Gene Symbol | CARD11 |
Entrez Gene ID | 84433 |
Full Name | caspase recruitment domain family member 11 |
Synonyms | BENTA,BIMP3,CARMA1,IMD11,IMD11A,PPBL |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008]. |
Disorder MIM: | |
Disorder Html: | B-cell expansion with NFKB and T-cell anergy, 616452 (3); Immunodeficiency 11A, 615206 (3); Immunodeficiency 11B with atopic dermatitis, 617638 (3) |