FGFBP2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FGFBP2
Entrez Gene ID	83888
Full Name	fibroblast growth factor binding protein 2
Synonyms	HBP17RP,KSP37
General protein information	Preferred Names fibroblast growth factor binding protein 2 Names fibroblast growth factor-binding protein 2 37 kDa killer-specific secretory protein FGF-BP2 FGF-binding protein 2 FGFBP-2 HBp17-RP HBp17-related protein killer-specific secretory protein of 37 kDa
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4p15.32
Summary	This gene encodes a member of the fibroblast growth factor binding protein family. The encoded protein is a serum protein that is selectively secreted by cytotoxic lymphocytes and may be involved in cytotoxic lymphocyte-mediated immunity. An increase in the amount of gene product may be associated with atopic asthma and mild extrinsic asthma.[provided by RefSeq Staff, Oct 2008].
Disorder MIM:	607713

mRNA and Protein(s)

mRNA	Protein	Name
NM_031950.3	NP_114156.1	fibroblast growth factor-binding protein 2 precursor
NM_031950.4	NP_114156.1	fibroblast growth factor-binding protein 2 precursor

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	fgfbp2a	XP_001332722.1
Xenopus tropicalis (tropical clawed frog)	fgfbp2	XP_002938685.1
Homo sapiens (human)	FGFBP2	NP_114156.1
	FGFBP2	XP_001100132.1
Danio rerio (zebrafish)	fgfbp2b	NP_001082995.1
Pan troglodytes (chimpanzee)	FGFBP2	XP_526532.2
Gallus gallus (chicken)	FGFBP2	NP_989778.1

Gene Ontology
Bibliography

Related articles in PubMed

Killer-specific secretory (Ksp37) gene expression in subjects with Down's syndrome.
Salemi M, Barone C, Morale MC, Caniglia S, Romano C, Salluzzo MG, Rando RG, Ragalmuto A, Bosco P, Romano C
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology37(5)793-5(2016 May)

Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans.
Jeff JM, Ritchie MD, Denny JC, Kho AN, Ramirez AH, Crosslin D, Armstrong L, Basford MA, Wolf WA, Pacheco JA, Chisholm RL, Roden DM, Hayes MG, Crawford DC
Annals of human genetics77(4)321-32(2013 Jul)

POLD2 and KSP37 (FGFBP2) correlate strongly with histology, stage and outcome in ovarian carcinomas.
Elgaaen BV, Haug KB, Wang J, Olstad OK, Fortunati D, Onsrud M, Staff AC, Sauer T, Gautvik KM
PloS one5(11)e13837(2010 Nov)

Identification of expressed genes characterizing long-term survival in malignant glioma patients.
Yamanaka R, Arao T, Yajima N, Tsuchiya N, Homma J, Tanaka R, Sano M, Oide A, Sekijima M, Nishio K
Oncogene25(44)5994-6002(2006 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results of this study suggest that the expression of Ksp37 gene might be associated with increased susceptibility of individuals with Down syndrome to EBV infections and autoimmune problems.
Title: Killer-specific secretory (Ksp37) gene expression in subjects with Down's syndrome.

Results suggest that POLD2 and KSP37 might be potential prognostic biomarkers.
Title: POLD2 and KSP37 (FGFBP2) correlate strongly with histology, stage and outcome in ovarian carcinomas.

Secreted from NK cells in decidua, elevated at late gestational period.
Title: Accumulation of CD16+ cells with secretion of Ksp37 in decidua at the end of pregnancy.

The following FGFBP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FGFBP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04720	NM_031950.4 Latest version!	Homo sapiens fibroblast growth factor binding protein 2 (FGFBP2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu04720	NM_031950.3	Homo sapiens fibroblast growth factor binding protein 2 (FGFBP2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FGFBP2 ( NM_031950.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_114156.1 Homo sapiens fibroblast growth factor binding protein 2 (FGFBP2), mRNA.

