GPR174 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GPR174
Entrez Gene ID	84636
Full Name	G protein-coupled receptor 174
Synonyms	FKSG79,GPCR17,LYPSR3
General protein information	Preferred Names G protein-coupled receptor 174 Names probable G-protein coupled receptor 174
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq21.1
Summary	This gene encodes a protein belonging to the G protein-coupled receptor superfamily. These proteins are characterized by the presence of seven alpha-helical transmembrane domains, and they activate or interact with various endogenous or exogenous ligands, including neurotransmitters, hormones, and odorant and taste substances. This family member is classified as an orphan receptor because the cognate ligand has not been identified. [provided by RefSeq, Sep 2011].
Disorder MIM:	300903

mRNA and Protein(s)

mRNA	Protein	Name
NM_032553.1	NP_115942.1	probable G-protein coupled receptor 174
NM_032553.2	NP_115942.1	probable G-protein coupled receptor 174

Pathways from BioSystems

Homologies

Homo sapiens (human)	GPR174	NP_115942.1
	GPR174	XP_001102084.1
Danio rerio (zebrafish)	LOC100151331	XP_005157230.1
Rattus norvegicus (Norway rat)	Gpr174	NP_001100408.1
Xenopus tropicalis (tropical clawed frog)	gpr174	XP_002940479.2
Mus musculus (house mouse)	Gpr174	NP_001028423.1
Gallus gallus (chicken)	GPR174	NP_001008464.1
Pan troglodytes (chimpanzee)	GPR174	XP_003317581.1
Canis lupus familiaris (dog)	LOC100683878	XP_005641583.1
Bos taurus (cattle)	GPR174	XP_005228017.1

Gene Ontology
Bibliography

Related articles in PubMed

RNASET2, GPR174, and PTPN22 gene polymorphisms are related to the risk of liver damage associated with the hyperthyroidism in patients with Graves' disease.
Zhang Q, Liu S, Guan Y, Chen Q, Zhang Q, Min X
Journal of clinical laboratory analysis(2017 May)

Alteration of gene expression profiling including GPR174 and GNG2 is associated with vasovagal syncope.
Huang YJ, Zhou ZW, Xu M, Ma QW, Yan JB, Wang JY, Zhang QQ, Huang M, Bao L
Pediatric cardiology36(3)475-80(2015 Mar)

Role of the X-linked gene GPR174 in autoimmune Addison's disease.
Napier C, Mitchell AL, Gan E, Wilson I, Pearce SH
The Journal of clinical endocrinology and metabolism100(1)E187-90(2015 Jan)

Lysophospholipid receptor nomenclature review: IUPHAR Review 8.
Kihara Y, Maceyka M, Spiegel S, Chun J
British journal of pharmacology171(15)3575-94(2014 Aug)

rs3827440, a nonsynonymous single nucleotide polymorphism within GPR174 gene in X chromosome, is associated with Graves' disease in Polish Caucasian population.
Szyma?ski K, Mi?kiewicz P, Pirko K, Jurecka-Lubieniecka B, Kula D, Hasse-Lazar K, Krajewski P, Bednarczuk T, P?oski R
Tissue antigens83(1)41-4(2014 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Alteration of gene expression profiling including GPR174 and GNG2 is associated with vasovagal syncope.
Title: Alteration of gene expression profiling including GPR174 and GNG2 is associated with vasovagal syncope.

We have demonstrated a significant association of this X chromosome-encoded immunoreceptor with autoimmune Addison's disease for the first time.
Title: Role of the X-linked gene GPR174 in autoimmune Addison's disease.

this study provides the first replication in a Caucasian population of the association between Graves' disease and the GPR174 rs3827440 single nucleotide polymorphism originally reported among Chinese.
Title: rs3827440, a nonsynonymous single nucleotide polymorphism within GPR174 gene in X chromosome, is associated with Graves' disease in Polish Caucasian population.

The finding of an X-linked risk locus for Graves' disease expands our understanding of the role of the X chromosome in disease susceptibility.
Title: An X chromosome-wide association analysis identifies variants in GPR174 as a risk factor for Graves' disease.

These results suggested that GPR174 was a putative LysoPS receptor conjugating with Galpha(s), and its expression induced morphological changes in CHO cells by constitutively activating adenylyl cycles accompanied with cell conjunctions and delay of proliferation.
Title: Expression of orphan G-protein coupled receptor GPR174 in CHO cells induced morphological changes and proliferation delay via increasing intracellular cAMP.

