COX14 cDNA ORF clone, Homo sapiens(Human)

Gene
Clones
gRNAs

Summary

Gene Symbol	COX14
Entrez Gene ID	84987
Full Name	COX14, cytochrome c oxidase assembly factor
Synonyms	C12orf62,PCAG1
General protein information	Preferred Names COX14, cytochrome c oxidase assembly factor Names cytochrome c oxidase assembly protein COX14 COX14 cytochrome c oxidase assembly homolog cytochrome c oxidase assembly homolog 14
Gene Type	protein-coding
Organism	Homo sapiens(Human)
Genome	Chromosome: 12 Map Location: 12q13.12
Summary	This gene encodes a small single-pass transmembrane protein that localizes to mitochondria. This protein may play a role in coordinating the early steps of cytochrome c oxidase (COX; also known as complex IV) subunit assembly and, in particular, the synthesis and assembly of the COX I subunit of the holoenzyme. Mutations in this gene have been associated with mitochondrial complex IV deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012].
Disorder MIM:	614478
Disorder Html:	?Mitochondrial complex IV deficiency, 220110 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001257134.2	NP_001244063.1	cytochrome c oxidase assembly protein COX14
NM_001257133.2	NP_001244062.1	cytochrome c oxidase assembly protein COX14
NM_001257134.1	NP_001244063.1	cytochrome c oxidase assembly protein COX14
NM_032901.3	NP_116290.1	cytochrome c oxidase assembly protein COX14
NM_032901.4	NP_116290.1	cytochrome c oxidase assembly protein COX14
NM_001257133.1	NP_001244062.1	cytochrome c oxidase assembly protein COX14
XM_011538898.1	XP_011537200.1	cytochrome c oxidase assembly protein COX14 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LOC100613511	XP_003952247.1
Mus musculus (house mouse)	Cox14	NP_899079.1
Bos taurus (cattle)	COX14	NP_001181993.1
Rattus norvegicus (Norway rat)	Cox14	XP_001060794.2
Homo sapiens (human)	COX14	NP_116290.1
	COX14	XP_002798615.1
Canis lupus familiaris (dog)	COX14	XP_003433591.1

Gene Ontology
Bibliography

Related articles in PubMed

Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein.
Richter-Dennerlein R, Oeljeklaus S, Lorenzi I, Rons?r C, Bareth B, Schendzielorz AB, Wang C, Warscheid B, Rehling P, Dennerlein S
Cell167(2)471-483.e10(2016 Oct)

Mutations in COA3 cause isolated complex IV deficiency associated with neuropathy, exercise intolerance, obesity, and short stature.
Ostergaard E, Weraarpachai W, Ravn K, Born AP, J?nson L, Duno M, Wibrand F, Shoubridge EA, Vissing J
Journal of medical genetics52(3)203-7(2015 Mar)

Identification of PCAG1 as a novel prostate cancer-associated gene.
Lai Y, Yu Z, Wang Y, Ye J
Molecular medicine reports7(3)755-60(2013 Mar)

Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase.
Szklarczyk R, Wanschers BF, Cuypers TD, Esseling JJ, Riemersma M, van den Brand MA, Gloerich J, Lasonder E, van den Heuvel LP, Nijtmans LG, Huynen MA
Genome biology13(2)R12(2012 Feb)

Mutations in C12orf62, a factor that couples COX I synthesis with cytochrome c oxidase assembly, cause fatal neonatal lactic acidosis.
Weraarpachai W, Sasarman F, Nishimura T, Antonicka H, Aur? K, R?tig A, Lomb?s A, Shoubridge EA
American journal of human genetics90(1)142-51(2012 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

COX14 was undetectable in COA3 subject fibroblasts, and that COA3 was undetectable in fibroblasts from a COX14 subject, demonstrating the interdependence of these two COX assembly factors
Title: Mutations in COA3 cause isolated complex IV deficiency associated with neuropathy, exercise intolerance, obesity, and short stature.