Price & Availability↑

CloneID	OHu04720
Clone ID Related Accession (Same CDS sequence)	NM_031950.3 , NM_031950.4
Accession Version	NM_031950.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 672bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	fibroblast growth factor-binding protein 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY358978.1, AC005598.6 and CN480296.1. On Oct 3, 2008 this sequence version replaced NM_031950.2. ##Evidence-Data-START## Transcript exon combination :: AY358978.1, BC025720.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01820693 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGTTCG TCCCCTGCCT CCTGCTGGTG ACCTTGTCCT GCCTGGGGAC TTTGGGTCAG 
GCCCCGAGGC AAAAGCAAGG AAGCACTGGG GAGGAATTCC ATTTCCAGAC TGGAGGGAGA 
GATTCCTGCA CTATGCGTCC CAGCAGCTTG GGGCAAGGTG CTGGAGAAGT CTGGCTTCGT 
GTCGACTGCC GCAACACAGA CCAGACCTAC TGGTGTGAGT ACAGGGGGCA GCCCAGCATG 
TGCCAGGCTT TCGCTGCTGA CCCCAAACCT TACTGGAATC AAGCCCTGCA GGAGCTGAGG 
CGCCTTCACC ATGCGTGCCA GGGGGCCCCG GTGCTTAGGC CATCCGTGTG CAGGGAGGCT 
GGACCCCAGG CCCATATGCA GCAGGTGACT TCCAGCCTCA AGGGCAGCCC AGAGCCCAAC 
CAGCAGCCTG AGGCTGGGAC GCCATCTCTG AGGCCCAAGG CCACAGTGAA ACTCACAGAA 
GCAACACAGC TGGGAAAGGA CTCGATGGAA GAGCTGGGAA AAGCCAAACC CACCACCCGA 
CCCACAGCCA AACCTACCCA GCCTGGACCC AGGCCCGGAG GGAATGAGGA AGCAAAGAAG 
AAGGCCTGGG AACATTGTTG GAAACCCTTC CAGGCCCTGT GCGCCTTTCT CATCAGCTTC 
TTCCGAGGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114156.1
CDS	108..779
Translation	MKFVPCLLLVTLSCLGTLGQAPRQKQGSTGEEFHFQTGGRDSCTMRPSSLGQGAGEVWLRVDCRNTDQTYWCEYRGQPSMCQAFAADPKPYWNQALQELRRLHHACQGAPVLRPSVCREAGPQAHMQQVTSSLKGSPEPNQQPEAGTPSLRPKATVKLTEATQLGKDSMEELGKAKPTTRPTAKPTQPGPRPGGNEEAKKKAWEHCWKPFQALCAFLISFFRG

Target ORF information:

RefSeq Version	NM_031950.3
Organism	Homo sapiens(human)
Definition	Homo sapiens fibroblast growth factor binding protein 2 (FGFBP2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031950.3

ORF Insert Sequence:

ATGAAGTTCG TCCCCTGCCT CCTGCTGGTG ACCTTGTCCT GCCTGGGGAC TTTGGGTCAG 
GCCCCGAGGC AAAAGCAAGG AAGCACTGGG GAGGAATTCC ATTTCCAGAC TGGAGGGAGA 
GATTCCTGCA CTATGCGTCC CAGCAGCTTG GGGCAAGGTG CTGGAGAAGT CTGGCTTCGT 
GTCGACTGCC GCAACACAGA CCAGACCTAC TGGTGTGAGT ACAGGGGGCA GCCCAGCATG 
TGCCAGGCTT TCGCTGCTGA CCCCAAACCT TACTGGAATC AAGCCCTGCA GGAGCTGAGG 
CGCCTTCACC ATGCGTGCCA GGGGGCCCCG GTGCTTAGGC CATCCGTGTG CAGGGAGGCT 
GGACCCCAGG CCCATATGCA GCAGGTGACT TCCAGCCTCA AGGGCAGCCC AGAGCCCAAC 
CAGCAGCCTG AGGCTGGGAC GCCATCTCTG AGGCCCAAGG CCACAGTGAA ACTCACAGAA 
GCAACACAGC TGGGAAAGGA CTCGATGGAA GAGCTGGGAA AAGCCAAACC CACCACCCGA 
CCCACAGCCA AACCTACCCA GCCTGGACCC AGGCCCGGAG GGAATGAGGA AGCAAAGAAG 
AAGGCCTGGG AACATTGTTG GAAACCCTTC CAGGCCCTGT GCGCCTTTCT CATCAGCTTC 
TTCCGAGGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FGFBP2 ( NM_031950.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_114156.1 Homo sapiens fibroblast growth factor binding protein 2 (FGFBP2), mRNA.

