ABRAXAS1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ABRAXAS1
Entrez Gene ID	84142
Full Name	abraxas 1, BRCA1 A complex subunit
Synonyms	ABRA1,CCDC98,FAM175A
General protein information	Preferred Names abraxas 1, BRCA1 A complex subunit Names BRCA1-A complex subunit Abraxas 1 BRCA1-A complex subunit Abraxas abraxas protein coiled-coil domain containing 98 family with sequence similarity 175 member A
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q21.23
Summary	This gene encodes a protein that binds to the C-terminal repeats of breast cancer 1 (BRCA1) through a phospho-SXXF motif. The encoded protein recruits ubiquitin interaction motif containing 1 protein to BRCA1 protein and is required for DNA damage resistance, DNA repair, and cell cycle checkpoint control. Pseudogenes of this gene are found on chromosomes 3 and 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].
Disorder MIM:	611143

mRNA and Protein(s)

mRNA	Protein	Name
NM_139076.2	NP_620775.2	BRCA1-A complex subunit Abraxas 1 isoform 1
XM_005263280.4	XP_005263337.1	BRCA1-A complex subunit Abraxas isoform X1
NM_001345962.1	NP_001332891.1	BRCA1-A complex subunit Abraxas 1 isoform 2
NM_001345962.2	NP_001332891.1	BRCA1-A complex subunit Abraxas 1 isoform 2
NM_139076.3	NP_620775.2	BRCA1-A complex subunit Abraxas 1 isoform 1
XM_005263280.5	XP_005263337.1	BRCA1-A complex subunit Abraxas 1 isoform X1

Pathways from BioSystems

Homologies

	LOC720625	XP_001116239.1
Mus musculus (house mouse)	Fam175a	NP_765993.1
Xenopus tropicalis (tropical clawed frog)	fam175a	NP_001037959.1
Pan troglodytes (chimpanzee)	CCDC98	XP_001135565.1
Canis lupus familiaris (dog)	FAM175A	XP_535636.3
Danio rerio (zebrafish)	fam175a	NP_001005993.1
Bos taurus (cattle)	FAM175A	NP_001015516.1
Rattus norvegicus (Norway rat)	Fam175a	NP_001009633.1
Homo sapiens (human)	FAM175A	NP_620775.2
Gallus gallus (chicken)	FAM175A	NP_001026315.2

Gene Ontology
Bibliography

Related articles in PubMed

Three-Dimensional Architecture of the Human BRCA1-A Histone Deubiquitinase Core Complex.
Kyrieleis OJP, McIntosh PB, Webb SR, Calder LJ, Lloyd J, Patel NA, Martin SR, Robinson CV, Rosenthal PB, Smerdon SJ
Cell reports17(12)3099-3106(2016 12)

Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites.
Wu Q, Paul A, Su D, Mehmood S, Foo TK, Ochi T, Bunting EL, Xia B, Robinson CV, Wang B, Blundell TL
Molecular cell61(3)434-448(2016 Feb)

ABRAXAS (FAM175A) and Breast Cancer Susceptibility: No Evidence of Association in the Breast Cancer Family Registry.
Renault AL, Lesueur F, Coulombe Y, Gobeil S, Soucy P, Hamdi Y, Desjardins S, Le Calvez-Kelm F, Vall?e M, Voegele C, , Hopper JL, Andrulis IL, Southey MC, John EM, Masson JY, Tavtigian SV, Simard J
PloS one11(6)e0156820(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our data also suggest how ataxia telangiectasia mutated (ATM)-dependent BRCA1 dimerization may stabilize self-association of the entire BRCA1-A complex.
Title: Three-Dimensional Architecture of the Human BRCA1-A Histone Deubiquitinase Core Complex.

Demonstrate a mechanism involving IR-induced phosphorylation and dimerization of the BRCT/Abraxas complex for regulating Abraxas-mediated recruitment of BRCA1 in response to IR.
Title: Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites.

Results identified 16 novel rare variants in FAM175A but no significant difference in allele frequencies between cases and controls was observed which suggest no evidence that rare variants in ABRAXAS are associated with increased breast cancer risk in the population studied.
Title: ABRAXAS (FAM175A) and Breast Cancer Susceptibility: No Evidence of Association in the Breast Cancer Family Registry.

The recurrent Abraxas c.1082G>A mutation connects to breast cancer predisposition.
Title: Breast cancer-associated Abraxas mutation disrupts nuclear localization and DNA damage response functions.

low expression correlates with better response to chemotherapy and longer survival in patients with advanced non small-cell lung cancer
Title: Tubulin, BRCA1, ERCC1, Abraxas, RAP80 mRNA expression, p53/p21 immunohistochemistry and clinical outcome in patients with advanced non small-cell lung cancer receiving first-line platinum-gemcitabine chemotherapy.

