LMNB2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LMNB2
Entrez Gene ID	84823
Full Name	lamin B2
Synonyms	EPM9,LAMB2,LMN2
General protein information	Preferred Names lamin B2 Names lamin-B2 lamin B3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.3
Summary	This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy. [provided by RefSeq, May 2012].
Disorder MIM:	150341
Disorder Html:	{Lipodystrophy, partial, acquired, susceptibility to}, 608709 (3); ?Epilepsy, progressive myoclonic, 9, 616540 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_032737.3	NP_116126.3	lamin-B2
NM_032737.4	NP_116126.3	lamin-B2

Pathways from BioSystems

Homologies

Caenorhabditis elegans (roundworm)	ifd-1	NP_001024830.1
Caenorhabditis elegans (roundworm)	ifa-3	NP_510649.3
Caenorhabditis elegans (roundworm)	ifa-4	NP_508836.4
Pan troglodytes (chimpanzee)	LMNB2	XP_524044.4
	LMNB2	XP_002801064.1
Gallus gallus (chicken)	LMNB2	NP_990616.1
Drosophila melanogaster (fruit fly)	LamC	NP_523742.2
Caenorhabditis elegans (roundworm)	ifd-2	NP_508160.1
Xenopus tropicalis (tropical clawed frog)	lmnb2	XP_002940085.1
Homo sapiens (human)	LMNB2	NP_116126.3
Bos taurus (cattle)	LMNB2	NP_001263282.1
Mus musculus (house mouse)	Lmnb2	NP_034852.2
Rattus norvegicus (Norway rat)	Lmnb2	XP_216850.6
Danio rerio (zebrafish)	lmnb2	NP_571077.2
Drosophila melanogaster (fruit fly)	Lam	NP_001245892.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011938	XP_320593.4
Caenorhabditis elegans (roundworm)	ifa-1	NP_001076764.1
Caenorhabditis elegans (roundworm)	ifb-1	NP_495136.1
Caenorhabditis elegans (roundworm)	F10C1.8	NP_495132.2
Caenorhabditis elegans (roundworm)	ifp-1	NP_509628.1
Caenorhabditis elegans (roundworm)	mua-6	NP_510648.1
Caenorhabditis elegans (roundworm)	ifb-2	NP_495134.1
Canis lupus familiaris (dog)	LMNB2	XP_542188.3
Caenorhabditis elegans (roundworm)	ifc-1	NP_503783.1
Caenorhabditis elegans (roundworm)	ifc-2	NP_001256975.1

Gene Ontology
Bibliography

Related articles in PubMed

Chromosomal aneuploidies induced upon Lamin B2 depletion are mislocalized in the interphase nucleus.
Ranade D, Koul S, Thompson J, Prasad KB, Sengupta K
Chromosoma126(2)223-244(2017 Mar)

Autophagy mediates degradation of nuclear lamina.
Dou Z, Xu C, Donahue G, Shimi T, Pan JA, Zhu J, Ivanov A, Capell BC, Drake AM, Shah PP, Catanzaro JM, Ricketts MD, Lamark T, Adam SA, Marmorstein R, Zong WX, Johansen T, Goldman RD, Adams PD, Berger SL
Nature527(7576)105-9(2015 Nov)

Mutation of the nuclear lamin gene LMNB2 in progressive myoclonus epilepsy with early ataxia.
Damiano JA, Afawi Z, Bahlo M, Mauermann M, Misk A, Arsov T, Oliver KL, Dahl HH, Shearer AE, Smith RJ, Hall NE, Mahmood K, Leventer RJ, Scheffer IE, Muona M, Lehesjoki AE, Korczyn AD, Herrmann H, Berkovic SF, Hildebrand MS
Human molecular genetics24(16)4483-90(2015 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

our studies strongly implicate an overarching role for Lamin B2 in the maintenance of nuclear architecture since loss of Lamin B2 relieves the spatial positional constraints required for maintaining conserved localization of aneuploid chromosome territories in the interphase nucleus.
Title: Chromosomal aneuploidies induced upon Lamin B2 depletion are mislocalized in the interphase nucleus.

