TXNDC17 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TXNDC17
Entrez Gene ID	84817
Full Name	thioredoxin domain containing 17
Synonyms	TRP14,TXNL5
General protein information	Preferred Names thioredoxin domain containing 17 Names thioredoxin domain-containing protein 17 14 kDa thioredoxin-related protein protein 42-9-9 testicular tissue protein Li 214 thioredoxin (Trx)-related protein, 14 kDa thioredoxin-like 5 thioredoxin-like protein 5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17p13.1
Disorder MIM:	616967

mRNA and Protein(s)

mRNA	Protein	Name
NM_032731.3	NP_116120.1	thioredoxin domain-containing protein 17
NM_032731.4	NP_116120.1	thioredoxin domain-containing protein 17

Pathways from BioSystems

Homologies

Homo sapiens (human)	TXNDC17	NP_116120.1
	TXNDC17	XP_001103113.1
Bos taurus (cattle)	TXNDC17	NP_001192750.1
Pan troglodytes (chimpanzee)	TXNDC17	XP_511988.2
Anopheles gambiae (African malaria mosquito)	GRX3	XP_318823.2
Danio rerio (zebrafish)	txndc17	NP_001003456.1
Mus musculus (house mouse)	Txndc17	NP_080835.1
Xenopus tropicalis (tropical clawed frog)	txndc17	XP_004911789.1
Rattus norvegicus (Norway rat)	Txndc17	NP_001099275.1
Gallus gallus (chicken)	TXNDC17	XP_415925.1
Drosophila melanogaster (fruit fly)	cl	NP_001260098.1

Gene Ontology
Bibliography

Related articles in PubMed

STAT3-dependent TXNDC17 expression mediates Taxol resistance through inducing autophagy in human colorectal cancer cells.
Zhang Z, Wang A, Li H, Zhi H, Lu F
Gene584(1)75-82(2016 Jun)

TXNDC17 promotes paclitaxel resistance via inducing autophagy in ovarian cancer.
Zhang SF, Wang XY, Fu ZQ, Peng QH, Zhang JY, Ye F, Fu YF, Zhou CY, Lu WG, Cheng XD, Xie X
Autophagy11(2)225-38(2015)

Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase.
Pader I, Sengupta R, Cebula M, Xu J, Lundberg JO, Holmgren A, Johansson K, Arn?r ES
Proceedings of the National Academy of Sciences of the United States of America111(19)6964-9(2014 May)

Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
Lee OH, Kim H, He Q, Baek HJ, Yang D, Chen LY, Liang J, Chae HK, Safari A, Liu D, Songyang Z
Molecular & cellular proteomics : MCP10(2)M110.001628(2011 Feb)

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

found STAT3 could bind promoter region of TXNDC17 (-623 bp to -58 bp relative to the transcription start site (TSS)) for regulating its expression
Title: STAT3-dependent TXNDC17 expression mediates Taxol resistance through inducing autophagy in human colorectal cancer cells.

TXNDC17, through participation of BECN1, induces autophagy and consequently results in paclitaxel resistance in ovarian cancer
Title: TXNDC17 promotes paclitaxel resistance via inducing autophagy in ovarian cancer.

The oxidoreductase activities of TRP14 thereby complement those of Trx1 and must therefore be considered for the full understanding of enzymatic control of cellular thiols and nitrosothiols.
Title: Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase.

LC8 binds IkappaBalpha in a redox-dependent manner and thereby prevents its phosphorylation by IKK. TRP14 contributes to this inhibitory activity by maintaining LC8 in a reduced state.
Title: Dynein light chain LC8 negatively regulates NF-kappaB through the redox-dependent interaction with IkappaBalpha.

Data report the crystal structure of human thioredoxin-related protein 14 determined at 1.8-angstrom resolution.
Title: Structural basis of cellular redox regulation by human TRP14.

The following TXNDC17 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TXNDC17 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu10697	NM_032731.4 Latest version!	Homo sapiens thioredoxin domain containing 17 (TXNDC17), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu10697	NM_032731.3	Homo sapiens thioredoxin domain containing 17 (TXNDC17), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TXNDC17 ( NM_032731.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_116120.1 Homo sapiens thioredoxin domain containing 17 (TXNDC17), mRNA.

Price & Availability↑

CloneID	OHu10697
Clone ID Related Accession (Same CDS sequence)	NM_032731.3 , NM_032731.4
Accession Version	NM_032731.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 372bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-19
Organism	Homo sapiens(human)
Product	thioredoxin domain-containing protein 17
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CA431010.1, BC006405.2 and AC004706.1. On Jul 25, 2007 this sequence version replaced NM_032731.2. ##Evidence-Data-START## Transcript exon combination :: HM005527.1, SRR1803617.7217.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGCCCGCT ATGAGGAGGT GAGCGTGTCC GGCTTCGAGG AGTTCCACCG GGCCGTGGAA 
CAGCACAATG GCAAGACCAT TTTCGCCTAC TTTACGGGTT CTAAGGACGC CGGGGGGAAA 
AGCTGGTGCC CCGACTGCGT GCAGGCTGAA CCAGTCGTAC GAGAGGGGCT GAAGCACATT 
AGTGAAGGAT GTGTGTTCAT CTACTGCCAA GTAGGAGAAA AGCCTTATTG GAAAGATCCA 
AATAATGACT TCAGAAAAAA CTTGAAAGTA ACAGCAGTGC CTACACTACT TAAGTATGGA 
ACACCTCAAA AACTGGTAGA ATCTGAGTGT CTTCAGGCCA ACCTGGTGGA AATGTTGTTC 
TCTGAAGATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_116120.1
CDS	182..553
Translation	MARYEEVSVSGFEEFHRAVEQHNGKTIFAYFTGSKDAGGKSWCPDCVQAEPVVREGLKHISEGCVFIYCQVGEKPYWKDPNNDFRKNLKVTAVPTLLKYGTPQKLVESECLQANLVEMLFSED

