DYNLRB1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DYNLRB1
Entrez Gene ID	83658
Full Name	dynein light chain roadblock-type 1
Synonyms	BITH,BLP,DNCL2A,DNLC2A,ROBLD1
General protein information	Preferred Names dynein light chain roadblock-type 1 Names dynein light chain roadblock-type 1 ROBL/LC7-like 1 bithoraxoid-like protein dynein, cytoplasmic, light polypeptide 2A dynein-associated protein Km23 roadblock domain-containing protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q11.22
Summary	This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013].
Disorder MIM:	607167

mRNA and Protein(s)

mRNA	Protein	Name
NM_001281729.1	NP_001268658.1	dynein light chain roadblock-type 1 isoform c
NM_001281728.1	NP_001268657.1	dynein light chain roadblock-type 1 isoform b
NM_014183.3	NP_054902.1	dynein light chain roadblock-type 1 isoform a
NM_177953.2	NP_808852.1	dynein light chain roadblock-type 1 isoform b
NM_001281727.1	NP_001268656.1	dynein light chain roadblock-type 1 isoform b
NM_001319157.1	NP_001306086.1	dynein light chain roadblock-type 1 isoform d

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Dynlrb1	NP_571985.1
Pan troglodytes (chimpanzee)	DYNLRB1	XP_514596.1
Canis lupus familiaris (dog)	DYNLRB1	NP_001239348.1
Bos taurus (cattle)	DYNLRB1	NP_001029614.1
Mus musculus (house mouse)	Dynlrb1	NP_080223.2
Gallus gallus (chicken)	DYNLRB1	XP_417328.3
Danio rerio (zebrafish)	dynlrb1	NP_957482.1
Caenorhabditis elegans (roundworm)	dyrb-1	NP_495943.1
Xenopus tropicalis (tropical clawed frog)	dynlrb1	NP_001093687.1
Homo sapiens (human)	DYNLRB1	NP_054902.1

Gene Ontology
Bibliography

Related articles in PubMed

Requirement for protein kinase A in the phosphorylation of the TGF? receptor-interacting protein km23-1 as a component of TGF? downstream effects.
Jin Q, Zhong Y, Mulder KM
Experimental cell research319(6)897-907(2013 Apr)

Decreased tumor progression and invasion by a novel anti-cell motility target for human colorectal carcinoma cells.
Jin Q, Liu G, Domeier PP, Ding W, Mulder KM
PloS one8(6)e66439(2013)

Role of km23-1 in RhoA/actin-based cell migration.
Jin Q, Pulipati NR, Zhou W, Staub CM, Liotta LA, Mulder KM
Biochemical and biophysical research communications428(3)333-8(2012 Nov)

The TGF? receptor-interacting protein km23-1/DYNLRB1 plays an adaptor role in TGF?1 autoinduction via its association with Ras.
Jin Q, Ding W, Mulder KM
The Journal of biological chemistry287(31)26453-63(2012 Jul)

Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.
Jakobsen L, Vanselow K, Skogs M, Toyoda Y, Lundberg E, Poser I, Falkenby LG, Bennetzen M, Westendorf J, Nigg EA, Uhlen M, Hyman AA, Andersen JS
The EMBO journal30(8)1520-35(2011 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TGFbeta regulates km23-1 interaction with the R1beta regulatory subunit of protein kinase A.
Title: Requirement for protein kinase A in the phosphorylation of the TGF? receptor-interacting protein km23-1 as a component of TGF? downstream effects.

Human colorectal carcinoma cells display decreased tumor progression and invasion when a novel anti-cell motility target, DYNLRB1, is being silenced.
Title: Decreased tumor progression and invasion by a novel anti-cell motility target for human colorectal carcinoma cells.

these findings demonstrate that km23-1 regulates RhoA and motility-associated actin modulating proteins, suggesting that km23-1 may represent a novel target for anti-metastatic therapy.
Title: Role of km23-1 in RhoA/actin-based cell migration.

km23-1 is required for TGFbeta1 autoinduction through Smad2-independent Ras/ERK/JNK pathways
Title: The TGF? receptor-interacting protein km23-1/DYNLRB1 plays an adaptor role in TGF?1 autoinduction via its association with Ras.