Mutation of the nuclear lamin gene LMNB2 in progressive myoclonus epilepsy with early ataxia.
Title: Mutation of the nuclear lamin gene LMNB2 in progressive myoclonus epilepsy with early ataxia.

Nuclear envelope remodelling during human spermiogenesis involves somatic B-type lamins and a spermatid-specific B3 lamin isoform.
Title: Nuclear envelope remodelling during human spermiogenesis involves somatic B-type lamins and a spermatid-specific B3 lamin isoform.

Treating normal human fibroblasts with farnesyltransferase inhibitors causes the accumulation of unprocessed lamin B2 and lamin A and a decrease in mature lamin B1
Title: Disruption of lamin B1 and lamin B2 processing and localization by farnesyltransferase inhibitors.

Mutation in LMNB2 gene is associated with partial lipodystrophy.
Title: A Chinese patient with acquired partial lipodystrophy caused by a novel mutation with LMNB2 gene.

The following LMNB2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LMNB2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21383	NM_032737.4 Latest version!	Homo sapiens lamin B2 (LMNB2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu21383	NM_032737.3	Homo sapiens lamin B2 (LMNB2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LMNB2 ( NM_032737.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_116126.3 Homo sapiens lamin B2 (LMNB2), mRNA.

Price & Availability↑

CloneID	OHu21383
Clone ID Related Accession (Same CDS sequence)	NM_032737.3 , NM_032737.4
Accession Version	NM_032737.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1863bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	lamin-B2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL560944.3, BC006551.2 and AC011522.8. This sequence is a reference standard in the RefSeqGene project. On May 22, 2012 this sequence version replaced NM_032737.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC006551.2, SRR1163655.19160.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCCCGC CGAGCCCGGG CCGCCGTCGG GAGCAGCGCA GGCCGCGAGC CGCCGCCACC 
ATGGCCACGC CGCTGCCCGG CCGCGCGGGC GGGCCCGCCA CGCCGCTGTC GCCCACGCGC 
CTGTCGCGGC TGCAGGAGAA GGAGGAGCTG CGCGAGCTCA ACGACCGCCT GGCGCACTAC 
ATCGACCGCG TCCGCGCGCT GGAGCTGGAG AACGACCGGC TCCTGCTCAA GATCTCAGAG 
AAGGAGGAGG TGACCACGCG CGAGGTGAGT GGCATCAAGG CGCTGTACGA GTCGGAGCTG 
GCCGATGCCC GGAGAGTCCT GGATGAGACG GCTCGAGAGC GTGCCCGGCT GCAGATAGAG 
ATTGGGAAGC TGAGGGCAGA GTTGGACGAG GTCAACAAGA GCGCCAAGAA GAGGGAGGGC 
