions in PEX19-binding and peroxisome biogenesis.

The following PEX3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PEX3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20745	NM_003630.3 Latest version!	Homo sapiens peroxisomal biogenesis factor 3 (PEX3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu20745	NM_003630.2	Homo sapiens peroxisomal biogenesis factor 3 (PEX3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PEX3 ( NM_003630.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003621.1 Homo sapiens peroxisomal biogenesis factor 3 (PEX3), mRNA.

Price & Availability↑

CloneID	OHu20745
Clone ID Related Accession (Same CDS sequence)	NM_003630.2 , NM_003630.3
Accession Version	NM_003630.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1122bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-27
Organism	Homo sapiens(human)
Product	peroxisomal biogenesis factor 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP377713.1, BC015506.1, AL031320.6, DB576209.1 and AU137342.1. This sequence is a reference standard in the RefSeqGene project. On Aug 16, 2008 this sequence version replaced NM_003630.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.49945.1, SRR1660807.100535.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGAGGT CTGTATGGAA TTTTCTGAAA CGCCACAAAA AGAAATGCAT CTTCCTGGGC 
ACGGTCCTTG GAGGAGTATA TATTCTGGGG AAATATGGAC AGAAGAAAAT CAGAGAAATA 
CAGGAAAGGG AGGCTGCAGA ATACATTGCC CAAGCACGAC GACAATATCA TTTTGAAAGT 
AACCAGAGGA CTTGCAATAT GACAGTGCTG TCCATGCTTC CAACACTGAG AGAGGCCTTA 
ATGCAGCAAC TGAATTCCGA GAGCCTCACA GCTCTGCTAA AAAACAGGCC TTCAAACAAG 
CTAGAAATAT GGGAGGATCT GAAGATAATA AGTTTCACAA GAAGTACTGT GGCTGTATAC 
AGTACCTGTA TGCTGGTTGT TCTTTTGCGG GTCCAGTTAA ACATAATTGG TGGATATATT 
TACCTGGATA ATGCAGCAGT TGGCAAAAAT GGCACTACAA TTCTTGCTCC CCCAGATGTC 
CAACAGCAGT ATTTATCAAG TATTCAGCAC CTACTTGGAG ATGGCCTGAC AGAATTGATC 
ACTGTCATTA AACAAGCTGT GCAGAAGGTT TTAGGAAGTG TTTCTCTTAA ACATTCTTTG 
TCCCTTTTGG ACTTGGAGCA AAAACTAAAA GAAATCAGAA ATCTCGTTGA GCAGCATAAG 
TCTTCTTCTT GGATTAATAA AGATGGATCC AAACCTTTAT TATGCCATTA TATGATGCCA 
GATGAAGAAA CTCCATTAGC AGTGCAGGCC TGTGGACTTT CTCCTCGAGA CATTACCACT 
ATTAAACTTC TCAATGAAAC TAGAGACATG TTGGAAAGCC CAGATTTTAG TACAGTTTTG 
AATACCTGTT TAAACCGAGG TTTTAGTAGA CTTCTAGACA ATATGGCTGA GTTCTTTCGA 
CCTACTGAAC AGGACCTGCA ACATGGTAAC TCTATGAATA GTCTTTCCAG TGTCAGCCTG 
CCTTTAGCTA AGATAATTCC AATAGTAAAC GGACAGATCC ATTCAGTTTG CAGTGAAACA 
CCTAGTCATT TTGTTCAGGA TCTGTTGACA ATGGAGCAAG TGAAAGACTT TGCTGCTAAT 
GTGTATGAAG CTTTTAGTAC CCCTCAGCAA CTGGAGAAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003621.1
CDS	263..1384
Translation	MLRSVWNFLKRHKKKCIFLGTVLGGVYILGKYGQKKIREIQEREAAEYIAQARRQYHFESNQRTCNMTVLSMLPTLREALMQQLNSESLTALLKNRPSNKLEIWEDLKIISFTRSTVAVYSTCMLVVLLRVQLNIIGGYIYLDNAAVGKNGTTILAPPDVQQQYLSSIQHLLGDGLTELITVIKQAVQKVLGSVSLKHSLSLLDLEQKLKEIRNLVEQHKSSSWINKDGSKPLLCHYMMPDEETPLAVQACGLSPRDITTIKLLNETRDMLESPDFSTVLNTCLNRGFSRLLDNMAEFFRPTEQDLQHGNSMNSLSSVSLPLAKIIPIVNGQIHSVCSETPSHFVQDLLTMEQVKDFAANVYEAFSTPQQLEK

Target ORF information:

RefSeq Version	NM_003630.2
Organism	Homo sapiens(human)
Definition	Homo sapiens peroxisomal biogenesis factor 3 (PEX3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003630.2

ORF Insert Sequence:

ATGCTGAGGT CTGTATGGAA TTTTCTGAAA CGCCACAAAA AGAAATGCAT CTTCCTGGGC 
ACGGTCCTTG GAGGAGTATA TATTCTGGGG AAATATGGAC AGAAGAAAAT CAGAGAAATA 
CAGGAAAGGG AGGCTGCAGA ATACATTGCC CAAGCACGAC GACAATATCA TTTTGAAAGT 
AACCAGAGGA CTTGCAATAT GACAGTGCTG TCCATGCTTC CAACACTGAG AGAGGCCTTA 
ATGCAGCAAC TGAATTCCGA GAGCCTCACA GCTCTGCTAA AAAACAGGCC TTCAAACAAG 
CTAGAAATAT GGGAGGATCT GAAGATAATA AGTTTCACAA GAAGTACTGT GGCTGTATAC 
AGTACCTGTA TGCTGGTTGT TCTTTTGCGG GTCCAGTTAA ACATAATTGG TGGATATATT 
TACCTGGATA ATGCAGCAGT TGGCAAAAAT GGCACTACAA TTCTTGCTCC CCCAGATGTC 
CAACAGCAGT ATTTATCAAG TATTCAGCAC CTACTTGGAG ATGGCCTGAC AGAATTGATC 
ACTGTCATTA AACAAGCTGT GCAGAAGGTT TTAGGAAGTG TTTCTCTTAA ACATTCTTTG 
TCCCTTTTGG ACTTGGAGCA AAAACTAAAA GAAATCAGAA ATCTCGTTGA GCAGCATAAG 
TCTTCTTCTT GGATTAATAA AGATGGATCC AAACCTTTAT TATGCCATTA TATGATGCCA 
GATGAAGAAA CTCCATTAGC AGTGCAGGCC TGTGGACTTT CTCCTCGAGA CATTACCACT 
ATTAAACTTC TCAATGAAAC TAGAGACATG TTGGAAAGCC CAGATTTTAG TACAGTTTTG 
AATACCTGTT TAAACCGAGG TTTTAGTAGA CTTCTAGACA ATATGGCTGA GTTCTTTCGA 
CCTACTGAAC AGGACCTGCA ACATGGTAAC TCTATGAATA GTCTTTCCAG TGTCAGCCTG 
CCTTTAGCTA AGATAATTCC AATAGTAAAC GGACAGATCC ATTCAGTTTG CAGTGAAACA 
CCTAGTCATT TTGTTCAGGA TCTGTTGACA ATGGAGCAAG TGAAAGACTT TGCTGCTAAT 
GTGTATGAAG CTTTTAGTAC CCCTCAGCAA CTGGAGAAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PEX3 ( NM_003630.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003621.1 Homo sapiens peroxisomal biogenesis factor 3 (PEX3), mRNA.

Price & Availability↑

CloneID	OHu20745
Clone ID Related Accession (Same CDS sequence)	NM_003630.2 , NM_003630.3
Accession Version	NM_003630.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1122bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	peroxisomal biogenesis factor 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP377713.1, BC015506.1, AL031320.6, DB576209.1 and AU137342.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_003630.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.32283.1, SRR1660807.49945.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000367591.5/ ENSP00000356563.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGAGGT CTGTATGGAA TTTTCTGAAA CGCCACAAAA AGAAATGCAT CTTCCTGGGC 
ACGGTCCTTG GAGGAGTATA TATTCTGGGG AAATATGGAC AGAAGAAAAT CAGAGAAATA 
CAGGAAAGGG AGGCTGCAGA ATACATTGCC CAAGCACGAC GACAATATCA TTTTGAAAGT 
AACCAGAGGA CTTGCAATAT GACAGTGCTG TCCATGCTTC CAACACTGAG AGAGGCCTTA 
ATGCAGCAAC TGAATTCCGA GAGCCTCACA GCTCTGCTAA AAAACAGGCC TTCAAACAAG 
CTAGAAATAT GGGAGGATCT GAAGATAATA AGTTTCACAA GAAGTACTGT GGCTGTATAC 
AGTACCTGTA TGCTGGTTGT TCTTTTGCGG GTCCAGTTAA ACATAATTGG TGGATATATT 
TACCTGGATA ATGCAGCAGT TGGCAAAAAT GGCACTACAA TTCTTGCTCC CCCAGATGTC 
CAACAGCAGT ATTTATCAAG TATTCAGCAC CTACTTGGAG ATGGCCTGAC AGAATTGATC 
ACTGTCATTA AACAAGCTGT GCAGAAGGTT TTAGGAAGTG TTTCTCTTAA ACATTCTTTG 
TCCCTTTTGG ACTTGGAGCA AAAACTAAAA GAAATCAGAA ATCTCGTTGA GCAGCATAAG 
TCTTCTTCTT GGATTAATAA AGATGGATCC AAACCTTTAT TATGCCATTA TATGATGCCA 
GATGAAGAAA CTCCATTAGC AGTGCAGGCC TGTGGACTTT CTCCTCGAGA CATTACCACT 
ATTAAACTTC TCAATGAAAC TAGAGACATG TTGGAAAGCC CAGATTTTAG TACAGTTTTG 
AATACCTGTT TAAACCGAGG TTTTAGTAGA CTTCTAGACA ATATGGCTGA GTTCTTTCGA 
CCTACTGAAC AGGACCTGCA ACATGGTAAC TCTATGAATA GTCTTTCCAG TGTCAGCCTG 
CCTTTAGCTA AGATAATTCC AATAGTAAAC GGACAGATCC ATTCAGTTTG CAGTGAAACA 
CCTAGTCATT TTGTTCAGGA TCTGTTGACA ATGGAGCAAG TGAAAGACTT TGCTGCTAAT 
GTGTATGAAG CTTTTAGTAC CCCTCAGCAA CTGGAGAAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003621.1
CDS	239..1360
Translation	MLRSVWNFLKRHKKKCIFLGTVLGGVYILGKYGQKKIREIQEREAAEYIAQARRQYHFESNQRTCNMTVLSMLPTLREALMQQLNSESLTALLKNRPSNKLEIWEDLKIISFTRSTVAVYSTCMLVVLLRVQLNIIGGYIYLDNAAVGKNGTTILAPPDVQQQYLSSIQHLLGDGLTELITVIKQAVQKVLGSVSLKHSLSLLDLEQKLKEIRNLVEQHKSSSWINKDGSKPLLCHYMMPDEETPLAVQACGLSPRDITTIKLLNETRDMLESPDFSTVLNTCLNRGFSRLLDNMAEFFRPTEQDLQHGNSMNSLSSVSLPLAKIIPIVNGQIHSVCSETPSHFVQDLLTMEQVKDFAANVYEAFSTPQQLEK

