PRSS12 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PRSS12
Entrez Gene ID	8492
Full Name	serine protease 12
Synonyms	BSSP-3,BSSP3,MRT1
General protein information	Preferred Names serine protease 12 Names neurotrypsin brain-specific serine protease 3 leydin protease, serine 12 protease, serine, 12 (neurotrypsin, motopsin)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q26
Summary	This gene encodes a member of the trypsin family of serine proteases and contains a signal peptide, a proline-rich region, a Kringle domain, four scavenger receptor cysteine-rich domains, and a trypsin-like serine protease domain. The protein, sometimes referred to as neurotrypsin or motopsin, is secreted from neuronal cells and localizes to the synaptic cleft. Studies in mice show that this protein cleaves a protein, agrin, that is important for the formation and maintenance of exitatory synapses. Defects in this gene cause a form of autosomal recessive cognitive impairment (MRT1). [provided by RefSeq, Jul 2017].
Disorder MIM:	606709
Disorder Html:	Mental retardation, autosomal recessive 1, 249500 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_003619.3	NP_003610.2	neurotrypsin precursor
XM_005263318.4	XP_005263375.1	neurotrypsin isoform X2
NM_003619.4	NP_003610.2	neurotrypsin precursor
XM_011532387.2	XP_011530689.1	neurotrypsin isoform X1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Prss12	NP_445956.1
Bos taurus (cattle)	PRSS12	NP_001180151.1
Mus musculus (house mouse)	Prss12	NP_032965.1
Gallus gallus (chicken)	PRSS12	XP_420637.4
	PRSS12	NP_001121559.1
Xenopus tropicalis (tropical clawed frog)	prss12	XP_002934300.2
Homo sapiens (human)	PRSS12	NP_003610.2
Pan troglodytes (chimpanzee)	PRSS12	NP_001065275.1
Canis lupus familiaris (dog)	PRSS12	XP_003434056.1
Danio rerio (zebrafish)	LOC566809	XP_001920299.2

Gene Ontology
Bibliography

Related articles in PubMed

A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
Kalsi G, Kuo PH, Aliev F, Alexander J, McMichael O, Patterson DG, Walsh D, Zhao Z, Schuckit M, Nurnberger J Jr, Edenberg H, Kramer J, Hesselbrock V, Tischfield JA, Vladimirov V, Prescott CA, Dick DM, Kendler KS, Riley BP
Human molecular genetics19(12)2497-506(2010 Jun)

Truncating neurotrypsin mutation in autosomal recessive nonsyndromic mental retardation.
Molinari F, Rio M, Meskenaite V, Encha-Razavi F, Aug? J, Bacq D, Briault S, Vekemans M, Munnich A, Atti?-Bitach T, Sonderegger P, Colleaux L
Science (New York, N.Y.)298(5599)1779-81(2002 Nov)

Cloning and structural analysis of leydin, a novel human serine protease expressed by the Leydig cells of the testis.
Poorafshar M, Hellman L
European journal of biochemistry261(1)244-50(1999 Apr)

Assignment of the gene encoding the neuronal multidomain serine protease neurotrypsin (PRSS12) to human chromosome band 4q25-->q26 by in situ hybridization.
Kozlov SV, Riegel M, Kinter J, Hintsch G, Cinelli P, Schinzel A, Sonderegger P
Cytogenetics and cell genetics84(1-2)107-8(1999)

Cloning and sequencing of the cDNA encoding human neurotrypsin.
Proba K, Gschwend TP, Sonderegger P
Biochimica et biophysica acta1396(2)143-7(1998 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.

4-base pair deletion in the neurotrypsin gene was associated with autosomal recessive nonsyndromic mental retardation; findings suggest that neurotrypsin-mediated proteolysis is required for normal synaptic function
Title: Truncating neurotrypsin mutation in autosomal recessive nonsyndromic mental retardation.

The following PRSS12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PRSS12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21891	NM_003619.4 Latest version!	Homo sapiens serine protease 12 (PRSS12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$439.50-$615.30 $879.00
OHu39192	XM_005263318.4 Latest version!	Homo sapiens serine protease 12 (PRSS12), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
OHu61846	XM_011532387.2 Latest version!	Homo sapiens serine protease 12 (PRSS12), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
View Old Accession Versions >>
OHu21891	NM_003619.3	Homo sapiens protease, serine 12 (PRSS12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$439.50-$615.30 $879.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PRSS12 ( NM_003619.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003610.2 Homo sapiens protease, serine 12 (PRSS12), mRNA.

