CIAO2A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CIAO2A
Entrez Gene ID	84191
Full Name	family with sequence similarity 96 member A
Synonyms	CIA2A
General protein information	Preferred Names family with sequence similarity 96 member A Names MIP18 family protein FAM96A
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q22.31

mRNA and Protein(s)

mRNA	Protein	Name
NM_032231.5	NP_115607.1	MIP18 family protein FAM96A isoform a precursor
NM_001014812.2	NP_001014812.1	cytosolic iron-sulfur assembly component 2A isoform b precursor
NM_032231.6	NP_115607.1	cytosolic iron-sulfur assembly component 2A isoform a precursor
NM_001289108.1	NP_001276037.1	cytosolic iron-sulfur assembly component 2A isoform b precursor
NM_032231.7	NP_115607.1	cytosolic iron-sulfur assembly component 2A isoform a precursor

Pathways from BioSystems

Homologies

Arabidopsis thaliana (thale cress)	AT3G50845	NP_001078267.1
Oryza sativa (rice)	Os03g0775500	NP_001051431.1
Xenopus tropicalis (tropical clawed frog)	LOC100489623	XP_002932995.1
Bos taurus (cattle)	FAM96A	NP_001030282.1
Drosophila melanogaster (fruit fly)	CG30152	NP_611509.1
Canis lupus familiaris (dog)	FAM96A	XP_535508.1
Mus musculus (house mouse)	Fam96a	NP_080911.1
Pan troglodytes (chimpanzee)	FAM96A	XP_510469.2
	LOC712029	XP_001100907.2
Homo sapiens (human)	FAM96A	NP_115607.1
Rattus norvegicus (Norway rat)	Fam96a	NP_001008328.1
Danio rerio (zebrafish)	zgc:73185	NP_998192.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007363	XP_308468.3

Gene Ontology
Bibliography

Related articles in PubMed

A multi-target protein of hTERTR-FAM96A presents significant anticancer potent in the treatment of hepatocellular carcinoma.
Zhang MY, Wang JP
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(4)1010428317698341(2017 Apr)

FAM96A is a novel pro-apoptotic tumor suppressor in gastrointestinal stromal tumors.
Schwamb B, Pick R, Fern?ndez SB, V?lp K, Heering J, D?tsch V, B?sser S, Jung J, Beinoraviciute-Kellner R, Wesely J, Z?rnig I, Hammerschmidt M, Nowak M, Penzel R, Zatloukal K, Joos S, Rieker RJ, Agaimy A, S?der S, Reid-Lombardo KM, Kendrick ML, Bardsley MR, Hayashi Y, Asuzu DT, Syed SA, Ordog T, Z?rnig M
International journal of cancer137(6)1318-29(2015 Sep)

Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.
Stehling O, Mascarenhas J, Vashisht AA, Sheftel AD, Niggemeyer B, R?sser R, Pierik AJ, Wohlschlegel JA, Lill R
Cell metabolism18(2)187-98(2013 Aug)

The mammalian DUF59 protein Fam96a forms two distinct types of domain-swapped dimer.
Chen KE, Richards AA, Ariffin JK, Ross IL, Sweet MJ, Kellie S, Kobe B, Martin JL
Acta crystallographica. Section D, Biological crystallography68(Pt 6)637-48(2012 Jun)

The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts.
Ozyildirim AM, Wistow GJ, Gao J, Wang J, Dickinson DP, Frierson HF Jr, Laurie GW
Investigative ophthalmology & visual science46(5)1572-80(2005 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

our data suggest that hTERTR-FAM96A may serve as an efficient anti-tumor agent for the treatment of hepatocellular carcinoma.
Title: A multi-target protein of hTERTR-FAM96A presents significant anticancer potent in the treatment of hepatocellular carcinoma.

FAM96A expression was much reduced in tumorigenic ICC-SCs.
Title: FAM96A is a novel pro-apoptotic tumor suppressor in gastrointestinal stromal tumors.

CIA2B-CIA1-MMS19 and CIA2A-CIA1 assist different branches of Fe/S protein assembly and intimately link this process to cellular iron regulation via IRP1 Fe/S cluster maturation and IRP2 stabilization.
Title: Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.

putative metal-binding site of bacterial DUF59 proteins is not conserved in Fam96a, but Fam96a interacts tightly in vitro with Ciao1, the cytosolic iron-assembly protein
Title: The mammalian DUF59 protein Fam96a forms two distinct types of domain-swapped dimer.