Findings indicate that km23-2 (DYNLRB2) is required for Smad3-dependent TGFbeta signaling. Km23-2 has functions in TGFbeta signaling that are distinct from those for km23-1 (DYNLRB1).
Title: Requirement of a dynein light chain in TGFbeta/Smad3 signaling.

The following DYNLRB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DYNLRB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16711	NM_001281727.1 Latest version!	Homo sapiens dynein light chain roadblock-type 1 (DYNLRB1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu16711	NM_177953.2 Latest version!	Homo sapiens dynein light chain roadblock-type 1 (DYNLRB1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu16711	NM_001281728.1 Latest version!	Homo sapiens dynein light chain roadblock-type 1 (DYNLRB1), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu16824	NM_014183.3 Latest version!	Homo sapiens dynein light chain roadblock-type 1 (DYNLRB1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu16833	NM_001281729.1 Latest version!	Homo sapiens dynein light chain roadblock-type 1 (DYNLRB1), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu53121	NM_001319157.1 Latest version!	Homo sapiens dynein light chain roadblock-type 1 (DYNLRB1), transcript variant 7, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DYNLRB1 ( NM_001281728.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001268657.1 Homo sapiens dynein light chain roadblock-type 1 (DYNLRB1), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu16711
Clone ID Related Accession (Same CDS sequence)	NM_001281728.1 , NM_177953.2 , NM_001281727.1
Accession Version	NM_001281728.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 192bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	dynein light chain roadblock-type 1 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB149456.1, BQ639804.1 and AF165516.1. Transcript Variant: This variant (4) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3, and 4 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.623813.1, BQ639804.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144120, SAMEA2145313 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACAACC CCACCACCAC CCAGTATGCC AGCCTCATGC ACAGCTTCAT CCTGAAGGCA 
CGGAGCACCG TGCGTGACAT CGACCCCCAG AACGATCTCA CCTTCCTTCG AATTCGCTCC 
AAGAAAAATG AAATTATGGT TGCACCAGAT AAAGACTATT TCCTGATTGT GATTCAGAAT 
CCAACCGAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001268657.1
CDS	250..441
Translation	MDNPTTTQYASLMHSFILKARSTVRDIDPQNDLTFLRIRSKKNEIMVAPDKDYFLIVIQNPTE

Target ORF information:

RefSeq Version	NM_001281728.1
Organism	Homo sapiens(human)
Definition	Homo sapiens dynein light chain roadblock-type 1 (DYNLRB1), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001281728.1

ORF Insert Sequence:

ATGGACAACC CCACCACCAC CCAGTATGCC AGCCTCATGC ACAGCTTCAT CCTGAAGGCA 
CGGAGCACCG TGCGTGACAT CGACCCCCAG AACGATCTCA CCTTCCTTCG AATTCGCTCC 
AAGAAAAATG AAATTATGGT TGCACCAGAT AAAGACTATT TCCTGATTGT GATTCAGAAT 
CCAACCGAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DYNLRB1 ( NM_177953.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_808852.1 Homo sapiens dynein light chain roadblock-type 1 (DYNLRB1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu16711
Clone ID Related Accession (Same CDS sequence)	NM_001281728.1 , NM_177953.2 , NM_001281727.1
Accession Version	NM_177953.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 192bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-04
Organism	Homo sapiens(human)
Product	dynein light chain roadblock-type 1 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB149456.1, BM791453.1 and AF165516.1. On Aug 1, 2013 this sequence version replaced NM_177953.1. Transcript Variant: This variant (2) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3, and 4 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG761048.1, ERR279849.1193.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2144120 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACAACC CCACCACCAC CCAGTATGCC AGCCTCATGC ACAGCTTCAT CCTGAAGGCA 
CGGAGCACCG TGCGTGACAT CGACCCCCAG AACGATCTCA CCTTCCTTCG AATTCGCTCC 
AAGAAAAATG AAATTATGGT TGCACCAGAT AAAGACTATT TCCTGATTGT GATTCAGAAT 
CCAACCGAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_808852.1
CDS	254..445
Translation	MDNPTTTQYASLMHSFILKARSTVRDIDPQNDLTFLRIRSKKNEIMVAPDKDYFLIVIQNPTE

