ATOH8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ATOH8
Entrez Gene ID	84913
Full Name	atonal bHLH transcription factor 8
Synonyms	HATH6,bHLHa21
General protein information	Preferred Names atonal bHLH transcription factor 8 Names protein atonal homolog 8 atonal homolog 6 atonal homolog 8 atonal homolog bHLH transcription factor 8 basic helix loop helix transcription factor 6 class A basic helix-loop-helix protein 21 helix-loop-helix protein hATH-6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p11.2

mRNA and Protein(s)

mRNA	Protein	Name
NM_032827.6	NP_116216.2	protein atonal homolog 8
NM_032827.7	NP_116216.2	protein atonal homolog 8
XM_011533139.1	XP_011531441.1	protein atonal homolog 8 isoform X1
XM_006712122.3	XP_006712185.1	protein atonal homolog 8 isoform X2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Atoh8	NP_722473.1
Homo sapiens (human)	ATOH8	NP_116216.2
Xenopus tropicalis (tropical clawed frog)	atoh8	XP_002937330.2
Pan troglodytes (chimpanzee)	ATOH8	XP_001168598.1
Bos taurus (cattle)	ATOH8	NP_001180033.1
Rattus norvegicus (Norway rat)	Atoh8	NP_001102711.1

Gene Ontology
Bibliography

Related articles in PubMed

High expression of atonal homolog 8 predicts a poor clinical outcome in patients with colorectal cancer and contributes to tumor progression.
Ye M, He Y, Lin H, Yang S, Zhou Y, Zhou L, Zhong J, Lu G, Zheng J, Xue ZX, Cai ZZ
Oncology reports37(5)2955-2963(2017 May)

MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease.
Hartmann D, Fiedler J, Sonnenschein K, Just A, Pfanne A, Zimmer K, Remke J, Foinquinos A, Butzlaff M, Schimmel K, Maegdefessel L, Hilfiker-Kleiner D, Lachmann N, Schober A, Froese N, Heineke J, Bauersachs J, Batkai S, Thum T
Circulation134(24)1973-1990(2016 Dec)

Downregulation of ATOH8 induced by EBV-encoded LMP1 contributes to the malignant phenotype of nasopharyngeal carcinoma.
Wang Z, Xie J, Yan M, Wang J, Wang X, Zhang J, Zhang Y, Li P, Lei X, Huang Q, Lin S, Guo X, Liu Q
Oncotarget7(18)26765-79(2016 May)

A novel interaction between ATOH8 and PPP3CB.
Chen J, Balakrishnan-Renuka A, Hagemann N, Theiss C, Chankiewitz V, Chen J, Pu Q, Erdmann KS, Brand-Saberi B
Histochemistry and cell biology145(1)5-16(2016 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data demonstrated that ATOH8 expression was upregulated in colorectal cancer (CRC) patients, and seems to increase the malignancy potential of CRC.
Title: High expression of atonal homolog 8 predicts a poor clinical outcome in patients with colorectal cancer and contributes to tumor progression.

These findings raise the possibility that ATOH8 is a pivotal regulator in nasopharyngeal carcinoma tumorigenesis
Title: Downregulation of ATOH8 induced by EBV-encoded LMP1 contributes to the malignant phenotype of nasopharyngeal carcinoma.

calcineurin mediates the subcellular localization of ATOH8, which reveals the regulation of ATOH8 transcriptional activity by calcium signaling via calcineurin.
Title: A novel interaction between ATOH8 and PPP3CB.

ATOH8 appears to be a tumor suppressor that induces stem-cell features and chemoresistance in HCC cells.
Title: Loss of ATOH8 Increases Stem Cell Features of Hepatocellular Carcinoma Cells.

Regeneration marker ATOH8 contributes to muscle cell differentiation in healthy and diseased human muscle tissue.
Title: ATOH8: a novel marker in human muscle fiber regeneration.

The following ATOH8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ATOH8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12565	NM_032827.7 Latest version!	Homo sapiens atonal bHLH transcription factor 8 (ATOH8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
OHu35644	XM_006712122.3 Latest version!	Homo sapiens atonal bHLH transcription factor 8 (ATOH8), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
OHu73849	XM_011533139.1 Latest version!	Homo sapiens atonal bHLH transcription factor 8 (ATOH8), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
View Old Accession Versions >>
OHu12565	NM_032827.6	Homo sapiens atonal bHLH transcription factor 8 (ATOH8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ATOH8 ( NM_032827.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_116216.2 Homo sapiens atonal bHLH transcription factor 8 (ATOH8), mRNA.

