UNC119B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	UNC119B
Entrez Gene ID	84747
Full Name	unc-119 lipid binding chaperone B
Synonyms	POC7B
General protein information	Preferred Names unc-119 lipid binding chaperone B Names protein unc-119 homolog B POC7 centriolar protein homolog B unc-119 homolog B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q24.31

mRNA and Protein(s)

mRNA	Protein	Name
NM_001080533.2	NP_001074002.1	protein unc-119 homolog B
NM_001080533.3	NP_001074002.1	protein unc-119 homolog B

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	unc119b	NP_001016815.1
Pan troglodytes (chimpanzee)	UNC119B	XP_001162824.1
Bos taurus (cattle)	UNC119B	NP_001193216.1
Rattus norvegicus (Norway rat)	Unc119b	NP_001099404.1
Gallus gallus (chicken)	UNC119B	XP_415263.2
Danio rerio (zebrafish)	unc119.1	NP_997952.1
Mus musculus (house mouse)	Unc119b	NP_780561.1
Homo sapiens (human)	UNC119B	NP_001074002.1
	UNC119B	XP_001090762.1
Canis lupus familiaris (dog)	UNC119B	XP_854302.2
Caenorhabditis elegans (roundworm)	unc-119	NP_001255088.1

Gene Ontology
Bibliography

Related articles in PubMed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R,
Nature communications711491(2016 May)

The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function.
Lokaj M, K?sling SK, Koerner C, Lange SM, van Beersum SE, van Reeuwijk J, Roepman R, Horn N, Ueffing M, Boldt K, Wittinghofer A
Structure (London, England : 1993)23(11)2122-32(2015 Nov)

An atlas of genetic influences on human blood metabolites.
Shin SY, Fauman EB, Petersen AK, Krumsiek J, Santos R, Huang J, Arnold M, Erte I, Forgetta V, Yang TP, Walter K, Menni C, Chen L, Vasquez L, Valdes AM, Hyde CL, Wang V, Ziemek D, Roberts P, Xi L, Grundberg E, , Waldenberger M, Richards JB, Mohney RP, Milburn MV, John SL, Trimmer J, Theis FJ, Overington JP, Suhre K, Brosnan MJ, Gieger C, Kastenm?ller G, Spector TD, Soranzo N
Nature genetics46(6)543-550(2014 Jun)

Uncoordinated (UNC)119: coordinating the trafficking of myristoylated proteins.
Constantine R, Zhang H, Gerstner CD, Frederick JM, Baehr W
Vision research7526-32(2012 Dec)

An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium.
Wright KJ, Baye LM, Olivier-Mason A, Mukhopadhyay S, Sang L, Kwong M, Wang W, Pretorius PR, Sheffield VC, Sengupta P, Slusarski DC, Jackson PK
Genes & development25(22)2347-60(2011 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

The following UNC119B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UNC119B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu01399	NM_001080533.3 Latest version!	Homo sapiens unc-119 lipid binding chaperone B (UNC119B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
View Old Accession Versions >>
OHu01399	NM_001080533.2	Homo sapiens unc-119 lipid binding chaperone B (UNC119B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

UNC119B ( NM_001080533.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001074002.1 Homo sapiens unc-119 lipid binding chaperone B (UNC119B), mRNA.

