FAM220A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FAM220A
Entrez Gene ID	84792
Full Name	family with sequence similarity 220 member A
Synonyms	ACPIN1,C7orf70,SIPAR
General protein information	Preferred Names family with sequence similarity 220 member A Names protein FAM220A STAT3-interacting protein as a repressor acrosomal protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p22.1
Disorder MIM:	616628

mRNA and Protein(s)

mRNA	Protein	Name
NM_001037163.1	NP_001032240.1	protein FAM220A
NM_001037163.2	NP_001032240.1	protein FAM220A

Pathways from BioSystems

Homologies

Homo sapiens (human)	FAM220A	NP_001032240.1
Canis lupus familiaris (dog)	FAM220A	XP_005621180.1
Rattus norvegicus (Norway rat)	Fam220a	NP_001017485.1
Pan troglodytes (chimpanzee)	FAM220A	XP_003318353.1
	LOC703785	XP_001090217.2
Mus musculus (house mouse)	Fam220a	NP_598464.3

Gene Ontology
Bibliography

Related articles in PubMed

Nuclear termination of STAT3 signaling through SIPAR (STAT3-Interacting Protein As a Repressor)-dependent recruitment of T cell tyrosine phosphatase TC-PTP.
Ren F, Geng Y, Minami T, Qiu Y, Feng Y, Liu C, Zhao J, Wang Y, Fan X, Wang Y, Li M, Li J, Chang Z
FEBS letters589(15)1890-6(2015 Jul)

SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma.
Ren F, Su F, Ning H, Wang Y, Geng Y, Feng Y, Wang Y, Zhang Y, Jin Z, Li Y, Jia B, Chang Z
Cellular signalling25(11)2272-80(2013 Nov)

Unique alternative translation from two open reading frames on Acpin1 mRNA yields an acrosomal protein and a salivary-gland-specific protein.
Ueda T, Manabe H, Tokuhiro K, Hirose M, Matsuoka Y, Miyagawa Y, Tsujimura A, Fujita K, Wada M, Okuyama A, Nishimune Y, Tanaka H
International journal of urology : official journal of the Japanese Urological Association16(7)639-46(2009 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results suggest that SIPAR terminates the activation of STAT3 through a dephosphorylation process that is dependent upon interaction with TC45 in the nucleus
Title: Nuclear termination of STAT3 signaling through SIPAR (STAT3-Interacting Protein As a Repressor)-dependent recruitment of T cell tyrosine phosphatase TC-PTP.

The following FAM220A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FAM220A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30911	NM_001037163.2 Latest version!	Homo sapiens family with sequence similarity 220 member A (FAM220A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu30911	NM_001037163.1	Homo sapiens family with sequence similarity 220 member A (FAM220A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FAM220A ( NM_001037163.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001032240.1 Homo sapiens family with sequence similarity 220 member A (FAM220A), mRNA.

Price & Availability↑

CloneID	OHu30911
Clone ID Related Accession (Same CDS sequence)	NM_001037163.1 , NM_001037163.2
Accession Version	NM_001037163.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 780bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	protein FAM220A
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP354450.1 and AF533707.1. On or before Mar 4, 2006 this sequence version replaced XM_930588.1, XM_942732.1, XM_935791.1. ##Evidence-Data-START## Transcript exon combination :: AF533707.1, BC142977.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGGACA GAAGAGGGCC CCTCGGCACC TGCCTGGCAC AAGTGCAGCA GGCCGGAGGA 
GGTGACTCGG ACAAACTATC ATGCAGCCTT AAGAAAAGAA TGCCGGAGGG CCCTTGGCCT 
GCAGATGCAC CCTCCTGGAT GAATAAGCCT GTGGTTGATG GAAATTCACA AAGTGAGGCA 
TTATCACTGG AAATGAGAAA GGATCCGAGC GGGGCTGGCC TCTGGCTTCA CAGTGGCGGC 
CCAGTGCTTC CATATGTGAG AGAATCAGTA AGAAGAAATC CAGCCTCAGC AGCCACTCCG 
AGCACAGCCG TGGGTTTGTT CCCTGCTCCA ACAGAGTGTT TTGCTCGGGT GTCCTGCAGT 
GGTGTTGAAG CTCTGGGGCG GCGAGACTGG CTGGGAGGAG GGCCCAGGGC CACTGACGGC 
CACAGAGGAC AGTGCCCCAA AGGAGAGCCT CGGGTGTCAC GACTGCCACG CCATCAAAAA 
GTGCCGGAAA TGGGAAGTTT TCAGGATGAC CCACCAAGTG CTTTTCCCAA GGGTCTGGGC 
TCTGAGTTGG AACCCGCTTG CCTGCACTCC ATCCTGTCTG CAACGCTGCA CGTGTATCCC 
GAAGTGCTCC TGAGTGAGGA GACAAAACGC ATTTTCCTTG ACCGTTTAAA GCCCATGTTT 
TCAAAGCAAA CAATAGAATT CAAGAAAATG CTTAAAAGCA CCTCAGATGG TCTGCAGATA 
ACACTGGGGT TACTGGCTCT GCAACCTTTT GAATTAGCAA ATACATTATG CCATAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001032240.1
CDS	469..1248
Translation	MRDRRGPLGTCLAQVQQAGGGDSDKLSCSLKKRMPEGPWPADAPSWMNKPVVDGNSQSEALSLEMRKDPSGAGLWLHSGGPVLPYVRESVRRNPASAATPSTAVGLFPAPTECFARVSCSGVEALGRRDWLGGGPRATDGHRGQCPKGEPRVSRLPRHQKVPEMGSFQDDPPSAFPKGLGSELEPACLHSILSATLHVYPEVLLSEETKRIFLDRLKPMFSKQTIEFKKMLKSTSDGLQITLGLLALQPFELANTLCHS