Price & Availability↑

CloneID	OHu21891
Clone ID Related Accession (Same CDS sequence)	NM_003619.3 , NM_003619.4
Accession Version	NM_003619.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2628bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	neurotrypsin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC007761.2, BG386264.1, AJ001531.1 and AC096762.3. This sequence is a reference standard in the RefSeqGene project. On Jul 8, 2010 this sequence version replaced NM_003619.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AJ001531.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACGCTCG CCCGCTTCGT GCTAGCCCTG ATGTTAGGGG CGCTCCCCGA AGTGGTCGGC 
TTTGATTCTG TCCTCAATGA TTCCCTCCAC CACAGCCACC GCCATTCGCC CCCTGCGGGT 
CCGCACTACC CCTATTACCT TCCCACCCAG CAGCGGCCCC CGAGGACGCG TCCGCCGCCG 
CCTCTCCCGC GCTTCCCGCG CCCCCCGCGG GCGCTCCCTG CCCAGCGCCC GCACGCCCTC 
CAGGCCGGGC ACACGCCCCG GCCGCACCCC TGGGGCTGCC CCGCCGGCGA GCCATGGGTC 
AGCGTGACGG ACTTCGGCGC CCCGTGTCTG CGGTGGGCGG AGGTGCCACC CTTCCTGGAG 
CGGTCGCCCC CAGCGAGCTG GGCTCAGCTG CGAGGACAGC GCCACAACTT TTGTCGGAGC 
CCCGACGGCG CGGGCAGACC CTGGTGTTTC TACGGAGACG CCCGTGGCAA GGTGGACTGG 
GGCTACTGCG ACTGCAGACA CGGATCAGTA CGACTTCGTG GCGGCAAAAA TGAGTTTGAA 
GGCACAGTGG AAGTATATGC AAGTGGAGTT TGGGGCACTG TCTGTAGCAG CCACTGGGAT 
GATTCTGATG CATCAGTCAT TTGTCACCAG CTGCAGCTGG GAGGAAAAGG AATAGCAAAA 
CAAACCCCGT TTTCTGGACT GGGCCTTATT CCCATTTATT GGAGCAATGT CCGTTGCCGA 
GGAGATGAAG AAAATATACT GCTTTGTGAA AAAGACATCT GGCAGGGTGG GGTGTGTCCT 
CAGAAGATGG CAGCTGCTGT CACGTGTAGC TTTTCCCATG GCCCAACGTT CCCCATCATT 
CGCCTTGCTG GAGGCAGCAG TGTGCATGAA GGCCGGGTGG AGCTCTACCA TGCTGGCCAG 
TGGGGAACCG TTTGTGATGA CCAATGGGAT GATGCCGATG CAGAAGTGAT CTGCAGGCAG 
CTGGGCCTCA GTGGCATTGC CAAAGCATGG CATCAGGCAT ATTTTGGGGA AGGGTCTGGC 
CCAGTTATGT TGGATGAAGT ACGCTGCACT GGGAATGAGC TTTCAATTGA GCAGTGTCCA 
AAGAGCTCCT GGGGAGAGCA TAACTGTGGC CATAAAGAAG ATGCTGGAGT GTCCTGTACC 
CCTCTAACAG ATGGGGTCAT CAGACTTGCA GGTGGGAAAG GCAGCCATGA GGGTCGCTTG 
GAGGTATATT ACAGAGGCCA GTGGGGAACT GTCTGTGATG ATGGCTGGAC TGAGCTGAAT 
ACATACGTGG TTTGTCGACA ATTGGGATTT AAATATGGTA AACAAGCATC TGCCAACCAT 
TTTGAAGAAA GCACAGGGCC CATATGGTTG GATGACGTCA GCTGCTCAGG AAAGGAAACC 
AGATTTCTTC AGTGTTCCAG GCGACAGTGG GGAAGGCATG ACTGCAGCCA CCGCGAAGAT 
GTTAGCATTG CCTGCTACCC TGGCGGCGAG GGACACAGGC TCTCTCTGGG TTTTCCTGTC 
AGACTGATGG ATGGAGAAAA TAAGAAAGAA GGACGAGTGG AGGTTTTTAT CAATGGCCAG 
TGGGGAACAA TCTGTGATGA TGGATGGACT GATAAGGATG CAGCTGTGAT CTGTCGTCAG 
CTTGGCTACA AGGGTCCTGC CAGAGCAAGA ACCATGGCTT ACTTTGGAGA AGGAAAAGGA 
CCCATCCATG TGGATAATGT GAAGTGCACA GGAAATGAGA GGTCCTTGGC TGACTGTATC 
AAGCAAGATA TTGGAAGACA CAACTGCCGC CACAGTGAAG ATGCAGGAGT TATTTGTGAT 
TATTTTGGCA AGAAGGCCTC AGGTAACAGT AATAAAGAGT CCCTCTCATC TGTTTGTGGC 
TTGAGATTAC TGCACCGTCG GCAGAAGCGG ATCATTGGTG GGAAAAATTC TTTAAGGGGT 
GGTTGGCCTT GGCAGGTTTC CCTCCGGCTG AAGTCATCCC ATGGAGATGG CAGGCTCCTC 
TGCGGGGCTA CGCTCCTGAG TAGCTGCTGG GTCCTCACAG CAGCACACTG TTTCAAGAGG 
TATGGCAACA GCACTAGGAG CTATGCTGTT AGGGTTGGAG ATTATCATAC TCTGGTACCA 
GAGGAGTTTG AGGAAGAAAT TGGAGTTCAA CAGATTGTGA TTCATCGGGA GTATCGACCC 
GACCGCAGTG ATTATGACAT AGCCCTGGTT AGATTACAAG GACCAGAAGA GCAATGTGCC 
AGATTCAGCA GCCATGTTTT GCCAGCCTGT TTACCACTCT GGAGAGAGAG GCCACAGAAA 
ACAGCATCCA ACTGTTACAT AACAGGATGG GGTGACACAG GACGAGCCTA TTCAAGAACA 
CTACAACAAG CAGCCATTCC CTTACTTCCT AAAAGGTTTT GTGAAGAACG TTATAAGGGT 
CGGTTTACAG GGAGAATGCT TTGTGCTGGA AACCTCCATG AACACAAACG CGTGGACAGC 
TGCCAGGGAG ACAGCGGAGG ACCACTCATG TGTGAACGGC CCGGAGAGAG CTGGGTGGTG 
TATGGGGTGA CCTCCTGGGG GTATGGCTGT GGAGTCAAGG ATTCTCCTGG TGTTTATACC 
AAAGTCTCAG CCTTTGTACC TTGGATAAAA AGTGTCACCA AACTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003610.2
CDS	48..2675
Translation	MTLARFVLALMLGALPEVVGFDSVLNDSLHHSHRHSPPAGPHYPYYLPTQQRPPRTRPPPPLPRFPRPPRALPAQRPHALQAGHTPRPHPWGCPAGEPWVSVTDFGAPCLRWAEVPPFLERSPPASWAQLRGQRHNFCRSPDGAGRPWCFYGDARGKVDWGYCDCRHGSVRLRGGKNEFEGTVEVYASGVWGTVCSSHWDDSDASVICHQLQLGGKGIAKQTPFSGLGLIPIYWSNVRCRGDEENILLCEKDIWQGGVCPQKMAAAVTCSFSHGPTFPIIRLAGGSSVHEGRVELYHAGQWGTVCDDQWDDADAEVICRQLGLSGIAKAWHQAYFGEGSGPVMLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSCTPLTDGVIRLAGGKGSHEGRLEVYYRGQWGTVCDDGWTELNTYVVCRQLGFKYGKQASANHFEESTGPIWLDDVSCSGKETRFLQCSRRQWGRHDCSHREDVSIACYPGGEGHRLSLGFPVRLMDGENKKEGRVEVFINGQWGTICDDGWTDKDAAVICRQLGYKGPARARTMAYFGEGKGPIHVDNVKCTGNERSLADCIKQDIGRHNCRHSEDAGVICDYFGKKASGNSNKESLSSVCGLRLLHRRQKRIIGGKNSLRGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVLTAAHCFKRYGNSTRSYAVRVGDYHTLVPEEFEEEIGVQQIVIHREYRPDRSDYDIALVRLQGPEEQCARFSSHVLPACLPLWRERPQKTASNCYITGWGDTGRAYSRTLQQAAIPLLPKRFCEERYKGRFTGRMLCAGNLHEHKRVDSCQGDSGGPLMCERPGESWVVYGVTSWGYGCGVKDSPGVYTKVSAFVPWIKSVTKL

Target ORF information:

RefSeq Version	NM_003619.3
Organism	Homo sapiens(human)
Definition	Homo sapiens protease, serine 12 (PRSS12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003619.3

ORF Insert Sequence:

ATGACGCTCG CCCGCTTCGT GCTAGCCCTG ATGTTAGGGG CGCTCCCCGA AGTGGTCGGC 
TTTGATTCTG TCCTCAATGA TTCCCTCCAC CACAGCCACC GCCATTCGCC CCCTGCGGGT 
CCGCACTACC CCTATTACCT TCCCACCCAG CAGCGGCCCC CGAGGACGCG TCCGCCGCCG 
CCTCTCCCGC GCTTCCCGCG CCCCCCGCGG GCGCTCCCTG CCCAGCGCCC GCACGCCCTC 
CAGGCCGGGC ACACGCCCCG GCCGCACCCC TGGGGCTGCC CCGCCGGCGA GCCATGGGTC 
AGCGTGACGG ACTTCGGCGC CCCGTGTCTG CGGTGGGCGG AGGTGCCACC CTTCCTGGAG 
CGGTCGCCCC CAGCGAGCTG GGCTCAGCTG CGAGGACAGC GCCACAACTT TTGTCGGAGC 
CCCGACGGCG CGGGCAGACC CTGGTGTTTC TACGGAGACG CCCGTGGCAA GGTGGACTGG 
GGCTACTGCG ACTGCAGACA CGGATCAGTA CGACTTCGTG GCGGCAAAAA TGAGTTTGAA 
GGCACAGTGG AAGTATATGC AAGTGGAGTT TGGGGCACTG TCTGTAGCAG CCACTGGGAT 
GATTCTGATG CATCAGTCAT TTGTCACCAG CTGCAGCTGG GAGGAAAAGG AATAGCAAAA 
CAAACCCCGT TTTCTGGACT GGGCCTTATT CCCATTTATT GGAGCAATGT CCGTTGCCGA 
GGAGATGAAG AAAATATACT GCTTTGTGAA AAAGACATCT GGCAGGGTGG GGTGTGTCCT 
CAGAAGATGG CAGCTGCTGT CACGTGTAGC TTTTCCCATG GCCCAACGTT CCCCATCATT 
CGCCTTGCTG GAGGCAGCAG TGTGCATGAA GGCCGGGTGG AGCTCTACCA TGCTGGCCAG 
TGGGGAACCG TTTGTGATGA CCAATGGGAT GATGCCGATG CAGAAGTGAT CTGCAGGCAG 
CTGGGCCTCA GTGGCATTGC CAAAGCATGG CATCAGGCAT ATTTTGGGGA AGGGTCTGGC 
CCAGTTATGT TGGATGAAGT ACGCTGCACT GGGAATGAGC TTTCAATTGA GCAGTGTCCA 
AAGAGCTCCT GGGGAGAGCA TAACTGTGGC CATAAAGAAG ATGCTGGAGT GTCCTGTACC 
CCTCTAACAG ATGGGGTCAT CAGACTTGCA GGTGGGAAAG GCAGCCATGA GGGTCGCTTG 
GAGGTATATT ACAGAGGCCA GTGGGGAACT GTCTGTGATG ATGGCTGGAC TGAGCTGAAT 
ACATACGTGG TTTGTCGACA ATTGGGATTT AAATATGGTA AACAAGCATC TGCCAACCAT 
TTTGAAGAAA GCACAGGGCC CATATGGTTG GATGACGTCA GCTGCTCAGG AAAGGAAACC 
AGATTTCTTC AGTGTTCCAG GCGACAGTGG GGAAGGCATG ACTGCAGCCA CCGCGAAGAT 
GTTAGCATTG CCTGCTACCC TGGCGGCGAG GGACACAGGC TCTCTCTGGG TTTTCCTGTC 
AGACTGATGG ATGGAGAAAA TAAGAAAGAA GGACGAGTGG AGGTTTTTAT CAATGGCCAG 
TGGGGAACAA TCTGTGATGA TGGATGGACT GATAAGGATG CAGCTGTGAT CTGTCGTCAG 
CTTGGCTACA AGGGTCCTGC CAGAGCAAGA ACCATGGCTT ACTTTGGAGA AGGAAAAGGA 
CCCATCCATG TGGATAATGT GAAGTGCACA GGAAATGAGA GGTCCTTGGC TGACTGTATC 
AAGCAAGATA TTGGAAGACA CAACTGCCGC CACAGTGAAG ATGCAGGAGT TATTTGTGAT 
TATTTTGGCA AGAAGGCCTC AGGTAACAGT AATAAAGAGT CCCTCTCATC TGTTTGTGGC 
TTGAGATTAC TGCACCGTCG GCAGAAGCGG ATCATTGGTG GGAAAAATTC TTTAAGGGGT 
GGTTGGCCTT GGCAGGTTTC CCTCCGGCTG AAGTCATCCC ATGGAGATGG CAGGCTCCTC 
TGCGGGGCTA CGCTCCTGAG TAGCTGCTGG GTCCTCACAG CAGCACACTG TTTCAAGAGG 
TATGGCAACA GCACTAGGAG CTATGCTGTT AGGGTTGGAG ATTATCATAC TCTGGTACCA 
GAGGAGTTTG AGGAAGAAAT TGGAGTTCAA CAGATTGTGA TTCATCGGGA GTATCGACCC 
GACCGCAGTG ATTATGACAT AGCCCTGGTT AGATTACAAG GACCAGAAGA GCAATGTGCC 
AGATTCAGCA GCCATGTTTT GCCAGCCTGT TTACCACTCT GGAGAGAGAG GCCACAGAAA 
ACAGCATCCA ACTGTTACAT AACAGGATGG GGTGACACAG GACGAGCCTA TTCAAGAACA 
CTACAACAAG CAGCCATTCC CTTACTTCCT AAAAGGTTTT GTGAAGAACG TTATAAGGGT 
CGGTTTACAG GGAGAATGCT TTGTGCTGGA AACCTCCATG AACACAAACG CGTGGACAGC 
TGCCAGGGAG ACAGCGGAGG ACCACTCATG TGTGAACGGC CCGGAGAGAG CTGGGTGGTG 
TATGGGGTGA CCTCCTGGGG GTATGGCTGT GGAGTCAAGG ATTCTCCTGG TGTTTATACC 
AAAGTCTCAG CCTTTGTACC TTGGATAAAA AGTGTCACCA AACTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRSS12 ( NM_003619.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003610.2 Homo sapiens serine protease 12 (PRSS12), mRNA.