Price & Availability↑

CloneID	OHu01399
Clone ID Related Accession (Same CDS sequence)	NM_001080533.2 , NM_001080533.3
Accession Version	NM_001080533.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 756bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	protein unc-119 homolog B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA324219.1, BC070088.1, AC069234.35 and AL137327.1. On Dec 5, 2012 this sequence version replaced NM_001080533.1. ##Evidence-Data-START## Transcript exon combination :: BC070088.1, SRR1803614.210752.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCGGGT CTAACCCGAA GGCTGCGGCC GCGGCGTCGG CGGCTGGGCC CGGGGGGCTG 
GTGGCTGGCA AGGAGGAGAA GAAGAAGGCG GGCGGCGGCG TCCTGAACCG CCTGAAGGCG 
CGGCGGCAGG CGCCCCACCA CGCGGCCGAC GACGGCGTCG GGGCAGCGGT CACGGAGCAG 
GAGCTGCTGG CGCTGGACAC CATCCGGCCC GAGCACGTCC TGCGCCTCAG CCGGGTCACC 
GAGAATTATT TATGTAAACC CGAAGACAAC ATCTACAGTA TTGATTTCAC CCGCTTCAAA 
ATTCGAGATT TGGAGACAGG GACAGTACTT TTTGAGATTG CCAAACCTTG CGTTTCAGAC 
CAGGAGGAGG ATGAGGAGGA GGGAGGTGGA GACGTGGACA TCAGCGCAGG ACGTTTTGTC 
CGCTATCAGT TCACACCGGC ATTTCTCCGC CTCCGGACAG TCGGGGCTAC GGTGGAGTTC 
ACAGTGGGAG ACAAACCTGT TTCAAACTTC CGGATGATCG AACGGCACTA TTTCCGGGAA 
CACTTGCTGA AAAACTTTGA CTTTGATTTT GGCTTCTGCA TCCCCAGCAG TAGGAACACT 
TGTGAACATA TCTATGAGTT TCCCCAGCTT TCGGAGGATG TCATTCGTCT AATGATTGAA 
AATCCTTACG AGACCCGCTC TGACAGCTTC TACTTTGTTG ACAACAAGCT GATAATGCAC 
AACAAGGCTG ATTATGCCTA TAATGGAGGC CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001074002.1
CDS	41..796
Translation	MSGSNPKAAAAASAAGPGGLVAGKEEKKKAGGGVLNRLKARRQAPHHAADDGVGAAVTEQELLALDTIRPEHVLRLSRVTENYLCKPEDNIYSIDFTRFKIRDLETGTVLFEIAKPCVSDQEEDEEEGGGDVDISAGRFVRYQFTPAFLRLRTVGATVEFTVGDKPVSNFRMIERHYFREHLLKNFDFDFGFCIPSSRNTCEHIYEFPQLSEDVIRLMIENPYETRSDSFYFVDNKLIMHNKADYAYNGGQ

Target ORF information:

RefSeq Version	NM_001080533.2
Organism	Homo sapiens(human)
Definition	Homo sapiens unc-119 lipid binding chaperone B (UNC119B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001080533.2

ORF Insert Sequence:

ATGAGCGGGT CTAACCCGAA GGCTGCGGCC GCGGCGTCGG CGGCTGGGCC CGGGGGGCTG 
GTGGCTGGCA AGGAGGAGAA GAAGAAGGCG GGCGGCGGCG TCCTGAACCG CCTGAAGGCG 
CGGCGGCAGG CGCCCCACCA CGCGGCCGAC GACGGCGTCG GGGCAGCGGT CACGGAGCAG 
GAGCTGCTGG CGCTGGACAC CATCCGGCCC GAGCACGTCC TGCGCCTCAG CCGGGTCACC 
GAGAATTATT TATGTAAACC CGAAGACAAC ATCTACAGTA TTGATTTCAC CCGCTTCAAA 
ATTCGAGATT TGGAGACAGG GACAGTACTT TTTGAGATTG CCAAACCTTG CGTTTCAGAC 
CAGGAGGAGG ATGAGGAGGA GGGAGGTGGA GACGTGGACA TCAGCGCAGG ACGTTTTGTC 
CGCTATCAGT TCACACCGGC ATTTCTCCGC CTCCGGACAG TCGGGGCTAC GGTGGAGTTC 
ACAGTGGGAG ACAAACCTGT TTCAAACTTC CGGATGATCG AACGGCACTA TTTCCGGGAA 
CACTTGCTGA AAAACTTTGA CTTTGATTTT GGCTTCTGCA TCCCCAGCAG TAGGAACACT 
TGTGAACATA TCTATGAGTT TCCCCAGCTT TCGGAGGATG TCATTCGTCT AATGATTGAA 
AATCCTTACG AGACCCGCTC TGACAGCTTC TACTTTGTTG ACAACAAGCT GATAATGCAC 
AACAAGGCTG ATTATGCCTA TAATGGAGGC CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UNC119B ( NM_001080533.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001074002.1 Homo sapiens unc-119 lipid binding chaperone B (UNC119B), mRNA.