The following ABRAXAS1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ABRAXAS1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06266	NM_139076.3 Latest version!	Homo sapiens abraxas 1, BRCA1 A complex subunit (ABRAXAS1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu39131	XM_005263280.5 Latest version!	Homo sapiens abraxas 1, BRCA1 A complex subunit (ABRAXAS1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OHu102475	NM_001345962.2 Latest version!	Homo sapiens abraxas 1, BRCA1 A complex subunit (ABRAXAS1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu102475	NM_001345962.1	Homo sapiens abraxas 1, BRCA1 A complex subunit (ABRAXAS1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu06266	NM_139076.2	Homo sapiens abraxas 1, BRCA1 A complex subunit (ABRAXAS1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu39131	XM_005263280.4	Homo sapiens family with sequence similarity 175 member A (FAM175A), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ABRAXAS1 ( NM_139076.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_620775.2 Homo sapiens abraxas 1, BRCA1 A complex subunit (ABRAXAS1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu06266
Clone ID Related Accession (Same CDS sequence)	NM_139076.2 , NM_139076.3
Accession Version	NM_139076.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1230bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	BRCA1-A complex subunit Abraxas 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA765424.1, AY358576.1, BC039573.1 and BQ775930.1. This sequence is a reference standard in the RefSeqGene project. On Jun 15, 2006 this sequence version replaced NM_139076.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.263088.1, SRR1660805.257266.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGGGG AGAGTACGTC GGCGGTGCTC TCGGGCTTTG TGCTCGGCGC ACTCGCTTTC 
CAGCACCTCA ACACGGACTC GGACACGGAA GGTTTTCTTC TTGGGGAAGT AAAAGGTGAA 
GCCAAGAACA GCATTACTGA TTCCCAAATG GATGATGTTG AAGTTGTTTA TACAATTGAC 
ATTCAGAAAT ATATTCCATG CTATCAGCTT TTTAGCTTTT ATAATTCTTC AGGCGAAGTA 
AATGAGCAAG CACTGAAGAA AATATTATCA AATGTCAAAA AGAATGTGGT AGGTTGGTAC 
AAATTCCGTC GTCATTCAGA TCAGATCATG ACGTTTAGAG AGAGGCTGCT TCACAAAAAC 
TTGCAGGAGC ATTTTTCAAA CCAAGACCTT GTTTTTCTGC TATTAACACC AAGTATAATA 
ACAGAAAGCT GCTCTACTCA TCGACTGGAA CATTCCTTAT ATAAACCTCA AAAAGGACTT 
TTTCACAGGG TACCTTTAGT GGTTGCCAAT CTGGGCATGT CTGAACAACT GGGTTATAAA 
ACTGTATCAG GTTCCTGTAT GTCCACTGGT TTTAGCCGAG CAGTACAAAC ACACAGCTCT 
AAATTTTTTG AAGAAGATGG ATCCTTAAAG GAGGTACATA AGATAAATGA AATGTATGCT 
TCATTACAAG AGGAATTAAA GAGTATATGC AAAAAAGTGG AAGACAGTGA ACAAGCAGTA 
GATAAACTAG TAAAGGATGT AAACAGATTA AAACGAGAAA TTGAGAAAAG GAGAGGAGCA 
CAGATTCAGG CAGCAAGAGA GAAGAACATC CAAAAAGACC CTCAGGAGAA CATTTTTCTT 
TGTCAGGCAT TACGGACCTT TTTTCCAAAT TCTGAATTTC TTCATTCATG TGTTATGTCT 
TTAAAAAATA GACATGTTTC TAAAAGTAGC TGTAACTACA ACCACCATCT CGATGTAGTA 
GACAATCTGA CCTTAATGGT AGAACACACT GACATTCCTG AAGCTAGTCC AGCTAGTACA 
CCACAAATCA TTAAGCATAA AGCCTTAGAC TTAGATGACA GATGGCAATT CAAGAGATCT 
CGGTTGTTAG ATACACAAGA CAAACGATCT AAAGCAGATA CTGGTAGTAG TAACCAAGAT 
AAAGCATCCA AAATGAGCAG CCCAGAAACA GATGAAGAAA TTGAAAAGAT GAAGGGTTTT 
GGTGAATATT CACGGTCTCC TACATTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620775.2
CDS	66..1295
Translation	MEGESTSAVLSGFVLGALAFQHLNTDSDTEGFLLGEVKGEAKNSITDSQMDDVEVVYTIDIQKYIPCYQLFSFYNSSGEVNEQALKKILSNVKKNVVGWYKFRRHSDQIMTFRERLLHKNLQEHFSNQDLVFLLLTPSIITESCSTHRLEHSLYKPQKGLFHRVPLVVANLGMSEQLGYKTVSGSCMSTGFSRAVQTHSSKFFEEDGSLKEVHKINEMYASLQEELKSICKKVEDSEQAVDKLVKDVNRLKREIEKRRGAQIQAAREKNIQKDPQENIFLCQALRTFFPNSEFLHSCVMSLKNRHVSKSSCNYNHHLDVVDNLTLMVEHTDIPEASPASTPQIIKHKALDLDDRWQFKRSRLLDTQDKRSKADTGSSNQDKASKMSSPETDEEIEKMKGFGEYSRSPTF

Target ORF information:

RefSeq Version	NM_139076.2
Organism	Homo sapiens(human)
Definition	Homo sapiens abraxas 1, BRCA1 A complex subunit (ABRAXAS1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_139076.2

ORF Insert Sequence:

ATGGAGGGGG AGAGTACGTC GGCGGTGCTC TCGGGCTTTG TGCTCGGCGC ACTCGCTTTC 
CAGCACCTCA ACACGGACTC GGACACGGAA GGTTTTCTTC TTGGGGAAGT AAAAGGTGAA 
GCCAAGAACA GCATTACTGA TTCCCAAATG GATGATGTTG AAGTTGTTTA TACAATTGAC 
ATTCAGAAAT ATATTCCATG CTATCAGCTT TTTAGCTTTT ATAATTCTTC AGGCGAAGTA 
AATGAGCAAG CACTGAAGAA AATATTATCA AATGTCAAAA AGAATGTGGT AGGTTGGTAC 
AAATTCCGTC GTCATTCAGA TCAGATCATG ACGTTTAGAG AGAGGCTGCT TCACAAAAAC 
TTGCAGGAGC ATTTTTCAAA CCAAGACCTT GTTTTTCTGC TATTAACACC AAGTATAATA 
ACAGAAAGCT GCTCTACTCA TCGACTGGAA CATTCCTTAT ATAAACCTCA AAAAGGACTT 
TTTCACAGGG TACCTTTAGT GGTTGCCAAT CTGGGCATGT CTGAACAACT GGGTTATAAA 
ACTGTATCAG GTTCCTGTAT GTCCACTGGT TTTAGCCGAG CAGTACAAAC ACACAGCTCT 
AAATTTTTTG AAGAAGATGG ATCCTTAAAG GAGGTACATA AGATAAATGA AATGTATGCT 
TCATTACAAG AGGAATTAAA GAGTATATGC AAAAAAGTGG AAGACAGTGA ACAAGCAGTA 
GATAAACTAG TAAAGGATGT AAACAGATTA AAACGAGAAA TTGAGAAAAG GAGAGGAGCA 
CAGATTCAGG CAGCAAGAGA GAAGAACATC CAAAAAGACC CTCAGGAGAA CATTTTTCTT 
TGTCAGGCAT TACGGACCTT TTTTCCAAAT TCTGAATTTC TTCATTCATG TGTTATGTCT 
TTAAAAAATA GACATGTTTC TAAAAGTAGC TGTAACTACA ACCACCATCT CGATGTAGTA 
GACAATCTGA CCTTAATGGT AGAACACACT GACATTCCTG AAGCTAGTCC AGCTAGTACA 
CCACAAATCA TTAAGCATAA AGCCTTAGAC TTAGATGACA GATGGCAATT CAAGAGATCT 
CGGTTGTTAG ATACACAAGA CAAACGATCT AAAGCAGATA CTGGTAGTAG TAACCAAGAT 
AAAGCATCCA AAATGAGCAG CCCAGAAACA GATGAAGAAA TTGAAAAGAT GAAGGGTTTT 
GGTGAATATT CACGGTCTCC TACATTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ABRAXAS1 ( NM_139076.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_620775.2 Homo sapiens abraxas 1, BRCA1 A complex subunit (ABRAXAS1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu06266
Clone ID Related Accession (Same CDS sequence)	NM_139076.2 , NM_139076.3
Accession Version	NM_139076.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1230bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	BRCA1-A complex subunit Abraxas 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC096768.3. On Nov 23, 2018 this sequence version replaced NM_139076.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.257266.1, SRR1803614.263088.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000321945.12/ ENSP00000369857.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGGGGG AGAGTACGTC GGCGGTGCTC TCGGGCTTTG TGCTCGGCGC ACTCGCTTTC 
CAGCACCTCA ACACGGACTC GGACACGGAA GGTTTTCTTC TTGGGGAAGT AAAAGGTGAA 
GCCAAGAACA GCATTACTGA TTCCCAAATG GATGATGTTG AAGTTGTTTA TACAATTGAC 
ATTCAGAAAT ATATTCCATG CTATCAGCTT TTTAGCTTTT ATAATTCTTC AGGCGAAGTA 
AATGAGCAAG CACTGAAGAA AATATTATCA AATGTCAAAA AGAATGTGGT AGGTTGGTAC 
AAATTCCGTC GTCATTCAGA TCAGATCATG ACGTTTAGAG AGAGGCTGCT TCACAAAAAC 
TTGCAGGAGC ATTTTTCAAA CCAAGACCTT GTTTTTCTGC TATTAACACC AAGTATAATA 
ACAGAAAGCT GCTCTACTCA TCGACTGGAA CATTCCTTAT ATAAACCTCA AAAAGGACTT 
TTTCACAGGG TACCTTTAGT GGTTGCCAAT CTGGGCATGT CTGAACAACT GGGTTATAAA 
ACTGTATCAG GTTCCTGTAT GTCCACTGGT TTTAGCCGAG CAGTACAAAC ACACAGCTCT 
AAATTTTTTG AAGAAGATGG ATCCTTAAAG GAGGTACATA AGATAAATGA AATGTATGCT 
TCATTACAAG AGGAATTAAA GAGTATATGC AAAAAAGTGG AAGACAGTGA ACAAGCAGTA 
GATAAACTAG TAAAGGATGT AAACAGATTA AAACGAGAAA TTGAGAAAAG GAGAGGAGCA 
CAGATTCAGG CAGCAAGAGA GAAGAACATC CAAAAAGACC CTCAGGAGAA CATTTTTCTT 
TGTCAGGCAT TACGGACCTT TTTTCCAAAT TCTGAATTTC TTCATTCATG TGTTATGTCT 
TTAAAAAATA GACATGTTTC TAAAAGTAGC TGTAACTACA ACCACCATCT CGATGTAGTA 
GACAATCTGA CCTTAATGGT AGAACACACT GACATTCCTG AAGCTAGTCC AGCTAGTACA 
CCACAAATCA TTAAGCATAA AGCCTTAGAC TTAGATGACA GATGGCAATT CAAGAGATCT 
CGGTTGTTAG ATACACAAGA CAAACGATCT AAAGCAGATA CTGGTAGTAG TAACCAAGAT 
AAAGCATCCA AAATGAGCAG CCCAGAAACA GATGAAGAAA TTGAAAAGAT GAAGGGTTTT 
GGTGAATATT CACGGTCTCC TACATTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620775.2
CDS	29..1258
Translation	MEGESTSAVLSGFVLGALAFQHLNTDSDTEGFLLGEVKGEAKNSITDSQMDDVEVVYTIDIQKYIPCYQLFSFYNSSGEVNEQALKKILSNVKKNVVGWYKFRRHSDQIMTFRERLLHKNLQEHFSNQDLVFLLLTPSIITESCSTHRLEHSLYKPQKGLFHRVPLVVANLGMSEQLGYKTVSGSCMSTGFSRAVQTHSSKFFEEDGSLKEVHKINEMYASLQEELKSICKKVEDSEQAVDKLVKDVNRLKREIEKRRGAQIQAAREKNIQKDPQENIFLCQALRTFFPNSEFLHSCVMSLKNRHVSKSSCNYNHHLDVVDNLTLMVEHTDIPEASPASTPQIIKHKALDLDDRWQFKRSRLLDTQDKRSKADTGSSNQDKASKMSSPETDEEIEKMKGFGEYSRSPTF