Price & Availability↑

CloneID	OHu12565
Clone ID Related Accession (Same CDS sequence)	NM_032827.6 , NM_032827.7
Accession Version	NM_032827.6	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 966bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	protein atonal homolog 8
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA629171.1, BC094832.1, BM671127.1, AC012454.8 and BQ018438.1. On Apr 10, 2009 this sequence version replaced NM_032827.5. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK074681.1, BC021207.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCACA TCCCGGTCCT CGAGGACGGG CCGTGGAAGA CCGTGTGCGT GAAGGAGCTG 
AACGGCCTTA AGAAGCTCAA GCGGAAAGGC AAGGAGCCGG CGCGGCGCGC GAACGGCTAT 
AAAACTTTCC GACTGGACTT GGAAGCGCCC GAGCCCCGCG CCGTAGCCAC CAACGGGCTG 
CGGGACAGGA CCCATCGGCT GCAGCCGGTC CCGGTACCGG TGCCGGTGCC AGTCCCAGTG 
GCGCCGGCCG TTCCCCCAAG AGGGGGCACG GACACAGCCG GGGAGCGCGG GGGCTCTCGG 
GCGCCCGAGG TCTCCGACGC GCGGAAACGC TGCTTCGCCC TAGGCGCAGT GGGGCCAGGA 
CTCCCCACGC CGCCGCCGCC GCCGCCTCCT GCGCCCCAGA GCCAGGCACC TGGGGGCCCA 
GAGGCACAGC CTTTCCGGGA GCCGGGTCTG CGTCCTCGCA TCTTGCTGTG CGCACCGCCC 
GCGCGCCCCG CGCCGTCAGC ACCCCCAGCA CCGCCAGCGC CCCCGGAGTC CACTGTGCGC 
CCTGCGCCCC CGACGCGCCC CGGGGAAAGT TCCTACTCGT CAATTTCACA CGTAATTTAC 
AATAACCACC AGGATTCCTC CGCGTCGCCT AGGAAACGAC CGGGCGAAGC GACTGCCGCC 
TCCTCCGAGA TCAAAGCCCT GCAGCAGACC CGGAGGCTCC TGGCGAACGC CAGGGAGCGG 
ACGCGGGTGC ACACCATCAG CGCAGCCTTC GAGGCGCTCA GGAAGCAGGT GCCGTGCTAC 
TCATATGGGC AGAAGCTGTC CAAACTGGCC ATCCTGAGGA TCGCCTGTAA CTACATCCTG 
TCCCTGGCGC GGCTGGCTGA CCTTGACTAC AGTGCCGACC ACAGCAACCT CAGCTTCTCC 
GAGTGTGTGC AGCGCTGCAC CCGCACCCTG CAGGCCGAGG GACGTGCCAA GAAGCGCAAG 
GAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_116216.2
CDS	405..1370
Translation	MKHIPVLEDGPWKTVCVKELNGLKKLKRKGKEPARRANGYKTFRLDLEAPEPRAVATNGLRDRTHRLQPVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGLPTPPPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAPPESTVRPAPPTRPGESSYSSISHVIYNNHQDSSASPRKRPGEATAASSEIKALQQTRRLLANARERTRVHTISAAFEALRKQVPCYSYGQKLSKLAILRIACNYILSLARLADLDYSADHSNLSFSECVQRCTRTLQAEGRAKKRKE

Target ORF information:

RefSeq Version	NM_032827.6
Organism	Homo sapiens(human)
Definition	Homo sapiens atonal bHLH transcription factor 8 (ATOH8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032827.6

ORF Insert Sequence:

ATGAAGCACA TCCCGGTCCT CGAGGACGGG CCGTGGAAGA CCGTGTGCGT GAAGGAGCTG 
AACGGCCTTA AGAAGCTCAA GCGGAAAGGC AAGGAGCCGG CGCGGCGCGC GAACGGCTAT 
AAAACTTTCC GACTGGACTT GGAAGCGCCC GAGCCCCGCG CCGTAGCCAC CAACGGGCTG 
CGGGACAGGA CCCATCGGCT GCAGCCGGTC CCGGTACCGG TGCCGGTGCC AGTCCCAGTG 
GCGCCGGCCG TTCCCCCAAG AGGGGGCACG GACACAGCCG GGGAGCGCGG GGGCTCTCGG 
GCGCCCGAGG TCTCCGACGC GCGGAAACGC TGCTTCGCCC TAGGCGCAGT GGGGCCAGGA 
CTCCCCACGC CGCCGCCGCC GCCGCCTCCT GCGCCCCAGA GCCAGGCACC TGGGGGCCCA 
GAGGCACAGC CTTTCCGGGA GCCGGGTCTG CGTCCTCGCA TCTTGCTGTG CGCACCGCCC 
GCGCGCCCCG CGCCGTCAGC ACCCCCAGCA CCGCCAGCGC CCCCGGAGTC CACTGTGCGC 
CCTGCGCCCC CGACGCGCCC CGGGGAAAGT TCCTACTCGT CAATTTCACA CGTAATTTAC 
AATAACCACC AGGATTCCTC CGCGTCGCCT AGGAAACGAC CGGGCGAAGC GACTGCCGCC 
TCCTCCGAGA TCAAAGCCCT GCAGCAGACC CGGAGGCTCC TGGCGAACGC CAGGGAGCGG 
ACGCGGGTGC ACACCATCAG CGCAGCCTTC GAGGCGCTCA GGAAGCAGGT GCCGTGCTAC 
TCATATGGGC AGAAGCTGTC CAAACTGGCC ATCCTGAGGA TCGCCTGTAA CTACATCCTG 
TCCCTGGCGC GGCTGGCTGA CCTTGACTAC AGTGCCGACC ACAGCAACCT CAGCTTCTCC 
GAGTGTGTGC AGCGCTGCAC CCGCACCCTG CAGGCCGAGG GACGTGCCAA GAAGCGCAAG 
GAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATOH8 ( NM_032827.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_116216.2 Homo sapiens atonal bHLH transcription factor 8 (ATOH8), mRNA.

Price & Availability↑

CloneID	OHu12565
Clone ID Related Accession (Same CDS sequence)	NM_032827.6 , NM_032827.7
Accession Version	NM_032827.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 966bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-17
Organism	Homo sapiens(human)
Product	protein atonal homolog 8
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA629171.1, BC094832.1, BM671127.1, AC012454.8 and BQ018438.1. On Nov 22, 2018 this sequence version replaced NM_032827.6. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC021207.2, AK027614.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000306279.4/ ENSP00000304676.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGCACA TCCCGGTCCT CGAGGACGGG CCGTGGAAGA CCGTGTGCGT GAAGGAGCTG 
AACGGCCTTA AGAAGCTCAA GCGGAAAGGC AAGGAGCCGG CGCGGCGCGC GAACGGCTAT 
AAAACTTTCC GACTGGACTT GGAAGCGCCC GAGCCCCGCG CCGTAGCCAC CAACGGGCTG 
CGGGACAGGA CCCATCGGCT GCAGCCGGTC CCGGTACCGG TGCCGGTGCC AGTCCCAGTG 
GCGCCGGCCG TTCCCCCAAG AGGGGGCACG GACACAGCCG GGGAGCGCGG GGGCTCTCGG 
GCGCCCGAGG TCTCCGACGC GCGGAAACGC TGCTTCGCCC TAGGCGCAGT GGGGCCAGGA 
CTCCCCACGC CGCCGCCGCC GCCGCCTCCT GCGCCCCAGA GCCAGGCACC TGGGGGCCCA 
GAGGCACAGC CTTTCCGGGA GCCGGGTCTG CGTCCTCGCA TCTTGCTGTG CGCACCGCCC 
GCGCGCCCCG CGCCGTCAGC ACCCCCAGCA CCGCCAGCGC CCCCGGAGTC CACTGTGCGC 
CCTGCGCCCC CGACGCGCCC CGGGGAAAGT TCCTACTCGT CAATTTCACA CGTAATTTAC 
AATAACCACC AGGATTCCTC CGCGTCGCCT AGGAAACGAC CGGGCGAAGC GACTGCCGCC 
TCCTCCGAGA TCAAAGCCCT GCAGCAGACC CGGAGGCTCC TGGCGAACGC CAGGGAGCGG 
ACGCGGGTGC ACACCATCAG CGCAGCCTTC GAGGCGCTCA GGAAGCAGGT GCCGTGCTAC 
TCATATGGGC AGAAGCTGTC CAAACTGGCC ATCCTGAGGA TCGCCTGTAA CTACATCCTG 
TCCCTGGCGC GGCTGGCTGA CCTTGACTAC AGTGCCGACC ACAGCAACCT CAGCTTCTCC 
GAGTGTGTGC AGCGCTGCAC CCGCACCCTG CAGGCCGAGG GACGTGCCAA GAAGCGCAAG 
GAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_116216.2
CDS	200..1165
Translation	MKHIPVLEDGPWKTVCVKELNGLKKLKRKGKEPARRANGYKTFRLDLEAPEPRAVATNGLRDRTHRLQPVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGLPTPPPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAPPESTVRPAPPTRPGESSYSSISHVIYNNHQDSSASPRKRPGEATAASSEIKALQQTRRLLANARERTRVHTISAAFEALRKQVPCYSYGQKLSKLAILRIACNYILSLARLADLDYSADHSNLSFSECVQRCTRTLQAEGRAKKRKE

