SOX14 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SOX14
Entrez Gene ID	8403
Full Name	SRY-box 14
Synonyms	SOX28
General protein information	Preferred Names SRY-box 14 Names transcription factor SOX-14 HMG box transcription factor SOX-14 SRY (sex determining region Y)-box 14
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q22.3
Summary	This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene are suggested to be responsible for the limb defects associated with blepharophimosis, ptosis, epicanthus inversus syndrome (BPES) and Mobius syndrome. [provided by RefSeq, Jul 2008].
Disorder MIM:	604747

mRNA and Protein(s)

mRNA	Protein	Name
NM_004189.4	NP_004180.1	transcription factor SOX-14
NM_004189.3	NP_004180.1	transcription factor SOX-14

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SOX14	NP_001157253.1
Rattus norvegicus (Norway rat)	Sox14	NP_001100320.1
Danio rerio (zebrafish)	sox14	NP_001032769.1
	SOX14	XP_001114754.1
Mus musculus (house mouse)	Sox14	NP_035570.1
Xenopus tropicalis (tropical clawed frog)	sox14	NP_001093703.1
Homo sapiens (human)	SOX14	NP_004180.1
Pan troglodytes (chimpanzee)	SOX14	XP_526317.2
Canis lupus familiaris (dog)	SOX14	XP_005634531.1
Gallus gallus (chicken)	SOX14	NP_990092.1

Gene Ontology
Bibliography

Related articles in PubMed

SOX10 is over-expressed in bladder cancer and contributes to the malignant bladder cancer cell behaviors.
Yin H, Qin C, Zhao Y, Du Y, Sheng Z, Wang Q, Song Q, Chen L, Liu C, Xu T
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico19(8)1035-1044(2017 Aug)

SOX14 promotes proliferation and invasion of cervical cancer cells through Wnt/?-catenin pathway.
Li F, Wang T, Tang S
International journal of clinical and experimental pathology8(2)1698-704(2015)

Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT.
Kim HY, Cho S, Yu J, Sung S, Kim H
BMB reports43(8)547-53(2010 Aug)

Tissue-specific Forkhead protein FOXA2 up-regulates SOX14 gene expression.
Popovic J, Klajn A, Petrovic I, Stevanovic M
Biochimica et biophysica acta1799(5-6)411-8(2010 May-Jun)

A census of human transcription factors: function, expression and evolution.
Vaquerizas JM, Kummerfeld SK, Teichmann SA, Luscombe NM
Nature reviews. Genetics10(4)252-63(2009 04)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these results demonstrate that SOX14 can promote proliferation and invasion capacity of cervical cancer cells by activating the Wnt/beta-catenin pathway.
Title: SOX14 promotes proliferation and invasion of cervical cancer cells through Wnt/?-catenin pathway.

Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT.

identified the positive control element and provided the first evidence that FOXA2 is involved in up-regulation of SOX14 expression in HepG2 and U87MG cell lines
Title: Tissue-specific Forkhead protein FOXA2 up-regulates SOX14 gene expression.

The following SOX14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SOX14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15429	NM_004189.4 Latest version!	Homo sapiens SRY-box transcription factor 14 (SOX14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu15429	NM_004189.3	Homo sapiens SRY-box 14 (SOX14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SOX14 ( NM_004189.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004180.1 Homo sapiens SRY-box transcription factor 14 (SOX14), mRNA.