Target ORF information:

RefSeq Version	NM_177953.2
Organism	Homo sapiens(human)
Definition	Homo sapiens dynein light chain roadblock-type 1 (DYNLRB1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177953.2

ORF Insert Sequence:

ATGGACAACC CCACCACCAC CCAGTATGCC AGCCTCATGC ACAGCTTCAT CCTGAAGGCA 
CGGAGCACCG TGCGTGACAT CGACCCCCAG AACGATCTCA CCTTCCTTCG AATTCGCTCC 
AAGAAAAATG AAATTATGGT TGCACCAGAT AAAGACTATT TCCTGATTGT GATTCAGAAT 
CCAACCGAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DYNLRB1 ( NM_001281727.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001268656.1 Homo sapiens dynein light chain roadblock-type 1 (DYNLRB1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu16711
Clone ID Related Accession (Same CDS sequence)	NM_001281728.1 , NM_177953.2 , NM_001281727.1
Accession Version	NM_001281727.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 192bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-04
Organism	Homo sapiens(human)
Product	dynein light chain roadblock-type 1 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB149456.1 and AF165516.1. Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3, and 4 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB149456.1, ERR279858.4146.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACAACC CCACCACCAC CCAGTATGCC AGCCTCATGC ACAGCTTCAT CCTGAAGGCA 
CGGAGCACCG TGCGTGACAT CGACCCCCAG AACGATCTCA CCTTCCTTCG AATTCGCTCC 
AAGAAAAATG AAATTATGGT TGCACCAGAT AAAGACTATT TCCTGATTGT GATTCAGAAT 
CCAACCGAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001268656.1
CDS	171..362
Translation	MDNPTTTQYASLMHSFILKARSTVRDIDPQNDLTFLRIRSKKNEIMVAPDKDYFLIVIQNPTE

Target ORF information:

RefSeq Version	NM_001281727.1
Organism	Homo sapiens(human)
Definition	Homo sapiens dynein light chain roadblock-type 1 (DYNLRB1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001281727.1

ORF Insert Sequence:

ATGGACAACC CCACCACCAC CCAGTATGCC AGCCTCATGC ACAGCTTCAT CCTGAAGGCA 
CGGAGCACCG TGCGTGACAT CGACCCCCAG AACGATCTCA CCTTCCTTCG AATTCGCTCC 
AAGAAAAATG AAATTATGGT TGCACCAGAT AAAGACTATT TCCTGATTGT GATTCAGAAT 
CCAACCGAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DYNLRB1 ( NM_014183.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_054902.1 Homo sapiens dynein light chain roadblock-type 1 (DYNLRB1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu16824
Clone ID Related Accession (Same CDS sequence)	NM_014183.3
Accession Version	NM_014183.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 291bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	dynein light chain roadblock-type 1 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB149456.1 and AF165516.1. On Aug 1, 2013 this sequence version replaced NM_014183.2. Transcript Variant: This variant (1) encodes isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF132750.1, SRR1163658.461331.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCAGAGG TGGAGGAGAC ACTGAAGCGA CTGCAGAGCC AGAAGGGAGT GCAGGGAATC 
ATCGTCGTGA ACACAGAAGG CATTCCCATC AAGAGCACCA TGGACAACCC CACCACCACC 
CAGTATGCCA GCCTCATGCA CAGCTTCATC CTGAAGGCAC GGAGCACCGT GCGTGACATC 
GACCCCCAGA ACGATCTCAC CTTCCTTCGA ATTCGCTCCA AGAAAAATGA AATTATGGTT 
GCACCAGATA AAGACTATTT CCTGATTGTG ATTCAGAATC CAACCGAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_054902.1
CDS	76..366
Translation	MAEVEETLKRLQSQKGVQGIIVVNTEGIPIKSTMDNPTTTQYASLMHSFILKARSTVRDIDPQNDLTFLRIRSKKNEIMVAPDKDYFLIVIQNPTE

