MS4A8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MS4A8
Entrez Gene ID	83661
Full Name	membrane spanning 4-domains A8
Synonyms	4SPAN4,CD20L5,MS4A4,MS4A8B
General protein information	Preferred Names membrane spanning 4-domains A8 Names membrane-spanning 4-domains subfamily A member 8 four-span transmembrane protein 4 membrane-spanning 4-domains, subfamily A, member 8B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q12.2
Summary	This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.3, among a cluster of family members. [provided by RefSeq, Jul 2008].
Disorder MIM:	606549

mRNA and Protein(s)

mRNA	Protein	Name
NM_031457.1	NP_113645.1	membrane-spanning 4-domains subfamily A member 8
NM_031457.2	NP_113645.1	membrane-spanning 4-domains subfamily A member 8

Pathways from BioSystems

Homologies

Homo sapiens (human)	MS4A8	NP_113645.1
Pan troglodytes (chimpanzee)	MS4A8B	XP_508463.2
Bos taurus (cattle)	MS4A8B	NP_001029228.1
Mus musculus (house mouse)	Ms4a8a	NP_071875.2
Rattus norvegicus (Norway rat)	Ms4a8	NP_001101989.1
	MS4A8B	XP_001085445.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification of the novel differentiation marker MS4A8B and its murine homolog MS4A8A in colonic epithelial cells lost during neoplastic transformation in human colon.
Michel J, Sch?nhaar K, Schledzewski K, Gkaniatsou C, Sticht C, Kellert B, Lasitschka F, G?raud C, Goerdt S, Schmieder A
Cell death & disease4e469(2013 Jan)

Structural organization of the human MS4A gene cluster on Chromosome 11q12.
Liang Y, Buckley TR, Tu L, Langdon SD, Tedder TF
Immunogenetics53(5)357-68(2001 Jul)

Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse.
Liang Y, Tedder TF
Genomics72(2)119-27(2001 Mar)

Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor.
Ishibashi K, Suzuki M, Sasaki S, Imai M
Gene264(1)87-93(2001 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MS4A8B is a novel differentiation marker of the intestinal epithelium that supports the maintenance of a physiological barrier function in the gut by modulating the transcriptome and by conferring an increased resistance to reactive oxygen species.
Title: Identification of the novel differentiation marker MS4A8B and its murine homolog MS4A8A in colonic epithelial cells lost during neoplastic transformation in human colon.

The following MS4A8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MS4A8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30845	NM_031457.2 Latest version!	Homo sapiens membrane spanning 4-domains A8 (MS4A8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu30845	NM_031457.1	Homo sapiens membrane spanning 4-domains A8 (MS4A8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MS4A8 ( NM_031457.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_113645.1 Homo sapiens membrane spanning 4-domains A8 (MS4A8), mRNA.

Price & Availability↑

CloneID	OHu30845
Clone ID Related Accession (Same CDS sequence)	NM_031457.1 , NM_031457.2
Accession Version	NM_031457.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 753bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	membrane-spanning 4-domains subfamily A member 8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF237905.1. ##Evidence-Data-START## Transcript exon combination :: AF237905.1, ERR279829.3052.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAATTCGA TGACTTCAGC AGTTCCGGTG GCCAATTCTG TGTTGGTGGT GGCACCCCAC 
AATGGTTATC CTGTGACCCC AGGAATTATG TCTCACGTGC CCCTGTATCC AAACAGCCAG 
CCGCAAGTCC ACCTAGTTCC TGGGAACCCA CCTAGTTTGG TGTCGAATGT GAATGGGCAG 
CCTGTGCAGA AAGCTCTGAA AGAAGGCAAA ACCTTGGGGG CCATCCAGAT CATCATTGGC 
CTGGCTCACA TCGGCCTCGG CTCCATCATG GCGACGGTTC TCGTAGGGGA ATACCTGTCT 
ATTTCATTCT ACGGAGGCTT TCCCTTCTGG GGAGGCTTGT GGTTTATCAT TTCAGGATCT 
CTCTCCGTGG CAGCAGAAAA TCAGCCATAT TCTTATTGCC TGCTGTCTGG CAGTTTGGGC 
TTGAACATCG TCAGTGCAAT CTGCTCTGCA GTTGGAGTCA TACTCTTCAT CACAGATCTA 
AGTATTCCCC ACCCATATGC CTACCCCGAC TATTATCCTT ACGCCTGGGG TGTGAACCCT 
GGAATGGCGA TTTCTGGCGT GCTGCTGGTC TTCTGCCTCC TGGAGTTTGG CATCGCATGC 
GCATCTTCCC ACTTTGGCTG CCAGTTGGTC TGCTGTCAAT CAAGCAATGT GAGTGTCATC 
TATCCAAACA TCTATGCAGC AAACCCAGTG ATCACCCCAG AACCGGTGAC CTCACCACCA 
AGTTATTCCA GTGAGATCCA AGCAAATAAG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113645.1
CDS	204..956
Translation	MNSMTSAVPVANSVLVVAPHNGYPVTPGIMSHVPLYPNSQPQVHLVPGNPPSLVSNVNGQPVQKALKEGKTLGAIQIIIGLAHIGLGSIMATVLVGEYLSISFYGGFPFWGGLWFIISGSLSVAAENQPYSYCLLSGSLGLNIVSAICSAVGVILFITDLSIPHPYAYPDYYPYAWGVNPGMAISGVLLVFCLLEFGIACASSHFGCQLVCCQSSNVSVIYPNIYAANPVITPEPVTSPPSYSSEIQANK

