NR0B2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NR0B2
Entrez Gene ID	8431
Full Name	nuclear receptor subfamily 0 group B member 2
Synonyms	SHP,SHP1
General protein information	Preferred Names nuclear receptor subfamily 0 group B member 2 Names nuclear receptor subfamily 0 group B member 2 nuclear receptor SHP orphan nuclear receptor SHP small heterodimer partner
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p36.11
Summary	The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008].
Disorder MIM:	604630
Disorder Html:	Obesity, mild, early-onset, 601665 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011542297.2	XP_011540599.1	nuclear receptor subfamily 0 group B member 2 isoform X1
NM_021969.3	NP_068804.1	nuclear receptor subfamily 0 group B member 2
XM_011542297.3	XP_011540599.1	nuclear receptor subfamily 0 group B member 2 isoform X1
NM_021969.2	NP_068804.1	nuclear receptor subfamily 0 group B member 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	NR0B2	NP_068804.1
Canis lupus familiaris (dog)	NR0B2	XP_005617781.1
Danio rerio (zebrafish)	nr0b2a	NP_001243120.1
Pan troglodytes (chimpanzee)	NR0B2	XP_001146990.1
Bos taurus (cattle)	NR0B2	XP_002685805.1
Mus musculus (house mouse)	Nr0b2	NP_035980.1
Xenopus tropicalis (tropical clawed frog)	nr0b2	XP_002936259.2
	NR0B2	XP_001110533.1
Rattus norvegicus (Norway rat)	Nr0b2	NP_476474.1
Gallus gallus (chicken)	NR0B2	NP_001026064.2

Gene Ontology
Bibliography

Related articles in PubMed

Functional assessment of genetic variants located in the promoter of SHP1 (NR0B2).
Prestin K, Olbert M, Hussner J, V?lzke H, Meyer Zu Schwabedissen HE
Pharmacogenetics and genomics27(11)410-415(2017 Nov)

Circadian rhythmicity: A functional connection between differentiated embryonic chondrocyte-1 (DEC1) and small heterodimer partner (SHP).
Marczak MM, Yan B
Archives of biochemistry and biophysics63111-18(2017 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study was performed to test the hypothesis that the SHP gene is a target gene of DEC1. Cotransfection demonstrated that DEC1 repressed the SHP promoter and attenuated the transactivation of the classic circadian activator complex of Clock/Bmal1.
Title: Circadian rhythmicity: A functional connection between differentiated embryonic chondrocyte-1 (DEC1) and small heterodimer partner (SHP).

The molecular dynamics and structural analysis of the small heterodimer partner in complex with glucocorticoid receptor is described.
Title: Structural Analysis of the Glucocorticoid Receptor Ligand-Binding Domain in Complex with Triamcinolone Acetonide and a Fragment of the Atypical Coregulator, Small Heterodimer Partner.

The finding that overexpression of HIF-1alpha increased the activity of the CYP7A1 promoter suggested that hypoxia decreased the expression of CYP7A1 in a HIF-1-independent manner.
Title: Hypoxic repression of CYP7A1 through a HIF-1?- and SHP-independent mechanism.

Results demonstrated a detrimental effect of Bcl2 and H19 associated with cholestatic liver fibrosis and an indispensable role of Shp to maintain normal liver function.
Title: Bcl2 is a critical regulator of bile acid homeostasis by dictating Shp and lncRNA H19 function.

Data suggest that LRH1/NR5A2 (liver receptor homologue-1) exhibits phospholipid-mediated allosteric control of protein-protein binding interface in interactions with TIF2 (co-activator; transcription intermediary factor 2) and SHP.
Title: Unexpected Allosteric Network Contributes to LRH-1 Co-regulator Selectivity.