Target ORF information:

RefSeq Version	NM_139076.3
Organism	Homo sapiens(human)
Definition	Homo sapiens abraxas 1, BRCA1 A complex subunit (ABRAXAS1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_139076.3

ORF Insert Sequence:

ATGGAGGGGG AGAGTACGTC GGCGGTGCTC TCGGGCTTTG TGCTCGGCGC ACTCGCTTTC 
CAGCACCTCA ACACGGACTC GGACACGGAA GGTTTTCTTC TTGGGGAAGT AAAAGGTGAA 
GCCAAGAACA GCATTACTGA TTCCCAAATG GATGATGTTG AAGTTGTTTA TACAATTGAC 
ATTCAGAAAT ATATTCCATG CTATCAGCTT TTTAGCTTTT ATAATTCTTC AGGCGAAGTA 
AATGAGCAAG CACTGAAGAA AATATTATCA AATGTCAAAA AGAATGTGGT AGGTTGGTAC 
AAATTCCGTC GTCATTCAGA TCAGATCATG ACGTTTAGAG AGAGGCTGCT TCACAAAAAC 
TTGCAGGAGC ATTTTTCAAA CCAAGACCTT GTTTTTCTGC TATTAACACC AAGTATAATA 
ACAGAAAGCT GCTCTACTCA TCGACTGGAA CATTCCTTAT ATAAACCTCA AAAAGGACTT 
TTTCACAGGG TACCTTTAGT GGTTGCCAAT CTGGGCATGT CTGAACAACT GGGTTATAAA 
ACTGTATCAG GTTCCTGTAT GTCCACTGGT TTTAGCCGAG CAGTACAAAC ACACAGCTCT 
AAATTTTTTG AAGAAGATGG ATCCTTAAAG GAGGTACATA AGATAAATGA AATGTATGCT 
TCATTACAAG AGGAATTAAA GAGTATATGC AAAAAAGTGG AAGACAGTGA ACAAGCAGTA 
GATAAACTAG TAAAGGATGT AAACAGATTA AAACGAGAAA TTGAGAAAAG GAGAGGAGCA 
CAGATTCAGG CAGCAAGAGA GAAGAACATC CAAAAAGACC CTCAGGAGAA CATTTTTCTT 
TGTCAGGCAT TACGGACCTT TTTTCCAAAT TCTGAATTTC TTCATTCATG TGTTATGTCT 
TTAAAAAATA GACATGTTTC TAAAAGTAGC TGTAACTACA ACCACCATCT CGATGTAGTA 
GACAATCTGA CCTTAATGGT AGAACACACT GACATTCCTG AAGCTAGTCC AGCTAGTACA 
CCACAAATCA TTAAGCATAA AGCCTTAGAC TTAGATGACA GATGGCAATT CAAGAGATCT 
CGGTTGTTAG ATACACAAGA CAAACGATCT AAAGCAGATA CTGGTAGTAG TAACCAAGAT 
AAAGCATCCA AAATGAGCAG CCCAGAAACA GATGAAGAAA TTGAAAAGAT GAAGGGTTTT 
GGTGAATATT CACGGTCTCC TACATTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ABRAXAS1 ( XM_005263280.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005263337.1 Homo sapiens family with sequence similarity 175 member A (FAM175A), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu39131
Clone ID Related Accession (Same CDS sequence)	XM_005263280.4 , XM_005263280.5
Accession Version	XM_005263280.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1083bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	BRCA1-A complex subunit Abraxas isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005263280.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATGATG TTGAAGTTGT TTATACAATT GACATTCAGA AATATATTCC ATGCTATCAG 
CTTTTTAGCT TTTATAATTC TTCAGGCGAA GTAAATGAGC AAGCACTGAA GAAAATATTA 
TCAAATGTCA AAAAGAATGT GGTAGGTTGG TACAAATTCC GTCGTCATTC AGATCAGATC 
ATGACGTTTA GAGAGAGGCT GCTTCACAAA AACTTGCAGG AGCATTTTTC AAACCAAGAC 
CTTGTTTTTC TGCTATTAAC ACCAAGTATA ATAACAGAAA GCTGCTCTAC TCATCGACTG 
GAACATTCCT TATATAAACC TCAAAAAGGA CTTTTTCACA GGGTACCTTT AGTGGTTGCC 
AATCTGGGCA TGTCTGAACA ACTGGGTTAT AAAACTGTAT CAGGTTCCTG TATGTCCACT 
GGTTTTAGCC GAGCAGTACA AACACACAGC TCTAAATTTT TTGAAGAAGA TGGATCCTTA 
AAGGAGGTAC ATAAGATAAA TGAAATGTAT GCTTCATTAC AAGAGGAATT AAAGAGTATA 
TGCAAAAAAG TGGAAGACAG TGAACAAGCA GTAGATAAAC TAGTAAAGGA TGTAAACAGA 
TTAAAACGAG AAATTGAGAA AAGGAGAGGA GCACAGATTC AGGCAGCAAG AGAGAAGAAC 
ATCCAAAAAG ACCCTCAGGA GAACATTTTT CTTTGTCAGG CATTACGGAC CTTTTTTCCA 
AATTCTGAAT TTCTTCATTC ATGTGTTATG TCTTTAAAAA ATAGACATGT TTCTAAAAGT 
AGCTGTAACT ACAACCACCA TCTCGATGTA GTAGACAATC TGACCTTAAT GGTAGAACAC 
ACTGACATTC CTGAAGCTAG TCCAGCTAGT ACACCACAAA TCATTAAGCA TAAAGCCTTA 
GACTTAGATG ACAGATGGCA ATTCAAGAGA TCTCGGTTGT TAGATACACA AGACAAACGA 
TCTAAAGCAG ATACTGGTAG TAGTAACCAA GATAAAGCAT CCAAAATGAG CAGCCCAGAA 
ACAGATGAAG AAATTGAAAA GATGAAGGGT TTTGGTGAAT ATTCACGGTC TCCTACATTT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005263337.1
CDS	346..1428
Translation	MDDVEVVYTIDIQKYIPCYQLFSFYNSSGEVNEQALKKILSNVKKNVVGWYKFRRHSDQIMTFRERLLHKNLQEHFSNQDLVFLLLTPSIITESCSTHRLEHSLYKPQKGLFHRVPLVVANLGMSEQLGYKTVSGSCMSTGFSRAVQTHSSKFFEEDGSLKEVHKINEMYASLQEELKSICKKVEDSEQAVDKLVKDVNRLKREIEKRRGAQIQAAREKNIQKDPQENIFLCQALRTFFPNSEFLHSCVMSLKNRHVSKSSCNYNHHLDVVDNLTLMVEHTDIPEASPASTPQIIKHKALDLDDRWQFKRSRLLDTQDKRSKADTGSSNQDKASKMSSPETDEEIEKMKGFGEYSRSPTF

