MFRP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MFRP
Entrez Gene ID	83552
Full Name	membrane frizzled-related protein
Synonyms	MCOP5,NNO2,RD6
General protein information	Preferred Names membrane frizzled-related protein Names membrane frizzled-related protein C1q and TNF related 5 membrane-type frizzled-related protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q23.3
Summary	This gene encodes a member of the frizzled-related protein family. The encoded protein plays an important role in eye development and mutations in this gene have been associated with nanophthalmos, posterior microphthalmia, retinitis pigmentosa, foveoschisis, and optic disc drusen. The protein is encoded by a bicistronic transcript which also encodes C1q and tumor necrosis factor related protein 5 (C1QTNF5). [provided by RefSeq, Jun 2013].
Disorder MIM:	606227
Disorder Html:	Microphthalmia, isolated 5, 611040 (3); Nanophthalmos 2, 609549 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_031433.3	NP_113621.1	membrane frizzled-related protein
NM_031433.4	NP_113621.1	membrane frizzled-related protein

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	MFRP	XP_546484.2
Mus musculus (house mouse)	Mfrp	NP_667337.1
Gallus gallus (chicken)	MFRP	XP_003642649.2
Danio rerio (zebrafish)	LOC101885305	XP_005173402.1
Homo sapiens (human)	MFRP	NP_113621.1
	MFRP	XP_001104956.1
Pan troglodytes (chimpanzee)	MFRP	XP_003952099.1
Bos taurus (cattle)	MFRP	NP_001192829.1
Rattus norvegicus (Norway rat)	Mfrp	NP_001101607.1

Gene Ontology
Bibliography

Related articles in PubMed

Co-inheritance of the membrane frizzled-related protein ocular phenotype and glycogen storage disease type Ib.
Mameesh M, Ganesh A, Harikrishna B, Al Zuhaibi S, Scott P, Al Kalbani S, Al Thihli K
Ophthalmic genetics38(6)544-548(2017 Dec)

Identification of MFRP Mutations in Chinese Families with High Hyperopia.
Xu Y, Guan L, Xiao X, Zhang J, Li S, Jiang H, Jia X, Yin Y, Guo X, Yang Z, Zhang Q
Optometry and vision science : official publication of the American Academy of Optometry93(1)19-26(2016 Jan)

Coexistence of KCNV2 associated cone dystrophy with supernormal rod electroretinogram and MFRP related oculopathy in a Turkish family.
Ritter M, Vodopiutz J, Lechner S, Moser E, Schmidt-Erfurth UM, Janecke AR
The British journal of ophthalmology97(2)169-73(2013 Feb)

Association of frizzled-related protein (MFRP) and heat shock protein 70 (HSP70) single nucleotide polymorphisms with primary angle closure in a Han Chinese population: Jiangsu Eye Study.
Shi H, Zhu R, Hu N, Shi J, Zhang J, Jiang L, Jiang H, Guan H
Molecular vision19128-34(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We report the MFRP-related ocular phenotype in three siblings with glycogen storage disease type 1b. Molecular genetic studies identified novel mutations in the MFRP and SLC37A4 genes.
Title: Co-inheritance of the membrane frizzled-related protein ocular phenotype and glycogen storage disease type Ib.

The current study expands our knowledge of the mutation spectrum of MFRP and its associated phenotypes. To our knowledge, this is the first report of MFRP mutations in a Chinese cohort.
Title: Identification of MFRP Mutations in Chinese Families with High Hyperopia.

Corneal diameter decreases with decreasing axial length, suggesting posterior microphthalmos and nanophthalmos represent a spectrum of high hyperopia rather than distinct phenotypes. In the Saudi population PRSS56 mutations are the major cause.
Title: Biometric and molecular characterization of clinically diagnosed posterior microphthalmos.

nanophthalmos and high hyperopia but without electrophysiological evidence of retinal dystrophy has also been associated with MFRP mutations.
Title: Coexistence of KCNV2 associated cone dystrophy with supernormal rod electroretinogram and MFRP related oculopathy in a Turkish family.