Price & Availability↑

CloneID	OHu15429
Clone ID Related Accession (Same CDS sequence)	NM_004189.4 , NM_004189.3
Accession Version	NM_004189.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 723bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	transcription factor SOX-14
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC007159.4. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_004189.3. Sequence Note: The RefSeq transcript was derived from the reference genome assembly. The genomic coordinates were determined from alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AK314127.1, BC106730.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000306087.3/ ENSP00000305343.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGTCCAAAC CTTCAGACCA CATCAAGCGG CCCATGAACG CCTTCATGGT ATGGTCCCGG 
GGCCAGCGGC GCAAGATGGC CCAGGAAAAC CCCAAGATGC ACAACTCGGA GATCAGCAAA 
CGCCTAGGTG CCGAATGGAA GCTTCTGTCC GAGGCAGAGA AGCGGCCATA CATCGATGAA 
GCCAAGCGGC TACGCGCCCA GCACATGAAG GAGCACCCTG ACTACAAGTA CCGACCTCGG 
CGCAAGCCCA AGAACCTGCT CAAGAAGGAC AGGTATGTCT TCCCCTTGCC CTACCTGGGC 
GACACGGACC CGCTCAAGGC GGCTGGCCTG CCCGTGGGGG CCTCCGACGG CCTCCTGAGC 
GCGCCCGAGA AAGCCCGGGC CTTCTTGCCG CCGGCCTCGG CGCCCTACTC CCTGCTGGAC 
CCCGCGCAGT TTAGCTCGAG CGCCATCCAG AAGATGGGCG AAGTGCCCCA CACCTTGGCT 
ACCGGCGCTC TGCCCTACGC GTCCACCCTG GGCTACCAGA ACGGCGCCTT CGGCAGCCTC 
AGCTGCCCCA GCCAGCACAC GCACACGCAC CCGTCCCCCA CCAACCCTGG CTACGTGGTG 
CCCTGTAACT GTACCGCCTG GTCTGCCTCC ACCCTGCAGC CCCCCGTCGC CTACATCCTC 
TTCCCAGGCA TGACCAAGAC TGGCATAGAC CCTTATTCGT CAGCCCACGC TACGGCCATG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004180.1
CDS	471..1193
Translation	MSKPSDHIKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSEAEKRPYIDEAKRLRAQHMKEHPDYKYRPRRKPKNLLKKDRYVFPLPYLGDTDPLKAAGLPVGASDGLLSAPEKARAFLPPASAPYSLLDPAQFSSSAIQKMGEVPHTLATGALPYASTLGYQNGAFGSLSCPSQHTHTHPSPTNPGYVVPCNCTAWSASTLQPPVAYILFPGMTKTGIDPYSSAHATAM

Target ORF information:

RefSeq Version	NM_004189.4
Organism	Homo sapiens(human)
Definition	Homo sapiens SRY-box transcription factor 14 (SOX14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004189.4

ORF Insert Sequence:

ATGTCCAAAC CTTCAGACCA CATCAAGCGG CCCATGAACG CCTTCATGGT ATGGTCCCGG 
GGCCAGCGGC GCAAGATGGC CCAGGAAAAC CCCAAGATGC ACAACTCGGA GATCAGCAAA 
CGCCTAGGTG CCGAATGGAA GCTTCTGTCC GAGGCAGAGA AGCGGCCATA CATCGATGAA 
GCCAAGCGGC TACGCGCCCA GCACATGAAG GAGCACCCTG ACTACAAGTA CCGACCTCGG 
CGCAAGCCCA AGAACCTGCT CAAGAAGGAC AGGTATGTCT TCCCCTTGCC CTACCTGGGC 
GACACGGACC CGCTCAAGGC GGCTGGCCTG CCCGTGGGGG CCTCCGACGG CCTCCTGAGC 
GCGCCCGAGA AAGCCCGGGC CTTCTTGCCG CCGGCCTCGG CGCCCTACTC CCTGCTGGAC 
CCCGCGCAGT TTAGCTCGAG CGCCATCCAG AAGATGGGCG AAGTGCCCCA CACCTTGGCT 
ACCGGCGCTC TGCCCTACGC GTCCACCCTG GGCTACCAGA ACGGCGCCTT CGGCAGCCTC 
AGCTGCCCCA GCCAGCACAC GCACACGCAC CCGTCCCCCA CCAACCCTGG CTACGTGGTG 
CCCTGTAACT GTACCGCCTG GTCTGCCTCC ACCCTGCAGC CCCCCGTCGC CTACATCCTC 
TTCCCAGGCA TGACCAAGAC TGGCATAGAC CCTTATTCGT CAGCCCACGC TACGGCCATG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SOX14 ( NM_004189.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004180.1 Homo sapiens SRY-box 14 (SOX14), mRNA.