The following CIAO2A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CIAO2A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15274	NM_032231.7 Latest version!	Homo sapiens cytosolic iron-sulfur assembly component 2A (CIAO2A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu14926	NM_001014812.2 Latest version!	Homo sapiens cytosolic iron-sulfur assembly component 2A (CIAO2A), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu14926	NM_001289108.1 Latest version!	Homo sapiens cytosolic iron-sulfur assembly component 2A (CIAO2A), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu15274	NM_032231.5	Homo sapiens family with sequence similarity 96 member A (FAM96A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu15274	NM_032231.6	Homo sapiens cytosolic iron-sulfur assembly component 2A (CIAO2A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CIAO2A ( NM_032231.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_115607.1 Homo sapiens family with sequence similarity 96 member A (FAM96A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu15274
Clone ID Related Accession (Same CDS sequence)	NM_032231.5 , NM_032231.6 , NM_032231.7
Accession Version	NM_032231.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 483bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	MIP18 family protein FAM96A isoform a precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM706342.1, CN421575.1, BC008865.2 and AA809560.1. On Jan 15, 2014 this sequence version replaced NM_032231.4. Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (a). ##Evidence-Data-START## Transcript exon combination :: SRR1163655.18135.1, SRR1163658.257660.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267769 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGCGGG TGTCCGGGCT GCTCTCCTGG ACGCTGAGCA GAGTCCTGTG GCTCTCCGGC 
CTCTCTGAGC CGGGAGCTGC CCGGCAGCCC CGGATCATGG AAGAGAAAGC GCTAGAAGTT 
TATGATTTGA TTAGAACTAT CCGGGACCCA GAAAAGCCCA ATACTTTAGA AGAACTGGAA 
GTGGTCTCGG AAAGTTGTGT GGAAGTTCAG GAGATAAATG AAGAAGAATA TCTGGTTATT 
ATCAGGTTCA CGCCAACAGT ACCTCATTGC TCTTTGGCGA CTCTTATTGG GCTGTGCTTA 
AGAGTAAAAC TTCAGCGATG TTTACCATTT AAACATAAGT TGGAAATCTA CATTTCTGAA 
GGAACCCACT CAACAGAAGA AGACATCAAT AAGCAGATAA ATGACAAAGA GCGAGTGGCA 
GCTGCAATGG AAAACCCCAA CTTACGGGAA ATTGTGGAAC AGTGTGTCCT TGAACCTGAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115607.1
CDS	241..723
Translation	MQRVSGLLSWTLSRVLWLSGLSEPGAARQPRIMEEKALEVYDLIRTIRDPEKPNTLEELEVVSESCVEVQEINEEEYLVIIRFTPTVPHCSLATLIGLCLRVKLQRCLPFKHKLEIYISEGTHSTEEDINKQINDKERVAAAMENPNLREIVEQCVLEPD

Target ORF information:

RefSeq Version	NM_032231.5
Organism	Homo sapiens(human)
Definition	Homo sapiens family with sequence similarity 96 member A (FAM96A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032231.5

ORF Insert Sequence:

ATGCAGCGGG TGTCCGGGCT GCTCTCCTGG ACGCTGAGCA GAGTCCTGTG GCTCTCCGGC 
CTCTCTGAGC CGGGAGCTGC CCGGCAGCCC CGGATCATGG AAGAGAAAGC GCTAGAAGTT 
TATGATTTGA TTAGAACTAT CCGGGACCCA GAAAAGCCCA ATACTTTAGA AGAACTGGAA 
GTGGTCTCGG AAAGTTGTGT GGAAGTTCAG GAGATAAATG AAGAAGAATA TCTGGTTATT 
ATCAGGTTCA CGCCAACAGT ACCTCATTGC TCTTTGGCGA CTCTTATTGG GCTGTGCTTA 
AGAGTAAAAC TTCAGCGATG TTTACCATTT AAACATAAGT TGGAAATCTA CATTTCTGAA 
GGAACCCACT CAACAGAAGA AGACATCAAT AAGCAGATAA ATGACAAAGA GCGAGTGGCA 
GCTGCAATGG AAAACCCCAA CTTACGGGAA ATTGTGGAAC AGTGTGTCCT TGAACCTGAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CIAO2A ( NM_032231.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_115607.1 Homo sapiens cytosolic iron-sulfur assembly component 2A (CIAO2A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu15274
Clone ID Related Accession (Same CDS sequence)	NM_032231.5 , NM_032231.6 , NM_032231.7
Accession Version	NM_032231.6	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 483bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	cytosolic iron-sulfur assembly component 2A isoform a precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CN421575.1 and BC008865.2. On Nov 22, 2018 this sequence version replaced NM_032231.5. Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (a). ##Evidence-Data-START## Transcript exon combination :: SRR1163657.272443.1, SRR1163657.9104.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267769 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGCGGG TGTCCGGGCT GCTCTCCTGG ACGCTGAGCA GAGTCCTGTG GCTCTCCGGC 
CTCTCTGAGC CGGGAGCTGC CCGGCAGCCC CGGATCATGG AAGAGAAAGC GCTAGAAGTT 
TATGATTTGA TTAGAACTAT CCGGGACCCA GAAAAGCCCA ATACTTTAGA AGAACTGGAA 
GTGGTCTCGG AAAGTTGTGT GGAAGTTCAG GAGATAAATG AAGAAGAATA TCTGGTTATT 
ATCAGGTTCA CGCCAACAGT ACCTCATTGC TCTTTGGCGA CTCTTATTGG GCTGTGCTTA 
AGAGTAAAAC TTCAGCGATG TTTACCATTT AAACATAAGT TGGAAATCTA CATTTCTGAA 
GGAACCCACT CAACAGAAGA AGACATCAAT AAGCAGATAA ATGACAAAGA GCGAGTGGCA 
GCTGCAATGG AAAACCCCAA CTTACGGGAA ATTGTGGAAC AGTGTGTCCT TGAACCTGAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115607.1
CDS	71..553
Translation	MQRVSGLLSWTLSRVLWLSGLSEPGAARQPRIMEEKALEVYDLIRTIRDPEKPNTLEELEVVSESCVEVQEINEEEYLVIIRFTPTVPHCSLATLIGLCLRVKLQRCLPFKHKLEIYISEGTHSTEEDINKQINDKERVAAAMENPNLREIVEQCVLEPD

