RNASE7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RNASE7
Entrez Gene ID	84659
Full Name	ribonuclease A family member 7
Synonyms	RAE1
General protein information	Preferred Names ribonuclease A family member 7 Names ribonuclease 7 RNase 7 SAP-2 ribonuclease, RNase A family, 7 skin-derived antimicrobial protein 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q11.2
Summary	The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein has broad-spectrum antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014].
Disorder MIM:	612484

mRNA and Protein(s)

mRNA	Protein	Name
NM_032572.4	NP_115961.3	ribonuclease 7 precursor
NM_032572.3	NP_115961.2	ribonuclease 7 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	RNASE7	XP_003314288.1
Bos taurus (cattle)	RNASE7	XP_002690702.1
	RNASE7	XP_001094178.1
Homo sapiens (human)	RNASE7	NP_115961.2

Gene Ontology
Bibliography

Related articles in PubMed

RNase7 but not psoriasin nor sPLA2-IIA associates to Mycobacterium tuberculosis during airway epithelial cells infection.
Torres-Juarez F, Touqui L, Leon-Contreras J, Rivas-Santiago C, Enciso-Moreno JA, Hern?ndez-Pando R, Rivas-Santiago B
Pathogens and disease(2018 Jan)

RNase 7 downregulates TH2 cytokine production by activated human T cells.
Kopfnagel V, Wagenknecht S, Brand L, Zeitvogel J, Harder J, Hofmann K, Kleine M, Werfel T
Allergy72(11)1694-1703(2017 Nov)

RNase 7 strongly promotes TLR9-mediated DNA sensing by human plasmacytoid dendritic cells.
Kopfnagel V, Wagenknecht S, Harder J, Hofmann K, Kleine M, Buch A, Sodeik B, Werfel T
The Journal of investigative dermatology(2017 Nov)

RNase 7 participates in cutaneous innate control of Corynebacterium amycolatum.
Walter S, Rademacher F, Kobinger N, Simanski M, Gl?ser R, Harder J
Scientific reports7(1)13862(2017 Oct)

The role of RNase 7 in innate cutaneous defense against Pseudomonas aeruginosa.
Rademacher F, Simanski M, Schr?der L, Mildner M, Harder J
Experimental dermatology26(3)227-233(2017 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Insulin and PI3K/AKT signaling are essential for RNase 7 expression and increased infection risks in diabetic patients may be secondary to suppressed RNase 7 production.
Title: Insulin and the phosphatidylinositol 3-kinase signaling pathway regulate Ribonuclease 7 expression in the human urinary tract.

This article provides an overview about the role of RNase 7 in cutaneous defense with focus on the molecular mechanism of the antimicrobial activity of RNase 7, the regulation of RNase 7 expression, and the role of RNase 7 in skin diseases. [review]
Title: RNase 7 in Cutaneous Defense.

RNH1 bound to RNase 7 and suppressed its antimicrobial activity by blocking its ability to bind the cell wall of uropathogenic bacteria.
Title: An endogenous ribonuclease inhibitor regulates the antimicrobial activity of ribonuclease 7 in the human urinary tract.

epidermal growth factor-dependent RNase 7 and human beta-defensin-3 expression upon infection with Trichophytum rubrum
Title: Infection of keratinocytes with Trichophytum rubrum induces epidermal growth factor-dependent RNase 7 and human beta-defensin-3 expression.

Levels of psoriasin, RNase 7 and hBD-3 expression - assessed by immunohistochemistry - varied between different body localisations.
Title: Differential expression and in vivo secretion of the antimicrobial peptides psoriasin (S100A7), RNase 7, human beta-defensin-2 and -3 in healthy human skin.

The following RNASE7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RNASE7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu30564	NM_032572.3 Latest version!	Homo sapiens ribonuclease A family member 7 (RNASE7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu107355	NM_032572.4 Latest version!	Homo sapiens ribonuclease A family member 7 (RNASE7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone	40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RNASE7 ( NM_032572.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_115961.2 Homo sapiens ribonuclease A family member 7 (RNASE7), mRNA.