Target ORF information:

RefSeq Version	NM_032827.7
Organism	Homo sapiens(human)
Definition	Homo sapiens atonal bHLH transcription factor 8 (ATOH8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032827.7

ORF Insert Sequence:

ATGAAGCACA TCCCGGTCCT CGAGGACGGG CCGTGGAAGA CCGTGTGCGT GAAGGAGCTG 
AACGGCCTTA AGAAGCTCAA GCGGAAAGGC AAGGAGCCGG CGCGGCGCGC GAACGGCTAT 
AAAACTTTCC GACTGGACTT GGAAGCGCCC GAGCCCCGCG CCGTAGCCAC CAACGGGCTG 
CGGGACAGGA CCCATCGGCT GCAGCCGGTC CCGGTACCGG TGCCGGTGCC AGTCCCAGTG 
GCGCCGGCCG TTCCCCCAAG AGGGGGCACG GACACAGCCG GGGAGCGCGG GGGCTCTCGG 
GCGCCCGAGG TCTCCGACGC GCGGAAACGC TGCTTCGCCC TAGGCGCAGT GGGGCCAGGA 
CTCCCCACGC CGCCGCCGCC GCCGCCTCCT GCGCCCCAGA GCCAGGCACC TGGGGGCCCA 
GAGGCACAGC CTTTCCGGGA GCCGGGTCTG CGTCCTCGCA TCTTGCTGTG CGCACCGCCC 
GCGCGCCCCG CGCCGTCAGC ACCCCCAGCA CCGCCAGCGC CCCCGGAGTC CACTGTGCGC 
CCTGCGCCCC CGACGCGCCC CGGGGAAAGT TCCTACTCGT CAATTTCACA CGTAATTTAC 
AATAACCACC AGGATTCCTC CGCGTCGCCT AGGAAACGAC CGGGCGAAGC GACTGCCGCC 
TCCTCCGAGA TCAAAGCCCT GCAGCAGACC CGGAGGCTCC TGGCGAACGC CAGGGAGCGG 
ACGCGGGTGC ACACCATCAG CGCAGCCTTC GAGGCGCTCA GGAAGCAGGT GCCGTGCTAC 
TCATATGGGC AGAAGCTGTC CAAACTGGCC ATCCTGAGGA TCGCCTGTAA CTACATCCTG 
TCCCTGGCGC GGCTGGCTGA CCTTGACTAC AGTGCCGACC ACAGCAACCT CAGCTTCTCC 
GAGTGTGTGC AGCGCTGCAC CCGCACCCTG CAGGCCGAGG GACGTGCCAA GAAGCGCAAG 
GAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATOH8 ( XM_006712122.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_006712185.1 Homo sapiens atonal bHLH transcription factor 8 (ATOH8), transcript variant X4, mRNA.

