RNASEH2C cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RNASEH2C
Entrez Gene ID	84153
Full Name	ribonuclease H2 subunit C
Synonyms	AGS3,AYP1
General protein information	Preferred Names ribonuclease H2 subunit C Names ribonuclease H2 subunit C RNase H1 small subunit RNase H2 subunit C aicardi-Goutieres syndrome 3 protein ribonuclease HI subunit C
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q13.1
Summary	This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	610330
Disorder Html:	Aicardi-Goutieres syndrome 3, 610329 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_032193.3	NP_115569.2	ribonuclease H2 subunit C
NM_032193.4	NP_115569.2	ribonuclease H2 subunit C

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	RNASEH2C	XP_852826.1
Rattus norvegicus (Norway rat)	Rnaseh2c	XP_002728902.1
Pan troglodytes (chimpanzee)	RNASEH2C	XP_508559.3
	LOC701279	XP_001089023.1
	RNASEH2C	XP_001085695.1
Mus musculus (house mouse)	Rnaseh2c	NP_080892.1
Homo sapiens (human)	RNASEH2C	NP_115569.2
Bos taurus (cattle)	RNASEH2C	NP_001039386.1

Gene Ontology
Bibliography

Related articles in PubMed

Neurologic Phenotypes Associated with Mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR1, and IFIH1: Aicardi-Gouti?res Syndrome and Beyond.
Livingston JH, Crow YJ
Neuropediatrics47(6)355-360(2016 Dec)

Altered spatio-temporal dynamics of RNase H2 complex assembly at replication and repair sites in Aicardi-Gouti?res syndrome.
Kind B, Muster B, Staroske W, Herce HD, Sachse R, Rapp A, Schmidt F, Koss S, Cardoso MC, Lee-Kirsch MA
Human molecular genetics23(22)5950-60(2014 Nov)

The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi-Gouti?res syndrome defects.
Figiel M, Chon H, Cerritelli SM, Cybulska M, Crouch RJ, Nowotny M
The Journal of biological chemistry286(12)10540-50(2011 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study reviewed that Neurologic Phenotypes Associated with Mutations in RNASEH2C in patients with Aicardi-Goutieres Syndrome.
Title: Neurologic Phenotypes Associated with Mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR1, and IFIH1: Aicardi-Gouti?res Syndrome and Beyond.

RNase H2 complex is assembled in the cytosol and imported into the nucleus in an RNase H2B-dependent manner.
Title: Altered spatio-temporal dynamics of RNase H2 complex assembly at replication and repair sites in Aicardi-Gouti?res syndrome.

Examination of the effect of several Aicardi-Goutieres Syndrome-related mutations in the C subunit of RNase H2.
Title: Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex.

Describes an RNASEH2C pseudogene that is located close to the SRY gene on chromosome Y.
Title: Evidence that the SRY protein is encoded by a single exon on the human Y chromosome.

The following RNASEH2C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RNASEH2C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20612	NM_032193.4 Latest version!	Homo sapiens ribonuclease H2 subunit C (RNASEH2C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu20612	NM_032193.3	Homo sapiens ribonuclease H2 subunit C (RNASEH2C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RNASEH2C ( NM_032193.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_115569.2 Homo sapiens ribonuclease H2 subunit C (RNASEH2C), mRNA.

Price & Availability↑

CloneID	OHu20612
Clone ID Related Accession (Same CDS sequence)	NM_032193.3 , NM_032193.4
Accession Version	NM_032193.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 495bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	ribonuclease H2 subunit C
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF346606.1, BC023588.2, AP001266.4 and BC000831.1. This sequence is a reference standard in the RefSeqGene project. On Aug 25, 2006 this sequence version replaced NM_032193.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF346606.1, SRR1803613.237853.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGAGCG GCGACGAAGC GGCCATCGAG AGGCACCGCG TCCACTTGCG CTCCGCCACA 
TTGCGCGACG CCGTACCCGC CACACTGCAT CTGCTGCCCT GCGAGGTTGC GGTGGACGGG 
CCCGCCCCGG TGGGGCGCTT CTTCACGCCC GCCATCCGCC AGGGCCCCGA GGGACTCGAA 
GTGTCGTTTC GGGGCCGCTG TCTACGGGGA GAGGAGGTGG CGGTGCCGCC TGGCCTCGTG 
GGATACGTGA TGGTGACAGA AGAGAAGAAG GTGTCGATGG GGAAGCCAGA CCCCTTGCGG 
GATTCCGGGA CTGACGACCA AGAGGAGGAG CCGCTGGAGC GGGACTTCGA CCGCTTCATT 
GGAGCCACTG CCAACTTCAG CCGCTTCACC CTGTGGGGTC TGGAGACCAT CCCTGGCCCG 
GATGCCAAAG TGCGTGGGGC CTTAACTTGG CCCAGCCTTG CGGCAGCGAT TCACGCACAG 
GTGCCCGAGG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115569.2
CDS	181..675
Translation	MESGDEAAIERHRVHLRSATLRDAVPATLHLLPCEVAVDGPAPVGRFFTPAIRQGPEGLEVSFRGRCLRGEEVAVPPGLVGYVMVTEEKKVSMGKPDPLRDSGTDDQEEEPLERDFDRFIGATANFSRFTLWGLETIPGPDAKVRGALTWPSLAAAIHAQVPED

Target ORF information:

RefSeq Version	NM_032193.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ribonuclease H2 subunit C (RNASEH2C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032193.3

ORF Insert Sequence:

ATGGAGAGCG GCGACGAAGC GGCCATCGAG AGGCACCGCG TCCACTTGCG CTCCGCCACA 
TTGCGCGACG CCGTACCCGC CACACTGCAT CTGCTGCCCT GCGAGGTTGC GGTGGACGGG 
CCCGCCCCGG TGGGGCGCTT CTTCACGCCC GCCATCCGCC AGGGCCCCGA GGGACTCGAA 
GTGTCGTTTC GGGGCCGCTG TCTACGGGGA GAGGAGGTGG CGGTGCCGCC TGGCCTCGTG 
GGATACGTGA TGGTGACAGA AGAGAAGAAG GTGTCGATGG GGAAGCCAGA CCCCTTGCGG 
GATTCCGGGA CTGACGACCA AGAGGAGGAG CCGCTGGAGC GGGACTTCGA CCGCTTCATT 
GGAGCCACTG CCAACTTCAG CCGCTTCACC CTGTGGGGTC TGGAGACCAT CCCTGGCCCG 
GATGCCAAAG TGCGTGGGGC CTTAACTTGG CCCAGCCTTG CGGCAGCGAT TCACGCACAG 
GTGCCCGAGG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RNASEH2C ( NM_032193.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_115569.2 Homo sapiens ribonuclease H2 subunit C (RNASEH2C), mRNA.

Price & Availability↑

CloneID	OHu20612
Clone ID Related Accession (Same CDS sequence)	NM_032193.3 , NM_032193.4
Accession Version	NM_032193.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 495bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Homo sapiens(human)
Product	ribonuclease H2 subunit C
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC023588.2, AP001266.4 and BC000831.1. On Aug 31, 2019 this sequence version replaced NM_032193.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.73915.1, SRR3476690.1048405.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGAGCG GCGACGAAGC GGCCATCGAG AGGCACCGCG TCCACTTGCG CTCCGCCACA 
TTGCGCGACG CCGTACCCGC CACACTGCAT CTGCTGCCCT GCGAGGTTGC GGTGGACGGG 
CCCGCCCCGG TGGGGCGCTT CTTCACGCCC GCCATCCGCC AGGGCCCCGA GGGACTCGAA 
GTGTCGTTTC GGGGCCGCTG TCTACGGGGA GAGGAGGTGG CGGTGCCGCC TGGCCTCGTG 
GGATACGTGA TGGTGACAGA AGAGAAGAAG GTGTCGATGG GGAAGCCAGA CCCCTTGCGG 
GATTCCGGGA CTGACGACCA AGAGGAGGAG CCGCTGGAGC GGGACTTCGA CCGCTTCATT 
GGAGCCACTG CCAACTTCAG CCGCTTCACC CTGTGGGGTC TGGAGACCAT CCCTGGCCCG 
GATGCCAAAG TGCGTGGGGC CTTAACTTGG CCCAGCCTTG CGGCAGCGAT TCACGCACAG 
GTGCCCGAGG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115569.2
CDS	41..535
Translation	MESGDEAAIERHRVHLRSATLRDAVPATLHLLPCEVAVDGPAPVGRFFTPAIRQGPEGLEVSFRGRCLRGEEVAVPPGLVGYVMVTEEKKVSMGKPDPLRDSGTDDQEEEPLERDFDRFIGATANFSRFTLWGLETIPGPDAKVRGALTWPSLAAAIHAQVPED

Target ORF information:

RefSeq Version	NM_032193.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ribonuclease H2 subunit C (RNASEH2C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032193.4

ORF Insert Sequence:

ATGGAGAGCG GCGACGAAGC GGCCATCGAG AGGCACCGCG TCCACTTGCG CTCCGCCACA 
TTGCGCGACG CCGTACCCGC CACACTGCAT CTGCTGCCCT GCGAGGTTGC GGTGGACGGG 
CCCGCCCCGG TGGGGCGCTT CTTCACGCCC GCCATCCGCC AGGGCCCCGA GGGACTCGAA 
GTGTCGTTTC GGGGCCGCTG TCTACGGGGA GAGGAGGTGG CGGTGCCGCC TGGCCTCGTG 
GGATACGTGA TGGTGACAGA AGAGAAGAAG GTGTCGATGG GGAAGCCAGA CCCCTTGCGG 
GATTCCGGGA CTGACGACCA AGAGGAGGAG CCGCTGGAGC GGGACTTCGA CCGCTTCATT 
GGAGCCACTG CCAACTTCAG CCGCTTCACC CTGTGGGGTC TGGAGACCAT CCCTGGCCCG 
GATGCCAAAG TGCGTGGGGC CTTAACTTGG CCCAGCCTTG CGGCAGCGAT TCACGCACAG 
GTGCCCGAGG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Neurologic Phenotypes Associated with Mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR1, and IFIH1: Aicardi-Gouti?res Syndrome and Beyond.
Neuropediatrics47(6)355-360(2016 Dec)
Livingston JH,Crow YJ

Altered spatio-temporal dynamics of RNase H2 complex assembly at replication and repair sites in Aicardi-Gouti?res syndrome.
Human molecular genetics23(22)5950-60(2014 Nov)
Kind B,Muster B,Staroske W,Herce HD,Sachse R,Rapp A,Schmidt F,Koss S,Cardoso MC,Lee-Kirsch MA

The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi-Gouti?res syndrome defects.
The Journal of biological chemistry286(12)10540-50(2011 Mar)
Figiel M,Chon H,Cerritelli SM,Cybulska M,Crouch RJ,Nowotny M

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RNASEH2C cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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