Gene Symbol | PLA2G6 |
Entrez Gene ID | 8398 |
Full Name | phospholipase A2 group VI |
Synonyms | CaI-PLA2,GVI,INAD1,IPLA2-VIA,NBIA2,NBIA2A,NBIA2B,PARK14,PLA2,PNPLA9,iPLA2,iPLA2beta |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010]. |
Disorder MIM: | |
Disorder Html: | Infantile neuroaxonal dystrophy 1, 256600 (3); Neurodegeneration with brain iron accumulation 2B, 610217 (3); Parkinson disease 14, autosomal recessive, 612953 (3) |