C15orf48 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	C15orf48
Entrez Gene ID	84419
Full Name	chromosome 15 open reading frame 48
Synonyms	FOAP-11,MIR147BHG,NMES1
General protein information	Preferred Names chromosome 15 open reading frame 48 Names normal mucosa of esophagus-specific gene 1 protein MIR147B host normal mucosa of esophagus specific 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q21.1
Summary	This gene was first identified in a study of human esophageal squamous cell carcinoma tissues. Levels of both the message and protein are reduced in carcinoma samples. In adult human tissues, this gene is expressed in the the esophagus, stomach, small intestine, colon and placenta. Alternatively spliced transcript variants that encode the same protein have been identified. [provided by RefSeq, Jun 2012].
Disorder MIM:	608409

mRNA and Protein(s)

mRNA	Protein	Name
NM_032413.3	NP_115789.1	normal mucosa of esophagus-specific gene 1 protein
NM_197955.2	NP_922946.1	normal mucosa of esophagus-specific gene 1 protein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	C15H15orf48	NP_001231606.1
	LOC713440	XP_001111799.1
Mus musculus (house mouse)	AA467197	NP_001004174.1
Homo sapiens (human)	C15orf48	NP_115789.1
Danio rerio (zebrafish)	zgc:153317	NP_001185677.1
Bos taurus (cattle)	C10H15orf48	NP_001193905.1
Rattus norvegicus (Norway rat)	MGC105649	NP_001008518.1
Canis lupus familiaris (dog)	LOC102152168	XP_005619487.1
Canis lupus familiaris (dog)	C30H15orf48	XP_005638429.1

Gene Ontology
Bibliography

Related articles in PubMed

Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.
Floyd BJ, Wilkerson EM, Veling MT, Minogue CE, Xia C, Beebe ET, Wrobel RL, Cho H, Kremer LS, Alston CL, Gromek KA, Dolan BK, Ulbrich A, Stefely JA, Bohl SL, Werner KM, Jochem A, Westphall MS, Rensvold JW, Taylor RW, Prokisch H, Kim JP, Coon JJ, Pagliarini DJ
Molecular cell63(4)621-632(2016 Aug)

A regulatory dendritic cell signature correlates with the clinical efficacy of allergen-specific sublingual immunotherapy.
Zimmer A, Bouley J, Le Mignon M, Pliquet E, Horiot S, Turfkruyer M, Baron-Bodo V, Horak F, Nony E, Louise A, Moussu H, Mascarell L, Moingeon P
The Journal of allergy and clinical immunology129(4)1020-30(2012 Apr)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

Analysis of the methylation status of genes up-regulated by the demethylating agent, 5-aza-2'-deoxycytidine, in esophageal squamous cell carcinoma.
Arai M, Imazeki F, Sakai Y, Mikata R, Tada M, Seki N, Shimada H, Ochiai T, Yokosuka O
Oncology reports20(2)405-12(2008 Aug)

Discovery of novel methylation biomarkers in cervical carcinoma by global demethylation and microarray analysis.
Sova P, Feng Q, Geiss G, Wood T, Strauss R, Rudolf V, Lieber A, Kiviat N
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology15(1)114-23(2006 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The negative correlation of NMES1 expression with esophageal oncogenesis suggests its suppressive role in tumorigenesis of the esophagus, while the precise function of NMES1 still needs further investigation.
Title: A novel gene, NMES1, downregulated in human esophageal squamous cell carcinoma.

The following C15orf48 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the C15orf48 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu56038	NM_032413.3 Latest version!	Homo sapiens chromosome 15 open reading frame 48 (C15orf48), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu56038	NM_197955.2 Latest version!	Homo sapiens chromosome 15 open reading frame 48 (C15orf48), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone	40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

C15orf48 ( NM_032413.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_115789.1 Homo sapiens chromosome 15 open reading frame 48 (C15orf48), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu56038
Clone ID Related Accession (Same CDS sequence)	NM_032413.3 , NM_197955.2
Accession Version	NM_032413.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 252bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	normal mucosa of esophagus-specific gene 1 protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB447060.1, BM312626.1, AF228422.1 and AA493534.1. On Jun 26, 2012 this sequence version replaced NM_032413.2. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: AF228422.1, AK026298.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGCTTTT TCCAACTCCT GATGAAAAGG AAGGAACTCA TTCCCTTGGT GGTGTTCATG 
ACTGTGGCGG CGGGTGGAGC CTCATCTTTC GCTGTGTATT CTCTTTGGAA AACCGATGTG 
ATCCTTGATC GAAAAAAAAA TCCAGAACCT TGGGAAACTG TGGACCCTAC TGTACCTCAA 
AAGCTTATAA CAATCAACCA ACAATGGAAA CCCATTGAAG AGTTGCAAAA TGTCCAAAGG 
GTGACCAAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115789.1
CDS	269..520
Translation	MSFFQLLMKRKELIPLVVFMTVAAGGASSFAVYSLWKTDVILDRKKNPEPWETVDPTVPQKLITINQQWKPIEELQNVQRVTK