Price & Availability↑

CloneID	OHu21891
Clone ID Related Accession (Same CDS sequence)	NM_003619.3 , NM_003619.4
Accession Version	NM_003619.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2628bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	neurotrypsin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC096762.3, BC007761.2, BG386264.1 and AJ001531.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_003619.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AJ001531.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000296498.3/ ENSP00000296498.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACGCTCG CCCGCTTCGT GCTAGCCCTG ATGTTAGGGG CGCTCCCCGA AGTGGTCGGC 
TTTGATTCTG TCCTCAATGA TTCCCTCCAC CACAGCCACC GCCATTCGCC CCCTGCGGGT 
CCGCACTACC CCTATTACCT TCCCACCCAG CAGCGGCCCC CGAGGACGCG TCCGCCGCCG 
CCTCTCCCGC GCTTCCCGCG CCCCCCGCGG GCGCTCCCTG CCCAGCGCCC GCACGCCCTC 
CAGGCCGGGC ACACGCCCCG GCCGCACCCC TGGGGCTGCC CCGCCGGCGA GCCATGGGTC 
AGCGTGACGG ACTTCGGCGC CCCGTGTCTG CGGTGGGCGG AGGTGCCACC CTTCCTGGAG 
CGGTCGCCCC CAGCGAGCTG GGCTCAGCTG CGAGGACAGC GCCACAACTT TTGTCGGAGC 
CCCGACGGCG CGGGCAGACC CTGGTGTTTC TACGGAGACG CCCGTGGCAA GGTGGACTGG 
GGCTACTGCG ACTGCAGACA CGGATCAGTA CGACTTCGTG GCGGCAAAAA TGAGTTTGAA 
GGCACAGTGG AAGTATATGC AAGTGGAGTT TGGGGCACTG TCTGTAGCAG CCACTGGGAT 
GATTCTGATG CATCAGTCAT TTGTCACCAG CTGCAGCTGG GAGGAAAAGG AATAGCAAAA 
CAAACCCCGT TTTCTGGACT GGGCCTTATT CCCATTTATT GGAGCAATGT CCGTTGCCGA 
GGAGATGAAG AAAATATACT GCTTTGTGAA AAAGACATCT GGCAGGGTGG GGTGTGTCCT 
CAGAAGATGG CAGCTGCTGT CACGTGTAGC TTTTCCCATG GCCCAACGTT CCCCATCATT 
CGCCTTGCTG GAGGCAGCAG TGTGCATGAA GGCCGGGTGG AGCTCTACCA TGCTGGCCAG 
TGGGGAACCG TTTGTGATGA CCAATGGGAT GATGCCGATG CAGAAGTGAT CTGCAGGCAG 
CTGGGCCTCA GTGGCATTGC CAAAGCATGG CATCAGGCAT ATTTTGGGGA AGGGTCTGGC 
CCAGTTATGT TGGATGAAGT ACGCTGCACT GGGAATGAGC TTTCAATTGA GCAGTGTCCA 
AAGAGCTCCT GGGGAGAGCA TAACTGTGGC CATAAAGAAG ATGCTGGAGT GTCCTGTACC 
CCTCTAACAG ATGGGGTCAT CAGACTTGCA GGTGGGAAAG GCAGCCATGA GGGTCGCTTG 
GAGGTATATT ACAGAGGCCA GTGGGGAACT GTCTGTGATG ATGGCTGGAC TGAGCTGAAT 
ACATACGTGG TTTGTCGACA ATTGGGATTT AAATATGGTA AACAAGCATC TGCCAACCAT 
TTTGAAGAAA GCACAGGGCC CATATGGTTG GATGACGTCA GCTGCTCAGG AAAGGAAACC 
AGATTTCTTC AGTGTTCCAG GCGACAGTGG GGAAGGCATG ACTGCAGCCA CCGCGAAGAT 
GTTAGCATTG CCTGCTACCC TGGCGGCGAG GGACACAGGC TCTCTCTGGG TTTTCCTGTC 
AGACTGATGG ATGGAGAAAA TAAGAAAGAA GGACGAGTGG AGGTTTTTAT CAATGGCCAG 
TGGGGAACAA TCTGTGATGA TGGATGGACT GATAAGGATG CAGCTGTGAT CTGTCGTCAG 
CTTGGCTACA AGGGTCCTGC CAGAGCAAGA ACCATGGCTT ACTTTGGAGA AGGAAAAGGA 
CCCATCCATG TGGATAATGT GAAGTGCACA GGAAATGAGA GGTCCTTGGC TGACTGTATC 
AAGCAAGATA TTGGAAGACA CAACTGCCGC CACAGTGAAG ATGCAGGAGT TATTTGTGAT 
TATTTTGGCA AGAAGGCCTC AGGTAACAGT AATAAAGAGT CCCTCTCATC TGTTTGTGGC 
TTGAGATTAC TGCACCGTCG GCAGAAGCGG ATCATTGGTG GGAAAAATTC TTTAAGGGGT 
GGTTGGCCTT GGCAGGTTTC CCTCCGGCTG AAGTCATCCC ATGGAGATGG CAGGCTCCTC 
TGCGGGGCTA CGCTCCTGAG TAGCTGCTGG GTCCTCACAG CAGCACACTG TTTCAAGAGG 
TATGGCAACA GCACTAGGAG CTATGCTGTT AGGGTTGGAG ATTATCATAC TCTGGTACCA 
GAGGAGTTTG AGGAAGAAAT TGGAGTTCAA CAGATTGTGA TTCATCGGGA GTATCGACCC 
GACCGCAGTG ATTATGACAT AGCCCTGGTT AGATTACAAG GACCAGAAGA GCAATGTGCC 
AGATTCAGCA GCCATGTTTT GCCAGCCTGT TTACCACTCT GGAGAGAGAG GCCACAGAAA 
ACAGCATCCA ACTGTTACAT AACAGGATGG GGTGACACAG GACGAGCCTA TTCAAGAACA 
CTACAACAAG CAGCCATTCC CTTACTTCCT AAAAGGTTTT GTGAAGAACG TTATAAGGGT 
CGGTTTACAG GGAGAATGCT TTGTGCTGGA AACCTCCATG AACACAAACG CGTGGACAGC 
TGCCAGGGAG ACAGCGGAGG ACCACTCATG TGTGAACGGC CCGGAGAGAG CTGGGTGGTG 
TATGGGGTGA CCTCCTGGGG GTATGGCTGT GGAGTCAAGG ATTCTCCTGG TGTTTATACC 
AAAGTCTCAG CCTTTGTACC TTGGATAAAA AGTGTCACCA AACTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003610.2
CDS	284..2911
Translation	MTLARFVLALMLGALPEVVGFDSVLNDSLHHSHRHSPPAGPHYPYYLPTQQRPPRTRPPPPLPRFPRPPRALPAQRPHALQAGHTPRPHPWGCPAGEPWVSVTDFGAPCLRWAEVPPFLERSPPASWAQLRGQRHNFCRSPDGAGRPWCFYGDARGKVDWGYCDCRHGSVRLRGGKNEFEGTVEVYASGVWGTVCSSHWDDSDASVICHQLQLGGKGIAKQTPFSGLGLIPIYWSNVRCRGDEENILLCEKDIWQGGVCPQKMAAAVTCSFSHGPTFPIIRLAGGSSVHEGRVELYHAGQWGTVCDDQWDDADAEVICRQLGLSGIAKAWHQAYFGEGSGPVMLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSCTPLTDGVIRLAGGKGSHEGRLEVYYRGQWGTVCDDGWTELNTYVVCRQLGFKYGKQASANHFEESTGPIWLDDVSCSGKETRFLQCSRRQWGRHDCSHREDVSIACYPGGEGHRLSLGFPVRLMDGENKKEGRVEVFINGQWGTICDDGWTDKDAAVICRQLGYKGPARARTMAYFGEGKGPIHVDNVKCTGNERSLADCIKQDIGRHNCRHSEDAGVICDYFGKKASGNSNKESLSSVCGLRLLHRRQKRIIGGKNSLRGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVLTAAHCFKRYGNSTRSYAVRVGDYHTLVPEEFEEEIGVQQIVIHREYRPDRSDYDIALVRLQGPEEQCARFSSHVLPACLPLWRERPQKTASNCYITGWGDTGRAYSRTLQQAAIPLLPKRFCEERYKGRFTGRMLCAGNLHEHKRVDSCQGDSGGPLMCERPGESWVVYGVTSWGYGCGVKDSPGVYTKVSAFVPWIKSVTKL