Target ORF information:

RefSeq Version	NM_003630.3
Organism	Homo sapiens(human)
Definition	Homo sapiens peroxisomal biogenesis factor 3 (PEX3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003630.3

ORF Insert Sequence:

ATGCTGAGGT CTGTATGGAA TTTTCTGAAA CGCCACAAAA AGAAATGCAT CTTCCTGGGC 
ACGGTCCTTG GAGGAGTATA TATTCTGGGG AAATATGGAC AGAAGAAAAT CAGAGAAATA 
CAGGAAAGGG AGGCTGCAGA ATACATTGCC CAAGCACGAC GACAATATCA TTTTGAAAGT 
AACCAGAGGA CTTGCAATAT GACAGTGCTG TCCATGCTTC CAACACTGAG AGAGGCCTTA 
ATGCAGCAAC TGAATTCCGA GAGCCTCACA GCTCTGCTAA AAAACAGGCC TTCAAACAAG 
CTAGAAATAT GGGAGGATCT GAAGATAATA AGTTTCACAA GAAGTACTGT GGCTGTATAC 
AGTACCTGTA TGCTGGTTGT TCTTTTGCGG GTCCAGTTAA ACATAATTGG TGGATATATT 
TACCTGGATA ATGCAGCAGT TGGCAAAAAT GGCACTACAA TTCTTGCTCC CCCAGATGTC 
CAACAGCAGT ATTTATCAAG TATTCAGCAC CTACTTGGAG ATGGCCTGAC AGAATTGATC 
ACTGTCATTA AACAAGCTGT GCAGAAGGTT TTAGGAAGTG TTTCTCTTAA ACATTCTTTG 
TCCCTTTTGG ACTTGGAGCA AAAACTAAAA GAAATCAGAA ATCTCGTTGA GCAGCATAAG 
TCTTCTTCTT GGATTAATAA AGATGGATCC AAACCTTTAT TATGCCATTA TATGATGCCA 
GATGAAGAAA CTCCATTAGC AGTGCAGGCC TGTGGACTTT CTCCTCGAGA CATTACCACT 
ATTAAACTTC TCAATGAAAC TAGAGACATG TTGGAAAGCC CAGATTTTAG TACAGTTTTG 
AATACCTGTT TAAACCGAGG TTTTAGTAGA CTTCTAGACA ATATGGCTGA GTTCTTTCGA 
CCTACTGAAC AGGACCTGCA ACATGGTAAC TCTATGAATA GTCTTTCCAG TGTCAGCCTG 
CCTTTAGCTA AGATAATTCC AATAGTAAAC GGACAGATCC ATTCAGTTTG CAGTGAAACA 
CCTAGTCATT TTGTTCAGGA TCTGTTGACA ATGGAGCAAG TGAAAGACTT TGCTGCTAAT 
GTGTATGAAG CTTTTAGTAC CCCTCAGCAA CTGGAGAAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Peroxin-dependent targeting of a lipid-droplet-destined membrane protein to ER subdomains.
Nature cell biology18(7)740-51(2016 07)
Schrul B,Kopito RR

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PEX3 cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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