Target ORF information:

RefSeq Version	XM_005263280.4
Organism	Homo sapiens(human)
Definition	Homo sapiens family with sequence similarity 175 member A (FAM175A), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005263280.4

ORF Insert Sequence:

ATGGATGATG TTGAAGTTGT TTATACAATT GACATTCAGA AATATATTCC ATGCTATCAG 
CTTTTTAGCT TTTATAATTC TTCAGGCGAA GTAAATGAGC AAGCACTGAA GAAAATATTA 
TCAAATGTCA AAAAGAATGT GGTAGGTTGG TACAAATTCC GTCGTCATTC AGATCAGATC 
ATGACGTTTA GAGAGAGGCT GCTTCACAAA AACTTGCAGG AGCATTTTTC AAACCAAGAC 
CTTGTTTTTC TGCTATTAAC ACCAAGTATA ATAACAGAAA GCTGCTCTAC TCATCGACTG 
GAACATTCCT TATATAAACC TCAAAAAGGA CTTTTTCACA GGGTACCTTT AGTGGTTGCC 
AATCTGGGCA TGTCTGAACA ACTGGGTTAT AAAACTGTAT CAGGTTCCTG TATGTCCACT 
GGTTTTAGCC GAGCAGTACA AACACACAGC TCTAAATTTT TTGAAGAAGA TGGATCCTTA 
AAGGAGGTAC ATAAGATAAA TGAAATGTAT GCTTCATTAC AAGAGGAATT AAAGAGTATA 
TGCAAAAAAG TGGAAGACAG TGAACAAGCA GTAGATAAAC TAGTAAAGGA TGTAAACAGA 
TTAAAACGAG AAATTGAGAA AAGGAGAGGA GCACAGATTC AGGCAGCAAG AGAGAAGAAC 
ATCCAAAAAG ACCCTCAGGA GAACATTTTT CTTTGTCAGG CATTACGGAC CTTTTTTCCA 
AATTCTGAAT TTCTTCATTC ATGTGTTATG TCTTTAAAAA ATAGACATGT TTCTAAAAGT 
AGCTGTAACT ACAACCACCA TCTCGATGTA GTAGACAATC TGACCTTAAT GGTAGAACAC 
ACTGACATTC CTGAAGCTAG TCCAGCTAGT ACACCACAAA TCATTAAGCA TAAAGCCTTA 
GACTTAGATG ACAGATGGCA ATTCAAGAGA TCTCGGTTGT TAGATACACA AGACAAACGA 
TCTAAAGCAG ATACTGGTAG TAGTAACCAA GATAAAGCAT CCAAAATGAG CAGCCCAGAA 
ACAGATGAAG AAATTGAAAA GATGAAGGGT TTTGGTGAAT ATTCACGGTC TCCTACATTT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ABRAXAS1 ( XM_005263280.5 ) cDNA ORF clone, Homo sapiens(human) -> XP_005263337.1 Homo sapiens abraxas 1, BRCA1 A complex subunit (ABRAXAS1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu39131
Clone ID Related Accession (Same CDS sequence)	XM_005263280.4 , XM_005263280.5
Accession Version	XM_005263280.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1083bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	BRCA1-A complex subunit Abraxas 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005263280.4. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATGATG TTGAAGTTGT TTATACAATT GACATTCAGA AATATATTCC ATGCTATCAG 
CTTTTTAGCT TTTATAATTC TTCAGGCGAA GTAAATGAGC AAGCACTGAA GAAAATATTA 
TCAAATGTCA AAAAGAATGT GGTAGGTTGG TACAAATTCC GTCGTCATTC AGATCAGATC 
ATGACGTTTA GAGAGAGGCT GCTTCACAAA AACTTGCAGG AGCATTTTTC AAACCAAGAC 
CTTGTTTTTC TGCTATTAAC ACCAAGTATA ATAACAGAAA GCTGCTCTAC TCATCGACTG 
GAACATTCCT TATATAAACC TCAAAAAGGA CTTTTTCACA GGGTACCTTT AGTGGTTGCC 
AATCTGGGCA TGTCTGAACA ACTGGGTTAT AAAACTGTAT CAGGTTCCTG TATGTCCACT 
GGTTTTAGCC GAGCAGTACA AACACACAGC TCTAAATTTT TTGAAGAAGA TGGATCCTTA 
AAGGAGGTAC ATAAGATAAA TGAAATGTAT GCTTCATTAC AAGAGGAATT AAAGAGTATA 
TGCAAAAAAG TGGAAGACAG TGAACAAGCA GTAGATAAAC TAGTAAAGGA TGTAAACAGA 
TTAAAACGAG AAATTGAGAA AAGGAGAGGA GCACAGATTC AGGCAGCAAG AGAGAAGAAC 
ATCCAAAAAG ACCCTCAGGA GAACATTTTT CTTTGTCAGG CATTACGGAC CTTTTTTCCA 
AATTCTGAAT TTCTTCATTC ATGTGTTATG TCTTTAAAAA ATAGACATGT TTCTAAAAGT 
AGCTGTAACT ACAACCACCA TCTCGATGTA GTAGACAATC TGACCTTAAT GGTAGAACAC 
ACTGACATTC CTGAAGCTAG TCCAGCTAGT ACACCACAAA TCATTAAGCA TAAAGCCTTA 
GACTTAGATG ACAGATGGCA ATTCAAGAGA TCTCGGTTGT TAGATACACA AGACAAACGA 
TCTAAAGCAG ATACTGGTAG TAGTAACCAA GATAAAGCAT CCAAAATGAG CAGCCCAGAA 
ACAGATGAAG AAATTGAAAA GATGAAGGGT TTTGGTGAAT ATTCACGGTC TCCTACATTT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005263337.1
CDS	346..1428
Translation	MDDVEVVYTIDIQKYIPCYQLFSFYNSSGEVNEQALKKILSNVKKNVVGWYKFRRHSDQIMTFRERLLHKNLQEHFSNQDLVFLLLTPSIITESCSTHRLEHSLYKPQKGLFHRVPLVVANLGMSEQLGYKTVSGSCMSTGFSRAVQTHSSKFFEEDGSLKEVHKINEMYASLQEELKSICKKVEDSEQAVDKLVKDVNRLKREIEKRRGAQIQAAREKNIQKDPQENIFLCQALRTFFPNSEFLHSCVMSLKNRHVSKSSCNYNHHLDVVDNLTLMVEHTDIPEASPASTPQIIKHKALDLDDRWQFKRSRLLDTQDKRSKADTGSSNQDKASKMSSPETDEEIEKMKGFGEYSRSPTF