Target ORF information:

RefSeq Version	NM_014183.3
Organism	Homo sapiens(human)
Definition	Homo sapiens dynein light chain roadblock-type 1 (DYNLRB1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014183.3

ORF Insert Sequence:

ATGGCAGAGG TGGAGGAGAC ACTGAAGCGA CTGCAGAGCC AGAAGGGAGT GCAGGGAATC 
ATCGTCGTGA ACACAGAAGG CATTCCCATC AAGAGCACCA TGGACAACCC CACCACCACC 
CAGTATGCCA GCCTCATGCA CAGCTTCATC CTGAAGGCAC GGAGCACCGT GCGTGACATC 
GACCCCCAGA ACGATCTCAC CTTCCTTCGA ATTCGCTCCA AGAAAAATGA AATTATGGTT 
GCACCAGATA AAGACTATTT CCTGATTGTG ATTCAGAATC CAACCGAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DYNLRB1 ( NM_001281729.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001268658.1 Homo sapiens dynein light chain roadblock-type 1 (DYNLRB1), transcript variant 5, mRNA.

Price & Availability↑

CloneID	OHu16833
Clone ID Related Accession (Same CDS sequence)	NM_001281729.1
Accession Version	NM_001281729.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	dynein light chain roadblock-type 1 isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB149456.1, BM561321.1 and AF165516.1. Transcript Variant: This variant (5) differs in its 5' UTR and coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a longer and distinct N-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM561321.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACTCAC AAAGGAGAGG CCCTCATTCT TGCCTTAAAA CTGCCCCTAA AGCCAAGCCT 
TTTCACTGGG AAGCCCTAGC TGCTTACCTT TTGGATACTA GCATTCCCAT CAAGAGCACC 
ATGGACAACC CCACCACCAC CCAGTATGCC AGCCTCATGC ACAGCTTCAT CCTGAAGGCA 
CGGAGCACCG TGCGTGACAT CGACCCCCAG AACGATCTCA CCTTCCTTCG AATTCGCTCC 
AAGAAAAATG AAATTATGGT TGCACCAGAT AAAGACTATT TCCTGATTGT GATTCAGAAT 
CCAACCGAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001268658.1
CDS	438..749
Translation	MNSQRRGPHSCLKTAPKAKPFHWEALAAYLLDTSIPIKSTMDNPTTTQYASLMHSFILKARSTVRDIDPQNDLTFLRIRSKKNEIMVAPDKDYFLIVIQNPTE

Target ORF information:

RefSeq Version	NM_001281729.1
Organism	Homo sapiens(human)
Definition	Homo sapiens dynein light chain roadblock-type 1 (DYNLRB1), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001281729.1

ORF Insert Sequence:

ATGAACTCAC AAAGGAGAGG CCCTCATTCT TGCCTTAAAA CTGCCCCTAA AGCCAAGCCT 
TTTCACTGGG AAGCCCTAGC TGCTTACCTT TTGGATACTA GCATTCCCAT CAAGAGCACC 
ATGGACAACC CCACCACCAC CCAGTATGCC AGCCTCATGC ACAGCTTCAT CCTGAAGGCA 
CGGAGCACCG TGCGTGACAT CGACCCCCAG AACGATCTCA CCTTCCTTCG AATTCGCTCC 
AAGAAAAATG AAATTATGGT TGCACCAGAT AAAGACTATT TCCTGATTGT GATTCAGAAT 
CCAACCGAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DYNLRB1 ( NM_001319157.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001306086.1 Homo sapiens dynein light chain roadblock-type 1 (DYNLRB1), transcript variant 7, mRNA.

