MGARP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MGARP
Entrez Gene ID	84709
Full Name	mitochondria localized glutamic acid rich protein
Synonyms	C4orf49,CESP-1,HUMMR,OSAP
General protein information	Preferred Names mitochondria localized glutamic acid rich protein Names protein MGARP corneal endothelium-specific protein 1 hypoxia up-regulated mitochondrial movement regulator protein ovary-specific acidic protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q31.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_032623.4	NP_116012.2	protein MGARP
NM_032623.3	NP_116012.2	protein MGARP

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MGARP	XP_001137849.1
Mus musculus (house mouse)	Mgarp	NP_080634.2
Rattus norvegicus (Norway rat)	Mgarp	NP_001103026.1
Homo sapiens (human)	MGARP	NP_116012.2
	MGARP	XP_001087713.1
Canis lupus familiaris (dog)	MGARP	XP_849928.1
Bos taurus (cattle)	MGARP	NP_001160083.1

Gene Ontology
Bibliography

Related articles in PubMed

Mitochondria-localized glutamic acid-rich protein (MGARP) gene transcription is regulated by Sp1.
Jin D, Li R, Mao D, Luo N, Wang Y, Chen S, Zhang S
PloS one7(11)e50053(2012)

The expression of a mitochondria-localized glutamic acid-rich protein (MGARP/OSAP) is under the regulation of the HPG axis.
Zhou M, Wang Y, Qi S, Wang J, Zhang S
Endocrinology152(6)2311-20(2011 Jun)

A mitochondria-localized glutamic acid-rich protein (MGARP/OSAP) is highly expressed in retina that exhibits a large area of intrinsic disorder.
Qi S, Wang Y, Zhou M, Ge Y, Yan Y, Wang J, Zhang SS, Zhang S
Molecular biology reports38(5)2869-77(2011 Jun)

During hypoxia, HUMMR joins the mitochondrial dance.
Li Y, Rempe DA
Cell cycle (Georgetown, Tex.)9(1)50-7(2010 Jan)

HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport.
Li Y, Lim S, Hoffman D, Aspenstrom P, Federoff HJ, Rempe DA
The Journal of cell biology185(6)1065-81(2009 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The present study identified a proximal core sequence in the MGARP promoter that is composed of two enriched Sp1 binding motifs and established Sp1 as one major MGARP transactivator.
Title: Mitochondria-localized glutamic acid-rich protein (MGARP) gene transcription is regulated by Sp1.

Results identify a mitochondria-localized glutamic acid-rich protein (MGARP/OSAP) as one of the highly expressed proteins in retina [MGARP].
Title: A mitochondria-localized glutamic acid-rich protein (MGARP/OSAP) is highly expressed in retina that exhibits a large area of intrinsic disorder.

OSAP is prominently expressed in steroidogenic tissues; results suggest that OSAP is involved in steroidogenesis, potentially through its ability to maintain mitochondrial abundance and morphology
Title: Expression of ovary-specific acidic protein in steroidogenic tissues: a possible role in steroidogenesis.

Results identify a novel mitochondria protein, hypoxia up-regulated mitochondrial movement regulator (HUMMR), which is expressed in neurons and is markedly induced by hypoxia-inducible factor 1 alpha (HIF-1alpha).
Title: HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport.

The following MGARP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MGARP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16277	NM_032623.4 Latest version!	Homo sapiens mitochondria localized glutamic acid rich protein (MGARP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu16277	NM_032623.3	Homo sapiens mitochondria localized glutamic acid rich protein (MGARP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MGARP ( NM_032623.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_116012.2 Homo sapiens mitochondria localized glutamic acid rich protein (MGARP), mRNA.