Target ORF information:

RefSeq Version	NM_003619.4
Organism	Homo sapiens(human)
Definition	Homo sapiens serine protease 12 (PRSS12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003619.4

ORF Insert Sequence:

ATGACGCTCG CCCGCTTCGT GCTAGCCCTG ATGTTAGGGG CGCTCCCCGA AGTGGTCGGC 
TTTGATTCTG TCCTCAATGA TTCCCTCCAC CACAGCCACC GCCATTCGCC CCCTGCGGGT 
CCGCACTACC CCTATTACCT TCCCACCCAG CAGCGGCCCC CGAGGACGCG TCCGCCGCCG 
CCTCTCCCGC GCTTCCCGCG CCCCCCGCGG GCGCTCCCTG CCCAGCGCCC GCACGCCCTC 
CAGGCCGGGC ACACGCCCCG GCCGCACCCC TGGGGCTGCC CCGCCGGCGA GCCATGGGTC 
AGCGTGACGG ACTTCGGCGC CCCGTGTCTG CGGTGGGCGG AGGTGCCACC CTTCCTGGAG 
CGGTCGCCCC CAGCGAGCTG GGCTCAGCTG CGAGGACAGC GCCACAACTT TTGTCGGAGC 
CCCGACGGCG CGGGCAGACC CTGGTGTTTC TACGGAGACG CCCGTGGCAA GGTGGACTGG 
GGCTACTGCG ACTGCAGACA CGGATCAGTA CGACTTCGTG GCGGCAAAAA TGAGTTTGAA 
GGCACAGTGG AAGTATATGC AAGTGGAGTT TGGGGCACTG TCTGTAGCAG CCACTGGGAT 
GATTCTGATG CATCAGTCAT TTGTCACCAG CTGCAGCTGG GAGGAAAAGG AATAGCAAAA 
CAAACCCCGT TTTCTGGACT GGGCCTTATT CCCATTTATT GGAGCAATGT CCGTTGCCGA 
GGAGATGAAG AAAATATACT GCTTTGTGAA AAAGACATCT GGCAGGGTGG GGTGTGTCCT 
CAGAAGATGG CAGCTGCTGT CACGTGTAGC TTTTCCCATG GCCCAACGTT CCCCATCATT 
CGCCTTGCTG GAGGCAGCAG TGTGCATGAA GGCCGGGTGG AGCTCTACCA TGCTGGCCAG 
TGGGGAACCG TTTGTGATGA CCAATGGGAT GATGCCGATG CAGAAGTGAT CTGCAGGCAG 
CTGGGCCTCA GTGGCATTGC CAAAGCATGG CATCAGGCAT ATTTTGGGGA AGGGTCTGGC 
CCAGTTATGT TGGATGAAGT ACGCTGCACT GGGAATGAGC TTTCAATTGA GCAGTGTCCA 
AAGAGCTCCT GGGGAGAGCA TAACTGTGGC CATAAAGAAG ATGCTGGAGT GTCCTGTACC 
CCTCTAACAG ATGGGGTCAT CAGACTTGCA GGTGGGAAAG GCAGCCATGA GGGTCGCTTG 
GAGGTATATT ACAGAGGCCA GTGGGGAACT GTCTGTGATG ATGGCTGGAC TGAGCTGAAT 
ACATACGTGG TTTGTCGACA ATTGGGATTT AAATATGGTA AACAAGCATC TGCCAACCAT 
TTTGAAGAAA GCACAGGGCC CATATGGTTG GATGACGTCA GCTGCTCAGG AAAGGAAACC 
AGATTTCTTC AGTGTTCCAG GCGACAGTGG GGAAGGCATG ACTGCAGCCA CCGCGAAGAT 
GTTAGCATTG CCTGCTACCC TGGCGGCGAG GGACACAGGC TCTCTCTGGG TTTTCCTGTC 
AGACTGATGG ATGGAGAAAA TAAGAAAGAA GGACGAGTGG AGGTTTTTAT CAATGGCCAG 
TGGGGAACAA TCTGTGATGA TGGATGGACT GATAAGGATG CAGCTGTGAT CTGTCGTCAG 
CTTGGCTACA AGGGTCCTGC CAGAGCAAGA ACCATGGCTT ACTTTGGAGA AGGAAAAGGA 
CCCATCCATG TGGATAATGT GAAGTGCACA GGAAATGAGA GGTCCTTGGC TGACTGTATC 
AAGCAAGATA TTGGAAGACA CAACTGCCGC CACAGTGAAG ATGCAGGAGT TATTTGTGAT 
TATTTTGGCA AGAAGGCCTC AGGTAACAGT AATAAAGAGT CCCTCTCATC TGTTTGTGGC 
TTGAGATTAC TGCACCGTCG GCAGAAGCGG ATCATTGGTG GGAAAAATTC TTTAAGGGGT 
GGTTGGCCTT GGCAGGTTTC CCTCCGGCTG AAGTCATCCC ATGGAGATGG CAGGCTCCTC 
TGCGGGGCTA CGCTCCTGAG TAGCTGCTGG GTCCTCACAG CAGCACACTG TTTCAAGAGG 
TATGGCAACA GCACTAGGAG CTATGCTGTT AGGGTTGGAG ATTATCATAC TCTGGTACCA 
GAGGAGTTTG AGGAAGAAAT TGGAGTTCAA CAGATTGTGA TTCATCGGGA GTATCGACCC 
GACCGCAGTG ATTATGACAT AGCCCTGGTT AGATTACAAG GACCAGAAGA GCAATGTGCC 
AGATTCAGCA GCCATGTTTT GCCAGCCTGT TTACCACTCT GGAGAGAGAG GCCACAGAAA 
ACAGCATCCA ACTGTTACAT AACAGGATGG GGTGACACAG GACGAGCCTA TTCAAGAACA 
CTACAACAAG CAGCCATTCC CTTACTTCCT AAAAGGTTTT GTGAAGAACG TTATAAGGGT 
CGGTTTACAG GGAGAATGCT TTGTGCTGGA AACCTCCATG AACACAAACG CGTGGACAGC 
TGCCAGGGAG ACAGCGGAGG ACCACTCATG TGTGAACGGC CCGGAGAGAG CTGGGTGGTG 
TATGGGGTGA CCTCCTGGGG GTATGGCTGT GGAGTCAAGG ATTCTCCTGG TGTTTATACC 
AAAGTCTCAG CCTTTGTACC TTGGATAAAA AGTGTCACCA AACTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRSS12 ( XM_005263318.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005263375.1 Homo sapiens serine protease 12 (PRSS12), transcript variant X2, mRNA.