The following NR0B2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NR0B2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26882	NM_021969.3 Latest version!	Homo sapiens nuclear receptor subfamily 0 group B member 2 (NR0B2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu61766	XM_011542297.3 Latest version!	Homo sapiens nuclear receptor subfamily 0 group B member 2 (NR0B2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu61766	XM_011542297.2	Homo sapiens nuclear receptor subfamily 0 group B member 2 (NR0B2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu26882	NM_021969.2	Homo sapiens nuclear receptor subfamily 0 group B member 2 (NR0B2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NR0B2 ( NM_021969.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_068804.1 Homo sapiens nuclear receptor subfamily 0 group B member 2 (NR0B2), mRNA.

Price & Availability↑

CloneID	OHu26882
Clone ID Related Accession (Same CDS sequence)	NM_021969.3 , NM_021969.2
Accession Version	NM_021969.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 774bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	nuclear receptor subfamily 0 group B member 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AI457167.1 and BC030207.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_021969.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189664.20848.1, SRR5189652.32856.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144835 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000254227.4/ ENSP00000254227.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCACCA GCCAACCAGG GGCCTGCCCA TGCCAGGGAG CTGCAAGCCG CCCCGCCATT 
CTCTACGCAC TTCTGAGCTC CAGCCTCAAG GCTGTCCCCC GACCCCGTAG CCGCTGCCTA 
TGTAGGCAGC ACCGGCCCGT CCAGCTATGT GCACCTCATC GCACCTGCCG GGAGGCCTTG 
GATGTTCTGG CCAAGACAGT GGCCTTCCTC AGGAACCTGC CATCCTTCTG GCAGCTGCCT 
CCCCAGGACC AGCGGCGGCT GCTGCAGGGT TGCTGGGGCC CCCTCTTCCT GCTTGGGTTG 
GCCCAAGATG CTGTGACCTT TGAGGTGGCT GAGGCCCCGG TGCCCAGCAT ACTCAAGAAG 
ATTCTGCTGG AGGAGCCCAG CAGCAGTGGA GGCAGTGGCC AACTGCCAGA CAGACCCCAG 
CCCTCCCTGG CTGCGGTGCA GTGGCTTCAA TGCTGTCTGG AGTCCTTCTG GAGCCTGGAG 
CTTAGCCCCA AGGAATATGC CTGCCTGAAA GGGACCATCC TCTTCAACCC CGATGTGCCA 
GGCCTCCAAG CCGCCTCCCA CATTGGGCAC CTGCAGCAGG AGGCTCACTG GGTGCTGTGT 
GAAGTCCTGG AACCCTGGTG CCCAGCAGCC CAAGGCCGCC TGACCCGTGT CCTCCTCACG 
GCCTCCACCC TCAAGTCCAT TCCGACCAGC CTGCTTGGGG ACCTCTTCTT TCGCCCTATC 
ATTGGAGATG TTGACATCGC TGGCCTTCTT GGGGACATGC TTTTGCTCAG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_068804.1
CDS	36..809
Translation	MSTSQPGACPCQGAASRPAILYALLSSSLKAVPRPRSRCLCRQHRPVQLCAPHRTCREALDVLAKTVAFLRNLPSFWQLPPQDQRRLLQGCWGPLFLLGLAQDAVTFEVAEAPVPSILKKILLEEPSSSGGSGQLPDRPQPSLAAVQWLQCCLESFWSLELSPKEYACLKGTILFNPDVPGLQAASHIGHLQQEAHWVLCEVLEPWCPAAQGRLTRVLLTASTLKSIPTSLLGDLFFRPIIGDVDIAGLLGDMLLLR

Target ORF information:

RefSeq Version	NM_021969.3
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear receptor subfamily 0 group B member 2 (NR0B2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021969.3

ORF Insert Sequence:

ATGAGCACCA GCCAACCAGG GGCCTGCCCA TGCCAGGGAG CTGCAAGCCG CCCCGCCATT 
CTCTACGCAC TTCTGAGCTC CAGCCTCAAG GCTGTCCCCC GACCCCGTAG CCGCTGCCTA 
TGTAGGCAGC ACCGGCCCGT CCAGCTATGT GCACCTCATC GCACCTGCCG GGAGGCCTTG 
GATGTTCTGG CCAAGACAGT GGCCTTCCTC AGGAACCTGC CATCCTTCTG GCAGCTGCCT 
CCCCAGGACC AGCGGCGGCT GCTGCAGGGT TGCTGGGGCC CCCTCTTCCT GCTTGGGTTG 
GCCCAAGATG CTGTGACCTT TGAGGTGGCT GAGGCCCCGG TGCCCAGCAT ACTCAAGAAG 
ATTCTGCTGG AGGAGCCCAG CAGCAGTGGA GGCAGTGGCC AACTGCCAGA CAGACCCCAG 
CCCTCCCTGG CTGCGGTGCA GTGGCTTCAA TGCTGTCTGG AGTCCTTCTG GAGCCTGGAG 
CTTAGCCCCA AGGAATATGC CTGCCTGAAA GGGACCATCC TCTTCAACCC CGATGTGCCA 
GGCCTCCAAG CCGCCTCCCA CATTGGGCAC CTGCAGCAGG AGGCTCACTG GGTGCTGTGT 
GAAGTCCTGG AACCCTGGTG CCCAGCAGCC CAAGGCCGCC TGACCCGTGT CCTCCTCACG 
GCCTCCACCC TCAAGTCCAT TCCGACCAGC CTGCTTGGGG ACCTCTTCTT TCGCCCTATC 
ATTGGAGATG TTGACATCGC TGGCCTTCTT GGGGACATGC TTTTGCTCAG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NR0B2 ( NM_021969.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_068804.1 Homo sapiens nuclear receptor subfamily 0 group B member 2 (NR0B2), mRNA.

Price & Availability↑

CloneID	OHu26882
Clone ID Related Accession (Same CDS sequence)	NM_021969.3 , NM_021969.2
Accession Version	NM_021969.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 774bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	nuclear receptor subfamily 0 group B member 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA930064.1, AI457167.1, BC030207.1 and AA872285.1. This sequence is a reference standard in the RefSeqGene project. On Oct 3, 2008 this sequence version replaced NM_021969.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC030207.1, ERR279874.433.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144835 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGAGCACCA GCCAACCAGG GGCCTGCCCA TGCCAGGGAG CTGCAAGCCG CCCCGCCATT 
CTCTACGCAC TTCTGAGCTC CAGCCTCAAG GCTGTCCCCC GACCCCGTAG CCGCTGCCTA 
TGTAGGCAGC ACCGGCCCGT CCAGCTATGT GCACCTCATC GCACCTGCCG GGAGGCCTTG 
GATGTTCTGG CCAAGACAGT GGCCTTCCTC AGGAACCTGC CATCCTTCTG GCAGCTGCCT 
CCCCAGGACC AGCGGCGGCT GCTGCAGGGT TGCTGGGGCC CCCTCTTCCT GCTTGGGTTG 
GCCCAAGATG CTGTGACCTT TGAGGTGGCT GAGGCCCCGG TGCCCAGCAT ACTCAAGAAG 
ATTCTGCTGG AGGAGCCCAG CAGCAGTGGA GGCAGTGGCC AACTGCCAGA CAGACCCCAG 
CCCTCCCTGG CTGCGGTGCA GTGGCTTCAA TGCTGTCTGG AGTCCTTCTG GAGCCTGGAG 
CTTAGCCCCA AGGAATATGC CTGCCTGAAA GGGACCATCC TCTTCAACCC CGATGTGCCA 
GGCCTCCAAG CCGCCTCCCA CATTGGGCAC CTGCAGCAGG AGGCTCACTG GGTGCTGTGT 
GAAGTCCTGG AACCCTGGTG CCCAGCAGCC CAAGGCCGCC TGACCCGTGT CCTCCTCACG 
GCCTCCACCC TCAAGTCCAT TCCGACCAGC CTGCTTGGGG ACCTCTTCTT TCGCCCTATC 
ATTGGAGATG TTGACATCGC TGGCCTTCTT GGGGACATGC TTTTGCTCAG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_068804.1
CDS	137..910
Translation	MSTSQPGACPCQGAASRPAILYALLSSSLKAVPRPRSRCLCRQHRPVQLCAPHRTCREALDVLAKTVAFLRNLPSFWQLPPQDQRRLLQGCWGPLFLLGLAQDAVTFEVAEAPVPSILKKILLEEPSSSGGSGQLPDRPQPSLAAVQWLQCCLESFWSLELSPKEYACLKGTILFNPDVPGLQAASHIGHLQQEAHWVLCEVLEPWCPAAQGRLTRVLLTASTLKSIPTSLLGDLFFRPIIGDVDIAGLLGDMLLLR