Price & Availability↑

CloneID	OHu30564
Clone ID Related Accession (Same CDS sequence)	NM_032572.3
Accession Version	NM_032572.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 471bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-23
Organism	Homo sapiens(human)
Product	ribonuclease 7 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB153740.1, AJ306610.1, AL161668.6 and AI150610.1. On Jul 24, 2007 this sequence version replaced NM_032572.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK292697.1, AY170392.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 12244054 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCACCGG CCAGAGCAGG ATTCTGCCCC CTTCTGCTGC TTCTGCTGCT GGGGCTGTGG 
GTGGCAGAGA TCCCAGTCAG TGCCAAGCCC AAGGGCATGA CCTCATCACA GTGGTTTAAA 
ATTCAGCACA TGCAGCCCAG CCCTCAAGCA TGCAACTCAG CCATGAAAAA CATTAACAAG 
CACACAAAAC GGTGCAAAGA CCTCAACACC TTCCTGCACG AGCCTTTCTC CAGTGTGGCC 
GCCACCTGCC AGACCCCCAA AATAGCCTGC AAGAATGGCG ATAAAAACTG CCACCAGAGC 
CACGGGGCCG TGTCCCTGAC CATGTGTAAG CTCACCTCAG GGAAGTATCC GAACTGCAGG 
TACAAAGAGA AGCGACAGAA CAAGTCTTAC GTAGTGGCCT GTAAGCCTCC CCAGAAAAAG 
GACTCTCAGC AATTCCACCT GGTTCCTGTA CACTTGGACA GAGTCCTTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115961.2
CDS	258..728
Translation	MAPARAGFCPLLLLLLLGLWVAEIPVSAKPKGMTSSQWFKIQHMQPSPQACNSAMKNINKHTKRCKDLNTFLHEPFSSVAATCQTPKIACKNGDKNCHQSHGAVSLTMCKLTSGKYPNCRYKEKRQNKSYVVACKPPQKKDSQQFHLVPVHLDRVL

Target ORF information:

RefSeq Version	NM_032572.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ribonuclease A family member 7 (RNASE7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032572.3

ORF Insert Sequence:

ATGGCACCGG CCAGAGCAGG ATTCTGCCCC CTTCTGCTGC TTCTGCTGCT GGGGCTGTGG 
GTGGCAGAGA TCCCAGTCAG TGCCAAGCCC AAGGGCATGA CCTCATCACA GTGGTTTAAA 
ATTCAGCACA TGCAGCCCAG CCCTCAAGCA TGCAACTCAG CCATGAAAAA CATTAACAAG 
CACACAAAAC GGTGCAAAGA CCTCAACACC TTCCTGCACG AGCCTTTCTC CAGTGTGGCC 
GCCACCTGCC AGACCCCCAA AATAGCCTGC AAGAATGGCG ATAAAAACTG CCACCAGAGC 
CACGGGGCCG TGTCCCTGAC CATGTGTAAG CTCACCTCAG GGAAGTATCC GAACTGCAGG 
TACAAAGAGA AGCGACAGAA CAAGTCTTAC GTAGTGGCCT GTAAGCCTCC CCAGAAAAAG 
GACTCTCAGC AATTCCACCT GGTTCCTGTA CACTTGGACA GAGTCCTTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RNASE7 ( NM_032572.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_115961.3 Homo sapiens ribonuclease A family member 7 (RNASE7), mRNA.