Target ORF information:

RefSeq Version	NM_032413.3
Organism	Homo sapiens(human)
Definition	Homo sapiens chromosome 15 open reading frame 48 (C15orf48), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032413.3

ORF Insert Sequence:

ATGAGCTTTT TCCAACTCCT GATGAAAAGG AAGGAACTCA TTCCCTTGGT GGTGTTCATG 
ACTGTGGCGG CGGGTGGAGC CTCATCTTTC GCTGTGTATT CTCTTTGGAA AACCGATGTG 
ATCCTTGATC GAAAAAAAAA TCCAGAACCT TGGGAAACTG TGGACCCTAC TGTACCTCAA 
AAGCTTATAA CAATCAACCA ACAATGGAAA CCCATTGAAG AGTTGCAAAA TGTCCAAAGG 
GTGACCAAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C15orf48 ( NM_197955.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_922946.1 Homo sapiens chromosome 15 open reading frame 48 (C15orf48), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu56038
Clone ID Related Accession (Same CDS sequence)	NM_032413.3 , NM_197955.2
Accession Version	NM_197955.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 252bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-10-12
Organism	Homo sapiens(human)
Product	normal mucosa of esophagus-specific gene 1 protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB447060.1, BM312626.1, BC021173.2, AF228422.1 and AA493534.1. On Jun 26, 2012 this sequence version replaced NM_197955.1. Transcript Variant: This variant (1) encodes the functional protein. Both variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: BI460346.1, BX102355.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCTTTT TCCAACTCCT GATGAAAAGG AAGGAACTCA TTCCCTTGGT GGTGTTCATG 
ACTGTGGCGG CGGGTGGAGC CTCATCTTTC GCTGTGTATT CTCTTTGGAA AACCGATGTG 
ATCCTTGATC GAAAAAAAAA TCCAGAACCT TGGGAAACTG TGGACCCTAC TGTACCTCAA 
AAGCTTATAA CAATCAACCA ACAATGGAAA CCCATTGAAG AGTTGCAAAA TGTCCAAAGG 
GTGACCAAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_922946.1
CDS	155..406
Translation	MSFFQLLMKRKELIPLVVFMTVAAGGASSFAVYSLWKTDVILDRKKNPEPWETVDPTVPQKLITINQQWKPIEELQNVQRVTK

Target ORF information:

RefSeq Version	NM_197955.2
Organism	Homo sapiens(human)
Definition	Homo sapiens chromosome 15 open reading frame 48 (C15orf48), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_197955.2

ORF Insert Sequence:

ATGAGCTTTT TCCAACTCCT GATGAAAAGG AAGGAACTCA TTCCCTTGGT GGTGTTCATG 
ACTGTGGCGG CGGGTGGAGC CTCATCTTTC GCTGTGTATT CTCTTTGGAA AACCGATGTG 
ATCCTTGATC GAAAAAAAAA TCCAGAACCT TGGGAAACTG TGGACCCTAC TGTACCTCAA 
AAGCTTATAA CAATCAACCA ACAATGGAAA CCCATTGAAG AGTTGCAAAA TGTCCAAAGG 
GTGACCAAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.
Molecular cell63(4)621-632(2016 Aug)
Floyd BJ,Wilkerson EM,Veling MT,Minogue CE,Xia C,Beebe ET,Wrobel RL,Cho H,Kremer LS,Alston CL,Gromek KA,Dolan BK,Ulbrich A,Stefely JA,Bohl SL,Werner KM,Jochem A,Westphall MS,Rensvold JW,Taylor RW,Prokisch H,Kim JP,Coon JJ,Pagliarini DJ

A regulatory dendritic cell signature correlates with the clinical efficacy of allergen-specific sublingual immunotherapy.
The Journal of allergy and clinical immunology129(4)1020-30(2012 Apr)
Zimmer A,Bouley J,Le Mignon M,Pliquet E,Horiot S,Turfkruyer M,Baron-Bodo V,Horak F,Nony E,Louise A,Moussu H,Mascarell L,Moingeon P

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

Analysis of the methylation status of genes up-regulated by the demethylating agent, 5-aza-2'-deoxycytidine, in esophageal squamous cell carcinoma.
Oncology reports20(2)405-12(2008 Aug)
Arai M,Imazeki F,Sakai Y,Mikata R,Tada M,Seki N,Shimada H,Ochiai T,Yokosuka O

Discovery of novel methylation biomarkers in cervical carcinoma by global demethylation and microarray analysis.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology15(1)114-23(2006 Jan)
Sova P,Feng Q,Geiss G,Wood T,Strauss R,Rudolf V,Lieber A,Kiviat N

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C15orf48 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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