GAGCTTACGG TGGCCCAGGG CCGTGTGAAG GACCTGGAGT CCCTGTTCCA CCGGAGCGAG 
GTGGAGCTGG CAGCTGCCCT CAGCGACAAG CGCGGCCTGG AGAGTGACGT GGCTGAGCTG 
CGGGCCCAGC TGGCCAAGGC CGAGGACGGT CATGCAGTGG CCAAAAAGCA GCTGGAGAAG 
GAGACGCTGA TGCGTGTGGA CCTGGAGAAC CGCTGCCAGA GCCTGCAGGA GGAGCTGGAC 
TTCCGGAAGA GTGTGTTCGA GGAGGAGGTG CGGGAGACGC GGCGGCGGCA CGAGCGGCGC 
CTGGTGGAGG TGGACAGCAG CCGGCAGCAG GAGTACGACT TCAAGATGGC ACAGGCGCTG 
GAGGAGCTGC GGAGCCAGCA CGACGAGCAA GTGCGGCTCT ACAAGCTGGA GCTGGAGCAG 
ACCTACCAGG CCAAGCTGGA CAGCGCCAAG CTGAGCTCTG ACCAGAACGA CAAGGCGGCC 
AGTGCGGCTC GCGAGGAGCT GAAGGAGGCC CGCATGCGCC TGGAGTCCCT CAGCTACCAG 
CTCTCCGGCC TCCAGAAGCA GGCCAGTGCC GCTGAAGATC GCATTCGGGA GCTGGAGGAG 
GCCATGGCCG GGGAGCGGGA CAAGTTCCGG AAGATGCTGG ACGCCAAGGA GCAGGAGATG 
ACGGAGATGC GGGACGTGAT GCAGCAGCAG CTGGCCGAGT ACCAGGAGCT GCTGGACGTG 
AAGCTGGCCC TGGACATGGA GATCAACGCC TACCGGAAGC TCCTGGAGGG CGAGGAGGAG 
AGGCTGAAGC TGTCCCCCAG CCCATCCTCG CGCGTCACCG TCTCACGAGC CACCTCGAGC 
AGCAGCGGCA GCTTGTCCGC CACCGGGCGC CTGGGCCGCA GTAAGCGGAA GCGGCTGGAG 
GTGGAGGAGC CCTTGGGCAG CGGCCCAAGC GTCCTGGGCA CGGGCACGGG TGGCAGCGGT 
GGCTTCCACC TGGCCCAGCA GGCCTCGGCC TCGGGTAGCG TCAGCATCGA GGAGATCGAC 
CTGGAGGGCA AGTTTGTGCA GCTCAAGAAC AACTCGGACA AGGATCAGTC TCTGGGGAAC 
TGGAGAATCA AGAGGCAGGT CTTGGAGGGG GAGGAGATCG CCTACAAGTT CACGCCCAAG 
TACATCCTGC GCGCCGGCCA GATGGTCACG GTGTGGGCAG CTGGTGCGGG GGTGGCCCAC 
AGCCCCCCCT CGACGCTGGT GTGGAAGGGC CAGAGCAGCT GGGGCACGGG CGAGAGCTTC 
CGCACCGTCC TGGTTAACGC GGATGGCGAG GAAGTGGCCA TGAGGACTGT GAAGAAGTCC 
TCGGTGATGC GTGAGAATGA GAATGGGGAG GAAGAGGAGG AGGAAGCCGA GTTTGGCGAG 
GAGGATCTTT TCCACCAACA GGGGGACCCG AGGACCACCT CAAGAGGCTG CTACGTGATG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_116126.3
CDS	36..1898
Translation	MSPPSPGRRREQRRPRAAATMATPLPGRAGGPATPLSPTRLSRLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTREVSGIKALYESELADARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSEVELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELDFRKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLELEQTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIRELEEAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSSGSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVLEGEEIAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESFRTVLVNADGEEVAMRTVKKSSVMRENENGEEEEEEAEFGEEDLFHQQGDPRTTSRGCYVM

Target ORF information:

RefSeq Version	NM_032737.3
Organism	Homo sapiens(human)
Definition	Homo sapiens lamin B2 (LMNB2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032737.3

ORF Insert Sequence:

ATGAGCCCGC CGAGCCCGGG CCGCCGTCGG GAGCAGCGCA GGCCGCGAGC CGCCGCCACC 
ATGGCCACGC CGCTGCCCGG CCGCGCGGGC GGGCCCGCCA CGCCGCTGTC GCCCACGCGC 
CTGTCGCGGC TGCAGGAGAA GGAGGAGCTG CGCGAGCTCA ACGACCGCCT GGCGCACTAC 
ATCGACCGCG TCCGCGCGCT GGAGCTGGAG AACGACCGGC TCCTGCTCAA GATCTCAGAG 
AAGGAGGAGG TGACCACGCG CGAGGTGAGT GGCATCAAGG CGCTGTACGA GTCGGAGCTG 
GCCGATGCCC GGAGAGTCCT GGATGAGACG GCTCGAGAGC GTGCCCGGCT GCAGATAGAG 
ATTGGGAAGC TGAGGGCAGA GTTGGACGAG GTCAACAAGA GCGCCAAGAA GAGGGAGGGC 
GAGCTTACGG TGGCCCAGGG CCGTGTGAAG GACCTGGAGT CCCTGTTCCA CCGGAGCGAG 
GTGGAGCTGG CAGCTGCCCT CAGCGACAAG CGCGGCCTGG AGAGTGACGT GGCTGAGCTG 
CGGGCCCAGC TGGCCAAGGC CGAGGACGGT CATGCAGTGG CCAAAAAGCA GCTGGAGAAG 
GAGACGCTGA TGCGTGTGGA CCTGGAGAAC CGCTGCCAGA GCCTGCAGGA GGAGCTGGAC 
TTCCGGAAGA GTGTGTTCGA GGAGGAGGTG CGGGAGACGC GGCGGCGGCA CGAGCGGCGC 
CTGGTGGAGG TGGACAGCAG CCGGCAGCAG GAGTACGACT TCAAGATGGC ACAGGCGCTG 
GAGGAGCTGC GGAGCCAGCA CGACGAGCAA GTGCGGCTCT ACAAGCTGGA GCTGGAGCAG 
ACCTACCAGG CCAAGCTGGA CAGCGCCAAG CTGAGCTCTG ACCAGAACGA CAAGGCGGCC 
AGTGCGGCTC GCGAGGAGCT GAAGGAGGCC CGCATGCGCC TGGAGTCCCT CAGCTACCAG 
CTCTCCGGCC TCCAGAAGCA GGCCAGTGCC GCTGAAGATC GCATTCGGGA GCTGGAGGAG 
GCCATGGCCG GGGAGCGGGA CAAGTTCCGG AAGATGCTGG ACGCCAAGGA GCAGGAGATG 
ACGGAGATGC GGGACGTGAT GCAGCAGCAG CTGGCCGAGT ACCAGGAGCT GCTGGACGTG 
AAGCTGGCCC TGGACATGGA GATCAACGCC TACCGGAAGC TCCTGGAGGG CGAGGAGGAG 
AGGCTGAAGC TGTCCCCCAG CCCATCCTCG CGCGTCACCG TCTCACGAGC CACCTCGAGC 
AGCAGCGGCA GCTTGTCCGC CACCGGGCGC CTGGGCCGCA GTAAGCGGAA GCGGCTGGAG 
GTGGAGGAGC CCTTGGGCAG CGGCCCAAGC GTCCTGGGCA CGGGCACGGG TGGCAGCGGT 
GGCTTCCACC TGGCCCAGCA GGCCTCGGCC TCGGGTAGCG TCAGCATCGA GGAGATCGAC 
CTGGAGGGCA AGTTTGTGCA GCTCAAGAAC AACTCGGACA AGGATCAGTC TCTGGGGAAC 
TGGAGAATCA AGAGGCAGGT CTTGGAGGGG GAGGAGATCG CCTACAAGTT CACGCCCAAG 
TACATCCTGC GCGCCGGCCA GATGGTCACG GTGTGGGCAG CTGGTGCGGG GGTGGCCCAC 
AGCCCCCCCT CGACGCTGGT GTGGAAGGGC CAGAGCAGCT GGGGCACGGG CGAGAGCTTC 
CGCACCGTCC TGGTTAACGC GGATGGCGAG GAAGTGGCCA TGAGGACTGT GAAGAAGTCC 
TCGGTGATGC GTGAGAATGA GAATGGGGAG GAAGAGGAGG AGGAAGCCGA GTTTGGCGAG 
GAGGATCTTT TCCACCAACA GGGGGACCCG AGGACCACCT CAAGAGGCTG CTACGTGATG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LMNB2 ( NM_032737.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_116126.3 Homo sapiens lamin B2 (LMNB2), mRNA.