Price & Availability↑

CloneID	OHu53121
Clone ID Related Accession (Same CDS sequence)	NM_001319157.1
Accession Version	NM_001319157.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 366bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-04
Organism	Homo sapiens(human)
Product	dynein light chain roadblock-type 1 isoform d
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB149456.1, AK294214.1 and AL136173.24. On Jan 27, 2016 this sequence version replaced XM_005260568.3. Transcript Variant: This variant (7) lacks an exon and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (d) is longer and has a distinct C-terminus compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK294214.1, SRR1803617.72823.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGAGG TGGAGGAGAC ACTGAAGCGA CTGCAGAGCC AGAAGGGAGT GCAGGGAATC 
ATCGTCGTGA ACACAGAAGG CATTCCCATC AAGAGCACCA TGGACAACCC CACCACCACC 
CAGTATGCCA GCCTCATGCA CAGCTTCATC CTGAAGGCAC GGAGCACCGT GCGTGACATC 
GACCCCCAGA ACGATCTCAC CTTCCTTCGA ATTCGCTCCA AGAAAAATGA AATTATGGTT 
GCACCAGGTA AGGGGTCTTC TACCTCCCCA TGTAGGAACA GACCTCATGG CACATTCTCT 
GTGGCTCATC AGGAGTCCTG GCACAGTGGT GTCTCCAGAG GATCCAAGCA GGGCCCGAGG 
AGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001306086.1
CDS	76..441
Translation	MAEVEETLKRLQSQKGVQGIIVVNTEGIPIKSTMDNPTTTQYASLMHSFILKARSTVRDIDPQNDLTFLRIRSKKNEIMVAPGKGSSTSPCRNRPHGTFSVAHQESWHSGVSRGSKQGPRS

Target ORF information:

RefSeq Version	NM_001319157.1
Organism	Homo sapiens(human)
Definition	Homo sapiens dynein light chain roadblock-type 1 (DYNLRB1), transcript variant 7, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001319157.1

ORF Insert Sequence:

ATGGCAGAGG TGGAGGAGAC ACTGAAGCGA CTGCAGAGCC AGAAGGGAGT GCAGGGAATC 
ATCGTCGTGA ACACAGAAGG CATTCCCATC AAGAGCACCA TGGACAACCC CACCACCACC 
CAGTATGCCA GCCTCATGCA CAGCTTCATC CTGAAGGCAC GGAGCACCGT GCGTGACATC 
GACCCCCAGA ACGATCTCAC CTTCCTTCGA ATTCGCTCCA AGAAAAATGA AATTATGGTT 
GCACCAGGTA AGGGGTCTTC TACCTCCCCA TGTAGGAACA GACCTCATGG CACATTCTCT 
GTGGCTCATC AGGAGTCCTG GCACAGTGGT GTCTCCAGAG GATCCAAGCA GGGCCCGAGG 
AGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Requirement for protein kinase A in the phosphorylation of the TGF? receptor-interacting protein km23-1 as a component of TGF? downstream effects.
Experimental cell research319(6)897-907(2013 Apr)
Jin Q,Zhong Y,Mulder KM

Decreased tumor progression and invasion by a novel anti-cell motility target for human colorectal carcinoma cells.
PloS one8(6)e66439(2013)
Jin Q,Liu G,Domeier PP,Ding W,Mulder KM

Role of km23-1 in RhoA/actin-based cell migration.
Biochemical and biophysical research communications428(3)333-8(2012 Nov)
Jin Q,Pulipati NR,Zhou W,Staub CM,Liotta LA,Mulder KM

The TGF? receptor-interacting protein km23-1/DYNLRB1 plays an adaptor role in TGF?1 autoinduction via its association with Ras.
The Journal of biological chemistry287(31)26453-63(2012 Jul)
Jin Q,Ding W,Mulder KM

Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.
The EMBO journal30(8)1520-35(2011 Apr)
Jakobsen L,Vanselow K,Skogs M,Toyoda Y,Lundberg E,Poser I,Falkenby LG,Bennetzen M,Westendorf J,Nigg EA,Uhlen M,Hyman AA,Andersen JS

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DYNLRB1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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