Target ORF information:

RefSeq Version	NM_032231.6
Organism	Homo sapiens(human)
Definition	Homo sapiens cytosolic iron-sulfur assembly component 2A (CIAO2A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032231.6

ORF Insert Sequence:

ATGCAGCGGG TGTCCGGGCT GCTCTCCTGG ACGCTGAGCA GAGTCCTGTG GCTCTCCGGC 
CTCTCTGAGC CGGGAGCTGC CCGGCAGCCC CGGATCATGG AAGAGAAAGC GCTAGAAGTT 
TATGATTTGA TTAGAACTAT CCGGGACCCA GAAAAGCCCA ATACTTTAGA AGAACTGGAA 
GTGGTCTCGG AAAGTTGTGT GGAAGTTCAG GAGATAAATG AAGAAGAATA TCTGGTTATT 
ATCAGGTTCA CGCCAACAGT ACCTCATTGC TCTTTGGCGA CTCTTATTGG GCTGTGCTTA 
AGAGTAAAAC TTCAGCGATG TTTACCATTT AAACATAAGT TGGAAATCTA CATTTCTGAA 
GGAACCCACT CAACAGAAGA AGACATCAAT AAGCAGATAA ATGACAAAGA GCGAGTGGCA 
GCTGCAATGG AAAACCCCAA CTTACGGGAA ATTGTGGAAC AGTGTGTCCT TGAACCTGAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CIAO2A ( NM_032231.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_115607.1 Homo sapiens cytosolic iron-sulfur assembly component 2A (CIAO2A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu15274
Clone ID Related Accession (Same CDS sequence)	NM_032231.5 , NM_032231.6 , NM_032231.7
Accession Version	NM_032231.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 483bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-14
Organism	Homo sapiens(human)
Product	cytosolic iron-sulfur assembly component 2A isoform a precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC021541.7. On Aug 31, 2019 this sequence version replaced NM_032231.6. Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (a). ##Evidence-Data-START## Transcript exon combination :: BM806638.1, BQ014706.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000300030.8/ ENSP00000300030.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGCGGG TGTCCGGGCT GCTCTCCTGG ACGCTGAGCA GAGTCCTGTG GCTCTCCGGC 
CTCTCTGAGC CGGGAGCTGC CCGGCAGCCC CGGATCATGG AAGAGAAAGC GCTAGAAGTT 
TATGATTTGA TTAGAACTAT CCGGGACCCA GAAAAGCCCA ATACTTTAGA AGAACTGGAA 
GTGGTCTCGG AAAGTTGTGT GGAAGTTCAG GAGATAAATG AAGAAGAATA TCTGGTTATT 
ATCAGGTTCA CGCCAACAGT ACCTCATTGC TCTTTGGCGA CTCTTATTGG GCTGTGCTTA 
AGAGTAAAAC TTCAGCGATG TTTACCATTT AAACATAAGT TGGAAATCTA CATTTCTGAA 
GGAACCCACT CAACAGAAGA AGACATCAAT AAGCAGATAA ATGACAAAGA GCGAGTGGCA 
GCTGCAATGG AAAACCCCAA CTTACGGGAA ATTGTGGAAC AGTGTGTCCT TGAACCTGAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115607.1
CDS	71..553
Translation	MQRVSGLLSWTLSRVLWLSGLSEPGAARQPRIMEEKALEVYDLIRTIRDPEKPNTLEELEVVSESCVEVQEINEEEYLVIIRFTPTVPHCSLATLIGLCLRVKLQRCLPFKHKLEIYISEGTHSTEEDINKQINDKERVAAAMENPNLREIVEQCVLEPD

