UTF1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	UTF1
Entrez Gene ID	8433
Full Name	undifferentiated embryonic cell transcription factor 1
General protein information	Preferred Names undifferentiated embryonic cell transcription factor 1 Names undifferentiated embryonic cell transcription factor 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q26.3
Summary	The protein encoded by this gene is a leucine zipper-containing transcriptional coactivator that may link the upstream activator ATF2 with the basal transcription complex. The encoded protein is closely associated with chromatin and is required for the proper differentiation of embryonic carcinoma and embryonic stem cells. Found nearly exclusively in pluripotent cells, this protein can also serve as a transcriptional repressor. [provided by RefSeq, Nov 2015].
Disorder MIM:	604130

mRNA and Protein(s)

mRNA	Protein	Name
NM_003577.2	NP_003568.2	undifferentiated embryonic cell transcription factor 1
NM_003577.3	NP_003568.2	undifferentiated embryonic cell transcription factor 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	UTF1	XP_003954547.1
Mus musculus (house mouse)	Utf1	NP_033508.1
	LOC719795	XP_001114488.1
Rattus norvegicus (Norway rat)	Utf1	NP_001124504.1
Homo sapiens (human)	UTF1	NP_003568.2

Gene Ontology
Bibliography

Related articles in PubMed

Expression profile of undifferentiated cell transcription factor 1 in normal and cancerous human epithelia.
Mouallif M, Albert A, Zeddou M, Ennaji MM, Delvenne P, Guenin S
International journal of experimental pathology95(4)251-9(2014 Aug)

The embryonic stem cell factor UTF1 serves as a reliable diagnostic marker for germinomas.
Pantazis G, Harter PN, Capper D, Kohlhof P, Mittelbronn M, Schittenhelm J
Pathology46(3)225-9(2014 Apr)

Undifferentiated embryonic cell transcription factor-1 (UTF1) inhibits the growth of cervical cancer cells by transactivating p27Kip1.
Wu XL, Zheng PS
Carcinogenesis34(7)1660-8(2013 Jul)

Regulation of pluripotency and self- renewal of ESCs through epigenetic-threshold modulation and mRNA pruning.
Jia J, Zheng X, Hu G, Cui K, Zhang J, Zhang A, Jiang H, Lu B, Yates J 3rd, Liu C, Zhao K, Zheng Y
Cell151(3)576-89(2012 Oct)

Aberrant promoter methylation and expression of UTF1 during cervical carcinogenesis.
Guenin S, Mouallif M, Deplus R, Lampe X, Krusy N, Calonne E, Delbecque K, Kridelka F, Fuks F, Ennaji MM, Delvenne P
PloS one7(8)e42704(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

With a sensitivity of 100% and a specificity of 97% in the detection of central nervous system (CNS) germinomas, UTF1 serves as a new reliable alternative in the diagnostic setting of CNS germ cell tumours.
Title: The embryonic stem cell factor UTF1 serves as a reliable diagnostic marker for germinomas.

UTF1 attenuates cell proliferation and is inactivated in cervical carcinogenesis through epigenetic modification.
Title: Undifferentiated embryonic cell transcription factor-1 (UTF1) inhibits the growth of cervical cancer cells by transactivating p27Kip1.

Utf1 couples the core pluripotency factors with Myc and PRC2 networks to promote the pluripotency and proliferation of embryonic stem cells.
Title: Regulation of pluripotency and self- renewal of ESCs through epigenetic-threshold modulation and mRNA pruning.

These findings strongly suggest that UTF1 promoter methylation profile might be a useful biomarker for cervical cancer diagnosis.
Title: Aberrant promoter methylation and expression of UTF1 during cervical carcinogenesis.

role for UTF1 in differentiation of matrix cells of the shaft as well as in suprabasal keratinocytes.
Title: Embryonic stem cell factors undifferentiated transcription factor-1 (UFT-1) and reduced expression protein-1 (REX-1) are widely expressed in human skin and may be involved in cutaneous differentiation but not in stem cell fate determination.

The following UTF1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UTF1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03400	NM_003577.3 Latest version!	Homo sapiens undifferentiated embryonic cell transcription factor 1 (UTF1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$195.30 $279.00
View Old Accession Versions >>
OHu03400	NM_003577.2	Homo sapiens undifferentiated embryonic cell transcription factor 1 (UTF1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$195.30 $279.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

UTF1 ( NM_003577.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003568.2 Homo sapiens undifferentiated embryonic cell transcription factor 1 (UTF1), mRNA.