Price & Availability↑

CloneID	OHu35644
Clone ID Related Accession (Same CDS sequence)	XM_006712122.3
Accession Version	XM_006712122.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 984bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	protein atonal homolog 8 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006712122.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGCACA TCCCGGTCCT CGAGGACGGG CCGTGGAAGA CCGTGTGCGT GAAGGAGCTG 
AACGGCCTTA AGAAGCTCAA GCGGAAAGGC AAGGAGCCGG CGCGGCGCGC GAACGGCTAT 
AAAACTTTCC GACTGGACTT GGAAGCGCCC GAGCCCCGCG CCGTAGCCAC CAACGGGCTG 
CGGGACAGGA CCCATCGGCT GCAGCCGGTC CCGGTACCGG TGCCGGTGCC AGTCCCAGTG 
GCGCCGGCCG TTCCCCCAAG AGGGGGCACG GACACAGCCG GGGAGCGCGG GGGCTCTCGG 
GCGCCCGAGG TCTCCGACGC GCGGAAACGC TGCTTCGCCC TAGGCGCAGT GGGGCCAGGA 
CTCCCCACGC CGCCGCCGCC GCCGCCTCCT GCGCCCCAGA GCCAGGCACC TGGGGGCCCA 
GAGGCACAGC CTTTCCGGGA GCCGGGTCTG CGTCCTCGCA TCTTGCTGTG CGCACCGCCC 
GCGCGCCCCG CGCCGTCAGC ACCCCCAGCA CCGCCAGCGC CCCCGGAGTC CACTGTGCGC 
CCTGCGCCCC CGACGCGCCC CGGGGAAAGT TCCTACTCGT CAATTTCACA CGTAATTTAC 
AATAACCACC AGGATTCCTC CGCGTCGCCT AGGAAACGAC CGGGCGAAGC GACTGCCGCC 
TCCTCCGAGA TCAAAGCCCT GCAGCAGACC CGGAGGCTCC TGGCGAACGC CAGGGAGCGG 
ACGCGGGTGC ACACCATCAG CGCAGCCTTC GAGGCGCTCA GGAAGCAGGT GCCGTGCTAC 
TCATATGGGC AGAAGCTGTC CAAACTGGCC ATCCTGAGGA TCGCCTGTAA CTACATCCTG 
TCCCTGGCGC GGCTGGCTGA CCTTGACTAC AGTGCCGACC ACAGCAACCT CAGCTTCTCC 
GAGTGTGTGC AGCGCTGCAC CCGCACCCTG CAGGCCGAGG GACGTGCCAA GAAGCGCAAG 
GAAAGTTCTT CTGCACGGCC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006712185.1
CDS	405..1388
Translation	MKHIPVLEDGPWKTVCVKELNGLKKLKRKGKEPARRANGYKTFRLDLEAPEPRAVATNGLRDRTHRLQPVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGLPTPPPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAPPESTVRPAPPTRPGESSYSSISHVIYNNHQDSSASPRKRPGEATAASSEIKALQQTRRLLANARERTRVHTISAAFEALRKQVPCYSYGQKLSKLAILRIACNYILSLARLADLDYSADHSNLSFSECVQRCTRTLQAEGRAKKRKESSSARP

Target ORF information:

RefSeq Version	XM_006712122.3
Organism	Homo sapiens(human)
Definition	Homo sapiens atonal bHLH transcription factor 8 (ATOH8), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006712122.3

ORF Insert Sequence:

ATGAAGCACA TCCCGGTCCT CGAGGACGGG CCGTGGAAGA CCGTGTGCGT GAAGGAGCTG 
AACGGCCTTA AGAAGCTCAA GCGGAAAGGC AAGGAGCCGG CGCGGCGCGC GAACGGCTAT 
AAAACTTTCC GACTGGACTT GGAAGCGCCC GAGCCCCGCG CCGTAGCCAC CAACGGGCTG 
CGGGACAGGA CCCATCGGCT GCAGCCGGTC CCGGTACCGG TGCCGGTGCC AGTCCCAGTG 
GCGCCGGCCG TTCCCCCAAG AGGGGGCACG GACACAGCCG GGGAGCGCGG GGGCTCTCGG 
GCGCCCGAGG TCTCCGACGC GCGGAAACGC TGCTTCGCCC TAGGCGCAGT GGGGCCAGGA 
CTCCCCACGC CGCCGCCGCC GCCGCCTCCT GCGCCCCAGA GCCAGGCACC TGGGGGCCCA 
GAGGCACAGC CTTTCCGGGA GCCGGGTCTG CGTCCTCGCA TCTTGCTGTG CGCACCGCCC 
GCGCGCCCCG CGCCGTCAGC ACCCCCAGCA CCGCCAGCGC CCCCGGAGTC CACTGTGCGC 
CCTGCGCCCC CGACGCGCCC CGGGGAAAGT TCCTACTCGT CAATTTCACA CGTAATTTAC 
AATAACCACC AGGATTCCTC CGCGTCGCCT AGGAAACGAC CGGGCGAAGC GACTGCCGCC 
TCCTCCGAGA TCAAAGCCCT GCAGCAGACC CGGAGGCTCC TGGCGAACGC CAGGGAGCGG 
ACGCGGGTGC ACACCATCAG CGCAGCCTTC GAGGCGCTCA GGAAGCAGGT GCCGTGCTAC 
TCATATGGGC AGAAGCTGTC CAAACTGGCC ATCCTGAGGA TCGCCTGTAA CTACATCCTG 
TCCCTGGCGC GGCTGGCTGA CCTTGACTAC AGTGCCGACC ACAGCAACCT CAGCTTCTCC 
GAGTGTGTGC AGCGCTGCAC CCGCACCCTG CAGGCCGAGG GACGTGCCAA GAAGCGCAAG 
GAAAGTTCTT CTGCACGGCC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATOH8 ( XM_011533139.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011531441.1 Homo sapiens atonal bHLH transcription factor 8 (ATOH8), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu73849
Clone ID Related Accession (Same CDS sequence)	XM_011533139.1
Accession Version	XM_011533139.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 987bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	protein atonal homolog 8 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGCACA TCCCGGTCCT CGAGGACGGG CCGTGGAAGA CCGTGTGCGT GAAGGAGCTG 
AACGGCCTTA AGAAGCTCAA GCGGAAAGGC AAGGAGCCGG CGCGGCGCGC GAACGGCTAT 
AAAACTTTCC GACTGGACTT GGAAGCGCCC GAGCCCCGCG CCGTAGCCAC CAACGGGCTG 
CGGGACAGGA CCCATCGGCT GCAGCCGGTC CCGGTACCGG TGCCGGTGCC AGTCCCAGTG 
GCGCCGGCCG TTCCCCCAAG AGGGGGCACG GACACAGCCG GGGAGCGCGG GGGCTCTCGG 
GCGCCCGAGG TCTCCGACGC GCGGAAACGC TGCTTCGCCC TAGGCGCAGT GGGGCCAGGA 
CTCCCCACGC CGCCGCCGCC GCCGCCTCCT GCGCCCCAGA GCCAGGCACC TGGGGGCCCA 
GAGGCACAGC CTTTCCGGGA GCCGGGTCTG CGTCCTCGCA TCTTGCTGTG CGCACCGCCC 
GCGCGCCCCG CGCCGTCAGC ACCCCCAGCA CCGCCAGCGC CCCCGGAGTC CACTGTGCGC 
CCTGCGCCCC CGACGCGCCC CGGGGAAAGT TCCTACTCGT CAATTTCACA CGTAATTTAC 
AATAACCACC AGGATTCCTC CGCGTCGCCT AGGAAACGAC CGGGCGAAGC GACTGCCGCC 
TCCTCCGAGA TCAAAGCCCT GCAGCAGACC CGGAGGCTCC TGGCGAACGC CAGGGAGCGG 
ACGCGGGTGC ACACCATCAG CGCAGCCTTC GAGGCGCTCA GGAAGCAGGT GCCGTGCTAC 
TCATATGGGC AGAAGCTGTC CAAACTGGCC ATCCTGAGGA TCGCCTGTAA CTACATCCTG 
TCCCTGGCGC GGCTGGCTGA CCTTGACTAC AGTGCCGACC ACAGCAACCT CAGCTTCTCC 
GAGTGTGTGC AGCGCTGCAC CCGCACCCTG CAGGCCGAGG GACGTGCCAA GAAGCGCAAG 
GACTTTTCGG AGCCTTTGAC ATGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011531441.1
CDS	405..1391
Translation	MKHIPVLEDGPWKTVCVKELNGLKKLKRKGKEPARRANGYKTFRLDLEAPEPRAVATNGLRDRTHRLQPVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGLPTPPPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAPPESTVRPAPPTRPGESSYSSISHVIYNNHQDSSASPRKRPGEATAASSEIKALQQTRRLLANARERTRVHTISAAFEALRKQVPCYSYGQKLSKLAILRIACNYILSLARLADLDYSADHSNLSFSECVQRCTRTLQAEGRAKKRKDFSEPLTC

