ADO cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ADO
Entrez Gene ID	84890
Full Name	2-aminoethanethiol dioxygenase
Synonyms	C10orf22
General protein information	Preferred Names 2-aminoethanethiol dioxygenase Names 2-aminoethanethiol dioxygenase 2-aminoethanethiol (cysteamine) dioxygenase cysteamine (2-aminoethanethiol) dioxygenase (ADO) cysteamine dioxygenase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q21.3
Summary	Human thiol dioxygenases include cysteine dioxygenase (CDO; MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase (ADO; EC 1.13.11.19). CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine (Dominy et al., 2007 [PubMed 17581819]).[supplied by OMIM, Mar 2008].
Disorder MIM:	611392

mRNA and Protein(s)

mRNA	Protein	Name
NM_032804.5	NP_116193.2	2-aminoethanethiol dioxygenase
NM_032804.6	NP_116193.2	2-aminoethanethiol dioxygenase

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	adob	NP_998358.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006807	XP_001237154.2
Bos taurus (cattle)	ADO	XP_002698897.1
Homo sapiens (human)	ADO	NP_116193.2
Pan troglodytes (chimpanzee)	ADO	XP_001161814.2
Danio rerio (zebrafish)	adoa	NP_001008634.1
Xenopus tropicalis (tropical clawed frog)	ado	XP_002939587.1
Canis lupus familiaris (dog)	LOC610687	XP_005629676.1
Rattus norvegicus (Norway rat)	Ado	NP_001101096.1
	ADO	XP_001092839.1
Canis lupus familiaris (dog)	ADO	XP_005618978.1
Mus musculus (house mouse)	Ado	NP_001005419.2
Drosophila melanogaster (fruit fly)	CG7550	NP_648176.1

Gene Ontology
Bibliography

Related articles in PubMed

Genome-wide association analysis of Vogt-Koyanagi-Harada syndrome identifies two new susceptibility loci at 1p31.2 and 10q21.3.
Hou S, Du L, Lei B, Pang CP, Zhang M, Zhuang W, Zhang M, Huang L, Gong B, Wang M, Zhang Q, Hu K, Zhou Q, Qi J, Wang C, Tian Y, Ye Z, Liang L, Yu H, Li H, Zhou Y, Cao Q, Liu Y, Bai L, Liao D, Kijlstra A, Xu J, Yang Z, Yang P
Nature genetics46(9)1007-11(2014 Sep)

Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
Hirota T, Takahashi A, Kubo M, Tsunoda T, Tomita K, Sakashita M, Yamada T, Fujieda S, Tanaka S, Doi S, Miyatake A, Enomoto T, Nishiyama C, Nakano N, Maeda K, Okumura K, Ogawa H, Ikeda S, Noguchi E, Sakamoto T, Hizawa N, Ebe K, Saeki H, Sasaki T, Ebihara T, Amagai M, Takeuchi S, Furue M, Nakamura Y, Tamari M
Nature genetics44(11)1222-6(2012 Nov)

Genetic variants associated with breast size also influence breast cancer risk.
Eriksson N, Benton GM, Do CB, Kiefer AK, Mountain JL, Hinds DA, Francke U, Tung JY
BMC medical genetics1353(2012 Jun)

Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma.
Postel-Vinay S, V?ron AS, Tirode F, Pierron G, Reynaud S, Kovar H, Oberlin O, Lapouble E, Ballet S, Lucchesi C, Kontny U, Gonz?lez-Neira A, Picci P, Alonso J, Patino-Garcia A, de Paillerets BB, Laud K, Dina C, Froguel P, Clavel-Chapelon F, Doz F, Michon J, Chanock SJ, Thomas G, Cox DG, Delattre O
Nature genetics44(3)323-7(2012 Feb)

A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
Kenny EE, Pe'er I, Karban A, Ozelius L, Mitchell AA, Ng SM, Erazo M, Ostrer H, Abraham C, Abreu MT, Atzmon G, Barzilai N, Brant SR, Bressman S, Burns ER, Chowers Y, Clark LN, Darvasi A, Doheny D, Duerr RH, Eliakim R, Giladi N, Gregersen PK, Hakonarson H, Jones MR, Marder K, McGovern DP, Mulle J, Orr-Urtreger A, Proctor DD, Pulver A, Rotter JI, Silverberg MS, Ullman T, Warren ST, Waterman M, Zhang W, Bergman A, Mayer L, Katz S, Desnick RJ, Cho JH, Peter I
PLoS genetics8(3)e1002559(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

when endogenous expression of the human ADO ortholog C10orf22 in HepG2/C3A cells was reduced by RNA-mediated interference, hypotaurine production decreased
Title: Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase.

