TMEM47 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TMEM47
Entrez Gene ID	83604
Full Name	transmembrane protein 47
Synonyms	BCMP1,TM4SF10,VAB-9
General protein information	Preferred Names transmembrane protein 47 Names transmembrane protein 47 brain cell membrane protein 1 transmembrane 4 superfamily member 10
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp21.1
Summary	This gene encodes a member of the PMP22/EMP/claudin protein family. The encoded protein is localized to the ER and the plasma membrane. In dogs, transcripts of this gene exist at high levels in the brain. [provided by RefSeq, Jul 2008].
Disorder MIM:	300698

mRNA and Protein(s)

mRNA	Protein	Name
NM_031442.4	NP_113630.1	transmembrane protein 47
NM_031442.3	NP_113630.1	transmembrane protein 47

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TMEM47	NP_001003045.1
Bos taurus (cattle)	TMEM47	NP_001069730.1
Mus musculus (house mouse)	Tmem47	NP_620090.1
Rattus norvegicus (Norway rat)	Tmem47	NP_001102787.1
Gallus gallus (chicken)	TMEM47	XP_416786.1
	TMEM47	XP_001082045.1
Xenopus tropicalis (tropical clawed frog)	tmem47	NP_988899.1
Danio rerio (zebrafish)	tmem47	NP_999928.1
Homo sapiens (human)	TMEM47	NP_113630.1

Gene Ontology
Bibliography

Related articles in PubMed

Vertebrate Claudin/PMP22/EMP22/MP20 family protein TMEM47 regulates epithelial cell junction maturation and morphogenesis.
Dong Y, Simske JS
Developmental dynamics : an official publication of the American Association of Anatomists245(6)653-66(2016 Jun)

A genome-wide association study of brain lesion distribution in multiple sclerosis.
Gourraud PA, Sdika M, Khankhanian P, Henry RG, Beheshtian A, Matthews PM, Hauser SL, Oksenberg JR, Pelletier D, Baranzini SE
Brain : a journal of neurology136(Pt 4)1012-24(2013 Apr)

TM4SF10 and ADAP interaction in podocytes: role in Fyn activity and nephrin phosphorylation.
Azhibekov TA, Wu Z, Padiyar A, Bruggeman LA, Simske JS
American journal of physiology. Cell physiology301(6)C1351-9(2011 Dec)

Novel markers of subclinical disease for Ewing family tumors from gene expression profiling.
Cheung IY, Feng Y, Danis K, Shukla N, Meyers P, Ladanyi M, Cheung NK
Clinical cancer research : an official journal of the American Association for Cancer Research13(23)6978-83(2007 Dec)

TM4SF10 gene sequencing in XLMR patients identifies common polymorphisms but no disease-associated mutation.
Christophe-Hobertus C, Kooy F, Gecz J, Abramowicz MJ, Holinski-Feder E, Schwartz C, Christophe D
BMC medical genetics522(2004 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TM4SF10, possibly through ADAP, may regulate Fyn activity
Title: TM4SF10 and ADAP interaction in podocytes: role in Fyn activity and nephrin phosphorylation.

Single nucleotide polymorphisms, but no disease-associated mutations, were identified in X-linked mental retardation patients.
Title: TM4SF10 gene sequencing in XLMR patients identifies common polymorphisms but no disease-associated mutation.

A 4-transmembrane protein, related to PMP22/EMPs and the Claudins, localizes to the plasma membrane and the ER. The mRNA is present in high amounts in brain.
Title: Identification of the gene encoding Brain Cell Membrane Protein 1 (BCMP1), a putative four-transmembrane protein distantly related to the Peripheral Myelin Protein 22 / Epithelial Membrane Proteins and the Claudins.

The following TMEM47 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TMEM47 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04616	NM_031442.4 Latest version!	Homo sapiens transmembrane protein 47 (TMEM47), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu04616	NM_031442.3	Homo sapiens transmembrane protein 47 (TMEM47), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TMEM47 ( NM_031442.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_113630.1 Homo sapiens transmembrane protein 47 (TMEM47), mRNA.