Target ORF information:

RefSeq Version	NM_001037163.1
Organism	Homo sapiens(human)
Definition	Homo sapiens family with sequence similarity 220 member A (FAM220A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037163.1

ORF Insert Sequence:

ATGAGGGACA GAAGAGGGCC CCTCGGCACC TGCCTGGCAC AAGTGCAGCA GGCCGGAGGA 
GGTGACTCGG ACAAACTATC ATGCAGCCTT AAGAAAAGAA TGCCGGAGGG CCCTTGGCCT 
GCAGATGCAC CCTCCTGGAT GAATAAGCCT GTGGTTGATG GAAATTCACA AAGTGAGGCA 
TTATCACTGG AAATGAGAAA GGATCCGAGC GGGGCTGGCC TCTGGCTTCA CAGTGGCGGC 
CCAGTGCTTC CATATGTGAG AGAATCAGTA AGAAGAAATC CAGCCTCAGC AGCCACTCCG 
AGCACAGCCG TGGGTTTGTT CCCTGCTCCA ACAGAGTGTT TTGCTCGGGT GTCCTGCAGT 
GGTGTTGAAG CTCTGGGGCG GCGAGACTGG CTGGGAGGAG GGCCCAGGGC CACTGACGGC 
CACAGAGGAC AGTGCCCCAA AGGAGAGCCT CGGGTGTCAC GACTGCCACG CCATCAAAAA 
GTGCCGGAAA TGGGAAGTTT TCAGGATGAC CCACCAAGTG CTTTTCCCAA GGGTCTGGGC 
TCTGAGTTGG AACCCGCTTG CCTGCACTCC ATCCTGTCTG CAACGCTGCA CGTGTATCCC 
GAAGTGCTCC TGAGTGAGGA GACAAAACGC ATTTTCCTTG ACCGTTTAAA GCCCATGTTT 
TCAAAGCAAA CAATAGAATT CAAGAAAATG CTTAAAAGCA CCTCAGATGG TCTGCAGATA 
ACACTGGGGT TACTGGCTCT GCAACCTTTT GAATTAGCAA ATACATTATG CCATAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FAM220A ( NM_001037163.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001032240.1 Homo sapiens family with sequence similarity 220 member A (FAM220A), mRNA.