Target ORF information:

RefSeq Version	NM_021969.2
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear receptor subfamily 0 group B member 2 (NR0B2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021969.2

ORF Insert Sequence:

ATGAGCACCA GCCAACCAGG GGCCTGCCCA TGCCAGGGAG CTGCAAGCCG CCCCGCCATT 
CTCTACGCAC TTCTGAGCTC CAGCCTCAAG GCTGTCCCCC GACCCCGTAG CCGCTGCCTA 
TGTAGGCAGC ACCGGCCCGT CCAGCTATGT GCACCTCATC GCACCTGCCG GGAGGCCTTG 
GATGTTCTGG CCAAGACAGT GGCCTTCCTC AGGAACCTGC CATCCTTCTG GCAGCTGCCT 
CCCCAGGACC AGCGGCGGCT GCTGCAGGGT TGCTGGGGCC CCCTCTTCCT GCTTGGGTTG 
GCCCAAGATG CTGTGACCTT TGAGGTGGCT GAGGCCCCGG TGCCCAGCAT ACTCAAGAAG 
ATTCTGCTGG AGGAGCCCAG CAGCAGTGGA GGCAGTGGCC AACTGCCAGA CAGACCCCAG 
CCCTCCCTGG CTGCGGTGCA GTGGCTTCAA TGCTGTCTGG AGTCCTTCTG GAGCCTGGAG 
CTTAGCCCCA AGGAATATGC CTGCCTGAAA GGGACCATCC TCTTCAACCC CGATGTGCCA 
GGCCTCCAAG CCGCCTCCCA CATTGGGCAC CTGCAGCAGG AGGCTCACTG GGTGCTGTGT 
GAAGTCCTGG AACCCTGGTG CCCAGCAGCC CAAGGCCGCC TGACCCGTGT CCTCCTCACG 
GCCTCCACCC TCAAGTCCAT TCCGACCAGC CTGCTTGGGG ACCTCTTCTT TCGCCCTATC 
ATTGGAGATG TTGACATCGC TGGCCTTCTT GGGGACATGC TTTTGCTCAG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NR0B2 ( XM_011542297.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011540599.1 Homo sapiens nuclear receptor subfamily 0 group B member 2 (NR0B2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu61766
Clone ID Related Accession (Same CDS sequence)	XM_011542297.2 , XM_011542297.3
Accession Version	XM_011542297.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 624bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	nuclear receptor subfamily 0 group B member 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011542297.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGCACCA GCCAACCAGG GGCCTGCCCA TGCCAGGGAG CTGCAAGCCG CCCCGCCATT 
CTCTACGCAC TTCTGAGCTC CAGCCTCAAG GCTGTCCCCC GACCCCGTAG CCGCTGCCTA 
TGTAGGCAGC ACCGGCCCGT CCAGCTATGT GCACCTCATC GCACCTGCCG GGAGGCCTTG 
GATGTTCTGG CCAAGACAGT GGCCTTCCTC AGGAACCTGC CATCCTTCTG GCAGCTGCCT 
CCCCAGGACC AGCGGCGGCT GCTGCAGGGT TGCTGGGGCC CCCTCTTCCT GCTTGGGTTG 
GCCCAAGATG CTGTGACCTT TGAGGTGGCT GAGGCCCCGG TGCCCAGCAT ACTCAAGAAG 
ATTCTGCTGG AGGAGCCCAG CAGCAGTGGA GGCAGTGGCC AACTGCCAGA CAGACCCCAG 
CCCTCCCTGG CTGCGGTGCA GTGGCTTCAA TGCTGTCTGG AGTCCTTCTG GAGCCTGGAG 
CTTAGCCCCA AGGAATATGC CTGCCTGAAA GGGACCATCC TCTTCAACCC CGATAAAGAA 
ACTGAAGCCC AGAGATTAAG TGACTTGCCC AAGGTCACCC AGCTAATAAG TGACAGTGCT 
GGGATTCATA CCCAGGAAGC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011540599.1
CDS	137..760
Translation	MSTSQPGACPCQGAASRPAILYALLSSSLKAVPRPRSRCLCRQHRPVQLCAPHRTCREALDVLAKTVAFLRNLPSFWQLPPQDQRRLLQGCWGPLFLLGLAQDAVTFEVAEAPVPSILKKILLEEPSSSGGSGQLPDRPQPSLAAVQWLQCCLESFWSLELSPKEYACLKGTILFNPDKETEAQRLSDLPKVTQLISDSAGIHTQEA