While PCAG1 mRNA was highly expressed in prostate cancer tissues, it was almost absent in all common normal tissues and paired adjacent normal prostate tissues.
Title: Identification of PCAG1 as a novel prostate cancer-associated gene.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following COX14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COX14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09966	NM_001257134.2 Latest version!	Homo sapiens cytochrome c oxidase assembly factor COX14 (COX14), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu09966	NM_032901.4 Latest version!	Homo sapiens cytochrome c oxidase assembly factor COX14 (COX14), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu09966	NM_001257133.2 Latest version!	Homo sapiens cytochrome c oxidase assembly factor COX14 (COX14), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu09966	XM_011538898.1 Latest version!	Homo sapiens COX14 cytochrome c oxidase assembly factor (COX14), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu09966	NM_001257134.1	Homo sapiens cytochrome c oxidase assembly factor COX14 (COX14), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu09966	NM_032901.3	Homo sapiens COX14, cytochrome c oxidase assembly factor (COX14), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu09966	NM_001257133.1	Homo sapiens cytochrome c oxidase assembly factor COX14 (COX14), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

COX14 ( NM_001257134.2 ) cDNA ORF clone, Homo sapiens(Human) -> NP_001244063.1 Homo sapiens cytochrome c oxidase assembly factor COX14 (COX14), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu09966
Clone ID Related Accession (Same CDS sequence)	NM_001257134.2 , NM_001257133.2 , NM_001257134.1 , NM_032901.3 , NM_032901.4 , NM_001257133.1 , XM_011538898.1
Accession Version	NM_001257134.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 174bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-06
Organism	Homo sapiens(human)
Product	cytochrome c oxidase assembly protein COX14
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC007849.2 and BG829783.1. On May 31, 2019 this sequence version replaced NM_001257134.1. Transcript Variant: This variant (3) has an additional segment in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: SRR7410570.505508.1, BG829783.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved gene product(s) localized to mito. :: PMID: 22356826, 22243966; reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121

ATGCCAACTG GCAAGCAGCT AGCTGACATT GGCTATAAGA CCTTCTCTAC CTCCATGATG 
CTTCTCACTG TGTATGGGGG GTACCTCTGC AGTGTCCGAG TCTACCACTA TTTCCAGTGG 
CGCAGGGCCC AGCGCCAGGC CGCAGAAGAA CAGAAGACCT CAGGAATCAT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001244063.1
CDS	271..444
Translation	MPTGKQLADIGYKTFSTSMMLLTVYGGYLCSVRVYHYFQWRRAQRQAAEEQKTSGIM

Target ORF information:

RefSeq Version	NM_001257134.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase assembly factor COX14 (COX14), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001257134.2

ORF Insert Sequence:

1
61
121

ATGCCAACTG GCAAGCAGCT AGCTGACATT GGCTATAAGA CCTTCTCTAC CTCCATGATG 
CTTCTCACTG TGTATGGGGG GTACCTCTGC AGTGTCCGAG TCTACCACTA TTTCCAGTGG 
CGCAGGGCCC AGCGCCAGGC CGCAGAAGAA CAGAAGACCT CAGGAATCAT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COX14 ( NM_001257133.2 ) cDNA ORF clone, Homo sapiens(Human) -> NP_001244062.1 Homo sapiens cytochrome c oxidase assembly factor COX14 (COX14), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu09966
Clone ID Related Accession (Same CDS sequence)	NM_001257134.2 , NM_001257133.2 , NM_001257134.1 , NM_032901.3 , NM_032901.4 , NM_001257133.1 , XM_011538898.1
Accession Version	NM_001257133.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 174bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	cytochrome c oxidase assembly protein COX14
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DW418935.1 and AI208662.1. This sequence is a reference standard in the RefSeqGene project. On May 31, 2019 this sequence version replaced NM_001257133.1. Transcript Variant: This variant (2) has an additional exon in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: AA180788.1, SRR1163657.71411.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 22356826, 22243966; reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121