Target ORF information:

RefSeq Version	XM_005263280.5
Organism	Homo sapiens(human)
Definition	Homo sapiens abraxas 1, BRCA1 A complex subunit (ABRAXAS1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005263280.5

ORF Insert Sequence:

ATGGATGATG TTGAAGTTGT TTATACAATT GACATTCAGA AATATATTCC ATGCTATCAG 
CTTTTTAGCT TTTATAATTC TTCAGGCGAA GTAAATGAGC AAGCACTGAA GAAAATATTA 
TCAAATGTCA AAAAGAATGT GGTAGGTTGG TACAAATTCC GTCGTCATTC AGATCAGATC 
ATGACGTTTA GAGAGAGGCT GCTTCACAAA AACTTGCAGG AGCATTTTTC AAACCAAGAC 
CTTGTTTTTC TGCTATTAAC ACCAAGTATA ATAACAGAAA GCTGCTCTAC TCATCGACTG 
GAACATTCCT TATATAAACC TCAAAAAGGA CTTTTTCACA GGGTACCTTT AGTGGTTGCC 
AATCTGGGCA TGTCTGAACA ACTGGGTTAT AAAACTGTAT CAGGTTCCTG TATGTCCACT 
GGTTTTAGCC GAGCAGTACA AACACACAGC TCTAAATTTT TTGAAGAAGA TGGATCCTTA 
AAGGAGGTAC ATAAGATAAA TGAAATGTAT GCTTCATTAC AAGAGGAATT AAAGAGTATA 
TGCAAAAAAG TGGAAGACAG TGAACAAGCA GTAGATAAAC TAGTAAAGGA TGTAAACAGA 
TTAAAACGAG AAATTGAGAA AAGGAGAGGA GCACAGATTC AGGCAGCAAG AGAGAAGAAC 
ATCCAAAAAG ACCCTCAGGA GAACATTTTT CTTTGTCAGG CATTACGGAC CTTTTTTCCA 
AATTCTGAAT TTCTTCATTC ATGTGTTATG TCTTTAAAAA ATAGACATGT TTCTAAAAGT 
AGCTGTAACT ACAACCACCA TCTCGATGTA GTAGACAATC TGACCTTAAT GGTAGAACAC 
ACTGACATTC CTGAAGCTAG TCCAGCTAGT ACACCACAAA TCATTAAGCA TAAAGCCTTA 
GACTTAGATG ACAGATGGCA ATTCAAGAGA TCTCGGTTGT TAGATACACA AGACAAACGA 
TCTAAAGCAG ATACTGGTAG TAGTAACCAA GATAAAGCAT CCAAAATGAG CAGCCCAGAA 
ACAGATGAAG AAATTGAAAA GATGAAGGGT TTTGGTGAAT ATTCACGGTC TCCTACATTT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ABRAXAS1 ( NM_001345962.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001332891.1 Homo sapiens abraxas 1, BRCA1 A complex subunit (ABRAXAS1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu102475
Clone ID Related Accession (Same CDS sequence)	NM_001345962.1 , NM_001345962.2
Accession Version	NM_001345962.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 903bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-08-10
Organism	Homo sapiens(human)
Product	BRCA1-A complex subunit Abraxas 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY040546.1, AK023676.1 and BQ775596.1. On Sep 16, 2016 this sequence version replaced XM_017008694.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK023676.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACGTTTA GAGAGAGGCT GCTTCACAAA AACTTGCAGG AGCATTTTTC AAACCAAGAC 
CTTGTTTTTC TGCTATTAAC ACCAAGTATA ATAACAGAAA GCTGCTCTAC TCATCGACTG 
GAACATTCCT TATATAAACC TCAAAAAGGA CTTTTTCACA GGGTACCTTT AGTGGTTGCC 
AATCTGGGCA TGTCTGAACA ACTGGGTTAT AAAACTGTAT CAGGTTCCTG TATGTCCACT 
GGTTTTAGCC GAGCAGTACA AACACACAGC TCTAAATTTT TTGAAGAAGA TGGATCCTTA 
AAGGAGGTAC ATAAGATAAA TGAAATGTAT GCTTCATTAC AAGAGGAATT AAAGAGTATA 
TGCAAAAAAG TGGAAGACAG TGAACAAGCA GTAGATAAAC TAGTAAAGGA TGTAAACAGA 
TTAAAACGAG AAATTGAGAA AAGGAGAGGA GCACAGATTC AGGCAGCAAG AGAGAAGAAC 
ATCCAAAAAG ACCCTCAGGA GAACATTTTT CTTTGTCAGG CATTACGGAC CTTTTTTCCA 
AATTCTGAAT TTCTTCATTC ATGTGTTATG TCTTTAAAAA ATAGACATGT TTCTAAAAGT 
AGCTGTAACT ACAACCACCA TCTCGATGTA GTAGACAATC TGACCTTAAT GGTAGAACAC 
ACTGACATTC CTGAAGCTAG TCCAGCTAGT ACACCACAAA TCATTAAGCA TAAAGCCTTA 
GACTTAGATG ACAGATGGCA ATTCAAGAGA TCTCGGTTGT TAGATACACA AGACAAACGA 
TCTAAAGCAG ATACTGGTAG TAGTAACCAA GATAAAGCAT CCAAAATGAG CAGCCCAGAA 
ACAGATGAAG AAATTGAAAA GATGAAGGGT TTTGGTGAAT ATTCACGGTC TCCTACATTT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001332891.1
CDS	367..1269
Translation	MTFRERLLHKNLQEHFSNQDLVFLLLTPSIITESCSTHRLEHSLYKPQKGLFHRVPLVVANLGMSEQLGYKTVSGSCMSTGFSRAVQTHSSKFFEEDGSLKEVHKINEMYASLQEELKSICKKVEDSEQAVDKLVKDVNRLKREIEKRRGAQIQAAREKNIQKDPQENIFLCQALRTFFPNSEFLHSCVMSLKNRHVSKSSCNYNHHLDVVDNLTLMVEHTDIPEASPASTPQIIKHKALDLDDRWQFKRSRLLDTQDKRSKADTGSSNQDKASKMSSPETDEEIEKMKGFGEYSRSPTF