Target ORF information:

RefSeq Version	NM_032231.7
Organism	Homo sapiens(human)
Definition	Homo sapiens cytosolic iron-sulfur assembly component 2A (CIAO2A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032231.7

ORF Insert Sequence:

ATGCAGCGGG TGTCCGGGCT GCTCTCCTGG ACGCTGAGCA GAGTCCTGTG GCTCTCCGGC 
CTCTCTGAGC CGGGAGCTGC CCGGCAGCCC CGGATCATGG AAGAGAAAGC GCTAGAAGTT 
TATGATTTGA TTAGAACTAT CCGGGACCCA GAAAAGCCCA ATACTTTAGA AGAACTGGAA 
GTGGTCTCGG AAAGTTGTGT GGAAGTTCAG GAGATAAATG AAGAAGAATA TCTGGTTATT 
ATCAGGTTCA CGCCAACAGT ACCTCATTGC TCTTTGGCGA CTCTTATTGG GCTGTGCTTA 
AGAGTAAAAC TTCAGCGATG TTTACCATTT AAACATAAGT TGGAAATCTA CATTTCTGAA 
GGAACCCACT CAACAGAAGA AGACATCAAT AAGCAGATAA ATGACAAAGA GCGAGTGGCA 
GCTGCAATGG AAAACCCCAA CTTACGGGAA ATTGTGGAAC AGTGTGTCCT TGAACCTGAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CIAO2A ( NM_001014812.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001014812.1 Homo sapiens cytosolic iron-sulfur assembly component 2A (CIAO2A), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu14926
Clone ID Related Accession (Same CDS sequence)	NM_001014812.2 , NM_001289108.1
Accession Version	NM_001014812.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-08
Organism	Homo sapiens(human)
Product	cytosolic iron-sulfur assembly component 2A isoform b precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM706342.1, CN421575.1, BQ269528.1, BC008865.2 and AA809560.1. On Jan 15, 2014 this sequence version replaced NM_001014812.1. Transcript Variant: This variant (2) lacks an internal coding exon that causes a frame-shift compared to variant 1. The resulting shorter isoform (b) has a distinct C-terminus compared to isoform a. Variants 2 and 3 encode the same isoform. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.125161.1, SRR1163655.589317.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267769 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGCGGG TGTCCGGGCT GCTCTCCTGG ACGCTGAGCA GAGTCCTGTG GCTCTCCGGC 
CTCTCTGAGC CGGGAGCTGC CCGGCAGCCC CGGATCATGG AAGAGAAAGC GCTAGAAGTT 
TATGATTTGA TTAGAACTAT CCGGGACCCA GAAAAGCCCA ATACTTTAGA AGAACTGGAA 
GTGGTCTCGG AAAGTTGTGT GGAAGTTCAG GAGATAAATG AAGAAGAATA TCTGGTTATT 
ATCAGGTTCA CGCCAACAGT ACCTCATTGC TCTTTGGCGA CTCTTATTGT TGGAAATCTA 
CATTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001014812.1
CDS	241..549
Translation	MQRVSGLLSWTLSRVLWLSGLSEPGAARQPRIMEEKALEVYDLIRTIRDPEKPNTLEELEVVSESCVEVQEINEEEYLVIIRFTPTVPHCSLATLIVGNLHF

Target ORF information:

RefSeq Version	NM_001014812.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cytosolic iron-sulfur assembly component 2A (CIAO2A), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001014812.2

ORF Insert Sequence:

ATGCAGCGGG TGTCCGGGCT GCTCTCCTGG ACGCTGAGCA GAGTCCTGTG GCTCTCCGGC 
CTCTCTGAGC CGGGAGCTGC CCGGCAGCCC CGGATCATGG AAGAGAAAGC GCTAGAAGTT 
TATGATTTGA TTAGAACTAT CCGGGACCCA GAAAAGCCCA ATACTTTAGA AGAACTGGAA 
GTGGTCTCGG AAAGTTGTGT GGAAGTTCAG GAGATAAATG AAGAAGAATA TCTGGTTATT 
ATCAGGTTCA CGCCAACAGT ACCTCATTGC TCTTTGGCGA CTCTTATTGT TGGAAATCTA 
CATTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CIAO2A ( NM_001289108.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001276037.1 Homo sapiens cytosolic iron-sulfur assembly component 2A (CIAO2A), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu14926
Clone ID Related Accession (Same CDS sequence)	NM_001014812.2 , NM_001289108.1
Accession Version	NM_001289108.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-08
Organism	Homo sapiens(human)
Product	cytosolic iron-sulfur assembly component 2A isoform b precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM706342.1, CN421575.1, AK304202.1, AC021541.7, CD722050.1, BC008865.2 and AA809560.1. Transcript Variant: This variant (3) lacks an internal coding exon that causes a frame-shift and differs at the 3' end compared to variant 1. The resulting shorter isoform (b) has a distinct C-terminus compared to isoform a. Variants 2 and 3 encode the same isoform. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.52813.1, SRR1803615.198006.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267769 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGCGGG TGTCCGGGCT GCTCTCCTGG ACGCTGAGCA GAGTCCTGTG GCTCTCCGGC 
CTCTCTGAGC CGGGAGCTGC CCGGCAGCCC CGGATCATGG AAGAGAAAGC GCTAGAAGTT 
TATGATTTGA TTAGAACTAT CCGGGACCCA GAAAAGCCCA ATACTTTAGA AGAACTGGAA 
GTGGTCTCGG AAAGTTGTGT GGAAGTTCAG GAGATAAATG AAGAAGAATA TCTGGTTATT 
ATCAGGTTCA CGCCAACAGT ACCTCATTGC TCTTTGGCGA CTCTTATTGT TGGAAATCTA 
CATTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001276037.1
CDS	241..549
Translation	MQRVSGLLSWTLSRVLWLSGLSEPGAARQPRIMEEKALEVYDLIRTIRDPEKPNTLEELEVVSESCVEVQEINEEEYLVIIRFTPTVPHCSLATLIVGNLHF

Target ORF information:

RefSeq Version	NM_001289108.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cytosolic iron-sulfur assembly component 2A (CIAO2A), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001289108.1

ORF Insert Sequence:

ATGCAGCGGG TGTCCGGGCT GCTCTCCTGG ACGCTGAGCA GAGTCCTGTG GCTCTCCGGC 
CTCTCTGAGC CGGGAGCTGC CCGGCAGCCC CGGATCATGG AAGAGAAAGC GCTAGAAGTT 
TATGATTTGA TTAGAACTAT CCGGGACCCA GAAAAGCCCA ATACTTTAGA AGAACTGGAA 
GTGGTCTCGG AAAGTTGTGT GGAAGTTCAG GAGATAAATG AAGAAGAATA TCTGGTTATT 
ATCAGGTTCA CGCCAACAGT ACCTCATTGC TCTTTGGCGA CTCTTATTGT TGGAAATCTA 
CATTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A multi-target protein of hTERTR-FAM96A presents significant anticancer potent in the treatment of hepatocellular carcinoma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(4)1010428317698341(2017 Apr)
Zhang MY,Wang JP

FAM96A is a novel pro-apoptotic tumor suppressor in gastrointestinal stromal tumors.
International journal of cancer137(6)1318-29(2015 Sep)
Schwamb B,Pick R,Fern?ndez SB,V?lp K,Heering J,D?tsch V,B?sser S,Jung J,Beinoraviciute-Kellner R,Wesely J,Z?rnig I,Hammerschmidt M,Nowak M,Penzel R,Zatloukal K,Joos S,Rieker RJ,Agaimy A,S?der S,Reid-Lombardo KM,Kendrick ML,Bardsley MR,Hayashi Y,Asuzu DT,Syed SA,Ordog T,Z?rnig M

Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.
Cell metabolism18(2)187-98(2013 Aug)
Stehling O,Mascarenhas J,Vashisht AA,Sheftel AD,Niggemeyer B,R?sser R,Pierik AJ,Wohlschlegel JA,Lill R

The mammalian DUF59 protein Fam96a forms two distinct types of domain-swapped dimer.
Acta crystallographica. Section D, Biological crystallography68(Pt 6)637-48(2012 Jun)
Chen KE,Richards AA,Ariffin JK,Ross IL,Sweet MJ,Kellie S,Kobe B,Martin JL

The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts.
Investigative ophthalmology & visual science46(5)1572-80(2005 May)
Ozyildirim AM,Wistow GJ,Gao J,Wang J,Dickinson DP,Frierson HF Jr,Laurie GW

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CIAO2A cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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