TM2D1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TM2D1
Entrez Gene ID	83941
Full Name	TM2 domain containing 1
Synonyms	BBP
General protein information	Preferred Names TM2 domain containing 1 Names TM2 domain-containing protein 1 Beta-amyloid peptide binding protein amyloid-beta-binding protein beta-amyloid-binding protein hBBP
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p31.3
Summary	The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer's disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death. Several transcript variants have been found for this gene. [provided by RefSeq, Feb 2016].
Disorder MIM:	610080

mRNA and Protein(s)

mRNA	Protein	Name
NM_032027.3	NP_114416.1	TM2 domain-containing protein 1 precursor
NM_032027.2	NP_114416.1	TM2 domain-containing protein 1 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Tm2d1	NP_444387.1
Rattus norvegicus (Norway rat)	Tm2d1	NP_001102140.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007485	XP_308388.3
Xenopus tropicalis (tropical clawed frog)	tm2d1	XP_004914000.1
Homo sapiens (human)	TM2D1	NP_114416.1
Canis lupus familiaris (dog)	LOC479551	XP_003639069.1
Caenorhabditis elegans (roundworm)	Y66D12A.21	NP_499481.2
Gallus gallus (chicken)	TM2D1	XP_001235553.2
Danio rerio (zebrafish)	tm2d1	NP_001092733.1
Danio rerio (zebrafish)	LOC100535396	XP_003201740.1
	TM2D1	XP_001084483.2
Pan troglodytes (chimpanzee)	TM2D1	XP_513448.3
Bos taurus (cattle)	TM2D1	NP_001073061.1
Drosophila melanogaster (fruit fly)	CG10795	NP_611583.1

Gene Ontology
Bibliography

Related articles in PubMed

The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production.
Cam JA, Zerbinatti CV, Knisely JM, Hecimovic S, Li Y, Bu G
The Journal of biological chemistry279(28)29639-46(2004 Jul)

Beta-amyloid peptide binding protein does not couple to G protein in a heterologous Xenopus expression system.
Lee Y, Chang DJ, Lee YS, Chang KA, Kim H, Yoon JS, Lee S, Suh YH, Kaang BK
Journal of neuroscience research73(2)255-9(2003 Jul)

The secretory beta-amyloid precursor protein is a motogen for human epidermal keratinocytes.
Kirfel G, Borm B, Rigort A, Herzog V
European journal of cell biology81(12)664-76(2002 Dec)

beta -Amyloid peptide-induced apoptosis regulated by a novel protein containing a g protein activation module.
Kajkowski EM, Lo CF, Ning X, Walker S, Sofia HJ, Wang W, Edris W, Chanda P, Wagner E, Vile S, Ryan K, McHendry-Rinde B, Smith SC, Wood A, Rhodes KJ, Kennedy JD, Bard J, Jacobsen JS, Ozenberger BA
The Journal of biological chemistry276(22)18748-56(2001 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings reveal that low density lipoprotein receptor-related protein 1B is a novel binding partner of beta-amyloid precursor protein (APP) that functions to decrease APP processing to amyloid beta peptides.
Title: The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production.

A two-electrode voltage-clamp technique is used to determine that BBP is not directly coupled to G alpha(i/o), G alpha(s), or G alpha(q) proteins and that BBP may need a component other than amyloid precursor protein to exert its toxic effect with A beta.
Title: Beta-amyloid peptide binding protein does not couple to G protein in a heterologous Xenopus expression system.

sAPP increased the proportion of migrating keratinocytes and their directional persistence. sAPP appeared to operate synergistically with fibronectin with respect to its motogenic effect.
Title: The secretory beta-amyloid precursor protein is a motogen for human epidermal keratinocytes.