Target ORF information:

RefSeq Version	NM_031457.1
Organism	Homo sapiens(human)
Definition	Homo sapiens membrane spanning 4-domains A8 (MS4A8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031457.1

ORF Insert Sequence:

ATGAATTCGA TGACTTCAGC AGTTCCGGTG GCCAATTCTG TGTTGGTGGT GGCACCCCAC 
AATGGTTATC CTGTGACCCC AGGAATTATG TCTCACGTGC CCCTGTATCC AAACAGCCAG 
CCGCAAGTCC ACCTAGTTCC TGGGAACCCA CCTAGTTTGG TGTCGAATGT GAATGGGCAG 
CCTGTGCAGA AAGCTCTGAA AGAAGGCAAA ACCTTGGGGG CCATCCAGAT CATCATTGGC 
CTGGCTCACA TCGGCCTCGG CTCCATCATG GCGACGGTTC TCGTAGGGGA ATACCTGTCT 
ATTTCATTCT ACGGAGGCTT TCCCTTCTGG GGAGGCTTGT GGTTTATCAT TTCAGGATCT 
CTCTCCGTGG CAGCAGAAAA TCAGCCATAT TCTTATTGCC TGCTGTCTGG CAGTTTGGGC 
TTGAACATCG TCAGTGCAAT CTGCTCTGCA GTTGGAGTCA TACTCTTCAT CACAGATCTA 
AGTATTCCCC ACCCATATGC CTACCCCGAC TATTATCCTT ACGCCTGGGG TGTGAACCCT 
GGAATGGCGA TTTCTGGCGT GCTGCTGGTC TTCTGCCTCC TGGAGTTTGG CATCGCATGC 
GCATCTTCCC ACTTTGGCTG CCAGTTGGTC TGCTGTCAAT CAAGCAATGT GAGTGTCATC 
TATCCAAACA TCTATGCAGC AAACCCAGTG ATCACCCCAG AACCGGTGAC CTCACCACCA 
AGTTATTCCA GTGAGATCCA AGCAAATAAG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MS4A8 ( NM_031457.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_113645.1 Homo sapiens membrane spanning 4-domains A8 (MS4A8), mRNA.