ATGCCAACTG GCAAGCAGCT AGCTGACATT GGCTATAAGA CCTTCTCTAC CTCCATGATG 
CTTCTCACTG TGTATGGGGG GTACCTCTGC AGTGTCCGAG TCTACCACTA TTTCCAGTGG 
CGCAGGGCCC AGCGCCAGGC CGCAGAAGAA CAGAAGACCT CAGGAATCAT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001244062.1
CDS	135..308
Translation	MPTGKQLADIGYKTFSTSMMLLTVYGGYLCSVRVYHYFQWRRAQRQAAEEQKTSGIM

Target ORF information:

RefSeq Version	NM_001257133.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase assembly factor COX14 (COX14), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001257133.2

ORF Insert Sequence:

1
61
121

ATGCCAACTG GCAAGCAGCT AGCTGACATT GGCTATAAGA CCTTCTCTAC CTCCATGATG 
CTTCTCACTG TGTATGGGGG GTACCTCTGC AGTGTCCGAG TCTACCACTA TTTCCAGTGG 
CGCAGGGCCC AGCGCCAGGC CGCAGAAGAA CAGAAGACCT CAGGAATCAT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COX14 ( NM_001257134.1 ) cDNA ORF clone, Homo sapiens(Human) -> NP_001244063.1 Homo sapiens cytochrome c oxidase assembly factor COX14 (COX14), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu09966
Clone ID Related Accession (Same CDS sequence)	NM_001257134.2 , NM_001257133.2 , NM_001257134.1 , NM_032901.3 , NM_032901.4 , NM_001257133.1 , XM_011538898.1
Accession Version	NM_001257134.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 174bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	cytochrome c oxidase assembly protein COX14
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP369305.1, BC007849.2, BG829783.1 and AI208662.1. Transcript Variant: This variant (3) has an additional segment in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: BG829783.1, BI668359.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved gene product(s) localized to mito. :: PMID: 22356826, 22243966; reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121

ATGCCAACTG GCAAGCAGCT AGCTGACATT GGCTATAAGA CCTTCTCTAC CTCCATGATG 
CTTCTCACTG TGTATGGGGG GTACCTCTGC AGTGTCCGAG TCTACCACTA TTTCCAGTGG 
CGCAGGGCCC AGCGCCAGGC CGCAGAAGAA CAGAAGACCT CAGGAATCAT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001244063.1
CDS	526..699
Translation	MPTGKQLADIGYKTFSTSMMLLTVYGGYLCSVRVYHYFQWRRAQRQAAEEQKTSGIM

Target ORF information:

RefSeq Version	NM_001257134.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase assembly factor COX14 (COX14), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001257134.1

ORF Insert Sequence:

1
61
121

ATGCCAACTG GCAAGCAGCT AGCTGACATT GGCTATAAGA CCTTCTCTAC CTCCATGATG 
CTTCTCACTG TGTATGGGGG GTACCTCTGC AGTGTCCGAG TCTACCACTA TTTCCAGTGG 
CGCAGGGCCC AGCGCCAGGC CGCAGAAGAA CAGAAGACCT CAGGAATCAT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COX14 ( NM_032901.3 ) cDNA ORF clone, Homo sapiens(Human) -> NP_116290.1 Homo sapiens COX14, cytochrome c oxidase assembly factor (COX14), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09966
Clone ID Related Accession (Same CDS sequence)	NM_001257134.2 , NM_001257133.2 , NM_001257134.1 , NM_032901.3 , NM_032901.4 , NM_001257133.1 , XM_011538898.1
Accession Version	NM_032901.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 174bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	cytochrome c oxidase assembly protein COX14
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP369305.1, BC007849.2 and AI208662.1. On Mar 14, 2012 this sequence version replaced NM_032901.2. Transcript Variant: This variant (1) represents the shortest transcript. Variants 1-3 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: BP369305.1, SRR1163655.580951.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 22356826, 22243966; reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121

ATGCCAACTG GCAAGCAGCT AGCTGACATT GGCTATAAGA CCTTCTCTAC CTCCATGATG 
CTTCTCACTG TGTATGGGGG GTACCTCTGC AGTGTCCGAG TCTACCACTA TTTCCAGTGG 
CGCAGGGCCC AGCGCCAGGC CGCAGAAGAA CAGAAGACCT CAGGAATCAT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_116290.1
CDS	330..503
Translation	MPTGKQLADIGYKTFSTSMMLLTVYGGYLCSVRVYHYFQWRRAQRQAAEEQKTSGIM