Target ORF information:

RefSeq Version	XM_011542297.2
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear receptor subfamily 0 group B member 2 (NR0B2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011542297.2

ORF Insert Sequence:

ATGAGCACCA GCCAACCAGG GGCCTGCCCA TGCCAGGGAG CTGCAAGCCG CCCCGCCATT 
CTCTACGCAC TTCTGAGCTC CAGCCTCAAG GCTGTCCCCC GACCCCGTAG CCGCTGCCTA 
TGTAGGCAGC ACCGGCCCGT CCAGCTATGT GCACCTCATC GCACCTGCCG GGAGGCCTTG 
GATGTTCTGG CCAAGACAGT GGCCTTCCTC AGGAACCTGC CATCCTTCTG GCAGCTGCCT 
CCCCAGGACC AGCGGCGGCT GCTGCAGGGT TGCTGGGGCC CCCTCTTCCT GCTTGGGTTG 
GCCCAAGATG CTGTGACCTT TGAGGTGGCT GAGGCCCCGG TGCCCAGCAT ACTCAAGAAG 
ATTCTGCTGG AGGAGCCCAG CAGCAGTGGA GGCAGTGGCC AACTGCCAGA CAGACCCCAG 
CCCTCCCTGG CTGCGGTGCA GTGGCTTCAA TGCTGTCTGG AGTCCTTCTG GAGCCTGGAG 
CTTAGCCCCA AGGAATATGC CTGCCTGAAA GGGACCATCC TCTTCAACCC CGATAAAGAA 
ACTGAAGCCC AGAGATTAAG TGACTTGCCC AAGGTCACCC AGCTAATAAG TGACAGTGCT 
GGGATTCATA CCCAGGAAGC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NR0B2 ( XM_011542297.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011540599.1 Homo sapiens nuclear receptor subfamily 0 group B member 2 (NR0B2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu61766
Clone ID Related Accession (Same CDS sequence)	XM_011542297.2 , XM_011542297.3
Accession Version	XM_011542297.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 624bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	nuclear receptor subfamily 0 group B member 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011542297.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGCACCA GCCAACCAGG GGCCTGCCCA TGCCAGGGAG CTGCAAGCCG CCCCGCCATT 
CTCTACGCAC TTCTGAGCTC CAGCCTCAAG GCTGTCCCCC GACCCCGTAG CCGCTGCCTA 
TGTAGGCAGC ACCGGCCCGT CCAGCTATGT GCACCTCATC GCACCTGCCG GGAGGCCTTG 
GATGTTCTGG CCAAGACAGT GGCCTTCCTC AGGAACCTGC CATCCTTCTG GCAGCTGCCT 
CCCCAGGACC AGCGGCGGCT GCTGCAGGGT TGCTGGGGCC CCCTCTTCCT GCTTGGGTTG 
GCCCAAGATG CTGTGACCTT TGAGGTGGCT GAGGCCCCGG TGCCCAGCAT ACTCAAGAAG 
ATTCTGCTGG AGGAGCCCAG CAGCAGTGGA GGCAGTGGCC AACTGCCAGA CAGACCCCAG 
CCCTCCCTGG CTGCGGTGCA GTGGCTTCAA TGCTGTCTGG AGTCCTTCTG GAGCCTGGAG 
CTTAGCCCCA AGGAATATGC CTGCCTGAAA GGGACCATCC TCTTCAACCC CGATAAAGAA 
ACTGAAGCCC AGAGATTAAG TGACTTGCCC AAGGTCACCC AGCTAATAAG TGACAGTGCT 
GGGATTCATA CCCAGGAAGC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011540599.1
CDS	171..794
Translation	MSTSQPGACPCQGAASRPAILYALLSSSLKAVPRPRSRCLCRQHRPVQLCAPHRTCREALDVLAKTVAFLRNLPSFWQLPPQDQRRLLQGCWGPLFLLGLAQDAVTFEVAEAPVPSILKKILLEEPSSSGGSGQLPDRPQPSLAAVQWLQCCLESFWSLELSPKEYACLKGTILFNPDKETEAQRLSDLPKVTQLISDSAGIHTQEA