The following GPR174 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GPR174 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu28238	NM_032553.2 Latest version!	Homo sapiens G protein-coupled receptor 174 (GPR174), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$265.30 $379.00
View Old Accession Versions >>
OHu28238	NM_032553.1	Homo sapiens G protein-coupled receptor 174 (GPR174), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GPR174 ( NM_032553.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_115942.1 Homo sapiens G protein-coupled receptor 174 (GPR174), mRNA.

Price & Availability↑

CloneID	OHu28238
Clone ID Related Accession (Same CDS sequence)	NM_032553.1 , NM_032553.2
Accession Version	NM_032553.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1002bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	probable G-protein coupled receptor 174
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF345567.1. This sequence is a reference standard in the RefSeqGene project. On Mar 29, 2008 this sequence version replaced XM_001715858.1. ##Evidence-Data-START## Transcript is intronless :: AF345567.1 [ECO:0000345] ##Evidence-Data-END##

ATGCCTGCTA ATTACACGTG TACCAGGCCA GATGGAGACA ATACAGATTT TCGATACTTT 
ATTTATGCAG TGACATACAC TGTCATTCTT GTGCCAGGTC TCATAGGGAA TATATTAGCC 
CTGTGGGTAT TCTATGGTTA TATGAAAGAA ACAAAACGAG CTGTGATATT TATGATAAAC 
TTAGCCATTG CTGACTTACT ACAAGTTCTT TCCTTGCCAC TGAGGATCTT CTACTACTTG 
AATCATGACT GGCCATTTGG GCCTGGTCTC TGCATGTTCT GTTTCTACCT GAAGTATGTC 
AACATGTATG CAAGCATCTA CTTCTTGGTC TGCATCAGTG TGCGACGATT TTGGTTTCTC 
ATGTACCCCT TTCGCTTCCA TGACTGCAAA CAGAAATATG ACCTGTACAT CAGCATTGCT 
GGCTGGCTGA TCATCTGCCT TGCCTGTGTA CTCTTTCCAC TCCTCAGAAC CAGTGATGAT 
ACCTCTGGCA ATAGGACCAA ATGCTTTGTG GATCTTCCTA CCAGGAATGT CAACCTGGCC 
CAGTCCGTTG TTATGATGAC CATTGGCGAG TTGATTGGGT TTGTAACTCC GCTTCTGATT 
GTCCTATATT GTACCTGGAA GACGGTTTTA TCACTGCAAG ATAAATATCC CATGGCCCAA 
GATCTTGGAG AGAAACAGAA AGCCTTGAAG ATGATTCTAA CCTGTGCAGG GGTATTCCTA 
ATTTGCTTTG CACCTTATCA TTTCAGTTTT CCTTTAGATT TCCTGGTGAA GTCCAATGAA 
ATTAAAAGCT GCCTAGCCAG AAGGGTGATT CTAATATTTC ATTCTGTGGC ATTGTGTCTT 
GCTAGTCTGA ATTCATGTCT TGACCCAGTC ATATACTACT TTTCCACTAA TGAGTTCCGA 
AGACGGCTTT CAAGACAAGA TTTGCATGAC AGCATCCAAC TCCATGCAAA ATCCTTTGTG 
AGTAACCATA CAGCTTCCAC CATGACACCT GAATTATGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115942.1
CDS	37..1038
Translation	MPANYTCTRPDGDNTDFRYFIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVIFMINLAIADLLQVLSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIYFLVCISVRRFWFLMYPFRFHDCKQKYDLYISIAGWLIICLACVLFPLLRTSDDTSGNRTKCFVDLPTRNVNLAQSVVMMTIGELIGFVTPLLIVLYCTWKTVLSLQDKYPMAQDLGEKQKALKMILTCAGVFLICFAPYHFSFPLDFLVKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFSTNEFRRRLSRQDLHDSIQLHAKSFVSNHTASTMTPELC

Target ORF information:

RefSeq Version	NM_032553.1
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein-coupled receptor 174 (GPR174), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032553.1

ORF Insert Sequence:

ATGCCTGCTA ATTACACGTG TACCAGGCCA GATGGAGACA ATACAGATTT TCGATACTTT 
ATTTATGCAG TGACATACAC TGTCATTCTT GTGCCAGGTC TCATAGGGAA TATATTAGCC 
CTGTGGGTAT TCTATGGTTA TATGAAAGAA ACAAAACGAG CTGTGATATT TATGATAAAC 
TTAGCCATTG CTGACTTACT ACAAGTTCTT TCCTTGCCAC TGAGGATCTT CTACTACTTG 
AATCATGACT GGCCATTTGG GCCTGGTCTC TGCATGTTCT GTTTCTACCT GAAGTATGTC 
AACATGTATG CAAGCATCTA CTTCTTGGTC TGCATCAGTG TGCGACGATT TTGGTTTCTC 
ATGTACCCCT TTCGCTTCCA TGACTGCAAA CAGAAATATG ACCTGTACAT CAGCATTGCT 
GGCTGGCTGA TCATCTGCCT TGCCTGTGTA CTCTTTCCAC TCCTCAGAAC CAGTGATGAT 
ACCTCTGGCA ATAGGACCAA ATGCTTTGTG GATCTTCCTA CCAGGAATGT CAACCTGGCC 
CAGTCCGTTG TTATGATGAC CATTGGCGAG TTGATTGGGT TTGTAACTCC GCTTCTGATT 
GTCCTATATT GTACCTGGAA GACGGTTTTA TCACTGCAAG ATAAATATCC CATGGCCCAA 
GATCTTGGAG AGAAACAGAA AGCCTTGAAG ATGATTCTAA CCTGTGCAGG GGTATTCCTA 
ATTTGCTTTG CACCTTATCA TTTCAGTTTT CCTTTAGATT TCCTGGTGAA GTCCAATGAA 
ATTAAAAGCT GCCTAGCCAG AAGGGTGATT CTAATATTTC ATTCTGTGGC ATTGTGTCTT 
GCTAGTCTGA ATTCATGTCT TGACCCAGTC ATATACTACT TTTCCACTAA TGAGTTCCGA 
AGACGGCTTT CAAGACAAGA TTTGCATGAC AGCATCCAAC TCCATGCAAA ATCCTTTGTG 
AGTAACCATA CAGCTTCCAC CATGACACCT GAATTATGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GPR174 ( NM_032553.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_115942.1 Homo sapiens G protein-coupled receptor 174 (GPR174), mRNA.

Price & Availability↑

CloneID	OHu28238
Clone ID Related Accession (Same CDS sequence)	NM_032553.1 , NM_032553.2
Accession Version	NM_032553.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1002bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	probable G-protein coupled receptor 174
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL590222.4. This sequence is a reference standard in the RefSeqGene project. On Sep 18, 2018 this sequence version replaced NM_032553.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: AF345567.1, BC104922.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCTGCTA ATTACACGTG TACCAGGCCA GATGGAGACA ATACAGATTT TCGATACTTT 
ATTTATGCAG TGACATACAC TGTCATTCTT GTGCCAGGTC TCATAGGGAA TATATTAGCC 
CTGTGGGTAT TCTATGGTTA TATGAAAGAA ACAAAACGAG CTGTGATATT TATGATAAAC 
TTAGCCATTG CTGACTTACT ACAAGTTCTT TCCTTGCCAC TGAGGATCTT CTACTACTTG 
AATCATGACT GGCCATTTGG GCCTGGTCTC TGCATGTTCT GTTTCTACCT GAAGTATGTC 
AACATGTATG CAAGCATCTA CTTCTTGGTC TGCATCAGTG TGCGACGATT TTGGTTTCTC 
ATGTACCCCT TTCGCTTCCA TGACTGCAAA CAGAAATATG ACCTGTACAT CAGCATTGCT 
GGCTGGCTGA TCATCTGCCT TGCCTGTGTA CTCTTTCCAC TCCTCAGAAC CAGTGATGAT 
ACCTCTGGCA ATAGGACCAA ATGCTTTGTG GATCTTCCTA CCAGGAATGT CAACCTGGCC 
CAGTCCGTTG TTATGATGAC CATTGGCGAG TTGATTGGGT TTGTAACTCC GCTTCTGATT 
GTCCTATATT GTACCTGGAA GACGGTTTTA TCACTGCAAG ATAAATATCC CATGGCCCAA 
GATCTTGGAG AGAAACAGAA AGCCTTGAAG ATGATTCTAA CCTGTGCAGG GGTATTCCTA 
ATTTGCTTTG CACCTTATCA TTTCAGTTTT CCTTTAGATT TCCTGGTGAA GTCCAATGAA 
ATTAAAAGCT GCCTAGCCAG AAGGGTGATT CTAATATTTC ATTCTGTGGC ATTGTGTCTT 
GCTAGTCTGA ATTCATGTCT TGACCCAGTC ATATACTACT TTTCCACTAA TGAGTTCCGA 
AGACGGCTTT CAAGACAAGA TTTGCATGAC AGCATCCAAC TCCATGCAAA ATCCTTTGTG 
AGTAACCATA CAGCTTCCAC CATGACACCT GAATTATGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115942.1
CDS	37..1038
Translation	MPANYTCTRPDGDNTDFRYFIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVIFMINLAIADLLQVLSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIYFLVCISVRRFWFLMYPFRFHDCKQKYDLYISIAGWLIICLACVLFPLLRTSDDTSGNRTKCFVDLPTRNVNLAQSVVMMTIGELIGFVTPLLIVLYCTWKTVLSLQDKYPMAQDLGEKQKALKMILTCAGVFLICFAPYHFSFPLDFLVKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFSTNEFRRRLSRQDLHDSIQLHAKSFVSNHTASTMTPELC

