Gene Symbol | FOXN1 |
Entrez Gene ID | 8456 |
Full Name | forkhead box N1 |
Synonyms | FKHL20,RONU,WHN |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq, Jul 2008]. |
Disorder MIM: | |
Disorder Html: | T-cell immunodeficiency, congenital alopecia, and nail dystrophy, 601705 (3) |