Target ORF information:

RefSeq Version	XM_011542297.3
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear receptor subfamily 0 group B member 2 (NR0B2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011542297.3

ORF Insert Sequence:

ATGAGCACCA GCCAACCAGG GGCCTGCCCA TGCCAGGGAG CTGCAAGCCG CCCCGCCATT 
CTCTACGCAC TTCTGAGCTC CAGCCTCAAG GCTGTCCCCC GACCCCGTAG CCGCTGCCTA 
TGTAGGCAGC ACCGGCCCGT CCAGCTATGT GCACCTCATC GCACCTGCCG GGAGGCCTTG 
GATGTTCTGG CCAAGACAGT GGCCTTCCTC AGGAACCTGC CATCCTTCTG GCAGCTGCCT 
CCCCAGGACC AGCGGCGGCT GCTGCAGGGT TGCTGGGGCC CCCTCTTCCT GCTTGGGTTG 
GCCCAAGATG CTGTGACCTT TGAGGTGGCT GAGGCCCCGG TGCCCAGCAT ACTCAAGAAG 
ATTCTGCTGG AGGAGCCCAG CAGCAGTGGA GGCAGTGGCC AACTGCCAGA CAGACCCCAG 
CCCTCCCTGG CTGCGGTGCA GTGGCTTCAA TGCTGTCTGG AGTCCTTCTG GAGCCTGGAG 
CTTAGCCCCA AGGAATATGC CTGCCTGAAA GGGACCATCC TCTTCAACCC CGATAAAGAA 
ACTGAAGCCC AGAGATTAAG TGACTTGCCC AAGGTCACCC AGCTAATAAG TGACAGTGCT 
GGGATTCATA CCCAGGAAGC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Functional assessment of genetic variants located in the promoter of SHP1 (NR0B2).
Pharmacogenetics and genomics27(11)410-415(2017 Nov)
Prestin K,Olbert M,Hussner J,V?lzke H,Meyer Zu Schwabedissen HE

Circadian rhythmicity: A functional connection between differentiated embryonic chondrocyte-1 (DEC1) and small heterodimer partner (SHP).
Archives of biochemistry and biophysics63111-18(2017 Oct)
Marczak MM,Yan B

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NR0B2 cDNA ORF clone, Homo sapiens(human)

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ORF Insert Sequence:

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ORF Insert Sequence:

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Target ORF information:

ORF Insert Sequence:

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