Among five single nucleotide polymorphism(SNP)s tested, only MFRP rs3814762 and heat shock protein (HSP)70 rs1043618 show nominal association with primary angle closure.
Title: Association of frizzled-related protein (MFRP) and heat shock protein 70 (HSP70) single nucleotide polymorphisms with primary angle closure in a Han Chinese population: Jiangsu Eye Study.

The following MFRP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MFRP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu08219	NM_031433.4 Latest version!	Homo sapiens membrane frizzled-related protein (MFRP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$244.50-$342.30 $489.00
View Old Accession Versions >>
OHu08219	NM_031433.3	Homo sapiens membrane frizzled-related protein (MFRP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$244.50-$342.30 $489.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MFRP ( NM_031433.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_113621.1 Homo sapiens membrane frizzled-related protein (MFRP), mRNA.

Price & Availability↑

CloneID	OHu08219
Clone ID Related Accession (Same CDS sequence)	NM_031433.3 , NM_031433.4
Accession Version	NM_031433.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1740bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	membrane frizzled-related protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP003396.1. This sequence is a reference standard in the RefSeqGene project. On Jun 5, 2013 this sequence version replaced NM_031433.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC036675.1, AJ862823.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## bicistronic transcript :: PMID: 12944416, 11263980 NMD candidate :: PMID: 11263980 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAGGACT TCTCAGATGT CATCCTCTGC ATGGAGGCAA CAGAATCGAG CAAGACCGAG 
TTCTGCAATC CTGCCTTCGA GCCTGAGTCT GGGCCACCCT GCCCTCCCCC AGTTTTCCCA 
GAGGATGCCA GCTACAGCGT CCCAGCTCCC TGGCATGGTC GGCGTCCTCG AGGGCTACGG 
CCAGACTGCC GCTTCTCCTG GCTCTGTGTC CTCCTGCTCT CCAGCCTGCT CCTCCTGCTG 