Price & Availability↑

CloneID	OHu04616
Clone ID Related Accession (Same CDS sequence)	NM_031442.4 , NM_031442.3
Accession Version	NM_031442.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 546bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	transmembrane protein 47
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC039242.1, CX788638.1 and AL596285.4. On Nov 22, 2018 this sequence version replaced NM_031442.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.12199.1, BC039242.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155974, SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000275954.4/ ENSP00000275954.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTTCGG CGGGCAGCGG CATGGAGGAG GTGCGCGTGT CGGTGCTGAC CCCCTTGAAG 
CTGGTCGGGC TGGTGTGCAT CTTCCTGGCG CTGTGTCTGG ACCTGGGGGC GGTGCTGAGC 
CCGGCCTGGG TCACAGCTGA CCACCAGTAC TACCTGTCGT TGTGGGAGTC CTGCCGGAAA 
CCCGCCAGCT TGGACATCTG GCACTGCGAG TCCACGCTCA GCAGCGATTG GCAGATTGCT 
ACTCTGGCTT TACTCCTGGG CGGCGCTGCC ATCATTCTCA TTGCATTCCT GGTGGGTTTG 
ATTTCTATCT GCGTGGGATC TCGAAGGCGT TTCTATAGAC CTGTTGCGGT CATGCTTTTT 
GCAGCAGTTG TTTTACAGGT TTGCAGCCTG GTCCTTTACC CAATCAAGTT CATTGAAACT 
GTGAGCTTGA AAATTTACCA TGAGTTCAAC TGGGGTTATG GCCTGGCCTG GGGTGCAACT 
ATATTTTCGT TTGGGGGTGC CATCCTTTAT TGCCTGAACC CTAAGAACTA TGAAGACTAC 
TACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113630.1
CDS	257..802
Translation	MASAGSGMEEVRVSVLTPLKLVGLVCIFLALCLDLGAVLSPAWVTADHQYYLSLWESCRKPASLDIWHCESTLSSDWQIATLALLLGGAAIILIAFLVGLISICVGSRRRFYRPVAVMLFAAVVLQVCSLVLYPIKFIETVSLKIYHEFNWGYGLAWGATIFSFGGAILYCLNPKNYEDYY

Target ORF information:

RefSeq Version	NM_031442.4
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 47 (TMEM47), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031442.4

ORF Insert Sequence:

ATGGCTTCGG CGGGCAGCGG CATGGAGGAG GTGCGCGTGT CGGTGCTGAC CCCCTTGAAG 
CTGGTCGGGC TGGTGTGCAT CTTCCTGGCG CTGTGTCTGG ACCTGGGGGC GGTGCTGAGC 
CCGGCCTGGG TCACAGCTGA CCACCAGTAC TACCTGTCGT TGTGGGAGTC CTGCCGGAAA 
CCCGCCAGCT TGGACATCTG GCACTGCGAG TCCACGCTCA GCAGCGATTG GCAGATTGCT 
ACTCTGGCTT TACTCCTGGG CGGCGCTGCC ATCATTCTCA TTGCATTCCT GGTGGGTTTG 
ATTTCTATCT GCGTGGGATC TCGAAGGCGT TTCTATAGAC CTGTTGCGGT CATGCTTTTT 
GCAGCAGTTG TTTTACAGGT TTGCAGCCTG GTCCTTTACC CAATCAAGTT CATTGAAACT 
GTGAGCTTGA AAATTTACCA TGAGTTCAAC TGGGGTTATG GCCTGGCCTG GGGTGCAACT 
ATATTTTCGT TTGGGGGTGC CATCCTTTAT TGCCTGAACC CTAAGAACTA TGAAGACTAC 
TACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM47 ( NM_031442.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_113630.1 Homo sapiens transmembrane protein 47 (TMEM47), mRNA.

