COX4I2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	COX4I2
Entrez Gene ID	84701
Full Name	cytochrome c oxidase subunit 4I2
Synonyms	COX4,COX4-2,COX4B,COX4L2,COXIV-2,dJ857M17.2
General protein information	Preferred Names cytochrome c oxidase subunit 4I2 Names cytochrome c oxidase subunit 4 isoform 2, mitochondrial COX IV-2 cytochrome c oxidase subunit IV isoform 2 (lung) cytochrome c oxidase subunit IV-like 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q11.21
Summary	Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation. [provided by RefSeq, Jul 2008].
Disorder MIM:	607976
Disorder Html:	Exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis, 612714 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_005260580.4	XP_005260637.1	cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X2
XM_005260579.4	XP_005260636.1	cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1
NM_032609.3	NP_115998.2	cytochrome c oxidase subunit 4 isoform 2, mitochondrial
XM_005260581.3	XP_005260638.1	cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X3
NM_032609.2	NP_115998.2	cytochrome c oxidase subunit 4 isoform 2, mitochondrial

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	COX4I2	XP_542949.3
Rattus norvegicus (Norway rat)	Cox4i2	NP_445924.1
Pan troglodytes (chimpanzee)	LOC469913	XP_525298.2
Xenopus tropicalis (tropical clawed frog)	cox4i2	NP_001016945.1
	COX4I2	XP_001110371.1
Mus musculus (house mouse)	Cox4i2	NP_444321.1
Homo sapiens (human)	COX4I2	NP_115998.2
Bos taurus (cattle)	COX4I2	NP_001180115.1

Gene Ontology
Bibliography

Related articles in PubMed

Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2.
Aras S, Pak O, Sommer N, Finley R Jr, H?ttemann M, Weissmann N, Grossman LI
Nucleic acids research41(4)2255-66(2013 Feb)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

Exocrine pancreatic insufficiency, dyserythropoeitic anemia, and calvarial hyperostosis are caused by a mutation in the COX4I2 gene.
Shteyer E, Saada A, Shaag A, Al-Hijawi FA, Kidess R, Revel-Vilk S, Elpeleg O
American journal of human genetics84(3)412-7(2009 Mar)

Polymorphisms in mitochondrial genes and prostate cancer risk.
Wang L, McDonnell SK, Hebbring SJ, Cunningham JM, St Sauver J, Cerhan JR, Isaya G, Schaid DJ, Thibodeau SN
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology17(12)3558-66(2008 Dec)

Transcription of mammalian cytochrome c oxidase subunit IV-2 is controlled by a novel conserved oxygen responsive element.
H?ttemann M, Lee I, Liu J, Grossman LI
The FEBS journal274(21)5737-48(2007 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Identification of three transcription factors that bind a conserved responsive element of the COX4I2 gene, namely recombination signal sequence-binding protein Jkappa (RBPJ), coiled-coil-helix-coiled-coil-helix domain 2 (CHCHD2) and CXXC finger protein 5 (CXXC5).
Title: Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Mutation analysis of COX4I2 is warranted in patients with malabsorption due to exocrine pancreatic insufficiency and in patients with dyserythropoeitic anemia.
Title: Exocrine pancreatic insufficiency, dyserythropoeitic anemia, and calvarial hyperostosis are caused by a mutation in the COX4I2 gene.

Observational study of gene-disease association. (HuGE Navigator)
Title: Polymorphisms in mitochondrial genes and prostate cancer risk.

COX4I2 is regulated by a novel oxygen sensitive promoter element (5'-GGACGTTCCCACG-3') conserved in mammals. Gene activity is maximal at 4% oxygen. Lung cytochrome c oxidase (COX) is 2.5 fold more active compared to liver COX, which lacks COX4I2.
Title: Transcription of mammalian cytochrome c oxidase subunit IV-2 is controlled by a novel conserved oxygen responsive element.

The following COX4I2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COX4I2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19363	NM_032609.3 Latest version!	Homo sapiens cytochrome c oxidase subunit 4I2 (COX4I2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu53129	XM_005260579.4 Latest version!	Homo sapiens cytochrome c oxidase subunit 4I2 (COX4I2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu53130	XM_005260580.4 Latest version!	Homo sapiens cytochrome c oxidase subunit 4I2 (COX4I2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu53131	XM_005260581.3 Latest version!	Homo sapiens cytochrome c oxidase subunit 4I2 (COX4I2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu19363	NM_032609.2	Homo sapiens cytochrome c oxidase subunit 4I2 (COX4I2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

COX4I2 ( NM_032609.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_115998.2 Homo sapiens cytochrome c oxidase subunit 4I2 (COX4I2), mRNA.