Target ORF information:

RefSeq Version	NM_001345962.1
Organism	Homo sapiens(human)
Definition	Homo sapiens abraxas 1, BRCA1 A complex subunit (ABRAXAS1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001345962.1

ORF Insert Sequence:

ATGACGTTTA GAGAGAGGCT GCTTCACAAA AACTTGCAGG AGCATTTTTC AAACCAAGAC 
CTTGTTTTTC TGCTATTAAC ACCAAGTATA ATAACAGAAA GCTGCTCTAC TCATCGACTG 
GAACATTCCT TATATAAACC TCAAAAAGGA CTTTTTCACA GGGTACCTTT AGTGGTTGCC 
AATCTGGGCA TGTCTGAACA ACTGGGTTAT AAAACTGTAT CAGGTTCCTG TATGTCCACT 
GGTTTTAGCC GAGCAGTACA AACACACAGC TCTAAATTTT TTGAAGAAGA TGGATCCTTA 
AAGGAGGTAC ATAAGATAAA TGAAATGTAT GCTTCATTAC AAGAGGAATT AAAGAGTATA 
TGCAAAAAAG TGGAAGACAG TGAACAAGCA GTAGATAAAC TAGTAAAGGA TGTAAACAGA 
TTAAAACGAG AAATTGAGAA AAGGAGAGGA GCACAGATTC AGGCAGCAAG AGAGAAGAAC 
ATCCAAAAAG ACCCTCAGGA GAACATTTTT CTTTGTCAGG CATTACGGAC CTTTTTTCCA 
AATTCTGAAT TTCTTCATTC ATGTGTTATG TCTTTAAAAA ATAGACATGT TTCTAAAAGT 
AGCTGTAACT ACAACCACCA TCTCGATGTA GTAGACAATC TGACCTTAAT GGTAGAACAC 
ACTGACATTC CTGAAGCTAG TCCAGCTAGT ACACCACAAA TCATTAAGCA TAAAGCCTTA 
GACTTAGATG ACAGATGGCA ATTCAAGAGA TCTCGGTTGT TAGATACACA AGACAAACGA 
TCTAAAGCAG ATACTGGTAG TAGTAACCAA GATAAAGCAT CCAAAATGAG CAGCCCAGAA 
ACAGATGAAG AAATTGAAAA GATGAAGGGT TTTGGTGAAT ATTCACGGTC TCCTACATTT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ABRAXAS1 ( NM_001345962.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001332891.1 Homo sapiens abraxas 1, BRCA1 A complex subunit (ABRAXAS1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu102475
Clone ID Related Accession (Same CDS sequence)	NM_001345962.1 , NM_001345962.2
Accession Version	NM_001345962.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 903bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-28
Organism	Homo sapiens(human)
Product	BRCA1-A complex subunit Abraxas 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC096768.3. On Jun 1, 2019 this sequence version replaced NM_001345962.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK023676.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACGTTTA GAGAGAGGCT GCTTCACAAA AACTTGCAGG AGCATTTTTC AAACCAAGAC 
CTTGTTTTTC TGCTATTAAC ACCAAGTATA ATAACAGAAA GCTGCTCTAC TCATCGACTG 
GAACATTCCT TATATAAACC TCAAAAAGGA CTTTTTCACA GGGTACCTTT AGTGGTTGCC 
AATCTGGGCA TGTCTGAACA ACTGGGTTAT AAAACTGTAT CAGGTTCCTG TATGTCCACT 
GGTTTTAGCC GAGCAGTACA AACACACAGC TCTAAATTTT TTGAAGAAGA TGGATCCTTA 
AAGGAGGTAC ATAAGATAAA TGAAATGTAT GCTTCATTAC AAGAGGAATT AAAGAGTATA 
TGCAAAAAAG TGGAAGACAG TGAACAAGCA GTAGATAAAC TAGTAAAGGA TGTAAACAGA 
TTAAAACGAG AAATTGAGAA AAGGAGAGGA GCACAGATTC AGGCAGCAAG AGAGAAGAAC 
ATCCAAAAAG ACCCTCAGGA GAACATTTTT CTTTGTCAGG CATTACGGAC CTTTTTTCCA 
AATTCTGAAT TTCTTCATTC ATGTGTTATG TCTTTAAAAA ATAGACATGT TTCTAAAAGT 
AGCTGTAACT ACAACCACCA TCTCGATGTA GTAGACAATC TGACCTTAAT GGTAGAACAC 
ACTGACATTC CTGAAGCTAG TCCAGCTAGT ACACCACAAA TCATTAAGCA TAAAGCCTTA 
GACTTAGATG ACAGATGGCA ATTCAAGAGA TCTCGGTTGT TAGATACACA AGACAAACGA 
TCTAAAGCAG ATACTGGTAG TAGTAACCAA GATAAAGCAT CCAAAATGAG CAGCCCAGAA 
ACAGATGAAG AAATTGAAAA GATGAAGGGT TTTGGTGAAT ATTCACGGTC TCCTACATTT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001332891.1
CDS	289..1191
Translation	MTFRERLLHKNLQEHFSNQDLVFLLLTPSIITESCSTHRLEHSLYKPQKGLFHRVPLVVANLGMSEQLGYKTVSGSCMSTGFSRAVQTHSSKFFEEDGSLKEVHKINEMYASLQEELKSICKKVEDSEQAVDKLVKDVNRLKREIEKRRGAQIQAAREKNIQKDPQENIFLCQALRTFFPNSEFLHSCVMSLKNRHVSKSSCNYNHHLDVVDNLTLMVEHTDIPEASPASTPQIIKHKALDLDDRWQFKRSRLLDTQDKRSKADTGSSNQDKASKMSSPETDEEIEKMKGFGEYSRSPTF