Price & Availability↑

CloneID	OHu03400
Clone ID Related Accession (Same CDS sequence)	NM_003577.2 , NM_003577.3
Accession Version	NM_003577.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1026bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	undifferentiated embryonic cell transcription factor 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY606112.1. On Jul 21, 2005 this sequence version replaced NM_003577.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY606112.1, AB011076.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155751, SAMN01820687 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGCTCC GGCCCCGCAG GCCGCCCCCG CTCGCGCCCC CCGCGCCGCC CTCGCCCGCC 
AGCCCCGACC CCGAGCCGCG GACACCCGGA GACGCCCCGG GGACCCCGCC CCGGAGGCCC 
GCCTCGCCCA GCGCGCTGGG GGAACTCGGG TTGCCGGTGT CCCCGGGCTC GGCGCAGCGC 
ACGCCCTGGA GCGCCCGGGA GACGGAGCTG CTGCTGGGGA CGCTGCTGCA ACCGGCCGTG 
TGGCGCGCGC TGCTCCTGGA CCGCCGCCAG GCCCTGCCCA CCTACCGCCG CGTGTCGGCC 
GCGCTGGCCC AGCAGCAGGT GCGCCGCACC CCCGCGCAGT GCCGCCGCCG CTACAAGTTC 
CTTAAAGACA AGTTTCGCGA GGCGCACGGC CAGCCGCCCG GGCCCTTCGA CGAGCAGATC 
CGGAAGCTCA TGGGGCTGCT GGGCGACAAC GGGCGCAAAC GGCCTCGCCG CCGCTCCCCG 
GGGTCCGGGC GCCCCCAGCG CGCCCGCCGC CCGGTCCCCA ACGCGCACGC GCCGGCTCCC 
AGCGAACCAG ACGCCACCCC GCTGCCCACC GCCCGCGACC GCGACGCGGA CCCCACCTGG 
ACGCTCCGCT TCAGCCCGTC CCCACCGAAG TCTGCGGACG CCTCCCCCGC CCCCGGCTCC 
CCGCCAGCTC CCGCCCCGAC CGCCCTCGCC ACCTGCATCC CCGAGGACCG CGCGCCCGTC 
CGCGGCCCCG GGTCCCCGCC GCCACCCCCG GCCCGCGAAG ACCCCGACTC GCCGCCCGGC 
CGCCCCGAGG ACTGCGCGCC CCCTCCGGCC GCGCCCCCGT CGCTGAACAC CGCCCTGCTG 
CAGACCCTGG GGCACCTGGG CGACATCGCG AACATCCTGG GCCCGCTGCG CGACCAGCTG 
CTGACCTTGA ACCAGCACGT GGAGCAGCTG CGCGGCGCCT TCGACCAGAC AGTGTCCCTG 
GCCGTGGGCT TCATTCTGGG CAGCGCGGCC GCCGAGCGAG GGGTCCTCAG GGACCCGTGC 
CAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003568.2
CDS	16..1041
Translation	MLLRPRRPPPLAPPAPPSPASPDPEPRTPGDAPGTPPRRPASPSALGELGLPVSPGSAQRTPWSARETELLLGTLLQPAVWRALLLDRRQALPTYRRVSAALAQQQVRRTPAQCRRRYKFLKDKFREAHGQPPGPFDEQIRKLMGLLGDNGRKRPRRRSPGSGRPQRARRPVPNAHAPAPSEPDATPLPTARDRDADPTWTLRFSPSPPKSADASPAPGSPPAPAPTALATCIPEDRAPVRGPGSPPPPPAREDPDSPPGRPEDCAPPPAAPPSLNTALLQTLGHLGDIANILGPLRDQLLTLNQHVEQLRGAFDQTVSLAVGFILGSAAAERGVLRDPCQ

Target ORF information:

RefSeq Version	NM_003577.2
Organism	Homo sapiens(human)
Definition	Homo sapiens undifferentiated embryonic cell transcription factor 1 (UTF1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003577.2

ORF Insert Sequence:

ATGCTGCTCC GGCCCCGCAG GCCGCCCCCG CTCGCGCCCC CCGCGCCGCC CTCGCCCGCC 
AGCCCCGACC CCGAGCCGCG GACACCCGGA GACGCCCCGG GGACCCCGCC CCGGAGGCCC 
GCCTCGCCCA GCGCGCTGGG GGAACTCGGG TTGCCGGTGT CCCCGGGCTC GGCGCAGCGC 
ACGCCCTGGA GCGCCCGGGA GACGGAGCTG CTGCTGGGGA CGCTGCTGCA ACCGGCCGTG 
TGGCGCGCGC TGCTCCTGGA CCGCCGCCAG GCCCTGCCCA CCTACCGCCG CGTGTCGGCC 
GCGCTGGCCC AGCAGCAGGT GCGCCGCACC CCCGCGCAGT GCCGCCGCCG CTACAAGTTC 
CTTAAAGACA AGTTTCGCGA GGCGCACGGC CAGCCGCCCG GGCCCTTCGA CGAGCAGATC 
CGGAAGCTCA TGGGGCTGCT GGGCGACAAC GGGCGCAAAC GGCCTCGCCG CCGCTCCCCG 
GGGTCCGGGC GCCCCCAGCG CGCCCGCCGC CCGGTCCCCA ACGCGCACGC GCCGGCTCCC 
AGCGAACCAG ACGCCACCCC GCTGCCCACC GCCCGCGACC GCGACGCGGA CCCCACCTGG 
ACGCTCCGCT TCAGCCCGTC CCCACCGAAG TCTGCGGACG CCTCCCCCGC CCCCGGCTCC 
CCGCCAGCTC CCGCCCCGAC CGCCCTCGCC ACCTGCATCC CCGAGGACCG CGCGCCCGTC 
CGCGGCCCCG GGTCCCCGCC GCCACCCCCG GCCCGCGAAG ACCCCGACTC GCCGCCCGGC 
CGCCCCGAGG ACTGCGCGCC CCCTCCGGCC GCGCCCCCGT CGCTGAACAC CGCCCTGCTG 
CAGACCCTGG GGCACCTGGG CGACATCGCG AACATCCTGG GCCCGCTGCG CGACCAGCTG 
CTGACCTTGA ACCAGCACGT GGAGCAGCTG CGCGGCGCCT TCGACCAGAC AGTGTCCCTG 
GCCGTGGGCT TCATTCTGGG CAGCGCGGCC GCCGAGCGAG GGGTCCTCAG GGACCCGTGC 
CAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UTF1 ( NM_003577.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003568.2 Homo sapiens undifferentiated embryonic cell transcription factor 1 (UTF1), mRNA.

Price & Availability↑

CloneID	OHu03400
Clone ID Related Accession (Same CDS sequence)	NM_003577.2 , NM_003577.3
Accession Version	NM_003577.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1026bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	undifferentiated embryonic cell transcription factor 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL445199.37 and AY606112.1. On Nov 23, 2018 this sequence version replaced NM_003577.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB011076.2, AY606112.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155751, SAMN01820687 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000304477.3/ ENSP00000305906.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGCTCC GGCCCCGCAG GCCGCCCCCG CTCGCGCCCC CCGCGCCGCC CTCGCCCGCC 
AGCCCCGACC CCGAGCCGCG GACACCCGGA GACGCCCCGG GGACCCCGCC CCGGAGGCCC 
GCCTCGCCCA GCGCGCTGGG GGAACTCGGG TTGCCGGTGT CCCCGGGCTC GGCGCAGCGC 
ACGCCCTGGA GCGCCCGGGA GACGGAGCTG CTGCTGGGGA CGCTGCTGCA ACCGGCCGTG 
TGGCGCGCGC TGCTCCTGGA CCGCCGCCAG GCCCTGCCCA CCTACCGCCG CGTGTCGGCC 
GCGCTGGCCC AGCAGCAGGT GCGCCGCACC CCCGCGCAGT GCCGCCGCCG CTACAAGTTC 
CTTAAAGACA AGTTTCGCGA GGCGCACGGC CAGCCGCCCG GGCCCTTCGA CGAGCAGATC 
CGGAAGCTCA TGGGGCTGCT GGGCGACAAC GGGCGCAAAC GGCCTCGCCG CCGCTCCCCG 
GGGTCCGGGC GCCCCCAGCG CGCCCGCCGC CCGGTCCCCA ACGCGCACGC GCCGGCTCCC 
AGCGAACCAG ACGCCACCCC GCTGCCCACC GCCCGCGACC GCGACGCGGA CCCCACCTGG 
ACGCTCCGCT TCAGCCCGTC CCCACCGAAG TCTGCGGACG CCTCCCCCGC CCCCGGCTCC 
CCGCCAGCTC CCGCCCCGAC CGCCCTCGCC ACCTGCATCC CCGAGGACCG CGCGCCCGTC 
CGCGGCCCCG GGTCCCCGCC GCCACCCCCG GCCCGCGAAG ACCCCGACTC GCCGCCCGGC 
CGCCCCGAGG ACTGCGCGCC CCCTCCGGCC GCGCCCCCGT CGCTGAACAC CGCCCTGCTG 
CAGACCCTGG GGCACCTGGG CGACATCGCG AACATCCTGG GCCCGCTGCG CGACCAGCTG 
CTGACCTTGA ACCAGCACGT GGAGCAGCTG CGCGGCGCCT TCGACCAGAC AGTGTCCCTG 
GCCGTGGGCT TCATTCTGGG CAGCGCGGCC GCCGAGCGAG GGGTCCTCAG GGACCCGTGC 
CAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003568.2
CDS	73..1098
Translation	MLLRPRRPPPLAPPAPPSPASPDPEPRTPGDAPGTPPRRPASPSALGELGLPVSPGSAQRTPWSARETELLLGTLLQPAVWRALLLDRRQALPTYRRVSAALAQQQVRRTPAQCRRRYKFLKDKFREAHGQPPGPFDEQIRKLMGLLGDNGRKRPRRRSPGSGRPQRARRPVPNAHAPAPSEPDATPLPTARDRDADPTWTLRFSPSPPKSADASPAPGSPPAPAPTALATCIPEDRAPVRGPGSPPPPPAREDPDSPPGRPEDCAPPPAAPPSLNTALLQTLGHLGDIANILGPLRDQLLTLNQHVEQLRGAFDQTVSLAVGFILGSAAAERGVLRDPCQ