Price & Availability↑

CloneID	OHu19363
Clone ID Related Accession (Same CDS sequence)	NM_032609.3 , NM_032609.2
Accession Version	NM_032609.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 516bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	cytochrome c oxidase subunit 4 isoform 2, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL117381.32. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_032609.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279827.447.1, BC057779.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000376075.4/ ENSP00000365243.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END##

ATGCTCCCCA GAGCTGCCTG GAGCTTGGTG CTGAGGAAAG GTGGAGGTGG AAGACGAGGG 
ATGCACAGCT CAGAAGGCAC CACCCGTGGT GGGGGGAAGA TGTCCCCCTA CACCAACTGC 
TATGCCCAGC GCTACTACCC CATGCCAGAA GAGCCCTTCT GCACAGAACT CAACGCTGAG 
GAGCAGGCCC TGAAGGAGAA GGAGAAGGGA AGCTGGACCC AGCTGACCCA CGCCGAAAAG 
GTGGCCTTGT ACCGGCTCCA GTTCAATGAG ACCTTTGCGG AGATGAACCG TCGCTCCAAT 
GAGTGGAAGA CAGTGATGGG TTGTGTCTTC TTCTTCATTG GATTCGCAGC TCTGGTGATT 
TGGTGGCAGC GGGTCTACGT ATTTCCTCCA AAGCCGATCA CCTTGACGGA CGAGCGGAAA 
GCCCAGCAGC TGCAGCGCAT GCTGGACATG AAGGTGAATC CTGTGCAGGG CCTGGCCTCC 
CGCTGGGACT ATGAGAAGAA GCAGTGGAAG AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115998.2
CDS	52..567
Translation	MLPRAAWSLVLRKGGGGRRGMHSSEGTTRGGGKMSPYTNCYAQRYYPMPEEPFCTELNAEEQALKEKEKGSWTQLTHAEKVALYRLQFNETFAEMNRRSNEWKTVMGCVFFFIGFAALVIWWQRVYVFPPKPITLTDERKAQQLQRMLDMKVNPVQGLASRWDYEKKQWKK

Target ORF information:

RefSeq Version	NM_032609.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase subunit 4I2 (COX4I2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032609.3

ORF Insert Sequence:

ATGCTCCCCA GAGCTGCCTG GAGCTTGGTG CTGAGGAAAG GTGGAGGTGG AAGACGAGGG 
ATGCACAGCT CAGAAGGCAC CACCCGTGGT GGGGGGAAGA TGTCCCCCTA CACCAACTGC 
TATGCCCAGC GCTACTACCC CATGCCAGAA GAGCCCTTCT GCACAGAACT CAACGCTGAG 
GAGCAGGCCC TGAAGGAGAA GGAGAAGGGA AGCTGGACCC AGCTGACCCA CGCCGAAAAG 
GTGGCCTTGT ACCGGCTCCA GTTCAATGAG ACCTTTGCGG AGATGAACCG TCGCTCCAAT 
GAGTGGAAGA CAGTGATGGG TTGTGTCTTC TTCTTCATTG GATTCGCAGC TCTGGTGATT 
TGGTGGCAGC GGGTCTACGT ATTTCCTCCA AAGCCGATCA CCTTGACGGA CGAGCGGAAA 
GCCCAGCAGC TGCAGCGCAT GCTGGACATG AAGGTGAATC CTGTGCAGGG CCTGGCCTCC 
CGCTGGGACT ATGAGAAGAA GCAGTGGAAG AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COX4I2 ( NM_032609.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_115998.2 Homo sapiens cytochrome c oxidase subunit 4I2 (COX4I2), mRNA.