Price & Availability↑

CloneID	OHu15429
Clone ID Related Accession (Same CDS sequence)	NM_004189.4 , NM_004189.3
Accession Version	NM_004189.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 723bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-24
Organism	Homo sapiens(human)
Product	transcription factor SOX-14
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC007159.4. This sequence is a reference standard in the RefSeqGene project. On Mar 10, 2011 this sequence version replaced NM_004189.2. Sequence Note: The RefSeq transcript was derived from the reference genome assembly. The genomic coordinates were determined from alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGTCCAAAC CTTCAGACCA CATCAAGCGG CCCATGAACG CCTTCATGGT ATGGTCCCGG 
GGCCAGCGGC GCAAGATGGC CCAGGAAAAC CCCAAGATGC ACAACTCGGA GATCAGCAAA 
CGCCTAGGTG CCGAATGGAA GCTTCTGTCC GAGGCAGAGA AGCGGCCATA CATCGATGAA 
GCCAAGCGGC TACGCGCCCA GCACATGAAG GAGCACCCTG ACTACAAGTA CCGACCTCGG 
CGCAAGCCCA AGAACCTGCT CAAGAAGGAC AGGTATGTCT TCCCCTTGCC CTACCTGGGC 
GACACGGACC CGCTCAAGGC GGCTGGCCTG CCCGTGGGGG CCTCCGACGG CCTCCTGAGC 
GCGCCCGAGA AAGCCCGGGC CTTCTTGCCG CCGGCCTCGG CGCCCTACTC CCTGCTGGAC 
CCCGCGCAGT TTAGCTCGAG CGCCATCCAG AAGATGGGCG AAGTGCCCCA CACCTTGGCT 
ACCGGCGCTC TGCCCTACGC GTCCACCCTG GGCTACCAGA ACGGCGCCTT CGGCAGCCTC 
AGCTGCCCCA GCCAGCACAC GCACACGCAC CCGTCCCCCA CCAACCCTGG CTACGTGGTG 
CCCTGTAACT GTACCGCCTG GTCTGCCTCC ACCCTGCAGC CCCCCGTCGC CTACATCCTC 
TTCCCAGGCA TGACCAAGAC TGGCATAGAC CCTTATTCGT CAGCCCACGC TACGGCCATG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004180.1
CDS	494..1216
Translation	MSKPSDHIKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSEAEKRPYIDEAKRLRAQHMKEHPDYKYRPRRKPKNLLKKDRYVFPLPYLGDTDPLKAAGLPVGASDGLLSAPEKARAFLPPASAPYSLLDPAQFSSSAIQKMGEVPHTLATGALPYASTLGYQNGAFGSLSCPSQHTHTHPSPTNPGYVVPCNCTAWSASTLQPPVAYILFPGMTKTGIDPYSSAHATAM

Target ORF information:

RefSeq Version	NM_004189.3
Organism	Homo sapiens(human)
Definition	Homo sapiens SRY-box 14 (SOX14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004189.3

ORF Insert Sequence:

ATGTCCAAAC CTTCAGACCA CATCAAGCGG CCCATGAACG CCTTCATGGT ATGGTCCCGG 
GGCCAGCGGC GCAAGATGGC CCAGGAAAAC CCCAAGATGC ACAACTCGGA GATCAGCAAA 
CGCCTAGGTG CCGAATGGAA GCTTCTGTCC GAGGCAGAGA AGCGGCCATA CATCGATGAA 
GCCAAGCGGC TACGCGCCCA GCACATGAAG GAGCACCCTG ACTACAAGTA CCGACCTCGG 
CGCAAGCCCA AGAACCTGCT CAAGAAGGAC AGGTATGTCT TCCCCTTGCC CTACCTGGGC 
GACACGGACC CGCTCAAGGC GGCTGGCCTG CCCGTGGGGG CCTCCGACGG CCTCCTGAGC 
GCGCCCGAGA AAGCCCGGGC CTTCTTGCCG CCGGCCTCGG CGCCCTACTC CCTGCTGGAC 
CCCGCGCAGT TTAGCTCGAG CGCCATCCAG AAGATGGGCG AAGTGCCCCA CACCTTGGCT 
ACCGGCGCTC TGCCCTACGC GTCCACCCTG GGCTACCAGA ACGGCGCCTT CGGCAGCCTC 
AGCTGCCCCA GCCAGCACAC GCACACGCAC CCGTCCCCCA CCAACCCTGG CTACGTGGTG 
CCCTGTAACT GTACCGCCTG GTCTGCCTCC ACCCTGCAGC CCCCCGTCGC CTACATCCTC 
TTCCCAGGCA TGACCAAGAC TGGCATAGAC CCTTATTCGT CAGCCCACGC TACGGCCATG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SOX10 is over-expressed in bladder cancer and contributes to the malignant bladder cancer cell behaviors.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico19(8)1035-1044(2017 Aug)
Yin H,Qin C,Zhao Y,Du Y,Sheng Z,Wang Q,Song Q,Chen L,Liu C,Xu T

SOX14 promotes proliferation and invasion of cervical cancer cells through Wnt/?-catenin pathway.
International journal of clinical and experimental pathology8(2)1698-704(2015)
Li F,Wang T,Tang S

Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT.
BMB reports43(8)547-53(2010 Aug)
Kim HY,Cho S,Yu J,Sung S,Kim H

Tissue-specific Forkhead protein FOXA2 up-regulates SOX14 gene expression.
Biochimica et biophysica acta1799(5-6)411-8(2010 May-Jun)
Popovic J,Klajn A,Petrovic I,Stevanovic M

A census of human transcription factors: function, expression and evolution.
Nature reviews. Genetics10(4)252-63(2009 04)
Vaquerizas JM,Kummerfeld SK,Teichmann SA,Luscombe NM

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SOX14 cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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