Price & Availability↑

CloneID	OHu04720
Clone ID Related Accession (Same CDS sequence)	NM_031950.3 , NM_031950.4
Accession Version	NM_031950.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 672bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	fibroblast growth factor-binding protein 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY358978.1, AC005598.6 and CN480296.1. On Nov 22, 2018 this sequence version replaced NM_031950.3. ##Evidence-Data-START## Transcript exon combination :: AY358978.1, BC025720.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01820693 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000259989.7/ ENSP00000259989.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGTTCG TCCCCTGCCT CCTGCTGGTG ACCTTGTCCT GCCTGGGGAC TTTGGGTCAG 
GCCCCGAGGC AAAAGCAAGG AAGCACTGGG GAGGAATTCC ATTTCCAGAC TGGAGGGAGA 
GATTCCTGCA CTATGCGTCC CAGCAGCTTG GGGCAAGGTG CTGGAGAAGT CTGGCTTCGT 
GTCGACTGCC GCAACACAGA CCAGACCTAC TGGTGTGAGT ACAGGGGGCA GCCCAGCATG 
TGCCAGGCTT TCGCTGCTGA CCCCAAACCT TACTGGAATC AAGCCCTGCA GGAGCTGAGG 
CGCCTTCACC ATGCGTGCCA GGGGGCCCCG GTGCTTAGGC CATCCGTGTG CAGGGAGGCT 
GGACCCCAGG CCCATATGCA GCAGGTGACT TCCAGCCTCA AGGGCAGCCC AGAGCCCAAC 
CAGCAGCCTG AGGCTGGGAC GCCATCTCTG AGGCCCAAGG CCACAGTGAA ACTCACAGAA 
GCAACACAGC TGGGAAAGGA CTCGATGGAA GAGCTGGGAA AAGCCAAACC CACCACCCGA 
CCCACAGCCA AACCTACCCA GCCTGGACCC AGGCCCGGAG GGAATGAGGA AGCAAAGAAG 
AAGGCCTGGG AACATTGTTG GAAACCCTTC CAGGCCCTGT GCGCCTTTCT CATCAGCTTC 
TTCCGAGGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114156.1
CDS	47..718
Translation	MKFVPCLLLVTLSCLGTLGQAPRQKQGSTGEEFHFQTGGRDSCTMRPSSLGQGAGEVWLRVDCRNTDQTYWCEYRGQPSMCQAFAADPKPYWNQALQELRRLHHACQGAPVLRPSVCREAGPQAHMQQVTSSLKGSPEPNQQPEAGTPSLRPKATVKLTEATQLGKDSMEELGKAKPTTRPTAKPTQPGPRPGGNEEAKKKAWEHCWKPFQALCAFLISFFRG

Target ORF information:

RefSeq Version	NM_031950.4
Organism	Homo sapiens(human)
Definition	Homo sapiens fibroblast growth factor binding protein 2 (FGFBP2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031950.4

ORF Insert Sequence:

ATGAAGTTCG TCCCCTGCCT CCTGCTGGTG ACCTTGTCCT GCCTGGGGAC TTTGGGTCAG 
GCCCCGAGGC AAAAGCAAGG AAGCACTGGG GAGGAATTCC ATTTCCAGAC TGGAGGGAGA 
GATTCCTGCA CTATGCGTCC CAGCAGCTTG GGGCAAGGTG CTGGAGAAGT CTGGCTTCGT 
GTCGACTGCC GCAACACAGA CCAGACCTAC TGGTGTGAGT ACAGGGGGCA GCCCAGCATG 
TGCCAGGCTT TCGCTGCTGA CCCCAAACCT TACTGGAATC AAGCCCTGCA GGAGCTGAGG 
CGCCTTCACC ATGCGTGCCA GGGGGCCCCG GTGCTTAGGC CATCCGTGTG CAGGGAGGCT 
GGACCCCAGG CCCATATGCA GCAGGTGACT TCCAGCCTCA AGGGCAGCCC AGAGCCCAAC 
CAGCAGCCTG AGGCTGGGAC GCCATCTCTG AGGCCCAAGG CCACAGTGAA ACTCACAGAA 
GCAACACAGC TGGGAAAGGA CTCGATGGAA GAGCTGGGAA AAGCCAAACC CACCACCCGA 
CCCACAGCCA AACCTACCCA GCCTGGACCC AGGCCCGGAG GGAATGAGGA AGCAAAGAAG 
AAGGCCTGGG AACATTGTTG GAAACCCTTC CAGGCCCTGT GCGCCTTTCT CATCAGCTTC 
TTCCGAGGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Killer-specific secretory (Ksp37) gene expression in subjects with Down's syndrome.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology37(5)793-5(2016 May)
Salemi M,Barone C,Morale MC,Caniglia S,Romano C,Salluzzo MG,Rando RG,Ragalmuto A,Bosco P,Romano C

Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans.
Annals of human genetics77(4)321-32(2013 Jul)
Jeff JM,Ritchie MD,Denny JC,Kho AN,Ramirez AH,Crosslin D,Armstrong L,Basford MA,Wolf WA,Pacheco JA,Chisholm RL,Roden DM,Hayes MG,Crawford DC

POLD2 and KSP37 (FGFBP2) correlate strongly with histology, stage and outcome in ovarian carcinomas.
PloS one5(11)e13837(2010 Nov)
Elgaaen BV,Haug KB,Wang J,Olstad OK,Fortunati D,Onsrud M,Staff AC,Sauer T,Gautvik KM

Identification of expressed genes characterizing long-term survival in malignant glioma patients.
Oncogene25(44)5994-6002(2006 Sep)
Yamanaka R,Arao T,Yajima N,Tsuchiya N,Homma J,Tanaka R,Sano M,Oide A,Sekijima M,Nishio K

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FGFBP2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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