Target ORF information:

RefSeq Version	NM_003577.3
Organism	Homo sapiens(human)
Definition	Homo sapiens undifferentiated embryonic cell transcription factor 1 (UTF1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003577.3

ORF Insert Sequence:

ATGCTGCTCC GGCCCCGCAG GCCGCCCCCG CTCGCGCCCC CCGCGCCGCC CTCGCCCGCC 
AGCCCCGACC CCGAGCCGCG GACACCCGGA GACGCCCCGG GGACCCCGCC CCGGAGGCCC 
GCCTCGCCCA GCGCGCTGGG GGAACTCGGG TTGCCGGTGT CCCCGGGCTC GGCGCAGCGC 
ACGCCCTGGA GCGCCCGGGA GACGGAGCTG CTGCTGGGGA CGCTGCTGCA ACCGGCCGTG 
TGGCGCGCGC TGCTCCTGGA CCGCCGCCAG GCCCTGCCCA CCTACCGCCG CGTGTCGGCC 
GCGCTGGCCC AGCAGCAGGT GCGCCGCACC CCCGCGCAGT GCCGCCGCCG CTACAAGTTC 
CTTAAAGACA AGTTTCGCGA GGCGCACGGC CAGCCGCCCG GGCCCTTCGA CGAGCAGATC 
CGGAAGCTCA TGGGGCTGCT GGGCGACAAC GGGCGCAAAC GGCCTCGCCG CCGCTCCCCG 
GGGTCCGGGC GCCCCCAGCG CGCCCGCCGC CCGGTCCCCA ACGCGCACGC GCCGGCTCCC 
AGCGAACCAG ACGCCACCCC GCTGCCCACC GCCCGCGACC GCGACGCGGA CCCCACCTGG 
ACGCTCCGCT TCAGCCCGTC CCCACCGAAG TCTGCGGACG CCTCCCCCGC CCCCGGCTCC 
CCGCCAGCTC CCGCCCCGAC CGCCCTCGCC ACCTGCATCC CCGAGGACCG CGCGCCCGTC 
CGCGGCCCCG GGTCCCCGCC GCCACCCCCG GCCCGCGAAG ACCCCGACTC GCCGCCCGGC 
CGCCCCGAGG ACTGCGCGCC CCCTCCGGCC GCGCCCCCGT CGCTGAACAC CGCCCTGCTG 
CAGACCCTGG GGCACCTGGG CGACATCGCG AACATCCTGG GCCCGCTGCG CGACCAGCTG 
CTGACCTTGA ACCAGCACGT GGAGCAGCTG CGCGGCGCCT TCGACCAGAC AGTGTCCCTG 
GCCGTGGGCT TCATTCTGGG CAGCGCGGCC GCCGAGCGAG GGGTCCTCAG GGACCCGTGC 
CAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression profile of undifferentiated cell transcription factor 1 in normal and cancerous human epithelia.
International journal of experimental pathology95(4)251-9(2014 Aug)
Mouallif M,Albert A,Zeddou M,Ennaji MM,Delvenne P,Guenin S

The embryonic stem cell factor UTF1 serves as a reliable diagnostic marker for germinomas.
Pathology46(3)225-9(2014 Apr)
Pantazis G,Harter PN,Capper D,Kohlhof P,Mittelbronn M,Schittenhelm J

Undifferentiated embryonic cell transcription factor-1 (UTF1) inhibits the growth of cervical cancer cells by transactivating p27Kip1.
Carcinogenesis34(7)1660-8(2013 Jul)
Wu XL,Zheng PS

Regulation of pluripotency and self- renewal of ESCs through epigenetic-threshold modulation and mRNA pruning.
Cell151(3)576-89(2012 Oct)
Jia J,Zheng X,Hu G,Cui K,Zhang J,Zhang A,Jiang H,Lu B,Yates J 3rd,Liu C,Zhao K,Zheng Y

Aberrant promoter methylation and expression of UTF1 during cervical carcinogenesis.
PloS one7(8)e42704(2012)
Guenin S,Mouallif M,Deplus R,Lampe X,Krusy N,Calonne E,Delbecque K,Kridelka F,Fuks F,Ennaji MM,Delvenne P

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UTF1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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