Price & Availability↑

CloneID	OHu01399
Clone ID Related Accession (Same CDS sequence)	NM_001080533.2 , NM_001080533.3
Accession Version	NM_001080533.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 756bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	protein unc-119 homolog B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA324219.1, BC070088.1, AC069234.35 and AL137327.1. On Nov 23, 2018 this sequence version replaced NM_001080533.2. ##Evidence-Data-START## Transcript exon combination :: BC070088.1, SRR1803614.210752.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000344651.5/ ENSP00000344942.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCGGGT CTAACCCGAA GGCTGCGGCC GCGGCGTCGG CGGCTGGGCC CGGGGGGCTG 
GTGGCTGGCA AGGAGGAGAA GAAGAAGGCG GGCGGCGGCG TCCTGAACCG CCTGAAGGCG 
CGGCGGCAGG CGCCCCACCA CGCGGCCGAC GACGGCGTCG GGGCAGCGGT CACGGAGCAG 
GAGCTGCTGG CGCTGGACAC CATCCGGCCC GAGCACGTCC TGCGCCTCAG CCGGGTCACC 
GAGAATTATT TATGTAAACC CGAAGACAAC ATCTACAGTA TTGATTTCAC CCGCTTCAAA 
ATTCGAGATT TGGAGACAGG GACAGTACTT TTTGAGATTG CCAAACCTTG CGTTTCAGAC 
CAGGAGGAGG ATGAGGAGGA GGGAGGTGGA GACGTGGACA TCAGCGCAGG ACGTTTTGTC 
CGCTATCAGT TCACACCGGC ATTTCTCCGC CTCCGGACAG TCGGGGCTAC GGTGGAGTTC 
ACAGTGGGAG ACAAACCTGT TTCAAACTTC CGGATGATCG AACGGCACTA TTTCCGGGAA 
CACTTGCTGA AAAACTTTGA CTTTGATTTT GGCTTCTGCA TCCCCAGCAG TAGGAACACT 
TGTGAACATA TCTATGAGTT TCCCCAGCTT TCGGAGGATG TCATTCGTCT AATGATTGAA 
AATCCTTACG AGACCCGCTC TGACAGCTTC TACTTTGTTG ACAACAAGCT GATAATGCAC 
AACAAGGCTG ATTATGCCTA TAATGGAGGC CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001074002.1
CDS	18..773
Translation	MSGSNPKAAAAASAAGPGGLVAGKEEKKKAGGGVLNRLKARRQAPHHAADDGVGAAVTEQELLALDTIRPEHVLRLSRVTENYLCKPEDNIYSIDFTRFKIRDLETGTVLFEIAKPCVSDQEEDEEEGGGDVDISAGRFVRYQFTPAFLRLRTVGATVEFTVGDKPVSNFRMIERHYFREHLLKNFDFDFGFCIPSSRNTCEHIYEFPQLSEDVIRLMIENPYETRSDSFYFVDNKLIMHNKADYAYNGGQ

Target ORF information:

RefSeq Version	NM_001080533.3
Organism	Homo sapiens(human)
Definition	Homo sapiens unc-119 lipid binding chaperone B (UNC119B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001080533.3

ORF Insert Sequence:

ATGAGCGGGT CTAACCCGAA GGCTGCGGCC GCGGCGTCGG CGGCTGGGCC CGGGGGGCTG 
GTGGCTGGCA AGGAGGAGAA GAAGAAGGCG GGCGGCGGCG TCCTGAACCG CCTGAAGGCG 
CGGCGGCAGG CGCCCCACCA CGCGGCCGAC GACGGCGTCG GGGCAGCGGT CACGGAGCAG 
GAGCTGCTGG CGCTGGACAC CATCCGGCCC GAGCACGTCC TGCGCCTCAG CCGGGTCACC 
GAGAATTATT TATGTAAACC CGAAGACAAC ATCTACAGTA TTGATTTCAC CCGCTTCAAA 
ATTCGAGATT TGGAGACAGG GACAGTACTT TTTGAGATTG CCAAACCTTG CGTTTCAGAC 
CAGGAGGAGG ATGAGGAGGA GGGAGGTGGA GACGTGGACA TCAGCGCAGG ACGTTTTGTC 
CGCTATCAGT TCACACCGGC ATTTCTCCGC CTCCGGACAG TCGGGGCTAC GGTGGAGTTC 
ACAGTGGGAG ACAAACCTGT TTCAAACTTC CGGATGATCG AACGGCACTA TTTCCGGGAA 
CACTTGCTGA AAAACTTTGA CTTTGATTTT GGCTTCTGCA TCCCCAGCAG TAGGAACACT 
TGTGAACATA TCTATGAGTT TCCCCAGCTT TCGGAGGATG TCATTCGTCT AATGATTGAA 
AATCCTTACG AGACCCGCTC TGACAGCTTC TACTTTGTTG ACAACAAGCT GATAATGCAC 
AACAAGGCTG ATTATGCCTA TAATGGAGGC CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Nature communications711491(2016 May)
Boldt K,van Reeuwijk J,Lu Q,Koutroumpas K,Nguyen TM,Texier Y,van Beersum SE,Horn N,Willer JR,Mans DA,Dougherty G,Lamers IJ,Coene KL,Arts HH,Betts MJ,Beyer T,Bolat E,Gloeckner CJ,Haidari K,Hetterschijt L,Iaconis D,Jenkins D,Klose F,Knapp B,Latour B,Letteboer SJ,Marcelis CL,Mitic D,Morleo M,Oud MM,Riemersma M,Rix S,Terhal PA,Toedt G,van Dam TJ,de Vrieze E,Wissinger Y,Wu KM,Apic G,Beales PL,Blacque OE,Gibson TJ,Huynen MA,Katsanis N,Kremer H,Omran H,van Wijk E,Wolfrum U,Kepes F,Davis EE,Franco B,Giles RH,Ueffing M,Russell RB,Roepman R,

The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function.
Structure (London, England : 1993)23(11)2122-32(2015 Nov)
Lokaj M,K?sling SK,Koerner C,Lange SM,van Beersum SE,van Reeuwijk J,Roepman R,Horn N,Ueffing M,Boldt K,Wittinghofer A

An atlas of genetic influences on human blood metabolites.
Nature genetics46(6)543-550(2014 Jun)
Shin SY,Fauman EB,Petersen AK,Krumsiek J,Santos R,Huang J,Arnold M,Erte I,Forgetta V,Yang TP,Walter K,Menni C,Chen L,Vasquez L,Valdes AM,Hyde CL,Wang V,Ziemek D,Roberts P,Xi L,Grundberg E,,Waldenberger M,Richards JB,Mohney RP,Milburn MV,John SL,Trimmer J,Theis FJ,Overington JP,Suhre K,Brosnan MJ,Gieger C,Kastenm?ller G,Spector TD,Soranzo N

Uncoordinated (UNC)119: coordinating the trafficking of myristoylated proteins.
Vision research7526-32(2012 Dec)
Constantine R,Zhang H,Gerstner CD,Frederick JM,Baehr W

An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium.
Genes & development25(22)2347-60(2011 Nov)
Wright KJ,Baye LM,Olivier-Mason A,Mukhopadhyay S,Sang L,Kwong M,Wang W,Pretorius PR,Sheffield VC,Sengupta P,Slusarski DC,Jackson PK

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UNC119B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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