Target ORF information:

RefSeq Version	NM_032553.2
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein-coupled receptor 174 (GPR174), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032553.2

ORF Insert Sequence:

ATGCCTGCTA ATTACACGTG TACCAGGCCA GATGGAGACA ATACAGATTT TCGATACTTT 
ATTTATGCAG TGACATACAC TGTCATTCTT GTGCCAGGTC TCATAGGGAA TATATTAGCC 
CTGTGGGTAT TCTATGGTTA TATGAAAGAA ACAAAACGAG CTGTGATATT TATGATAAAC 
TTAGCCATTG CTGACTTACT ACAAGTTCTT TCCTTGCCAC TGAGGATCTT CTACTACTTG 
AATCATGACT GGCCATTTGG GCCTGGTCTC TGCATGTTCT GTTTCTACCT GAAGTATGTC 
AACATGTATG CAAGCATCTA CTTCTTGGTC TGCATCAGTG TGCGACGATT TTGGTTTCTC 
ATGTACCCCT TTCGCTTCCA TGACTGCAAA CAGAAATATG ACCTGTACAT CAGCATTGCT 
GGCTGGCTGA TCATCTGCCT TGCCTGTGTA CTCTTTCCAC TCCTCAGAAC CAGTGATGAT 
ACCTCTGGCA ATAGGACCAA ATGCTTTGTG GATCTTCCTA CCAGGAATGT CAACCTGGCC 
CAGTCCGTTG TTATGATGAC CATTGGCGAG TTGATTGGGT TTGTAACTCC GCTTCTGATT 
GTCCTATATT GTACCTGGAA GACGGTTTTA TCACTGCAAG ATAAATATCC CATGGCCCAA 
GATCTTGGAG AGAAACAGAA AGCCTTGAAG ATGATTCTAA CCTGTGCAGG GGTATTCCTA 
ATTTGCTTTG CACCTTATCA TTTCAGTTTT CCTTTAGATT TCCTGGTGAA GTCCAATGAA 
ATTAAAAGCT GCCTAGCCAG AAGGGTGATT CTAATATTTC ATTCTGTGGC ATTGTGTCTT 
GCTAGTCTGA ATTCATGTCT TGACCCAGTC ATATACTACT TTTCCACTAA TGAGTTCCGA 
AGACGGCTTT CAAGACAAGA TTTGCATGAC AGCATCCAAC TCCATGCAAA ATCCTTTGTG 
AGTAACCATA CAGCTTCCAC CATGACACCT GAATTATGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

RNASET2, GPR174, and PTPN22 gene polymorphisms are related to the risk of liver damage associated with the hyperthyroidism in patients with Graves' disease.
Journal of clinical laboratory analysis(2017 May)
Zhang Q,Liu S,Guan Y,Chen Q,Zhang Q,Min X

Alteration of gene expression profiling including GPR174 and GNG2 is associated with vasovagal syncope.
Pediatric cardiology36(3)475-80(2015 Mar)
Huang YJ,Zhou ZW,Xu M,Ma QW,Yan JB,Wang JY,Zhang QQ,Huang M,Bao L

Role of the X-linked gene GPR174 in autoimmune Addison's disease.
The Journal of clinical endocrinology and metabolism100(1)E187-90(2015 Jan)
Napier C,Mitchell AL,Gan E,Wilson I,Pearce SH

Lysophospholipid receptor nomenclature review: IUPHAR Review 8.
British journal of pharmacology171(15)3575-94(2014 Aug)
Kihara Y,Maceyka M,Spiegel S,Chun J

rs3827440, a nonsynonymous single nucleotide polymorphism within GPR174 gene in X chromosome, is associated with Graves' disease in Polish Caucasian population.
Tissue antigens83(1)41-4(2014 Jan)
Szyma?ski K,Mi?kiewicz P,Pirko K,Jurecka-Lubieniecka B,Kula D,Hasse-Lazar K,Krajewski P,Bednarczuk T,P?oski R

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GPR174 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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