CTTGGGCTGC TGGTGGCCAT CATCCTGGCC CAGCTGCAGG CTGCACCCCC ATCTGGGGCG 
TCCCATAGCC CACTGCCTGC CGGAGGCCTT ACCACGACCA CCACCACCCC CACCATCACC 
ACCTCTCAGG CAGCTGGGAC CCCTAAAGGG CAGCAGGAGT CAGGCGTGAG CCCCTCCCCA 
CAGTCCACCT GTGGAGGCCT CCTCTCTGGC CCAAGGGGCT TCTTCAGCAG CCCTAACTAC 
CCAGACCCTT ACCCCCCCAA CACCCACTGC GTGTGGCATA TCCAGGTGGC CACAGACCAT 
GCAATACAGC TCAAGATCGA AGCCCTCAGC ATAGAGAGTG TGGCCTCTTG CCTTTTTGAT 
CGCTTGGAAC TCTCCCCTGA GCCTGAAGGC CCCCTCCTCA GGGTTTGTGG AAGGGTGCCT 
CCCCCCACGC TCAACACCAA TGCCAGCCAC CTCCTGGTGG TCTTCGTCTC TGACAGCAGT 
GTGGAAGGAT TTGGTTTCCA TGCCTGGTAC CAGGCTATGG CCCCTGGGCG CGGGAGCTGT 
GCCCATGATG AGTTCCGCTG TGACCAGCTC ATCTGCCTGC TACCTGACTC AGTGTGTGAT 
GGTTTTGCCA ACTGTGCTGA CGGCAGTGAT GAGACCAATT GCAGTGCCAA GTTCTCGGGG 
TGTGGGGGGA ATCTGACTGG CCTCCAGGGC ACTTTCTCTA CTCCCAGCTA CCTGCAGCAG 
TACCCTCACC AACTGCTCTG CACCTGGCAT ATCTCGGTGC CTGCCGGACA CAGCATAGAA 
CTACAGTTCC ACAACTTCAG CCTGGAGGCT CAGGACGAGT GCAAGTTTGA CTACGTGGAG 
GTGTATGAGA CCAGCAGCTC AGGGGCCTTC AGCCTCCTGG GCAGGTTCTG TGGAGCAGAG 
CCACCCCCCC ACCTCGTCTC CTCGCACCAT GAGCTGGCTG TGCTGTTTAG GACAGATCAT 
GGCATCAGCA GTGGAGGCTT CTCAGCCACC TACCTGGCCT TCAATGCCAC GGAGAACCCC 
TGTGGGCCCA GTGAGCTCTC CTGCCAGGCA GGAGGGTGTA AGGGTGTGCA GTGGATGTGT 
GACATGTGGA GAGACTGCAC CGATGGCAGC GATGACAACT GCAGCGGCCC CTTGTTCCCA 
CCCCCAGAGC TGGCCTGTGA GCCTGTCCAG GTGGAGATGT GCCTCGGTCT GAGCTACAAC 
ACCACAGCCT TCCCTAACAT CTGGGTGGGC ATGATCACCC AGGAGGAGGT GGTAGAGGTC 
CTCAGCGGTT ACAAGAGCCT GACAAGCCTG CCCTGCTACC AGCATTTCCG GAGGCTCCTG 
TGTGGGCTGC TTGTGCCCCG TTGCACCCCA CTAGGCAGTG TTCTGCCCCC TTGCCGCTCT 
GTCTGCCAGG AAGCGGAGCA CCAGTGCCAG TCTGGCCTGG CACTACTGGG CACCCCCTGG 
CCCTTCAACT GCAACAGGCT GCCAGAGGCA GCTGACCTGG AAGCTTGTGC CCAGCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113621.1
CDS	161..1900
Translation	MKDFSDVILCMEATESSKTEFCNPAFEPESGPPCPPPVFPEDASYSVPAPWHGRRPRGLRPDCRFSWLCVLLLSSLLLLLLGLLVAIILAQLQAAPPSGASHSPLPAGGLTTTTTTPTITTSQAAGTPKGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQAGGCKGVQWMCDMWRDCTDGSDDNCSGPLFPPPELACEPVQVEMCLGLSYNTTAFPNIWVGMITQEEVVEVLSGYKSLTSLPCYQHFRRLLCGLLVPRCTPLGSVLPPCRSVCQEAEHQCQSGLALLGTPWPFNCNRLPEAADLEACAQP