Price & Availability↑

CloneID	OHu30845
Clone ID Related Accession (Same CDS sequence)	NM_031457.1 , NM_031457.2
Accession Version	NM_031457.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 753bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	membrane-spanning 4-domains subfamily A member 8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF237905.1. On Nov 22, 2018 this sequence version replaced NM_031457.1. ##Evidence-Data-START## Transcript exon combination :: BC022895.1, AF237905.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000300226.7/ ENSP00000300226.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAATTCGA TGACTTCAGC AGTTCCGGTG GCCAATTCTG TGTTGGTGGT GGCACCCCAC 
AATGGTTATC CTGTGACCCC AGGAATTATG TCTCACGTGC CCCTGTATCC AAACAGCCAG 
CCGCAAGTCC ACCTAGTTCC TGGGAACCCA CCTAGTTTGG TGTCGAATGT GAATGGGCAG 
CCTGTGCAGA AAGCTCTGAA AGAAGGCAAA ACCTTGGGGG CCATCCAGAT CATCATTGGC 
CTGGCTCACA TCGGCCTCGG CTCCATCATG GCGACGGTTC TCGTAGGGGA ATACCTGTCT 
ATTTCATTCT ACGGAGGCTT TCCCTTCTGG GGAGGCTTGT GGTTTATCAT TTCAGGATCT 
CTCTCCGTGG CAGCAGAAAA TCAGCCATAT TCTTATTGCC TGCTGTCTGG CAGTTTGGGC 
TTGAACATCG TCAGTGCAAT CTGCTCTGCA GTTGGAGTCA TACTCTTCAT CACAGATCTA 
AGTATTCCCC ACCCATATGC CTACCCCGAC TATTATCCTT ACGCCTGGGG TGTGAACCCT 
GGAATGGCGA TTTCTGGCGT GCTGCTGGTC TTCTGCCTCC TGGAGTTTGG CATCGCATGC 
GCATCTTCCC ACTTTGGCTG CCAGTTGGTC TGCTGTCAAT CAAGCAATGT GAGTGTCATC 
TATCCAAACA TCTATGCAGC AAACCCAGTG ATCACCCCAG AACCGGTGAC CTCACCACCA 
AGTTATTCCA GTGAGATCCA AGCAAATAAG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113645.1
CDS	166..918
Translation	MNSMTSAVPVANSVLVVAPHNGYPVTPGIMSHVPLYPNSQPQVHLVPGNPPSLVSNVNGQPVQKALKEGKTLGAIQIIIGLAHIGLGSIMATVLVGEYLSISFYGGFPFWGGLWFIISGSLSVAAENQPYSYCLLSGSLGLNIVSAICSAVGVILFITDLSIPHPYAYPDYYPYAWGVNPGMAISGVLLVFCLLEFGIACASSHFGCQLVCCQSSNVSVIYPNIYAANPVITPEPVTSPPSYSSEIQANK

Target ORF information:

RefSeq Version	NM_031457.2
Organism	Homo sapiens(human)
Definition	Homo sapiens membrane spanning 4-domains A8 (MS4A8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031457.2

ORF Insert Sequence:

ATGAATTCGA TGACTTCAGC AGTTCCGGTG GCCAATTCTG TGTTGGTGGT GGCACCCCAC 
AATGGTTATC CTGTGACCCC AGGAATTATG TCTCACGTGC CCCTGTATCC AAACAGCCAG 
CCGCAAGTCC ACCTAGTTCC TGGGAACCCA CCTAGTTTGG TGTCGAATGT GAATGGGCAG 
CCTGTGCAGA AAGCTCTGAA AGAAGGCAAA ACCTTGGGGG CCATCCAGAT CATCATTGGC 
CTGGCTCACA TCGGCCTCGG CTCCATCATG GCGACGGTTC TCGTAGGGGA ATACCTGTCT 
ATTTCATTCT ACGGAGGCTT TCCCTTCTGG GGAGGCTTGT GGTTTATCAT TTCAGGATCT 
CTCTCCGTGG CAGCAGAAAA TCAGCCATAT TCTTATTGCC TGCTGTCTGG CAGTTTGGGC 
TTGAACATCG TCAGTGCAAT CTGCTCTGCA GTTGGAGTCA TACTCTTCAT CACAGATCTA 
AGTATTCCCC ACCCATATGC CTACCCCGAC TATTATCCTT ACGCCTGGGG TGTGAACCCT 
GGAATGGCGA TTTCTGGCGT GCTGCTGGTC TTCTGCCTCC TGGAGTTTGG CATCGCATGC 
GCATCTTCCC ACTTTGGCTG CCAGTTGGTC TGCTGTCAAT CAAGCAATGT GAGTGTCATC 
TATCCAAACA TCTATGCAGC AAACCCAGTG ATCACCCCAG AACCGGTGAC CTCACCACCA 
AGTTATTCCA GTGAGATCCA AGCAAATAAG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of the novel differentiation marker MS4A8B and its murine homolog MS4A8A in colonic epithelial cells lost during neoplastic transformation in human colon.
Cell death & disease4e469(2013 Jan)
Michel J,Sch?nhaar K,Schledzewski K,Gkaniatsou C,Sticht C,Kellert B,Lasitschka F,G?raud C,Goerdt S,Schmieder A

Structural organization of the human MS4A gene cluster on Chromosome 11q12.
Immunogenetics53(5)357-68(2001 Jul)
Liang Y,Buckley TR,Tu L,Langdon SD,Tedder TF

Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse.
Genomics72(2)119-27(2001 Mar)
Liang Y,Tedder TF

Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor.
Gene264(1)87-93(2001 Feb)
Ishibashi K,Suzuki M,Sasaki S,Imai M

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MS4A8 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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