Price & Availability↑

CloneID	OHu16277
Clone ID Related Accession (Same CDS sequence)	NM_032623.4 , NM_032623.3
Accession Version	NM_032623.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 723bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	protein MGARP
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF484960.1. On Nov 22, 2018 this sequence version replaced NM_032623.3. ##Evidence-Data-START## Transcript exon combination :: AF329088.1, AF484960.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267761 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology MANE Ensembl match :: ENST00000398955.2/ ENSP00000381928.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTATCTCC GCAGGGCGGT CTCCAAGACT CTGGCGCTGC CGCTGAGGGC GCCCCCCAAC 
CCCGCGCCGC TCGGAAAGGA CGCATCTCTG CGCCGGATGT CATCTAACAG ATTCCCTGGA 
TCATCTGGAT CAAATATGAT TTATTATCTG GTTGTAGGCG TCACAGTCAG TGCTGGTGGA 
TATTATGCTT ACAAGACAGT CACATCAGAC CAAGCCAAAC ACACAGAACA TAAAACAAAT 
TTGAAAGAAA AAACAAAAGC AGAGATACAT CCATTTCAAG GTGAAAAGGA GAATGTTGCG 
GAAACTGAGA AAGCAAGTTC AGAAGCCCCA GAAGAACTTA TAGTGGAAGC TGAGGTGGTA 
GATGCTGAAG AAAGTCCCAG TGCTACAGTT GTGGTCATAA AAGAGGCATC TGCCTGTCCA 
GGTCACGTGG AGGCTGCTCC GGAGACCACA GCAGTCAGTG CTGAAACCGG GCCAGAGGTC 
ACAGATGCAG CGGCGAGGGA AACCACGGAA GTAAACCCTG AAACAACCCC AGAGGTTACA 
AATGCTGCCC TGGATGAAGC TGTCACCATC GATAATGATA AAGATACAAC AAAGAACGAA 
ACCTCTGATG AATATGCTGA ACTAGAAGAA GAAAATTCTC CAGCTGAGTC AGAGTCCTCT 
GCTGGAGATG ATTTACAGGA GGAAGCCAGT GTTGGCTCTG AGGCTGCTTC GGCTCAAGGC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_116012.2
CDS	68..790
Translation	MYLRRAVSKTLALPLRAPPNPAPLGKDASLRRMSSNRFPGSSGSNMIYYLVVGVTVSAGGYYAYKTVTSDQAKHTEHKTNLKEKTKAEIHPFQGEKENVAETEKASSEAPEELIVEAEVVDAEESPSATVVVIKEASACPGHVEAAPETTAVSAETGPEVTDAAARETTEVNPETTPEVTNAALDEAVTIDNDKDTTKNETSDEYAELEEENSPAESESSAGDDLQEEASVGSEAASAQG

Target ORF information:

RefSeq Version	NM_032623.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondria localized glutamic acid rich protein (MGARP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032623.4

ORF Insert Sequence:

ATGTATCTCC GCAGGGCGGT CTCCAAGACT CTGGCGCTGC CGCTGAGGGC GCCCCCCAAC 
CCCGCGCCGC TCGGAAAGGA CGCATCTCTG CGCCGGATGT CATCTAACAG ATTCCCTGGA 
TCATCTGGAT CAAATATGAT TTATTATCTG GTTGTAGGCG TCACAGTCAG TGCTGGTGGA 
TATTATGCTT ACAAGACAGT CACATCAGAC CAAGCCAAAC ACACAGAACA TAAAACAAAT 
TTGAAAGAAA AAACAAAAGC AGAGATACAT CCATTTCAAG GTGAAAAGGA GAATGTTGCG 
GAAACTGAGA AAGCAAGTTC AGAAGCCCCA GAAGAACTTA TAGTGGAAGC TGAGGTGGTA 
GATGCTGAAG AAAGTCCCAG TGCTACAGTT GTGGTCATAA AAGAGGCATC TGCCTGTCCA 
GGTCACGTGG AGGCTGCTCC GGAGACCACA GCAGTCAGTG CTGAAACCGG GCCAGAGGTC 
ACAGATGCAG CGGCGAGGGA AACCACGGAA GTAAACCCTG AAACAACCCC AGAGGTTACA 
AATGCTGCCC TGGATGAAGC TGTCACCATC GATAATGATA AAGATACAAC AAAGAACGAA 
ACCTCTGATG AATATGCTGA ACTAGAAGAA GAAAATTCTC CAGCTGAGTC AGAGTCCTCT 
GCTGGAGATG ATTTACAGGA GGAAGCCAGT GTTGGCTCTG AGGCTGCTTC GGCTCAAGGC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MGARP ( NM_032623.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_116012.2 Homo sapiens mitochondria localized glutamic acid rich protein (MGARP), mRNA.