Price & Availability↑

CloneID	OHu21383
Clone ID Related Accession (Same CDS sequence)	NM_032737.3 , NM_032737.4
Accession Version	NM_032737.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1863bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-22
Organism	Homo sapiens(human)
Product	lamin-B2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL560944.3, BC006551.2 and AC011522.8. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_032737.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC006551.2, SRR1163655.19160.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000325327.4/ ENSP00000327054.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCCCGC CGAGCCCGGG CCGCCGTCGG GAGCAGCGCA GGCCGCGAGC CGCCGCCACC 
ATGGCCACGC CGCTGCCCGG CCGCGCGGGC GGGCCCGCCA CGCCGCTGTC GCCCACGCGC 
CTGTCGCGGC TGCAGGAGAA GGAGGAGCTG CGCGAGCTCA ACGACCGCCT GGCGCACTAC 
ATCGACCGCG TCCGCGCGCT GGAGCTGGAG AACGACCGGC TCCTGCTCAA GATCTCAGAG 
AAGGAGGAGG TGACCACGCG CGAGGTGAGT GGCATCAAGG CGCTGTACGA GTCGGAGCTG 
GCCGATGCCC GGAGAGTCCT GGATGAGACG GCTCGAGAGC GTGCCCGGCT GCAGATAGAG 
ATTGGGAAGC TGAGGGCAGA GTTGGACGAG GTCAACAAGA GCGCCAAGAA GAGGGAGGGC 
GAGCTTACGG TGGCCCAGGG CCGTGTGAAG GACCTGGAGT CCCTGTTCCA CCGGAGCGAG 
GTGGAGCTGG CAGCTGCCCT CAGCGACAAG CGCGGCCTGG AGAGTGACGT GGCTGAGCTG 
CGGGCCCAGC TGGCCAAGGC CGAGGACGGT CATGCAGTGG CCAAAAAGCA GCTGGAGAAG 
GAGACGCTGA TGCGTGTGGA CCTGGAGAAC CGCTGCCAGA GCCTGCAGGA GGAGCTGGAC 
TTCCGGAAGA GTGTGTTCGA GGAGGAGGTG CGGGAGACGC GGCGGCGGCA CGAGCGGCGC 
CTGGTGGAGG TGGACAGCAG CCGGCAGCAG GAGTACGACT TCAAGATGGC ACAGGCGCTG 
GAGGAGCTGC GGAGCCAGCA CGACGAGCAA GTGCGGCTCT ACAAGCTGGA GCTGGAGCAG 
ACCTACCAGG CCAAGCTGGA CAGCGCCAAG CTGAGCTCTG ACCAGAACGA CAAGGCGGCC 
AGTGCGGCTC GCGAGGAGCT GAAGGAGGCC CGCATGCGCC TGGAGTCCCT CAGCTACCAG 
CTCTCCGGCC TCCAGAAGCA GGCCAGTGCC GCTGAAGATC GCATTCGGGA GCTGGAGGAG 
GCCATGGCCG GGGAGCGGGA CAAGTTCCGG AAGATGCTGG ACGCCAAGGA GCAGGAGATG 
ACGGAGATGC GGGACGTGAT GCAGCAGCAG CTGGCCGAGT ACCAGGAGCT GCTGGACGTG 
AAGCTGGCCC TGGACATGGA GATCAACGCC TACCGGAAGC TCCTGGAGGG CGAGGAGGAG 
AGGCTGAAGC TGTCCCCCAG CCCATCCTCG CGCGTCACCG TCTCACGAGC CACCTCGAGC 
AGCAGCGGCA GCTTGTCCGC CACCGGGCGC CTGGGCCGCA GTAAGCGGAA GCGGCTGGAG 
GTGGAGGAGC CCTTGGGCAG CGGCCCAAGC GTCCTGGGCA CGGGCACGGG TGGCAGCGGT 
GGCTTCCACC TGGCCCAGCA GGCCTCGGCC TCGGGTAGCG TCAGCATCGA GGAGATCGAC 
CTGGAGGGCA AGTTTGTGCA GCTCAAGAAC AACTCGGACA AGGATCAGTC TCTGGGGAAC 
TGGAGAATCA AGAGGCAGGT CTTGGAGGGG GAGGAGATCG CCTACAAGTT CACGCCCAAG 
TACATCCTGC GCGCCGGCCA GATGGTCACG GTGTGGGCAG CTGGTGCGGG GGTGGCCCAC 
AGCCCCCCCT CGACGCTGGT GTGGAAGGGC CAGAGCAGCT GGGGCACGGG CGAGAGCTTC 
CGCACCGTCC TGGTTAACGC GGATGGCGAG GAAGTGGCCA TGAGGACTGT GAAGAAGTCC 
TCGGTGATGC GTGAGAATGA GAATGGGGAG GAAGAGGAGG AGGAAGCCGA GTTTGGCGAG 
GAGGATCTTT TCCACCAACA GGGGGACCCG AGGACCACCT CAAGAGGCTG CTACGTGATG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_116126.3
CDS	27..1889
Translation	MSPPSPGRRREQRRPRAAATMATPLPGRAGGPATPLSPTRLSRLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTREVSGIKALYESELADARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSEVELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELDFRKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLELEQTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIRELEEAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSSGSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVLEGEEIAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESFRTVLVNADGEEVAMRTVKKSSVMRENENGEEEEEEAEFGEEDLFHQQGDPRTTSRGCYVM

