Gene Symbol | ORAI1 |
Entrez Gene ID | 84876 |
Full Name | ORAI calcium release-activated calcium modulator 1 |
Synonyms | CRACM1,IMD9,ORAT1,TAM2,TMEM142A |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]. |
Disorder MIM: | |
Disorder Html: | Immunodeficiency 9, 612782 (3); Myopathy, tubular aggregate, 2, 615883 (3) |