The following TM2D1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TM2D1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17159	NM_032027.3 Latest version!	Homo sapiens TM2 domain containing 1 (TM2D1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu17159	NM_032027.2	Homo sapiens TM2 domain containing 1 (TM2D1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TM2D1 ( NM_032027.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_114416.1 Homo sapiens TM2 domain containing 1 (TM2D1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17159
Clone ID Related Accession (Same CDS sequence)	NM_032027.3 , NM_032027.2
Accession Version	NM_032027.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 624bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-29
Organism	Homo sapiens(human)
Product	TM2 domain-containing protein 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC099791.2. On Nov 30, 2018 this sequence version replaced NM_032027.2. Transcript Variant: This variant (1) represents the protein-coding transcript. ##Evidence-Data-START## Transcript exon combination :: BC029486.1, SRR5189658.3674.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000606498.5/ ENSP00000475700.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCCG CCTGGCCGTC TGGTCCGTCT GCTCCGGAGG CCGTGACGGC CAGACTCGTT 
GGTGTCCTGT GGTTCGTCTC AGTCACTACA GGACCCTGGG GGGCTGTTGC CACCTCCGCC 
GGGGGCGAGG AGTCGCTTAA GTGCGAGGAC CTCAAAGTGG GACAATATAT TTGTAAAGAT 
CCAAAAATAA ATGACGCTAC GCAAGAACCA GTTAACTGTA CAAACTACAC AGCTCATGTT 
TCCTGTTTTC CAGCACCCAA CATAACTTGT AAGGATTCCA GTGGCAATGA AACACATTTT 
ACTGGGAACG AAGTTGGTTT TTTCAAGCCC ATATCTTGCC GAAATGTAAA TGGCTATTCC 
TACAAAGTGG CAGTCGCATT GTCTCTTTTT CTTGGATGGT TGGGAGCAGA TCGATTTTAC 
CTTGGATACC CTGCTTTGGG TTTGTTAAAG TTTTGCACTG TAGGGTTTTG TGGAATTGGG 
AGCCTAATTG ATTTCATTCT TATTTCAATG CAGATTGTTG GACCTTCAGA TGGAAGTAGT 
TACATTATAG ATTACTATGG AACCAGACTT ACAAGACTGA GTATTACTAA TGAAACATTT 
AGAAAAACGC AATTATATCC ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114416.1
CDS	22..645
Translation	MAAAWPSGPSAPEAVTARLVGVLWFVSVTTGPWGAVATSAGGEESLKCEDLKVGQYICKDPKINDATQEPVNCTNYTAHVSCFPAPNITCKDSSGNETHFTGNEVGFFKPISCRNVNGYSYKVAVALSLFLGWLGADRFYLGYPALGLLKFCTVGFCGIGSLIDFILISMQIVGPSDGSSYIIDYYGTRLTRLSITNETFRKTQLYP

Target ORF information:

RefSeq Version	NM_032027.3
Organism	Homo sapiens(human)
Definition	Homo sapiens TM2 domain containing 1 (TM2D1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032027.3

ORF Insert Sequence:

ATGGCGGCCG CCTGGCCGTC TGGTCCGTCT GCTCCGGAGG CCGTGACGGC CAGACTCGTT 
GGTGTCCTGT GGTTCGTCTC AGTCACTACA GGACCCTGGG GGGCTGTTGC CACCTCCGCC 
GGGGGCGAGG AGTCGCTTAA GTGCGAGGAC CTCAAAGTGG GACAATATAT TTGTAAAGAT 
CCAAAAATAA ATGACGCTAC GCAAGAACCA GTTAACTGTA CAAACTACAC AGCTCATGTT 
TCCTGTTTTC CAGCACCCAA CATAACTTGT AAGGATTCCA GTGGCAATGA AACACATTTT 
ACTGGGAACG AAGTTGGTTT TTTCAAGCCC ATATCTTGCC GAAATGTAAA TGGCTATTCC 
TACAAAGTGG CAGTCGCATT GTCTCTTTTT CTTGGATGGT TGGGAGCAGA TCGATTTTAC 
CTTGGATACC CTGCTTTGGG TTTGTTAAAG TTTTGCACTG TAGGGTTTTG TGGAATTGGG 
AGCCTAATTG ATTTCATTCT TATTTCAATG CAGATTGTTG GACCTTCAGA TGGAAGTAGT 
TACATTATAG ATTACTATGG AACCAGACTT ACAAGACTGA GTATTACTAA TGAAACATTT 
AGAAAAACGC AATTATATCC ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TM2D1 ( NM_032027.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_114416.1 Homo sapiens TM2 domain containing 1 (TM2D1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17159
Clone ID Related Accession (Same CDS sequence)	NM_032027.3 , NM_032027.2
Accession Version	NM_032027.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 624bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-25
Organism	Homo sapiens(human)
Product	TM2 domain-containing protein 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF353990.1. On Dec 14, 2001 this sequence version replaced NM_032027.1. Transcript Variant: This variant (1) represents the protein-coding transcript. ##Evidence-Data-START## Transcript exon combination :: AF353990.1, SRR1660809.8485.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal (PMID:11278849) ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCCG CCTGGCCGTC TGGTCCGTCT GCTCCGGAGG CCGTGACGGC CAGACTCGTT 
GGTGTCCTGT GGTTCGTCTC AGTCACTACA GGACCCTGGG GGGCTGTTGC CACCTCCGCC 
GGGGGCGAGG AGTCGCTTAA GTGCGAGGAC CTCAAAGTGG GACAATATAT TTGTAAAGAT 
CCAAAAATAA ATGACGCTAC GCAAGAACCA GTTAACTGTA CAAACTACAC AGCTCATGTT 
TCCTGTTTTC CAGCACCCAA CATAACTTGT AAGGATTCCA GTGGCAATGA AACACATTTT 
ACTGGGAACG AAGTTGGTTT TTTCAAGCCC ATATCTTGCC GAAATGTAAA TGGCTATTCC 
TACAAAGTGG CAGTCGCATT GTCTCTTTTT CTTGGATGGT TGGGAGCAGA TCGATTTTAC 
CTTGGATACC CTGCTTTGGG TTTGTTAAAG TTTTGCACTG TAGGGTTTTG TGGAATTGGG 
AGCCTAATTG ATTTCATTCT TATTTCAATG CAGATTGTTG GACCTTCAGA TGGAAGTAGT 
TACATTATAG ATTACTATGG AACCAGACTT ACAAGACTGA GTATTACTAA TGAAACATTT 
AGAAAAACGC AATTATATCC ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114416.1
CDS	304..927
Translation	MAAAWPSGPSAPEAVTARLVGVLWFVSVTTGPWGAVATSAGGEESLKCEDLKVGQYICKDPKINDATQEPVNCTNYTAHVSCFPAPNITCKDSSGNETHFTGNEVGFFKPISCRNVNGYSYKVAVALSLFLGWLGADRFYLGYPALGLLKFCTVGFCGIGSLIDFILISMQIVGPSDGSSYIIDYYGTRLTRLSITNETFRKTQLYP