Target ORF information:

RefSeq Version	XM_011533139.1
Organism	Homo sapiens(human)
Definition	Homo sapiens atonal bHLH transcription factor 8 (ATOH8), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011533139.1

ORF Insert Sequence:

ATGAAGCACA TCCCGGTCCT CGAGGACGGG CCGTGGAAGA CCGTGTGCGT GAAGGAGCTG 
AACGGCCTTA AGAAGCTCAA GCGGAAAGGC AAGGAGCCGG CGCGGCGCGC GAACGGCTAT 
AAAACTTTCC GACTGGACTT GGAAGCGCCC GAGCCCCGCG CCGTAGCCAC CAACGGGCTG 
CGGGACAGGA CCCATCGGCT GCAGCCGGTC CCGGTACCGG TGCCGGTGCC AGTCCCAGTG 
GCGCCGGCCG TTCCCCCAAG AGGGGGCACG GACACAGCCG GGGAGCGCGG GGGCTCTCGG 
GCGCCCGAGG TCTCCGACGC GCGGAAACGC TGCTTCGCCC TAGGCGCAGT GGGGCCAGGA 
CTCCCCACGC CGCCGCCGCC GCCGCCTCCT GCGCCCCAGA GCCAGGCACC TGGGGGCCCA 
GAGGCACAGC CTTTCCGGGA GCCGGGTCTG CGTCCTCGCA TCTTGCTGTG CGCACCGCCC 
GCGCGCCCCG CGCCGTCAGC ACCCCCAGCA CCGCCAGCGC CCCCGGAGTC CACTGTGCGC 
CCTGCGCCCC CGACGCGCCC CGGGGAAAGT TCCTACTCGT CAATTTCACA CGTAATTTAC 
AATAACCACC AGGATTCCTC CGCGTCGCCT AGGAAACGAC CGGGCGAAGC GACTGCCGCC 
TCCTCCGAGA TCAAAGCCCT GCAGCAGACC CGGAGGCTCC TGGCGAACGC CAGGGAGCGG 
ACGCGGGTGC ACACCATCAG CGCAGCCTTC GAGGCGCTCA GGAAGCAGGT GCCGTGCTAC 
TCATATGGGC AGAAGCTGTC CAAACTGGCC ATCCTGAGGA TCGCCTGTAA CTACATCCTG 
TCCCTGGCGC GGCTGGCTGA CCTTGACTAC AGTGCCGACC ACAGCAACCT CAGCTTCTCC 
GAGTGTGTGC AGCGCTGCAC CCGCACCCTG CAGGCCGAGG GACGTGCCAA GAAGCGCAAG 
GACTTTTCGG AGCCTTTGAC ATGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High expression of atonal homolog 8 predicts a poor clinical outcome in patients with colorectal cancer and contributes to tumor progression.
Oncology reports37(5)2955-2963(2017 May)
Ye M,He Y,Lin H,Yang S,Zhou Y,Zhou L,Zhong J,Lu G,Zheng J,Xue ZX,Cai ZZ

MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease.
Circulation134(24)1973-1990(2016 Dec)
Hartmann D,Fiedler J,Sonnenschein K,Just A,Pfanne A,Zimmer K,Remke J,Foinquinos A,Butzlaff M,Schimmel K,Maegdefessel L,Hilfiker-Kleiner D,Lachmann N,Schober A,Froese N,Heineke J,Bauersachs J,Batkai S,Thum T

Downregulation of ATOH8 induced by EBV-encoded LMP1 contributes to the malignant phenotype of nasopharyngeal carcinoma.
Oncotarget7(18)26765-79(2016 May)
Wang Z,Xie J,Yan M,Wang J,Wang X,Zhang J,Zhang Y,Li P,Lei X,Huang Q,Lin S,Guo X,Liu Q

A novel interaction between ATOH8 and PPP3CB.
Histochemistry and cell biology145(1)5-16(2016 Jan)
Chen J,Balakrishnan-Renuka A,Hagemann N,Theiss C,Chankiewitz V,Chen J,Pu Q,Erdmann KS,Brand-Saberi B

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ATOH8 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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