Price & Availability↑

CloneID	OHu04616
Clone ID Related Accession (Same CDS sequence)	NM_031442.4 , NM_031442.3
Accession Version	NM_031442.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 546bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	transmembrane protein 47
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC039242.1, CX788638.1 and AL596285.4. On Mar 1, 2008 this sequence version replaced NM_031442.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC039242.1, SRR1660805.48582.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155974, SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTTCGG CGGGCAGCGG CATGGAGGAG GTGCGCGTGT CGGTGCTGAC CCCCTTGAAG 
CTGGTCGGGC TGGTGTGCAT CTTCCTGGCG CTGTGTCTGG ACCTGGGGGC GGTGCTGAGC 
CCGGCCTGGG TCACAGCTGA CCACCAGTAC TACCTGTCGT TGTGGGAGTC CTGCCGGAAA 
CCCGCCAGCT TGGACATCTG GCACTGCGAG TCCACGCTCA GCAGCGATTG GCAGATTGCT 
ACTCTGGCTT TACTCCTGGG CGGCGCTGCC ATCATTCTCA TTGCATTCCT GGTGGGTTTG 
ATTTCTATCT GCGTGGGATC TCGAAGGCGT TTCTATAGAC CTGTTGCGGT CATGCTTTTT 
GCAGCAGTTG TTTTACAGGT TTGCAGCCTG GTCCTTTACC CAATCAAGTT CATTGAAACT 
GTGAGCTTGA AAATTTACCA TGAGTTCAAC TGGGGTTATG GCCTGGCCTG GGGTGCAACT 
ATATTTTCGT TTGGGGGTGC CATCCTTTAT TGCCTGAACC CTAAGAACTA TGAAGACTAC 
TACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113630.1
CDS	260..805
Translation	MASAGSGMEEVRVSVLTPLKLVGLVCIFLALCLDLGAVLSPAWVTADHQYYLSLWESCRKPASLDIWHCESTLSSDWQIATLALLLGGAAIILIAFLVGLISICVGSRRRFYRPVAVMLFAAVVLQVCSLVLYPIKFIETVSLKIYHEFNWGYGLAWGATIFSFGGAILYCLNPKNYEDYY

Target ORF information:

RefSeq Version	NM_031442.3
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 47 (TMEM47), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031442.3

ORF Insert Sequence:

ATGGCTTCGG CGGGCAGCGG CATGGAGGAG GTGCGCGTGT CGGTGCTGAC CCCCTTGAAG 
CTGGTCGGGC TGGTGTGCAT CTTCCTGGCG CTGTGTCTGG ACCTGGGGGC GGTGCTGAGC 
CCGGCCTGGG TCACAGCTGA CCACCAGTAC TACCTGTCGT TGTGGGAGTC CTGCCGGAAA 
CCCGCCAGCT TGGACATCTG GCACTGCGAG TCCACGCTCA GCAGCGATTG GCAGATTGCT 
ACTCTGGCTT TACTCCTGGG CGGCGCTGCC ATCATTCTCA TTGCATTCCT GGTGGGTTTG 
ATTTCTATCT GCGTGGGATC TCGAAGGCGT TTCTATAGAC CTGTTGCGGT CATGCTTTTT 
GCAGCAGTTG TTTTACAGGT TTGCAGCCTG GTCCTTTACC CAATCAAGTT CATTGAAACT 
GTGAGCTTGA AAATTTACCA TGAGTTCAAC TGGGGTTATG GCCTGGCCTG GGGTGCAACT 
ATATTTTCGT TTGGGGGTGC CATCCTTTAT TGCCTGAACC CTAAGAACTA TGAAGACTAC 
TACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Vertebrate Claudin/PMP22/EMP22/MP20 family protein TMEM47 regulates epithelial cell junction maturation and morphogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists245(6)653-66(2016 Jun)
Dong Y,Simske JS

A genome-wide association study of brain lesion distribution in multiple sclerosis.
Brain : a journal of neurology136(Pt 4)1012-24(2013 Apr)
Gourraud PA,Sdika M,Khankhanian P,Henry RG,Beheshtian A,Matthews PM,Hauser SL,Oksenberg JR,Pelletier D,Baranzini SE

TM4SF10 and ADAP interaction in podocytes: role in Fyn activity and nephrin phosphorylation.
American journal of physiology. Cell physiology301(6)C1351-9(2011 Dec)
Azhibekov TA,Wu Z,Padiyar A,Bruggeman LA,Simske JS

Novel markers of subclinical disease for Ewing family tumors from gene expression profiling.
Clinical cancer research : an official journal of the American Association for Cancer Research13(23)6978-83(2007 Dec)
Cheung IY,Feng Y,Danis K,Shukla N,Meyers P,Ladanyi M,Cheung NK

TM4SF10 gene sequencing in XLMR patients identifies common polymorphisms but no disease-associated mutation.
BMC medical genetics522(2004 Sep)
Christophe-Hobertus C,Kooy F,Gecz J,Abramowicz MJ,Holinski-Feder E,Schwartz C,Christophe D

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TMEM47 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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