Price & Availability↑

CloneID	OHu19363
Clone ID Related Accession (Same CDS sequence)	NM_032609.3 , NM_032609.2
Accession Version	NM_032609.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 516bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Homo sapiens(human)
Product	cytochrome c oxidase subunit 4 isoform 2, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF257180.1. This sequence is a reference standard in the RefSeqGene project. On Dec 30, 2001 this sequence version replaced NM_032609.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF257180.1, ERR279827.447.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGCTCCCCA GAGCTGCCTG GAGCTTGGTG CTGAGGAAAG GTGGAGGTGG AAGACGAGGG 
ATGCACAGCT CAGAAGGCAC CACCCGTGGT GGGGGGAAGA TGTCCCCCTA CACCAACTGC 
TATGCCCAGC GCTACTACCC CATGCCAGAA GAGCCCTTCT GCACAGAACT CAACGCTGAG 
GAGCAGGCCC TGAAGGAGAA GGAGAAGGGA AGCTGGACCC AGCTGACCCA CGCCGAAAAG 
GTGGCCTTGT ACCGGCTCCA GTTCAATGAG ACCTTTGCGG AGATGAACCG TCGCTCCAAT 
GAGTGGAAGA CAGTGATGGG TTGTGTCTTC TTCTTCATTG GATTCGCAGC TCTGGTGATT 
TGGTGGCAGC GGGTCTACGT ATTTCCTCCA AAGCCGATCA CCTTGACGGA CGAGCGGAAA 
GCCCAGCAGC TGCAGCGCAT GCTGGACATG AAGGTGAATC CTGTGCAGGG CCTGGCCTCC 
CGCTGGGACT ATGAGAAGAA GCAGTGGAAG AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115998.2
CDS	76..591
Translation	MLPRAAWSLVLRKGGGGRRGMHSSEGTTRGGGKMSPYTNCYAQRYYPMPEEPFCTELNAEEQALKEKEKGSWTQLTHAEKVALYRLQFNETFAEMNRRSNEWKTVMGCVFFFIGFAALVIWWQRVYVFPPKPITLTDERKAQQLQRMLDMKVNPVQGLASRWDYEKKQWKK

Target ORF information:

RefSeq Version	NM_032609.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase subunit 4I2 (COX4I2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032609.2

ORF Insert Sequence:

ATGCTCCCCA GAGCTGCCTG GAGCTTGGTG CTGAGGAAAG GTGGAGGTGG AAGACGAGGG 
ATGCACAGCT CAGAAGGCAC CACCCGTGGT GGGGGGAAGA TGTCCCCCTA CACCAACTGC 
TATGCCCAGC GCTACTACCC CATGCCAGAA GAGCCCTTCT GCACAGAACT CAACGCTGAG 
GAGCAGGCCC TGAAGGAGAA GGAGAAGGGA AGCTGGACCC AGCTGACCCA CGCCGAAAAG 
GTGGCCTTGT ACCGGCTCCA GTTCAATGAG ACCTTTGCGG AGATGAACCG TCGCTCCAAT 
GAGTGGAAGA CAGTGATGGG TTGTGTCTTC TTCTTCATTG GATTCGCAGC TCTGGTGATT 
TGGTGGCAGC GGGTCTACGT ATTTCCTCCA AAGCCGATCA CCTTGACGGA CGAGCGGAAA 
GCCCAGCAGC TGCAGCGCAT GCTGGACATG AAGGTGAATC CTGTGCAGGG CCTGGCCTCC 
CGCTGGGACT ATGAGAAGAA GCAGTGGAAG AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COX4I2 ( XM_005260579.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005260636.1 Homo sapiens cytochrome c oxidase subunit 4I2 (COX4I2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu53129
Clone ID Related Accession (Same CDS sequence)	XM_005260579.4
Accession Version	XM_005260579.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 531bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005260579.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCACCCT GGGCCTGTTC CTACCACACT TCCCATGTTC CCATGATCCC ACTCCTTGGT 
CCAAGGTCAA GTTTCTCCAG GAAATGGAGT GCGCGGGCCC GTGGTGGGGG GAAGATGTCC 
CCCTACACCA ACTGCTATGC CCAGCGCTAC TACCCCATGC CAGAAGAGCC CTTCTGCACA 
GAACTCAACG CTGAGGAGCA GGCCCTGAAG GAGAAGGAGA AGGGAAGCTG GACCCAGCTG 
ACCCACGCCG AAAAGGTGGC CTTGTACCGG CTCCAGTTCA ATGAGACCTT TGCGGAGATG 
AACCGTCGCT CCAATGAGTG GAAGACAGTG ATGGGTTGTG TCTTCTTCTT CATTGGATTC 
GCAGCTCTGG TGATTTGGTG GCAGCGGGTC TACGTATTTC CTCCAAAGCC GATCACCTTG 
ACGGACGAGC GGAAAGCCCA GCAGCTGCAG CGCATGCTGG ACATGAAGGT GAATCCTGTG 
CAGGGCCTGG CCTCCCGCTG GGACTATGAG AAGAAGCAGT GGAAGAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005260636.1
CDS	63..593
Translation	MPPWACSYHTSHVPMIPLLGPRSSFSRKWSARARGGGKMSPYTNCYAQRYYPMPEEPFCTELNAEEQALKEKEKGSWTQLTHAEKVALYRLQFNETFAEMNRRSNEWKTVMGCVFFFIGFAALVIWWQRVYVFPPKPITLTDERKAQQLQRMLDMKVNPVQGLASRWDYEKKQWKK