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CloneID	OHu39192
Clone ID Related Accession (Same CDS sequence)	XM_005263318.4
Accession Version	XM_005263318.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1668bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	neurotrypsin isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005263318.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACGCTCG CCCGCTTCGT GCTAGCCCTG ATGTTAGGGG CGCTCCCCGA AGTGGTCGGC 
TTTGATTCTG TCCTCAATGA TTCCCTCCAC CACAGCCACC GCCATTCGCC CCCTGCGGGT 
CCGCACTACC CCTATTACCT TCCCACCCAG CAGCGGCCCC CGAGGACGCG TCCGCCGCCG 
CCTCTCCCGC GCTTCCCGCG CCCCCCGCGG GCGCTCCCTG CCCAGCGCCC GCACGCCCTC 
CAGGCCGGGC ACACGCCCCG GCCGCACCCC TGGGGCTGCC CCGCCGGCGA GCCATGGGTC 
AGCGTGACGG ACTTCGGCGC CCCGTGTCTG CGGTGGGCGG AGGTGCCACC CTTCCTGGAG 
CGGTCGCCCC CAGCGAGCTG GGCTCAGCTG CGAGGACAGC GCCACAACTT TTGTCGGAGC 
CCCGACGGCG CGGGCAGACC CTGGTGTTTC TACGGAGACG CCCGTGGCAA GGTGGACTGG 
GGCTACTGCG ACTGCAGACA CGGATCAGTA CGACTTCGTG GCGGCAAAAA TGAGTTTGAA 
GGCACAGTGG AAGTATATGC AAGTGGAGTT TGGGGCACTG TCTGTAGCAG CCACTGGGAT 
GATTCTGATG CATCAGTCAT TTGTCACCAG CTGCAGCTGG GAGGAAAAGG AATAGCAAAA 
CAAACCCCGT TTTCTGGACT GGGCCTTATT CCCATTTATT GGAGCAATGT CCGTTGCCGA 
GGAGATGAAG AAAATATACT GCTTTGTGAA AAAGACATCT GGCAGGGTGG GGTGTGTCCT 
CAGAAGATGG CAGCTGCTGT CACGTGTAGC TTTTCCCATG GCCCAACGTT CCCCATCATT 
CGCCTTGCTG GAGGCAGCAG TGTGCATGAA GGCCGGGTGG AGCTCTACCA TGCTGGCCAG 
TGGGGAACCG TTTGTGATGA CCAATGGGAT GATGCCGATG CAGAAGTGAT CTGCAGGCAG 
CTGGGCCTCA GTGGCATTGC CAAAGCATGG CATCAGGCAT ATTTTGGGGA AGGGTCTGGC 
CCAGTTATGT TGGATGAAGT ACGCTGCACT GGGAATGAGC TTTCAATTGA GCAGTGTCCA 
AAGAGCTCCT GGGGAGAGCA TAACTGTGGC CATAAAGAAG ATGCTGGAGT GTCCTGTACC 
CCTCTAACAG ATGGGGTCAT CAGACTTGCA GGTGGGAAAG GCAGCCATGA GGGTCGCTTG 
GAGGTATATT ACAGAGGCCA GTGGGGAACT GTCTGTGATG ATGGCTGGAC TGAGCTGAAT 
ACATACGTGG TTTGTCGACA ATTGGGATTT AAATATGGTA AACAAGCATC TGCCAACCAT 
TTTGAAGAAA GCACAGGGCC CATATGGTTG GATGACGTCA GCTGCTCAGG AAAGGAAACC 
AGATTTCTTC AGTGTTCCAG GCGACAGTGG GGAAGGCATG ACTGCAGCCA CCGCGAAGAT 
GTTAGCATTG CCTGCTACCC TGGCGGCGAG GGACACAGGC TCTCTCTGGG TTTTCCTGTC 
AGACTGATGG ATGGAGAAAA TAAGAAAGAA GGACGAGTGG AGGTTTTTAT CAATGGCCAG 
TGGGGAACAA TCTGTGATGA TGGATGGACT GATAAGGATG CAGCTGTGAT CTGTCGTCAG 
CTTGGCTACA ACATTATTTG CAATAGCCAA GATGTGGAAA CAGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005263375.1
CDS	321..1988
Translation	MTLARFVLALMLGALPEVVGFDSVLNDSLHHSHRHSPPAGPHYPYYLPTQQRPPRTRPPPPLPRFPRPPRALPAQRPHALQAGHTPRPHPWGCPAGEPWVSVTDFGAPCLRWAEVPPFLERSPPASWAQLRGQRHNFCRSPDGAGRPWCFYGDARGKVDWGYCDCRHGSVRLRGGKNEFEGTVEVYASGVWGTVCSSHWDDSDASVICHQLQLGGKGIAKQTPFSGLGLIPIYWSNVRCRGDEENILLCEKDIWQGGVCPQKMAAAVTCSFSHGPTFPIIRLAGGSSVHEGRVELYHAGQWGTVCDDQWDDADAEVICRQLGLSGIAKAWHQAYFGEGSGPVMLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSCTPLTDGVIRLAGGKGSHEGRLEVYYRGQWGTVCDDGWTELNTYVVCRQLGFKYGKQASANHFEESTGPIWLDDVSCSGKETRFLQCSRRQWGRHDCSHREDVSIACYPGGEGHRLSLGFPVRLMDGENKKEGRVEVFINGQWGTICDDGWTDKDAAVICRQLGYNIICNSQDVETA

Target ORF information:

RefSeq Version	XM_005263318.4
Organism	Homo sapiens(human)
Definition	Homo sapiens serine protease 12 (PRSS12), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005263318.4

ORF Insert Sequence:

ATGACGCTCG CCCGCTTCGT GCTAGCCCTG ATGTTAGGGG CGCTCCCCGA AGTGGTCGGC 
TTTGATTCTG TCCTCAATGA TTCCCTCCAC CACAGCCACC GCCATTCGCC CCCTGCGGGT 
CCGCACTACC CCTATTACCT TCCCACCCAG CAGCGGCCCC CGAGGACGCG TCCGCCGCCG 
CCTCTCCCGC GCTTCCCGCG CCCCCCGCGG GCGCTCCCTG CCCAGCGCCC GCACGCCCTC 
CAGGCCGGGC ACACGCCCCG GCCGCACCCC TGGGGCTGCC CCGCCGGCGA GCCATGGGTC 
AGCGTGACGG ACTTCGGCGC CCCGTGTCTG CGGTGGGCGG AGGTGCCACC CTTCCTGGAG 
CGGTCGCCCC CAGCGAGCTG GGCTCAGCTG CGAGGACAGC GCCACAACTT TTGTCGGAGC 
CCCGACGGCG CGGGCAGACC CTGGTGTTTC TACGGAGACG CCCGTGGCAA GGTGGACTGG 
GGCTACTGCG ACTGCAGACA CGGATCAGTA CGACTTCGTG GCGGCAAAAA TGAGTTTGAA 
GGCACAGTGG AAGTATATGC AAGTGGAGTT TGGGGCACTG TCTGTAGCAG CCACTGGGAT 
GATTCTGATG CATCAGTCAT TTGTCACCAG CTGCAGCTGG GAGGAAAAGG AATAGCAAAA 
CAAACCCCGT TTTCTGGACT GGGCCTTATT CCCATTTATT GGAGCAATGT CCGTTGCCGA 
GGAGATGAAG AAAATATACT GCTTTGTGAA AAAGACATCT GGCAGGGTGG GGTGTGTCCT 
CAGAAGATGG CAGCTGCTGT CACGTGTAGC TTTTCCCATG GCCCAACGTT CCCCATCATT 
CGCCTTGCTG GAGGCAGCAG TGTGCATGAA GGCCGGGTGG AGCTCTACCA TGCTGGCCAG 
TGGGGAACCG TTTGTGATGA CCAATGGGAT GATGCCGATG CAGAAGTGAT CTGCAGGCAG 
CTGGGCCTCA GTGGCATTGC CAAAGCATGG CATCAGGCAT ATTTTGGGGA AGGGTCTGGC 
CCAGTTATGT TGGATGAAGT ACGCTGCACT GGGAATGAGC TTTCAATTGA GCAGTGTCCA 
AAGAGCTCCT GGGGAGAGCA TAACTGTGGC CATAAAGAAG ATGCTGGAGT GTCCTGTACC 
CCTCTAACAG ATGGGGTCAT CAGACTTGCA GGTGGGAAAG GCAGCCATGA GGGTCGCTTG 
GAGGTATATT ACAGAGGCCA GTGGGGAACT GTCTGTGATG ATGGCTGGAC TGAGCTGAAT 
ACATACGTGG TTTGTCGACA ATTGGGATTT AAATATGGTA AACAAGCATC TGCCAACCAT 
TTTGAAGAAA GCACAGGGCC CATATGGTTG GATGACGTCA GCTGCTCAGG AAAGGAAACC 
AGATTTCTTC AGTGTTCCAG GCGACAGTGG GGAAGGCATG ACTGCAGCCA CCGCGAAGAT 
GTTAGCATTG CCTGCTACCC TGGCGGCGAG GGACACAGGC TCTCTCTGGG TTTTCCTGTC 
AGACTGATGG ATGGAGAAAA TAAGAAAGAA GGACGAGTGG AGGTTTTTAT CAATGGCCAG 
TGGGGAACAA TCTGTGATGA TGGATGGACT GATAAGGATG CAGCTGTGAT CTGTCGTCAG 
CTTGGCTACA ACATTATTTG CAATAGCCAA GATGTGGAAA CAGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRSS12 ( XM_011532387.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011530689.1 Homo sapiens serine protease 12 (PRSS12), transcript variant X1, mRNA.

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CloneID	OHu61846
Clone ID Related Accession (Same CDS sequence)	XM_011532387.2
Accession Version	XM_011532387.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1722bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	neurotrypsin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011532387.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACGCTCG CCCGCTTCGT GCTAGCCCTG ATGTTAGGGG CGCTCCCCGA AGTGGTCGGC 
TTTGATTCTG TCCTCAATGA TTCCCTCCAC CACAGCCACC GCCATTCGCC CCCTGCGGGT 
CCGCACTACC CCTATTACCT TCCCACCCAG CAGCGGCCCC CGAGGACGCG TCCGCCGCCG 
CCTCTCCCGC GCTTCCCGCG CCCCCCGCGG GCGCTCCCTG CCCAGCGCCC GCACGCCCTC 
CAGGCCGGGC ACACGCCCCG GCCGCACCCC TGGGGCTGCC CCGCCGGCGA GCCATGGGTC 
AGCGTGACGG ACTTCGGCGC CCCGTGTCTG CGGTGGGCGG AGGTGCCACC CTTCCTGGAG 
CGGTCGCCCC CAGCGAGCTG GGCTCAGCTG CGAGGACAGC GCCACAACTT TTGTCGGAGC 
CCCGACGGCG CGGGCAGACC CTGGTGTTTC TACGGAGACG CCCGTGGCAA GGTGGACTGG 
GGCTACTGCG ACTGCAGACA CGGATCAGTA CGACTTCGTG GCGGCAAAAA TGAGTTTGAA 
GGCACAGTGG AAGTATATGC AAGTGGAGTT TGGGGCACTG TCTGTAGCAG CCACTGGGAT 
GATTCTGATG CATCAGTCAT TTGTCACCAG CTGCAGCTGG GAGGAAAAGG AATAGCAAAA 
CAAACCCCGT TTTCTGGACT GGGCCTTATT CCCATTTATT GGAGCAATGT CCGTTGCCGA 
GGAGATGAAG AAAATATACT GCTTTGTGAA AAAGACATCT GGCAGGGTGG GGTGTGTCCT 
CAGAAGATGG CAGCTGCTGT CACGTGTAGC TTTTCCCATG GCCCAACGTT CCCCATCATT 
CGCCTTGCTG GAGGCAGCAG TGTGCATGAA GGCCGGGTGG AGCTCTACCA TGCTGGCCAG 
TGGGGAACCG TTTGTGATGA CCAATGGGAT GATGCCGATG CAGAAGTGAT CTGCAGGCAG 
CTGGGCCTCA GTGGCATTGC CAAAGCATGG CATCAGGCAT ATTTTGGGGA AGGGTCTGGC 
CCAGTTATGT TGGATGAAGT ACGCTGCACT GGGAATGAGC TTTCAATTGA GCAGTGTCCA 
AAGAGCTCCT GGGGAGAGCA TAACTGTGGC CATAAAGAAG ATGCTGGAGT GTCCTGTACC 
CCTCTAACAG ATGGGGTCAT CAGACTTGCA GGTGGGAAAG GCAGCCATGA GGGTCGCTTG 
GAGGTATATT ACAGAGGCCA GTGGGGAACT GTCTGTGATG ATGGCTGGAC TGAGCTGAAT 
ACATACGTGG TTTGTCGACA ATTGGGATTT AAATATGGTA AACAAGCATC TGCCAACCAT 
TTTGAAGAAA GCACAGGGCC CATATGGTTG GATGACGTCA GCTGCTCAGG AAAGGAAACC 
AGATTTCTTC AGTGTTCCAG GCGACAGTGG GGAAGGCATG ACTGCAGCCA CCGCGAAGAT 
GTTAGCATTG CCTGCTACCC TGGCGGCGAG GGACACAGGC TCTCTCTGGG TTTTCCTGTC 
AGACTGATGG ATGGAGAAAA TAAGAAAGAA GGACGAGTGG AGGTTTTTAT CAATGGCCAG 
TGGGGAACAA TCTGTGATGA TGGATGGACT GATAAGGATG CAGCTGTGAT CTGTCGTCAG 
CTTGGCTACA AAGGCTTTCA AACTTTGGAG GAATGCACTG CGGTAGGATT TGGAGTGAGT 
GCAAGATATG CTTTTTGTGA AGTGAGAGAA GAGAAATTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011530689.1
CDS	323..2044
Translation	MTLARFVLALMLGALPEVVGFDSVLNDSLHHSHRHSPPAGPHYPYYLPTQQRPPRTRPPPPLPRFPRPPRALPAQRPHALQAGHTPRPHPWGCPAGEPWVSVTDFGAPCLRWAEVPPFLERSPPASWAQLRGQRHNFCRSPDGAGRPWCFYGDARGKVDWGYCDCRHGSVRLRGGKNEFEGTVEVYASGVWGTVCSSHWDDSDASVICHQLQLGGKGIAKQTPFSGLGLIPIYWSNVRCRGDEENILLCEKDIWQGGVCPQKMAAAVTCSFSHGPTFPIIRLAGGSSVHEGRVELYHAGQWGTVCDDQWDDADAEVICRQLGLSGIAKAWHQAYFGEGSGPVMLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSCTPLTDGVIRLAGGKGSHEGRLEVYYRGQWGTVCDDGWTELNTYVVCRQLGFKYGKQASANHFEESTGPIWLDDVSCSGKETRFLQCSRRQWGRHDCSHREDVSIACYPGGEGHRLSLGFPVRLMDGENKKEGRVEVFINGQWGTICDDGWTDKDAAVICRQLGYKGFQTLEECTAVGFGVSARYAFCEVREEKF