Target ORF information:

RefSeq Version	NM_031433.3
Organism	Homo sapiens(human)
Definition	Homo sapiens membrane frizzled-related protein (MFRP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031433.3

ORF Insert Sequence:

ATGAAGGACT TCTCAGATGT CATCCTCTGC ATGGAGGCAA CAGAATCGAG CAAGACCGAG 
TTCTGCAATC CTGCCTTCGA GCCTGAGTCT GGGCCACCCT GCCCTCCCCC AGTTTTCCCA 
GAGGATGCCA GCTACAGCGT CCCAGCTCCC TGGCATGGTC GGCGTCCTCG AGGGCTACGG 
CCAGACTGCC GCTTCTCCTG GCTCTGTGTC CTCCTGCTCT CCAGCCTGCT CCTCCTGCTG 
CTTGGGCTGC TGGTGGCCAT CATCCTGGCC CAGCTGCAGG CTGCACCCCC ATCTGGGGCG 
TCCCATAGCC CACTGCCTGC CGGAGGCCTT ACCACGACCA CCACCACCCC CACCATCACC 
ACCTCTCAGG CAGCTGGGAC CCCTAAAGGG CAGCAGGAGT CAGGCGTGAG CCCCTCCCCA 
CAGTCCACCT GTGGAGGCCT CCTCTCTGGC CCAAGGGGCT TCTTCAGCAG CCCTAACTAC 
CCAGACCCTT ACCCCCCCAA CACCCACTGC GTGTGGCATA TCCAGGTGGC CACAGACCAT 
GCAATACAGC TCAAGATCGA AGCCCTCAGC ATAGAGAGTG TGGCCTCTTG CCTTTTTGAT 
CGCTTGGAAC TCTCCCCTGA GCCTGAAGGC CCCCTCCTCA GGGTTTGTGG AAGGGTGCCT 
CCCCCCACGC TCAACACCAA TGCCAGCCAC CTCCTGGTGG TCTTCGTCTC TGACAGCAGT 
GTGGAAGGAT TTGGTTTCCA TGCCTGGTAC CAGGCTATGG CCCCTGGGCG CGGGAGCTGT 
GCCCATGATG AGTTCCGCTG TGACCAGCTC ATCTGCCTGC TACCTGACTC AGTGTGTGAT 
GGTTTTGCCA ACTGTGCTGA CGGCAGTGAT GAGACCAATT GCAGTGCCAA GTTCTCGGGG 
TGTGGGGGGA ATCTGACTGG CCTCCAGGGC ACTTTCTCTA CTCCCAGCTA CCTGCAGCAG 
TACCCTCACC AACTGCTCTG CACCTGGCAT ATCTCGGTGC CTGCCGGACA CAGCATAGAA 
CTACAGTTCC ACAACTTCAG CCTGGAGGCT CAGGACGAGT GCAAGTTTGA CTACGTGGAG 
GTGTATGAGA CCAGCAGCTC AGGGGCCTTC AGCCTCCTGG GCAGGTTCTG TGGAGCAGAG 
CCACCCCCCC ACCTCGTCTC CTCGCACCAT GAGCTGGCTG TGCTGTTTAG GACAGATCAT 
GGCATCAGCA GTGGAGGCTT CTCAGCCACC TACCTGGCCT TCAATGCCAC GGAGAACCCC 
TGTGGGCCCA GTGAGCTCTC CTGCCAGGCA GGAGGGTGTA AGGGTGTGCA GTGGATGTGT 
GACATGTGGA GAGACTGCAC CGATGGCAGC GATGACAACT GCAGCGGCCC CTTGTTCCCA 
CCCCCAGAGC TGGCCTGTGA GCCTGTCCAG GTGGAGATGT GCCTCGGTCT GAGCTACAAC 
ACCACAGCCT TCCCTAACAT CTGGGTGGGC ATGATCACCC AGGAGGAGGT GGTAGAGGTC 
CTCAGCGGTT ACAAGAGCCT GACAAGCCTG CCCTGCTACC AGCATTTCCG GAGGCTCCTG 
TGTGGGCTGC TTGTGCCCCG TTGCACCCCA CTAGGCAGTG TTCTGCCCCC TTGCCGCTCT 
GTCTGCCAGG AAGCGGAGCA CCAGTGCCAG TCTGGCCTGG CACTACTGGG CACCCCCTGG 
CCCTTCAACT GCAACAGGCT GCCAGAGGCA GCTGACCTGG AAGCTTGTGC CCAGCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MFRP ( NM_031433.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_113621.1 Homo sapiens membrane frizzled-related protein (MFRP), mRNA.