Target ORF information:

RefSeq Version	NM_032731.3
Organism	Homo sapiens(human)
Definition	Homo sapiens thioredoxin domain containing 17 (TXNDC17), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032731.3

ORF Insert Sequence:

ATGGCCCGCT ATGAGGAGGT GAGCGTGTCC GGCTTCGAGG AGTTCCACCG GGCCGTGGAA 
CAGCACAATG GCAAGACCAT TTTCGCCTAC TTTACGGGTT CTAAGGACGC CGGGGGGAAA 
AGCTGGTGCC CCGACTGCGT GCAGGCTGAA CCAGTCGTAC GAGAGGGGCT GAAGCACATT 
AGTGAAGGAT GTGTGTTCAT CTACTGCCAA GTAGGAGAAA AGCCTTATTG GAAAGATCCA 
AATAATGACT TCAGAAAAAA CTTGAAAGTA ACAGCAGTGC CTACACTACT TAAGTATGGA 
ACACCTCAAA AACTGGTAGA ATCTGAGTGT CTTCAGGCCA ACCTGGTGGA AATGTTGTTC 
TCTGAAGATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TXNDC17 ( NM_032731.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_116120.1 Homo sapiens thioredoxin domain containing 17 (TXNDC17), mRNA.

Price & Availability↑

CloneID	OHu10697
Clone ID Related Accession (Same CDS sequence)	NM_032731.3 , NM_032731.4
Accession Version	NM_032731.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 372bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-19
Organism	Homo sapiens(human)
Product	thioredoxin domain-containing protein 17
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC006405.2 and AC004706.1. On May 17, 2019 this sequence version replaced NM_032731.3. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.281281.1, SRR1803615.59320.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000250101.10/ ENSP00000250101.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCCCGCT ATGAGGAGGT GAGCGTGTCC GGCTTCGAGG AGTTCCACCG GGCCGTGGAA 
CAGCACAATG GCAAGACCAT TTTCGCCTAC TTTACGGGTT CTAAGGACGC CGGGGGGAAA 
AGCTGGTGCC CCGACTGCGT GCAGGCTGAA CCAGTCGTAC GAGAGGGGCT GAAGCACATT 
AGTGAAGGAT GTGTGTTCAT CTACTGCCAA GTAGGAGAAA AGCCTTATTG GAAAGATCCA 
AATAATGACT TCAGAAAAAA CTTGAAAGTA ACAGCAGTGC CTACACTACT TAAGTATGGA 
ACACCTCAAA AACTGGTAGA ATCTGAGTGT CTTCAGGCCA ACCTGGTGGA AATGTTGTTC 
TCTGAAGATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_116120.1
CDS	24..395
Translation	MARYEEVSVSGFEEFHRAVEQHNGKTIFAYFTGSKDAGGKSWCPDCVQAEPVVREGLKHISEGCVFIYCQVGEKPYWKDPNNDFRKNLKVTAVPTLLKYGTPQKLVESECLQANLVEMLFSED

Target ORF information:

RefSeq Version	NM_032731.4
Organism	Homo sapiens(human)
Definition	Homo sapiens thioredoxin domain containing 17 (TXNDC17), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032731.4

ORF Insert Sequence:

ATGGCCCGCT ATGAGGAGGT GAGCGTGTCC GGCTTCGAGG AGTTCCACCG GGCCGTGGAA 
CAGCACAATG GCAAGACCAT TTTCGCCTAC TTTACGGGTT CTAAGGACGC CGGGGGGAAA 
AGCTGGTGCC CCGACTGCGT GCAGGCTGAA CCAGTCGTAC GAGAGGGGCT GAAGCACATT 
AGTGAAGGAT GTGTGTTCAT CTACTGCCAA GTAGGAGAAA AGCCTTATTG GAAAGATCCA 
AATAATGACT TCAGAAAAAA CTTGAAAGTA ACAGCAGTGC CTACACTACT TAAGTATGGA 
ACACCTCAAA AACTGGTAGA ATCTGAGTGT CTTCAGGCCA ACCTGGTGGA AATGTTGTTC 
TCTGAAGATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

STAT3-dependent TXNDC17 expression mediates Taxol resistance through inducing autophagy in human colorectal cancer cells.
Gene584(1)75-82(2016 Jun)
Zhang Z,Wang A,Li H,Zhi H,Lu F

TXNDC17 promotes paclitaxel resistance via inducing autophagy in ovarian cancer.
Autophagy11(2)225-38(2015)
Zhang SF,Wang XY,Fu ZQ,Peng QH,Zhang JY,Ye F,Fu YF,Zhou CY,Lu WG,Cheng XD,Xie X

Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase.
Proceedings of the National Academy of Sciences of the United States of America111(19)6964-9(2014 May)
Pader I,Sengupta R,Cebula M,Xu J,Lundberg JO,Holmgren A,Johansson K,Arn?r ES

Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
Molecular & cellular proteomics : MCP10(2)M110.001628(2011 Feb)
Lee OH,Kim H,He Q,Baek HJ,Yang D,Chen LY,Liang J,Chae HK,Safari A,Liu D,Songyang Z

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)
Gonzales PA,Pisitkun T,Hoffert JD,Tchapyjnikov D,Star RA,Kleta R,Wang NS,Knepper MA

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TXNDC17 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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