Target ORF information:

RefSeq Version	XM_005260579.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase subunit 4I2 (COX4I2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005260579.4

ORF Insert Sequence:

ATGCCACCCT GGGCCTGTTC CTACCACACT TCCCATGTTC CCATGATCCC ACTCCTTGGT 
CCAAGGTCAA GTTTCTCCAG GAAATGGAGT GCGCGGGCCC GTGGTGGGGG GAAGATGTCC 
CCCTACACCA ACTGCTATGC CCAGCGCTAC TACCCCATGC CAGAAGAGCC CTTCTGCACA 
GAACTCAACG CTGAGGAGCA GGCCCTGAAG GAGAAGGAGA AGGGAAGCTG GACCCAGCTG 
ACCCACGCCG AAAAGGTGGC CTTGTACCGG CTCCAGTTCA ATGAGACCTT TGCGGAGATG 
AACCGTCGCT CCAATGAGTG GAAGACAGTG ATGGGTTGTG TCTTCTTCTT CATTGGATTC 
GCAGCTCTGG TGATTTGGTG GCAGCGGGTC TACGTATTTC CTCCAAAGCC GATCACCTTG 
ACGGACGAGC GGAAAGCCCA GCAGCTGCAG CGCATGCTGG ACATGAAGGT GAATCCTGTG 
CAGGGCCTGG CCTCCCGCTG GGACTATGAG AAGAAGCAGT GGAAGAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COX4I2 ( XM_005260580.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005260637.1 Homo sapiens cytochrome c oxidase subunit 4I2 (COX4I2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu53130
Clone ID Related Accession (Same CDS sequence)	XM_005260580.4
Accession Version	XM_005260580.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005260580.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCACCCT GGGCCTGTTC CTACCACACT TCCCATGTTC CCATGATCCC ACTCCTTGGT 
CCAAGGTCAA GTTTCTCCAG GAAATGGAGT GCGCGGGCCC GTGGTGGGGG GAAGATGTCC 
CCCTACACCA ACTGCTATGC CCAGCGCTAC TACCCCATGC CAGAAGAGCC CTTCTGCACA 
GAACTCAACG CTGAGGAGCA GGCCCTGAAG GAGAAGGAGA AGGGAAGCTG GACCCAGCTG 
ACCCACGCCG AAAAGGTGGC CTTATTTCCT CCAAAGCCGA TCACCTTGAC GGACGAGCGG 
AAAGCCCAGC AGCTGCAGCG CATGCTGGAC ATGAAGGTGA ATCCTGTGCA GGGCCTGGCC 
TCCCGCTGGG ACTATGAGAA GAAGCAGTGG AAGAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005260637.1
CDS	76..474
Translation	MPPWACSYHTSHVPMIPLLGPRSSFSRKWSARARGGGKMSPYTNCYAQRYYPMPEEPFCTELNAEEQALKEKEKGSWTQLTHAEKVALFPPKPITLTDERKAQQLQRMLDMKVNPVQGLASRWDYEKKQWKK

Target ORF information:

RefSeq Version	XM_005260580.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase subunit 4I2 (COX4I2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005260580.4

ORF Insert Sequence:

ATGCCACCCT GGGCCTGTTC CTACCACACT TCCCATGTTC CCATGATCCC ACTCCTTGGT 
CCAAGGTCAA GTTTCTCCAG GAAATGGAGT GCGCGGGCCC GTGGTGGGGG GAAGATGTCC 
CCCTACACCA ACTGCTATGC CCAGCGCTAC TACCCCATGC CAGAAGAGCC CTTCTGCACA 
GAACTCAACG CTGAGGAGCA GGCCCTGAAG GAGAAGGAGA AGGGAAGCTG GACCCAGCTG 
ACCCACGCCG AAAAGGTGGC CTTATTTCCT CCAAAGCCGA TCACCTTGAC GGACGAGCGG 
AAAGCCCAGC AGCTGCAGCG CATGCTGGAC ATGAAGGTGA ATCCTGTGCA GGGCCTGGCC 
TCCCGCTGGG ACTATGAGAA GAAGCAGTGG AAGAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COX4I2 ( XM_005260581.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005260638.1 Homo sapiens cytochrome c oxidase subunit 4I2 (COX4I2), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu53131
Clone ID Related Accession (Same CDS sequence)	XM_005260581.3
Accession Version	XM_005260581.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 384bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005260581.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCCCCA GAGCTGCCTG GAGCTTGGTG CTGAGGAAAG GTGGAGGTGG AAGACGAGGG 
ATGCACAGCT CAGAAGGCAC CACCCGTGGT GGGGGGAAGA TGTCCCCCTA CACCAACTGC 
TATGCCCAGC GCTACTACCC CATGCCAGAA GAGCCCTTCT GCACAGAACT CAACGCTGAG 
GAGCAGGCCC TGAAGGAGAA GGAGAAGGGA AGCTGGACCC AGCTGACCCA CGCCGAAAAG 
GTGGCCTTAT TTCCTCCAAA GCCGATCACC TTGACGGACG AGCGGAAAGC CCAGCAGCTG 
CAGCGCATGC TGGACATGAA GGTGAATCCT GTGCAGGGCC TGGCCTCCCG CTGGGACTAT 
GAGAAGAAGC AGTGGAAGAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005260638.1
CDS	108..491
Translation	MLPRAAWSLVLRKGGGGRRGMHSSEGTTRGGGKMSPYTNCYAQRYYPMPEEPFCTELNAEEQALKEKEKGSWTQLTHAEKVALFPPKPITLTDERKAQQLQRMLDMKVNPVQGLASRWDYEKKQWKK

Target ORF information:

RefSeq Version	XM_005260581.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase subunit 4I2 (COX4I2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005260581.3

ORF Insert Sequence:

ATGCTCCCCA GAGCTGCCTG GAGCTTGGTG CTGAGGAAAG GTGGAGGTGG AAGACGAGGG 
ATGCACAGCT CAGAAGGCAC CACCCGTGGT GGGGGGAAGA TGTCCCCCTA CACCAACTGC 
TATGCCCAGC GCTACTACCC CATGCCAGAA GAGCCCTTCT GCACAGAACT CAACGCTGAG 
GAGCAGGCCC TGAAGGAGAA GGAGAAGGGA AGCTGGACCC AGCTGACCCA CGCCGAAAAG 
GTGGCCTTAT TTCCTCCAAA GCCGATCACC TTGACGGACG AGCGGAAAGC CCAGCAGCTG 
CAGCGCATGC TGGACATGAA GGTGAATCCT GTGCAGGGCC TGGCCTCCCG CTGGGACTAT 
GAGAAGAAGC AGTGGAAGAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2.
Nucleic acids research41(4)2255-66(2013 Feb)
Aras S,Pak O,Sommer N,Finley R Jr,H?ttemann M,Weissmann N,Grossman LI

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

Exocrine pancreatic insufficiency, dyserythropoeitic anemia, and calvarial hyperostosis are caused by a mutation in the COX4I2 gene.
American journal of human genetics84(3)412-7(2009 Mar)
Shteyer E,Saada A,Shaag A,Al-Hijawi FA,Kidess R,Revel-Vilk S,Elpeleg O

Polymorphisms in mitochondrial genes and prostate cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology17(12)3558-66(2008 Dec)
Wang L,McDonnell SK,Hebbring SJ,Cunningham JM,St Sauver J,Cerhan JR,Isaya G,Schaid DJ,Thibodeau SN

Transcription of mammalian cytochrome c oxidase subunit IV-2 is controlled by a novel conserved oxygen responsive element.
The FEBS journal274(21)5737-48(2007 Nov)
H?ttemann M,Lee I,Liu J,Grossman LI

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COX4I2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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