Target ORF information:

RefSeq Version	NM_032027.2
Organism	Homo sapiens(human)
Definition	Homo sapiens TM2 domain containing 1 (TM2D1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032027.2

ORF Insert Sequence:

ATGGCGGCCG CCTGGCCGTC TGGTCCGTCT GCTCCGGAGG CCGTGACGGC CAGACTCGTT 
GGTGTCCTGT GGTTCGTCTC AGTCACTACA GGACCCTGGG GGGCTGTTGC CACCTCCGCC 
GGGGGCGAGG AGTCGCTTAA GTGCGAGGAC CTCAAAGTGG GACAATATAT TTGTAAAGAT 
CCAAAAATAA ATGACGCTAC GCAAGAACCA GTTAACTGTA CAAACTACAC AGCTCATGTT 
TCCTGTTTTC CAGCACCCAA CATAACTTGT AAGGATTCCA GTGGCAATGA AACACATTTT 
ACTGGGAACG AAGTTGGTTT TTTCAAGCCC ATATCTTGCC GAAATGTAAA TGGCTATTCC 
TACAAAGTGG CAGTCGCATT GTCTCTTTTT CTTGGATGGT TGGGAGCAGA TCGATTTTAC 
CTTGGATACC CTGCTTTGGG TTTGTTAAAG TTTTGCACTG TAGGGTTTTG TGGAATTGGG 
AGCCTAATTG ATTTCATTCT TATTTCAATG CAGATTGTTG GACCTTCAGA TGGAAGTAGT 
TACATTATAG ATTACTATGG AACCAGACTT ACAAGACTGA GTATTACTAA TGAAACATTT 
AGAAAAACGC AATTATATCC ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production.
The Journal of biological chemistry279(28)29639-46(2004 Jul)
Cam JA,Zerbinatti CV,Knisely JM,Hecimovic S,Li Y,Bu G

Beta-amyloid peptide binding protein does not couple to G protein in a heterologous Xenopus expression system.
Journal of neuroscience research73(2)255-9(2003 Jul)
Lee Y,Chang DJ,Lee YS,Chang KA,Kim H,Yoon JS,Lee S,Suh YH,Kaang BK

The secretory beta-amyloid precursor protein is a motogen for human epidermal keratinocytes.
European journal of cell biology81(12)664-76(2002 Dec)
Kirfel G,Borm B,Rigort A,Herzog V

beta -Amyloid peptide-induced apoptosis regulated by a novel protein containing a g protein activation module.
The Journal of biological chemistry276(22)18748-56(2001 Jun)
Kajkowski EM,Lo CF,Ning X,Walker S,Sofia HJ,Wang W,Edris W,Chanda P,Wagner E,Vile S,Ryan K,McHendry-Rinde B,Smith SC,Wood A,Rhodes KJ,Kennedy JD,Bard J,Jacobsen JS,Ozenberger BA

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TM2D1 cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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