Price & Availability↑

CloneID	OHu107355
Clone ID Related Accession (Same CDS sequence)	NM_032572.4
Accession Version	NM_032572.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 471bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-15
Organism	Homo sapiens(human)
Product	ribonuclease 7 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL161668.6. On Nov 23, 2018 this sequence version replaced NM_032572.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ306610.1, AY170392.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000298690.5/ ENSP00000298690.3 Protein has antimicrobial activity :: PMID: 12244054 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCACCGG CCAGAGCAGG ATTCTGCCCC CTTCTGCTGC TTCTGCTGCT GGGGCTGTGG 
GTGGCAGAGA TCCCAGTCAG TGCCAAGCCC AAGGGCATGA CCTCATCACA GTGGTTTAAA 
ATTCAGCACA TGCAGCCCAG CCCTCAAGCA TGCAACTCAG CCATGAAAAA CATTAACAAG 
CACACAAAAC GGTGCAAAGA CCTCAACACC TTCCTGCACG AGCCTTTCTC CAGTGTGGCC 
GCCACCTGCC AGACCCCCAA AATAGCCTGC AAGAATGGCG ATAAAAACTG CCACCAGAGC 
CACGGGGCCG TGTCCCTGAC CATGTGTAAG CTCACCTCAG GGAAGCATCC GAACTGCAGG 
TACAAAGAGA AGCGACAGAA CAAGTCTTAC GTAGTGGCCT GTAAGCCTCC CCAGAAAAAG 
GACTCTCAGC AATTCCACCT GGTTCCTGTA CACTTGGACA GAGTCCTTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115961.3
CDS	122..592
Translation	MAPARAGFCPLLLLLLLGLWVAEIPVSAKPKGMTSSQWFKIQHMQPSPQACNSAMKNINKHTKRCKDLNTFLHEPFSSVAATCQTPKIACKNGDKNCHQSHGAVSLTMCKLTSGKHPNCRYKEKRQNKSYVVACKPPQKKDSQQFHLVPVHLDRVL

Target ORF information:

RefSeq Version	NM_032572.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ribonuclease A family member 7 (RNASE7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032572.4

ORF Insert Sequence:

ATGGCACCGG CCAGAGCAGG ATTCTGCCCC CTTCTGCTGC TTCTGCTGCT GGGGCTGTGG 
GTGGCAGAGA TCCCAGTCAG TGCCAAGCCC AAGGGCATGA CCTCATCACA GTGGTTTAAA 
ATTCAGCACA TGCAGCCCAG CCCTCAAGCA TGCAACTCAG CCATGAAAAA CATTAACAAG 
CACACAAAAC GGTGCAAAGA CCTCAACACC TTCCTGCACG AGCCTTTCTC CAGTGTGGCC 
GCCACCTGCC AGACCCCCAA AATAGCCTGC AAGAATGGCG ATAAAAACTG CCACCAGAGC 
CACGGGGCCG TGTCCCTGAC CATGTGTAAG CTCACCTCAG GGAAGCATCC GAACTGCAGG 
TACAAAGAGA AGCGACAGAA CAAGTCTTAC GTAGTGGCCT GTAAGCCTCC CCAGAAAAAG 
GACTCTCAGC AATTCCACCT GGTTCCTGTA CACTTGGACA GAGTCCTTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

RNase7 but not psoriasin nor sPLA2-IIA associates to Mycobacterium tuberculosis during airway epithelial cells infection.
Pathogens and disease(2018 Jan)
Torres-Juarez F,Touqui L,Leon-Contreras J,Rivas-Santiago C,Enciso-Moreno JA,Hern?ndez-Pando R,Rivas-Santiago B

RNase 7 downregulates TH2 cytokine production by activated human T cells.
Allergy72(11)1694-1703(2017 Nov)
Kopfnagel V,Wagenknecht S,Brand L,Zeitvogel J,Harder J,Hofmann K,Kleine M,Werfel T

RNase 7 strongly promotes TLR9-mediated DNA sensing by human plasmacytoid dendritic cells.
The Journal of investigative dermatology(2017 Nov)
Kopfnagel V,Wagenknecht S,Harder J,Hofmann K,Kleine M,Buch A,Sodeik B,Werfel T

RNase 7 participates in cutaneous innate control of Corynebacterium amycolatum.
Scientific reports7(1)13862(2017 Oct)
Walter S,Rademacher F,Kobinger N,Simanski M,Gl?ser R,Harder J

The role of RNase 7 in innate cutaneous defense against Pseudomonas aeruginosa.
Experimental dermatology26(3)227-233(2017 Mar)
Rademacher F,Simanski M,Schr?der L,Mildner M,Harder J

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RNASE7 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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