The following ADO gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ADO cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29608	NM_032804.6 Latest version!	Homo sapiens 2-aminoethanethiol dioxygenase (ADO), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu29608	NM_032804.5	Homo sapiens 2-aminoethanethiol dioxygenase (ADO), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ADO ( NM_032804.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_116193.2 Homo sapiens 2-aminoethanethiol dioxygenase (ADO), mRNA.

Price & Availability↑

CloneID	OHu29608
Clone ID Related Accession (Same CDS sequence)	NM_032804.5 , NM_032804.6
Accession Version	NM_032804.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 813bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-22
Organism	Homo sapiens(human)
Product	2-aminoethanethiol dioxygenase
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK127694.1, BC028589.2 and BC067740.1. On Apr 3, 2005 this sequence version replaced NM_032804.4.

ATGCCCCGAG ACAACATGGC CTCCTTGATC CAACGGATCG CCCGCCAGGC TTGCCTCACC 
TTCCGGGGCA GCGGGGGCGG CCGCGGCGCT TCCGATCGCG ACGCGGCTTC TGGCCCGGAG 
GCGCCGATGC AGCCGGGCTT CCCCGAGAAC CTGAGCAAGC TGAAGAGCCT CCTGACCCAG 
CTCCGCGCCG AGGACTTGAA CATCGCCCCG CGCAAGGCCA CACTGCAGCC GCTGCCGCCC 
AACCTGCCGC CAGTCACCTA CATGCACATC TACGAGACGG ACGGCTTCAG CCTGGGCGTG 
TTCCTGCTCA AGAGCGGCAC GTCCATCCCG CTGCACGACC ACCCGGGCAT GCACGGCATG 
CTCAAGGTGC TGTACGGCAC CGTGCGCATC AGCTGCATGG ACAAGCTAGA CGCGGGCGGC 
GGGCAACGGC CGCGGGCCTT GCCGCCCGAG CAGCAGTTCG AGCCGCCGCT GCAGCCCCGG 
GAGCGAGAAG CCGTGCGGCC GGGCGTGCTG CGTTCGCGGG CCGAGTACAC CGAGGCCAGC 
GGCCCCTGCA TCCTCACACC GCACCGGGAC AACCTGCACC AGATCGACGC CGTGGAAGGG 
CCTGCCGCCT TCCTGGACAT CCTGGCCCCG CCCTACGACC CGGACGATGG CCGGGACTGC 
CACTATTACC GGGTGCTGGA GCCGGTCAGG CCCAAGGAGG CCTCCAGCTC GGCCTGTGAC 
CTGCCTCGAG AGGTGTGGCT CCTGGAGACC CCACAGGCCG ATGACTTCTG GTGCGAGGGA 
GAACCCTATC CAGGTCCCAA GGTCTTCCCT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_116193.2
CDS	305..1117
Translation	MPRDNMASLIQRIARQACLTFRGSGGGRGASDRDAASGPEAPMQPGFPENLSKLKSLLTQLRAEDLNIAPRKATLQPLPPNLPPVTYMHIYETDGFSLGVFLLKSGTSIPLHDHPGMHGMLKVLYGTVRISCMDKLDAGGGQRPRALPPEQQFEPPLQPREREAVRPGVLRSRAEYTEASGPCILTPHRDNLHQIDAVEGPAAFLDILAPPYDPDDGRDCHYYRVLEPVRPKEASSSACDLPREVWLLETPQADDFWCEGEPYPGPKVFP

Target ORF information:

RefSeq Version	NM_032804.5
Organism	Homo sapiens(human)
Definition	Homo sapiens 2-aminoethanethiol dioxygenase (ADO), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032804.5

ORF Insert Sequence:

ATGCCCCGAG ACAACATGGC CTCCTTGATC CAACGGATCG CCCGCCAGGC TTGCCTCACC 
TTCCGGGGCA GCGGGGGCGG CCGCGGCGCT TCCGATCGCG ACGCGGCTTC TGGCCCGGAG 
GCGCCGATGC AGCCGGGCTT CCCCGAGAAC CTGAGCAAGC TGAAGAGCCT CCTGACCCAG 
CTCCGCGCCG AGGACTTGAA CATCGCCCCG CGCAAGGCCA CACTGCAGCC GCTGCCGCCC 
AACCTGCCGC CAGTCACCTA CATGCACATC TACGAGACGG ACGGCTTCAG CCTGGGCGTG 
TTCCTGCTCA AGAGCGGCAC GTCCATCCCG CTGCACGACC ACCCGGGCAT GCACGGCATG 
CTCAAGGTGC TGTACGGCAC CGTGCGCATC AGCTGCATGG ACAAGCTAGA CGCGGGCGGC 
GGGCAACGGC CGCGGGCCTT GCCGCCCGAG CAGCAGTTCG AGCCGCCGCT GCAGCCCCGG 
GAGCGAGAAG CCGTGCGGCC GGGCGTGCTG CGTTCGCGGG CCGAGTACAC CGAGGCCAGC 
GGCCCCTGCA TCCTCACACC GCACCGGGAC AACCTGCACC AGATCGACGC CGTGGAAGGG 
CCTGCCGCCT TCCTGGACAT CCTGGCCCCG CCCTACGACC CGGACGATGG CCGGGACTGC 
CACTATTACC GGGTGCTGGA GCCGGTCAGG CCCAAGGAGG CCTCCAGCTC GGCCTGTGAC 
CTGCCTCGAG AGGTGTGGCT CCTGGAGACC CCACAGGCCG ATGACTTCTG GTGCGAGGGA 
GAACCCTATC CAGGTCCCAA GGTCTTCCCT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ADO ( NM_032804.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_116193.2 Homo sapiens 2-aminoethanethiol dioxygenase (ADO), mRNA.

Price & Availability↑

CloneID	OHu29608
Clone ID Related Accession (Same CDS sequence)	NM_032804.5 , NM_032804.6
Accession Version	NM_032804.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 813bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	2-aminoethanethiol dioxygenase
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL133417.11, AK127694.1, BC028589.2 and BC067740.1. On May 17, 2019 this sequence version replaced NM_032804.5. ##Evidence-Data-START## Transcript is intronless :: BC028589.2, SRR1803613.253940.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000373783.3/ ENSP00000362888.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCCCCGAG ACAACATGGC CTCCTTGATC CAACGGATCG CCCGCCAGGC TTGCCTCACC 
TTCCGGGGCA GCGGGGGCGG CCGCGGCGCT TCCGATCGCG ACGCGGCTTC TGGCCCGGAG 
GCGCCGATGC AGCCGGGCTT CCCCGAGAAC CTGAGCAAGC TGAAGAGCCT CCTGACCCAG 
CTCCGCGCCG AGGACTTGAA CATCGCCCCG CGCAAGGCCA CACTGCAGCC GCTGCCGCCC 
AACCTGCCGC CAGTCACCTA CATGCACATC TACGAGACGG ACGGCTTCAG CCTGGGCGTG 
TTCCTGCTCA AGAGCGGCAC GTCCATCCCG CTGCACGACC ACCCGGGCAT GCACGGCATG 
CTCAAGGTGC TGTACGGCAC CGTGCGCATC AGCTGCATGG ACAAGCTAGA CGCGGGCGGC 
GGGCAACGGC CGCGGGCCTT GCCGCCCGAG CAGCAGTTCG AGCCGCCGCT GCAGCCCCGG 
GAGCGAGAAG CCGTGCGGCC GGGCGTGCTG CGTTCGCGGG CCGAGTACAC CGAGGCCAGC 
GGCCCCTGCA TCCTCACACC GCACCGGGAC AACCTGCACC AGATCGACGC CGTGGAAGGG 
CCTGCCGCCT TCCTGGACAT CCTGGCCCCG CCCTACGACC CGGACGATGG CCGGGACTGC 
CACTATTACC GGGTGCTGGA GCCGGTCAGG CCCAAGGAGG CCTCCAGCTC GGCCTGTGAC 
CTGCCTCGAG AGGTGTGGCT CCTGGAGACC CCACAGGCCG ATGACTTCTG GTGCGAGGGA 
GAACCCTATC CAGGTCCCAA GGTCTTCCCT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_116193.2
CDS	341..1153
Translation	MPRDNMASLIQRIARQACLTFRGSGGGRGASDRDAASGPEAPMQPGFPENLSKLKSLLTQLRAEDLNIAPRKATLQPLPPNLPPVTYMHIYETDGFSLGVFLLKSGTSIPLHDHPGMHGMLKVLYGTVRISCMDKLDAGGGQRPRALPPEQQFEPPLQPREREAVRPGVLRSRAEYTEASGPCILTPHRDNLHQIDAVEGPAAFLDILAPPYDPDDGRDCHYYRVLEPVRPKEASSSACDLPREVWLLETPQADDFWCEGEPYPGPKVFP

Target ORF information:

RefSeq Version	NM_032804.6
Organism	Homo sapiens(human)
Definition	Homo sapiens 2-aminoethanethiol dioxygenase (ADO), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032804.6

ORF Insert Sequence:

ATGCCCCGAG ACAACATGGC CTCCTTGATC CAACGGATCG CCCGCCAGGC TTGCCTCACC 
TTCCGGGGCA GCGGGGGCGG CCGCGGCGCT TCCGATCGCG ACGCGGCTTC TGGCCCGGAG 
GCGCCGATGC AGCCGGGCTT CCCCGAGAAC CTGAGCAAGC TGAAGAGCCT CCTGACCCAG 
CTCCGCGCCG AGGACTTGAA CATCGCCCCG CGCAAGGCCA CACTGCAGCC GCTGCCGCCC 
AACCTGCCGC CAGTCACCTA CATGCACATC TACGAGACGG ACGGCTTCAG CCTGGGCGTG 
TTCCTGCTCA AGAGCGGCAC GTCCATCCCG CTGCACGACC ACCCGGGCAT GCACGGCATG 
CTCAAGGTGC TGTACGGCAC CGTGCGCATC AGCTGCATGG ACAAGCTAGA CGCGGGCGGC 
GGGCAACGGC CGCGGGCCTT GCCGCCCGAG CAGCAGTTCG AGCCGCCGCT GCAGCCCCGG 
GAGCGAGAAG CCGTGCGGCC GGGCGTGCTG CGTTCGCGGG CCGAGTACAC CGAGGCCAGC 
GGCCCCTGCA TCCTCACACC GCACCGGGAC AACCTGCACC AGATCGACGC CGTGGAAGGG 
CCTGCCGCCT TCCTGGACAT CCTGGCCCCG CCCTACGACC CGGACGATGG CCGGGACTGC 
CACTATTACC GGGTGCTGGA GCCGGTCAGG CCCAAGGAGG CCTCCAGCTC GGCCTGTGAC 
CTGCCTCGAG AGGTGTGGCT CCTGGAGACC CCACAGGCCG ATGACTTCTG GTGCGAGGGA 
GAACCCTATC CAGGTCCCAA GGTCTTCCCT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome-wide association analysis of Vogt-Koyanagi-Harada syndrome identifies two new susceptibility loci at 1p31.2 and 10q21.3.
Nature genetics46(9)1007-11(2014 Sep)
Hou S,Du L,Lei B,Pang CP,Zhang M,Zhuang W,Zhang M,Huang L,Gong B,Wang M,Zhang Q,Hu K,Zhou Q,Qi J,Wang C,Tian Y,Ye Z,Liang L,Yu H,Li H,Zhou Y,Cao Q,Liu Y,Bai L,Liao D,Kijlstra A,Xu J,Yang Z,Yang P

Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
Nature genetics44(11)1222-6(2012 Nov)
Hirota T,Takahashi A,Kubo M,Tsunoda T,Tomita K,Sakashita M,Yamada T,Fujieda S,Tanaka S,Doi S,Miyatake A,Enomoto T,Nishiyama C,Nakano N,Maeda K,Okumura K,Ogawa H,Ikeda S,Noguchi E,Sakamoto T,Hizawa N,Ebe K,Saeki H,Sasaki T,Ebihara T,Amagai M,Takeuchi S,Furue M,Nakamura Y,Tamari M

Genetic variants associated with breast size also influence breast cancer risk.
BMC medical genetics1353(2012 Jun)
Eriksson N,Benton GM,Do CB,Kiefer AK,Mountain JL,Hinds DA,Francke U,Tung JY

Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma.
Nature genetics44(3)323-7(2012 Feb)
Postel-Vinay S,V?ron AS,Tirode F,Pierron G,Reynaud S,Kovar H,Oberlin O,Lapouble E,Ballet S,Lucchesi C,Kontny U,Gonz?lez-Neira A,Picci P,Alonso J,Patino-Garcia A,de Paillerets BB,Laud K,Dina C,Froguel P,Clavel-Chapelon F,Doz F,Michon J,Chanock SJ,Thomas G,Cox DG,Delattre O

A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
PLoS genetics8(3)e1002559(2012)
Kenny EE,Pe'er I,Karban A,Ozelius L,Mitchell AA,Ng SM,Erazo M,Ostrer H,Abraham C,Abreu MT,Atzmon G,Barzilai N,Brant SR,Bressman S,Burns ER,Chowers Y,Clark LN,Darvasi A,Doheny D,Duerr RH,Eliakim R,Giladi N,Gregersen PK,Hakonarson H,Jones MR,Marder K,McGovern DP,Mulle J,Orr-Urtreger A,Proctor DD,Pulver A,Rotter JI,Silverberg MS,Ullman T,Warren ST,Waterman M,Zhang W,Bergman A,Mayer L,Katz S,Desnick RJ,Cho JH,Peter I

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ADO cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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