Target ORF information:

RefSeq Version	NM_032737.4
Organism	Homo sapiens(human)
Definition	Homo sapiens lamin B2 (LMNB2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032737.4

ORF Insert Sequence:

ATGAGCCCGC CGAGCCCGGG CCGCCGTCGG GAGCAGCGCA GGCCGCGAGC CGCCGCCACC 
ATGGCCACGC CGCTGCCCGG CCGCGCGGGC GGGCCCGCCA CGCCGCTGTC GCCCACGCGC 
CTGTCGCGGC TGCAGGAGAA GGAGGAGCTG CGCGAGCTCA ACGACCGCCT GGCGCACTAC 
ATCGACCGCG TCCGCGCGCT GGAGCTGGAG AACGACCGGC TCCTGCTCAA GATCTCAGAG 
AAGGAGGAGG TGACCACGCG CGAGGTGAGT GGCATCAAGG CGCTGTACGA GTCGGAGCTG 
GCCGATGCCC GGAGAGTCCT GGATGAGACG GCTCGAGAGC GTGCCCGGCT GCAGATAGAG 
ATTGGGAAGC TGAGGGCAGA GTTGGACGAG GTCAACAAGA GCGCCAAGAA GAGGGAGGGC 
GAGCTTACGG TGGCCCAGGG CCGTGTGAAG GACCTGGAGT CCCTGTTCCA CCGGAGCGAG 
GTGGAGCTGG CAGCTGCCCT CAGCGACAAG CGCGGCCTGG AGAGTGACGT GGCTGAGCTG 
CGGGCCCAGC TGGCCAAGGC CGAGGACGGT CATGCAGTGG CCAAAAAGCA GCTGGAGAAG 
GAGACGCTGA TGCGTGTGGA CCTGGAGAAC CGCTGCCAGA GCCTGCAGGA GGAGCTGGAC 
TTCCGGAAGA GTGTGTTCGA GGAGGAGGTG CGGGAGACGC GGCGGCGGCA CGAGCGGCGC 
CTGGTGGAGG TGGACAGCAG CCGGCAGCAG GAGTACGACT TCAAGATGGC ACAGGCGCTG 
GAGGAGCTGC GGAGCCAGCA CGACGAGCAA GTGCGGCTCT ACAAGCTGGA GCTGGAGCAG 
ACCTACCAGG CCAAGCTGGA CAGCGCCAAG CTGAGCTCTG ACCAGAACGA CAAGGCGGCC 
AGTGCGGCTC GCGAGGAGCT GAAGGAGGCC CGCATGCGCC TGGAGTCCCT CAGCTACCAG 
CTCTCCGGCC TCCAGAAGCA GGCCAGTGCC GCTGAAGATC GCATTCGGGA GCTGGAGGAG 
GCCATGGCCG GGGAGCGGGA CAAGTTCCGG AAGATGCTGG ACGCCAAGGA GCAGGAGATG 
ACGGAGATGC GGGACGTGAT GCAGCAGCAG CTGGCCGAGT ACCAGGAGCT GCTGGACGTG 
AAGCTGGCCC TGGACATGGA GATCAACGCC TACCGGAAGC TCCTGGAGGG CGAGGAGGAG 
AGGCTGAAGC TGTCCCCCAG CCCATCCTCG CGCGTCACCG TCTCACGAGC CACCTCGAGC 
AGCAGCGGCA GCTTGTCCGC CACCGGGCGC CTGGGCCGCA GTAAGCGGAA GCGGCTGGAG 