Target ORF information:

RefSeq Version	NM_032901.3
Organism	Homo sapiens(human)
Definition	Homo sapiens COX14, cytochrome c oxidase assembly factor (COX14), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032901.3

ORF Insert Sequence:

1
61
121

ATGCCAACTG GCAAGCAGCT AGCTGACATT GGCTATAAGA CCTTCTCTAC CTCCATGATG 
CTTCTCACTG TGTATGGGGG GTACCTCTGC AGTGTCCGAG TCTACCACTA TTTCCAGTGG 
CGCAGGGCCC AGCGCCAGGC CGCAGAAGAA CAGAAGACCT CAGGAATCAT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COX14 ( NM_032901.4 ) cDNA ORF clone, Homo sapiens(Human) -> NP_116290.1 Homo sapiens cytochrome c oxidase assembly factor COX14 (COX14), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09966
Clone ID Related Accession (Same CDS sequence)	NM_001257134.2 , NM_001257133.2 , NM_001257134.1 , NM_032901.3 , NM_032901.4 , NM_001257133.1 , XM_011538898.1
Accession Version	NM_032901.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 174bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	cytochrome c oxidase assembly protein COX14
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC007849.2 and AI208662.1. On Nov 22, 2018 this sequence version replaced NM_032901.3. Transcript Variant: This variant (1) represents the shortest transcript. Variants 1-3 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.446910.1, AL697834.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 22356826, 22243966; reported by MitoCarta MANE Ensembl match :: ENST00000550487.6/ ENSP00000446524.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

1
61
121

ATGCCAACTG GCAAGCAGCT AGCTGACATT GGCTATAAGA CCTTCTCTAC CTCCATGATG 
CTTCTCACTG TGTATGGGGG GTACCTCTGC AGTGTCCGAG TCTACCACTA TTTCCAGTGG 
CGCAGGGCCC AGCGCCAGGC CGCAGAAGAA CAGAAGACCT CAGGAATCAT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_116290.1
CDS	75..248
Translation	MPTGKQLADIGYKTFSTSMMLLTVYGGYLCSVRVYHYFQWRRAQRQAAEEQKTSGIM

Target ORF information:

RefSeq Version	NM_032901.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase assembly factor COX14 (COX14), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032901.4

ORF Insert Sequence:

1
61
121

ATGCCAACTG GCAAGCAGCT AGCTGACATT GGCTATAAGA CCTTCTCTAC CTCCATGATG 
CTTCTCACTG TGTATGGGGG GTACCTCTGC AGTGTCCGAG TCTACCACTA TTTCCAGTGG 
CGCAGGGCCC AGCGCCAGGC CGCAGAAGAA CAGAAGACCT CAGGAATCAT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COX14 ( NM_001257133.1 ) cDNA ORF clone, Homo sapiens(Human) -> NP_001244062.1 Homo sapiens cytochrome c oxidase assembly factor COX14 (COX14), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu09966
Clone ID Related Accession (Same CDS sequence)	NM_001257134.2 , NM_001257133.2 , NM_001257134.1 , NM_032901.3 , NM_032901.4 , NM_001257133.1 , XM_011538898.1
Accession Version	NM_001257133.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 174bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	cytochrome c oxidase assembly protein COX14
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP369305.1, BC007849.2, DW418935.1 and AI208662.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (2) has an additional exon in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.71411.1, AA180829.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 22356826, 22243966; reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121

ATGCCAACTG GCAAGCAGCT AGCTGACATT GGCTATAAGA CCTTCTCTAC CTCCATGATG 
CTTCTCACTG TGTATGGGGG GTACCTCTGC AGTGTCCGAG TCTACCACTA TTTCCAGTGG 
CGCAGGGCCC AGCGCCAGGC CGCAGAAGAA CAGAAGACCT CAGGAATCAT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001244062.1
CDS	390..563
Translation	MPTGKQLADIGYKTFSTSMMLLTVYGGYLCSVRVYHYFQWRRAQRQAAEEQKTSGIM