Target ORF information:

RefSeq Version	NM_001345962.2
Organism	Homo sapiens(human)
Definition	Homo sapiens abraxas 1, BRCA1 A complex subunit (ABRAXAS1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001345962.2

ORF Insert Sequence:

ATGACGTTTA GAGAGAGGCT GCTTCACAAA AACTTGCAGG AGCATTTTTC AAACCAAGAC 
CTTGTTTTTC TGCTATTAAC ACCAAGTATA ATAACAGAAA GCTGCTCTAC TCATCGACTG 
GAACATTCCT TATATAAACC TCAAAAAGGA CTTTTTCACA GGGTACCTTT AGTGGTTGCC 
AATCTGGGCA TGTCTGAACA ACTGGGTTAT AAAACTGTAT CAGGTTCCTG TATGTCCACT 
GGTTTTAGCC GAGCAGTACA AACACACAGC TCTAAATTTT TTGAAGAAGA TGGATCCTTA 
AAGGAGGTAC ATAAGATAAA TGAAATGTAT GCTTCATTAC AAGAGGAATT AAAGAGTATA 
TGCAAAAAAG TGGAAGACAG TGAACAAGCA GTAGATAAAC TAGTAAAGGA TGTAAACAGA 
TTAAAACGAG AAATTGAGAA AAGGAGAGGA GCACAGATTC AGGCAGCAAG AGAGAAGAAC 
ATCCAAAAAG ACCCTCAGGA GAACATTTTT CTTTGTCAGG CATTACGGAC CTTTTTTCCA 
AATTCTGAAT TTCTTCATTC ATGTGTTATG TCTTTAAAAA ATAGACATGT TTCTAAAAGT 
AGCTGTAACT ACAACCACCA TCTCGATGTA GTAGACAATC TGACCTTAAT GGTAGAACAC 
ACTGACATTC CTGAAGCTAG TCCAGCTAGT ACACCACAAA TCATTAAGCA TAAAGCCTTA 
GACTTAGATG ACAGATGGCA ATTCAAGAGA TCTCGGTTGT TAGATACACA AGACAAACGA 
TCTAAAGCAG ATACTGGTAG TAGTAACCAA GATAAAGCAT CCAAAATGAG CAGCCCAGAA 
ACAGATGAAG AAATTGAAAA GATGAAGGGT TTTGGTGAAT ATTCACGGTC TCCTACATTT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Three-Dimensional Architecture of the Human BRCA1-A Histone Deubiquitinase Core Complex.
Cell reports17(12)3099-3106(2016 12)
Kyrieleis OJP,McIntosh PB,Webb SR,Calder LJ,Lloyd J,Patel NA,Martin SR,Robinson CV,Rosenthal PB,Smerdon SJ

Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites.
Molecular cell61(3)434-448(2016 Feb)
Wu Q,Paul A,Su D,Mehmood S,Foo TK,Ochi T,Bunting EL,Xia B,Robinson CV,Wang B,Blundell TL

ABRAXAS (FAM175A) and Breast Cancer Susceptibility: No Evidence of Association in the Breast Cancer Family Registry.
PloS one11(6)e0156820(2016)
Renault AL,Lesueur F,Coulombe Y,Gobeil S,Soucy P,Hamdi Y,Desjardins S,Le Calvez-Kelm F,Vall?e M,Voegele C,,Hopper JL,Andrulis IL,Southey MC,John EM,Masson JY,Tavtigian SV,Simard J

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ABRAXAS1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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