GTGGAGGAGC CCTTGGGCAG CGGCCCAAGC GTCCTGGGCA CGGGCACGGG TGGCAGCGGT 
GGCTTCCACC TGGCCCAGCA GGCCTCGGCC TCGGGTAGCG TCAGCATCGA GGAGATCGAC 
CTGGAGGGCA AGTTTGTGCA GCTCAAGAAC AACTCGGACA AGGATCAGTC TCTGGGGAAC 
TGGAGAATCA AGAGGCAGGT CTTGGAGGGG GAGGAGATCG CCTACAAGTT CACGCCCAAG 
TACATCCTGC GCGCCGGCCA GATGGTCACG GTGTGGGCAG CTGGTGCGGG GGTGGCCCAC 
AGCCCCCCCT CGACGCTGGT GTGGAAGGGC CAGAGCAGCT GGGGCACGGG CGAGAGCTTC 
CGCACCGTCC TGGTTAACGC GGATGGCGAG GAAGTGGCCA TGAGGACTGT GAAGAAGTCC 
TCGGTGATGC GTGAGAATGA GAATGGGGAG GAAGAGGAGG AGGAAGCCGA GTTTGGCGAG 
GAGGATCTTT TCCACCAACA GGGGGACCCG AGGACCACCT CAAGAGGCTG CTACGTGATG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Chromosomal aneuploidies induced upon Lamin B2 depletion are mislocalized in the interphase nucleus.
Chromosoma126(2)223-244(2017 Mar)
Ranade D,Koul S,Thompson J,Prasad KB,Sengupta K

Autophagy mediates degradation of nuclear lamina.
Nature527(7576)105-9(2015 Nov)
Dou Z,Xu C,Donahue G,Shimi T,Pan JA,Zhu J,Ivanov A,Capell BC,Drake AM,Shah PP,Catanzaro JM,Ricketts MD,Lamark T,Adam SA,Marmorstein R,Zong WX,Johansen T,Goldman RD,Adams PD,Berger SL

Mutation of the nuclear lamin gene LMNB2 in progressive myoclonus epilepsy with early ataxia.
Human molecular genetics24(16)4483-90(2015 Aug)
Damiano JA,Afawi Z,Bahlo M,Mauermann M,Misk A,Arsov T,Oliver KL,Dahl HH,Shearer AE,Smith RJ,Hall NE,Mahmood K,Leventer RJ,Scheffer IE,Muona M,Lehesjoki AE,Korczyn AD,Herrmann H,Berkovic SF,Hildebrand MS

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LMNB2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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