Target ORF information:

RefSeq Version	NM_001257133.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase assembly factor COX14 (COX14), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001257133.1

ORF Insert Sequence:

1
61
121

ATGCCAACTG GCAAGCAGCT AGCTGACATT GGCTATAAGA CCTTCTCTAC CTCCATGATG 
CTTCTCACTG TGTATGGGGG GTACCTCTGC AGTGTCCGAG TCTACCACTA TTTCCAGTGG 
CGCAGGGCCC AGCGCCAGGC CGCAGAAGAA CAGAAGACCT CAGGAATCAT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COX14 ( XM_011538898.1 ) cDNA ORF clone, Homo sapiens(Human) -> XP_011537200.1 Homo sapiens COX14 cytochrome c oxidase assembly factor (COX14), transcript variant X1, mRNA.

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CloneID	OHu09966
Clone ID Related Accession (Same CDS sequence)	NM_001257134.2 , NM_001257133.2 , NM_001257134.1 , NM_032901.3 , NM_032901.4 , NM_001257133.1 , XM_011538898.1
Accession Version	XM_011538898.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 174bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	cytochrome c oxidase assembly protein COX14 isoform X1
Comment

1
61
121

ATGCCAACTG GCAAGCAGCT AGCTGACATT GGCTATAAGA CCTTCTCTAC CTCCATGATG 
CTTCTCACTG TGTATGGGGG GTACCTCTGC AGTGTCCGAG TCTACCACTA TTTCCAGTGG 
CGCAGGGCCC AGCGCCAGGC CGCAGAAGAA CAGAAGACCT CAGGAATCAT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011537200.1
Translation	MPTGKQLADIGYKTFSTSMMLLTVYGGYLCSVRVYHYFQWRRAQRQAAEEQKTSGIM

Target ORF information:

RefSeq Version	XM_011538898.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens COX14 cytochrome c oxidase assembly factor (COX14), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011538898.1

ORF Insert Sequence:

1
61
121

ATGCCAACTG GCAAGCAGCT AGCTGACATT GGCTATAAGA CCTTCTCTAC CTCCATGATG 
CTTCTCACTG TGTATGGGGG GTACCTCTGC AGTGTCCGAG TCTACCACTA TTTCCAGTGG 
CGCAGGGCCC AGCGCCAGGC CGCAGAAGAA CAGAAGACCT CAGGAATCAT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein.
Cell167(2)471-483.e10(2016 Oct)
Richter-Dennerlein R,Oeljeklaus S,Lorenzi I,Rons?r C,Bareth B,Schendzielorz AB,Wang C,Warscheid B,Rehling P,Dennerlein S

Mutations in COA3 cause isolated complex IV deficiency associated with neuropathy, exercise intolerance, obesity, and short stature.
Journal of medical genetics52(3)203-7(2015 Mar)
Ostergaard E,Weraarpachai W,Ravn K,Born AP,J?nson L,Duno M,Wibrand F,Shoubridge EA,Vissing J

Identification of PCAG1 as a novel prostate cancer-associated gene.
Molecular medicine reports7(3)755-60(2013 Mar)
Lai Y,Yu Z,Wang Y,Ye J

Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase.
Genome biology13(2)R12(2012 Feb)
Szklarczyk R,Wanschers BF,Cuypers TD,Esseling JJ,Riemersma M,van den Brand MA,Gloerich J,Lasonder E,van den Heuvel LP,Nijtmans LG,Huynen MA

Mutations in C12orf62, a factor that couples COX I synthesis with cytochrome c oxidase assembly, cause fatal neonatal lactic acidosis.
American journal of human genetics90(1)142-51(2012 Jan)
Weraarpachai W,Sasarman F,Nishimura T,Antonicka H,Aur? K,R?tig A,Lomb?s A,Shoubridge EA

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COX14 cDNA ORF clone, Homo sapiens(Human)

Gene

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gRNAs

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Target ORF information:

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ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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