Price & Availability↑

CloneID	OHu30911
Clone ID Related Accession (Same CDS sequence)	NM_001037163.1 , NM_001037163.2
Accession Version	NM_001037163.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 780bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	protein FAM220A
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC009412.6, BP354450.1 and AF533707.1. On Nov 22, 2018 this sequence version replaced NM_001037163.1. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.450904.1, SRR3476690.81585.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000313324.9/ ENSP00000317289.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGGGACA GAAGAGGGCC CCTCGGCACC TGCCTGGCAC AAGTGCAGCA GGCCGGAGGA 
GGTGACTCGG ACAAACTATC ATGCAGCCTT AAGAAAAGAA TGCCGGAGGG CCCTTGGCCT 
GCAGATGCAC CCTCCTGGAT GAATAAGCCT GTGGTTGATG GAAATTCACA AAGTGAGGCA 
TTATCACTGG AAATGAGAAA GGATCCGAGC GGGGCTGGCC TCTGGCTTCA CAGTGGCGGC 
CCAGTGCTTC CATATGTGAG AGAATCAGTA AGAAGAAATC CAGCCTCAGC AGCCACTCCG 
AGCACAGCCG TGGGTTTGTT CCCTGCTCCA ACAGAGTGTT TTGCTCGGGT GTCCTGCAGT 
GGTGTTGAAG CTCTGGGGCG GCGAGACTGG CTGGGAGGAG GGCCCAGGGC CACTGACGGC 
CACAGAGGAC AGTGCCCCAA AGGAGAGCCT CGGGTGTCAC GACTGCCACG CCATCAAAAA 
GTGCCGGAAA TGGGAAGTTT TCAGGATGAC CCACCAAGTG CTTTTCCCAA GGGTCTGGGC 
TCTGAGTTGG AACCCGCTTG CCTGCACTCC ATCCTGTCTG CAACGCTGCA CGTGTATCCC 
GAAGTGCTCC TGAGTGAGGA GACAAAACGC ATTTTCCTTG ACCGTTTAAA GCCCATGTTT 
TCAAAGCAAA CAATAGAATT CAAGAAAATG CTTAAAAGCA CCTCAGATGG TCTGCAGATA 
ACACTGGGGT TACTGGCTCT GCAACCTTTT GAATTAGCAA ATACATTATG CCATAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001032240.1
CDS	477..1256
Translation	MRDRRGPLGTCLAQVQQAGGGDSDKLSCSLKKRMPEGPWPADAPSWMNKPVVDGNSQSEALSLEMRKDPSGAGLWLHSGGPVLPYVRESVRRNPASAATPSTAVGLFPAPTECFARVSCSGVEALGRRDWLGGGPRATDGHRGQCPKGEPRVSRLPRHQKVPEMGSFQDDPPSAFPKGLGSELEPACLHSILSATLHVYPEVLLSEETKRIFLDRLKPMFSKQTIEFKKMLKSTSDGLQITLGLLALQPFELANTLCHS

Target ORF information:

RefSeq Version	NM_001037163.2
Organism	Homo sapiens(human)
Definition	Homo sapiens family with sequence similarity 220 member A (FAM220A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037163.2

ORF Insert Sequence:

ATGAGGGACA GAAGAGGGCC CCTCGGCACC TGCCTGGCAC AAGTGCAGCA GGCCGGAGGA 
GGTGACTCGG ACAAACTATC ATGCAGCCTT AAGAAAAGAA TGCCGGAGGG CCCTTGGCCT 
GCAGATGCAC CCTCCTGGAT GAATAAGCCT GTGGTTGATG GAAATTCACA AAGTGAGGCA 
TTATCACTGG AAATGAGAAA GGATCCGAGC GGGGCTGGCC TCTGGCTTCA CAGTGGCGGC 
CCAGTGCTTC CATATGTGAG AGAATCAGTA AGAAGAAATC CAGCCTCAGC AGCCACTCCG 
AGCACAGCCG TGGGTTTGTT CCCTGCTCCA ACAGAGTGTT TTGCTCGGGT GTCCTGCAGT 
GGTGTTGAAG CTCTGGGGCG GCGAGACTGG CTGGGAGGAG GGCCCAGGGC CACTGACGGC 
CACAGAGGAC AGTGCCCCAA AGGAGAGCCT CGGGTGTCAC GACTGCCACG CCATCAAAAA 
GTGCCGGAAA TGGGAAGTTT TCAGGATGAC CCACCAAGTG CTTTTCCCAA GGGTCTGGGC 
TCTGAGTTGG AACCCGCTTG CCTGCACTCC ATCCTGTCTG CAACGCTGCA CGTGTATCCC 
GAAGTGCTCC TGAGTGAGGA GACAAAACGC ATTTTCCTTG ACCGTTTAAA GCCCATGTTT 
TCAAAGCAAA CAATAGAATT CAAGAAAATG CTTAAAAGCA CCTCAGATGG TCTGCAGATA 
ACACTGGGGT TACTGGCTCT GCAACCTTTT GAATTAGCAA ATACATTATG CCATAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nuclear termination of STAT3 signaling through SIPAR (STAT3-Interacting Protein As a Repressor)-dependent recruitment of T cell tyrosine phosphatase TC-PTP.
FEBS letters589(15)1890-6(2015 Jul)
Ren F,Geng Y,Minami T,Qiu Y,Feng Y,Liu C,Zhao J,Wang Y,Fan X,Wang Y,Li M,Li J,Chang Z

SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma.
Cellular signalling25(11)2272-80(2013 Nov)
Ren F,Su F,Ning H,Wang Y,Geng Y,Feng Y,Wang Y,Zhang Y,Jin Z,Li Y,Jia B,Chang Z

Unique alternative translation from two open reading frames on Acpin1 mRNA yields an acrosomal protein and a salivary-gland-specific protein.
International journal of urology : official journal of the Japanese Urological Association16(7)639-46(2009 Jul)
Ueda T,Manabe H,Tokuhiro K,Hirose M,Matsuoka Y,Miyagawa Y,Tsujimura A,Fujita K,Wada M,Okuyama A,Nishimune Y,Tanaka H

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FAM220A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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