Price & Availability↑

CloneID	OHu16277
Clone ID Related Accession (Same CDS sequence)	NM_032623.4 , NM_032623.3
Accession Version	NM_032623.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 723bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	protein MGARP
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF484960.1. On Nov 1, 2006 this sequence version replaced NM_032623.2. ##Evidence-Data-START## Transcript exon combination :: AF484960.1, AF329088.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267761 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGTATCTCC GCAGGGCGGT CTCCAAGACT CTGGCGCTGC CGCTGAGGGC GCCCCCCAAC 
CCCGCGCCGC TCGGAAAGGA CGCATCTCTG CGCCGGATGT CATCTAACAG ATTCCCTGGA 
TCATCTGGAT CAAATATGAT TTATTATCTG GTTGTAGGCG TCACAGTCAG TGCTGGTGGA 
TATTATGCTT ACAAGACAGT CACATCAGAC CAAGCCAAAC ACACAGAACA TAAAACAAAT 
TTGAAAGAAA AAACAAAAGC AGAGATACAT CCATTTCAAG GTGAAAAGGA GAATGTTGCG 
GAAACTGAGA AAGCAAGTTC AGAAGCCCCA GAAGAACTTA TAGTGGAAGC TGAGGTGGTA 
GATGCTGAAG AAAGTCCCAG TGCTACAGTT GTGGTCATAA AAGAGGCATC TGCCTGTCCA 
GGTCACGTGG AGGCTGCTCC GGAGACCACA GCAGTCAGTG CTGAAACCGG GCCAGAGGTC 
ACAGATGCAG CGGCGAGGGA AACCACGGAA GTAAACCCTG AAACAACCCC AGAGGTTACA 
AATGCTGCCC TGGATGAAGC TGTCACCATC GATAATGATA AAGATACAAC AAAGAACGAA 
ACCTCTGATG AATATGCTGA ACTAGAAGAA GAAAATTCTC CAGCTGAGTC AGAGTCCTCT 
GCTGGAGATG ATTTACAGGA GGAAGCCAGT GTTGGCTCTG AGGCTGCTTC GGCTCAAGGC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_116012.2
CDS	181..903
Translation	MYLRRAVSKTLALPLRAPPNPAPLGKDASLRRMSSNRFPGSSGSNMIYYLVVGVTVSAGGYYAYKTVTSDQAKHTEHKTNLKEKTKAEIHPFQGEKENVAETEKASSEAPEELIVEAEVVDAEESPSATVVVIKEASACPGHVEAAPETTAVSAETGPEVTDAAARETTEVNPETTPEVTNAALDEAVTIDNDKDTTKNETSDEYAELEEENSPAESESSAGDDLQEEASVGSEAASAQG

Target ORF information:

RefSeq Version	NM_032623.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondria localized glutamic acid rich protein (MGARP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032623.3

ORF Insert Sequence:

ATGTATCTCC GCAGGGCGGT CTCCAAGACT CTGGCGCTGC CGCTGAGGGC GCCCCCCAAC 
CCCGCGCCGC TCGGAAAGGA CGCATCTCTG CGCCGGATGT CATCTAACAG ATTCCCTGGA 
TCATCTGGAT CAAATATGAT TTATTATCTG GTTGTAGGCG TCACAGTCAG TGCTGGTGGA 
TATTATGCTT ACAAGACAGT CACATCAGAC CAAGCCAAAC ACACAGAACA TAAAACAAAT 
TTGAAAGAAA AAACAAAAGC AGAGATACAT CCATTTCAAG GTGAAAAGGA GAATGTTGCG 
GAAACTGAGA AAGCAAGTTC AGAAGCCCCA GAAGAACTTA TAGTGGAAGC TGAGGTGGTA 
GATGCTGAAG AAAGTCCCAG TGCTACAGTT GTGGTCATAA AAGAGGCATC TGCCTGTCCA 
GGTCACGTGG AGGCTGCTCC GGAGACCACA GCAGTCAGTG CTGAAACCGG GCCAGAGGTC 
ACAGATGCAG CGGCGAGGGA AACCACGGAA GTAAACCCTG AAACAACCCC AGAGGTTACA 
AATGCTGCCC TGGATGAAGC TGTCACCATC GATAATGATA AAGATACAAC AAAGAACGAA 
ACCTCTGATG AATATGCTGA ACTAGAAGAA GAAAATTCTC CAGCTGAGTC AGAGTCCTCT 
GCTGGAGATG ATTTACAGGA GGAAGCCAGT GTTGGCTCTG AGGCTGCTTC GGCTCAAGGC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mitochondria-localized glutamic acid-rich protein (MGARP) gene transcription is regulated by Sp1.
PloS one7(11)e50053(2012)
Jin D,Li R,Mao D,Luo N,Wang Y,Chen S,Zhang S

The expression of a mitochondria-localized glutamic acid-rich protein (MGARP/OSAP) is under the regulation of the HPG axis.
Endocrinology152(6)2311-20(2011 Jun)
Zhou M,Wang Y,Qi S,Wang J,Zhang S

A mitochondria-localized glutamic acid-rich protein (MGARP/OSAP) is highly expressed in retina that exhibits a large area of intrinsic disorder.
Molecular biology reports38(5)2869-77(2011 Jun)
Qi S,Wang Y,Zhou M,Ge Y,Yan Y,Wang J,Zhang SS,Zhang S

During hypoxia, HUMMR joins the mitochondrial dance.
Cell cycle (Georgetown, Tex.)9(1)50-7(2010 Jan)
Li Y,Rempe DA

HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport.
The Journal of cell biology185(6)1065-81(2009 Jun)
Li Y,Lim S,Hoffman D,Aspenstrom P,Federoff HJ,Rempe DA

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MGARP cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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