Target ORF information:

RefSeq Version	XM_011532387.2
Organism	Homo sapiens(human)
Definition	Homo sapiens serine protease 12 (PRSS12), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011532387.2

ORF Insert Sequence:

ATGACGCTCG CCCGCTTCGT GCTAGCCCTG ATGTTAGGGG CGCTCCCCGA AGTGGTCGGC 
TTTGATTCTG TCCTCAATGA TTCCCTCCAC CACAGCCACC GCCATTCGCC CCCTGCGGGT 
CCGCACTACC CCTATTACCT TCCCACCCAG CAGCGGCCCC CGAGGACGCG TCCGCCGCCG 
CCTCTCCCGC GCTTCCCGCG CCCCCCGCGG GCGCTCCCTG CCCAGCGCCC GCACGCCCTC 
CAGGCCGGGC ACACGCCCCG GCCGCACCCC TGGGGCTGCC CCGCCGGCGA GCCATGGGTC 
AGCGTGACGG ACTTCGGCGC CCCGTGTCTG CGGTGGGCGG AGGTGCCACC CTTCCTGGAG 
CGGTCGCCCC CAGCGAGCTG GGCTCAGCTG CGAGGACAGC GCCACAACTT TTGTCGGAGC 
CCCGACGGCG CGGGCAGACC CTGGTGTTTC TACGGAGACG CCCGTGGCAA GGTGGACTGG 
GGCTACTGCG ACTGCAGACA CGGATCAGTA CGACTTCGTG GCGGCAAAAA TGAGTTTGAA 
GGCACAGTGG AAGTATATGC AAGTGGAGTT TGGGGCACTG TCTGTAGCAG CCACTGGGAT 
GATTCTGATG CATCAGTCAT TTGTCACCAG CTGCAGCTGG GAGGAAAAGG AATAGCAAAA 
CAAACCCCGT TTTCTGGACT GGGCCTTATT CCCATTTATT GGAGCAATGT CCGTTGCCGA 
GGAGATGAAG AAAATATACT GCTTTGTGAA AAAGACATCT GGCAGGGTGG GGTGTGTCCT 
CAGAAGATGG CAGCTGCTGT CACGTGTAGC TTTTCCCATG GCCCAACGTT CCCCATCATT 
CGCCTTGCTG GAGGCAGCAG TGTGCATGAA GGCCGGGTGG AGCTCTACCA TGCTGGCCAG 
TGGGGAACCG TTTGTGATGA CCAATGGGAT GATGCCGATG CAGAAGTGAT CTGCAGGCAG 
CTGGGCCTCA GTGGCATTGC CAAAGCATGG CATCAGGCAT ATTTTGGGGA AGGGTCTGGC 
CCAGTTATGT TGGATGAAGT ACGCTGCACT GGGAATGAGC TTTCAATTGA GCAGTGTCCA 
AAGAGCTCCT GGGGAGAGCA TAACTGTGGC CATAAAGAAG ATGCTGGAGT GTCCTGTACC 
CCTCTAACAG ATGGGGTCAT CAGACTTGCA GGTGGGAAAG GCAGCCATGA GGGTCGCTTG 
GAGGTATATT ACAGAGGCCA GTGGGGAACT GTCTGTGATG ATGGCTGGAC TGAGCTGAAT 
ACATACGTGG TTTGTCGACA ATTGGGATTT AAATATGGTA AACAAGCATC TGCCAACCAT 
TTTGAAGAAA GCACAGGGCC CATATGGTTG GATGACGTCA GCTGCTCAGG AAAGGAAACC 
AGATTTCTTC AGTGTTCCAG GCGACAGTGG GGAAGGCATG ACTGCAGCCA CCGCGAAGAT 
GTTAGCATTG CCTGCTACCC TGGCGGCGAG GGACACAGGC TCTCTCTGGG TTTTCCTGTC 
AGACTGATGG ATGGAGAAAA TAAGAAAGAA GGACGAGTGG AGGTTTTTAT CAATGGCCAG 
TGGGGAACAA TCTGTGATGA TGGATGGACT GATAAGGATG CAGCTGTGAT CTGTCGTCAG 
CTTGGCTACA AAGGCTTTCA AACTTTGGAG GAATGCACTG CGGTAGGATT TGGAGTGAGT 
GCAAGATATG CTTTTTGTGA AGTGAGAGAA GAGAAATTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
Human molecular genetics19(12)2497-506(2010 Jun)
Kalsi G,Kuo PH,Aliev F,Alexander J,McMichael O,Patterson DG,Walsh D,Zhao Z,Schuckit M,Nurnberger J Jr,Edenberg H,Kramer J,Hesselbrock V,Tischfield JA,Vladimirov V,Prescott CA,Dick DM,Kendler KS,Riley BP

Truncating neurotrypsin mutation in autosomal recessive nonsyndromic mental retardation.
Science (New York, N.Y.)298(5599)1779-81(2002 Nov)
Molinari F,Rio M,Meskenaite V,Encha-Razavi F,Aug? J,Bacq D,Briault S,Vekemans M,Munnich A,Atti?-Bitach T,Sonderegger P,Colleaux L

Cloning and structural analysis of leydin, a novel human serine protease expressed by the Leydig cells of the testis.
European journal of biochemistry261(1)244-50(1999 Apr)
Poorafshar M,Hellman L

Assignment of the gene encoding the neuronal multidomain serine protease neurotrypsin (PRSS12) to human chromosome band 4q25-->q26 by in situ hybridization.
Cytogenetics and cell genetics84(1-2)107-8(1999)
Kozlov SV,Riegel M,Kinter J,Hintsch G,Cinelli P,Schinzel A,Sonderegger P

Cloning and sequencing of the cDNA encoding human neurotrypsin.
Biochimica et biophysica acta1396(2)143-7(1998 Mar)
Proba K,Gschwend TP,Sonderegger P

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PRSS12 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

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