Price & Availability↑

CloneID	OHu08219
Clone ID Related Accession (Same CDS sequence)	NM_031433.3 , NM_031433.4
Accession Version	NM_031433.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1740bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	membrane frizzled-related protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP003396.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_031433.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC036675.1, AJ862823.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## bicistronic transcript :: PMID: 12944416, 11263980 MANE Ensembl match :: ENST00000619721.6/ ENSP00000481824.1 NMD candidate :: PMID: 11263980 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGGACT TCTCAGATGT CATCCTCTGC ATGGAGGCAA CAGAATCGAG CAAGACCGAG 
TTCTGCAATC CTGCCTTCGA GCCTGAGTCT GGGCCACCCT GCCCTCCCCC AGTTTTCCCA 
GAGGATGCCA GCTACAGCGT CCCAGCTCCC TGGCATGGTC GGCGTCCTCG AGGGCTACGG 
CCAGACTGCC GCTTCTCCTG GCTCTGTGTC CTCCTGCTCT CCAGCCTGCT CCTCCTGCTG 
CTTGGGCTGC TGGTGGCCAT CATCCTGGCC CAGCTGCAGG CTGCACCCCC ATCTGGGGCG 
TCCCATAGCC CACTGCCTGC CGGAGGCCTT ACCACGACCA CCACCACCCC CACCATCACC 
ACCTCTCAGG CAGCTGGGAC CCCTAAAGGG CAGCAGGAGT CAGGCGTGAG CCCCTCCCCA 
CAGTCCACCT GTGGAGGCCT CCTCTCTGGC CCAAGGGGCT TCTTCAGCAG CCCTAACTAC 
CCAGACCCTT ACCCCCCCAA CACCCACTGC GTGTGGCATA TCCAGGTGGC CACAGACCAT 
GCAATACAGC TCAAGATCGA AGCCCTCAGC ATAGAGAGTG TGGCCTCTTG CCTTTTTGAT 
CGCTTGGAAC TCTCCCCTGA GCCTGAAGGC CCCCTCCTCA GGGTTTGTGG AAGGGTGCCT 
CCCCCCACGC TCAACACCAA TGCCAGCCAC CTCCTGGTGG TCTTCGTCTC TGACAGCAGT 
GTGGAAGGAT TTGGTTTCCA TGCCTGGTAC CAGGCTATGG CCCCTGGGCG CGGGAGCTGT 
GCCCATGATG AGTTCCGCTG TGACCAGCTC ATCTGCCTGC TACCTGACTC AGTGTGTGAT 
GGTTTTGCCA ACTGTGCTGA CGGCAGTGAT GAGACCAATT GCAGTGCCAA GTTCTCGGGG 
TGTGGGGGGA ATCTGACTGG CCTCCAGGGC ACTTTCTCTA CTCCCAGCTA CCTGCAGCAG 
TACCCTCACC AACTGCTCTG CACCTGGCAT ATCTCGGTGC CTGCCGGACA CAGCATAGAA 
CTACAGTTCC ACAACTTCAG CCTGGAGGCT CAGGACGAGT GCAAGTTTGA CTACGTGGAG 
GTGTATGAGA CCAGCAGCTC AGGGGCCTTC AGCCTCCTGG GCAGGTTCTG TGGAGCAGAG 
CCACCCCCCC ACCTCGTCTC CTCGCACCAT GAGCTGGCTG TGCTGTTTAG GACAGATCAT 
GGCATCAGCA GTGGAGGCTT CTCAGCCACC TACCTGGCCT TCAATGCCAC GGAGAACCCC 
TGTGGGCCCA GTGAGCTCTC CTGCCAGGCA GGAGGGTGTA AGGGTGTGCA GTGGATGTGT 
GACATGTGGA GAGACTGCAC CGATGGCAGC GATGACAACT GCAGCGGCCC CTTGTTCCCA 
CCCCCAGAGC TGGCCTGTGA GCCTGTCCAG GTGGAGATGT GCCTCGGTCT GAGCTACAAC 
ACCACAGCCT TCCCTAACAT CTGGGTGGGC ATGATCACCC AGGAGGAGGT GGTAGAGGTC 
CTCAGCGGTT ACAAGAGCCT GACAAGCCTG CCCTGCTACC AGCATTTCCG GAGGCTCCTG 
TGTGGGCTGC TTGTGCCCCG TTGCACCCCA CTAGGCAGTG TTCTGCCCCC TTGCCGCTCT 
GTCTGCCAGG AAGCGGAGCA CCAGTGCCAG TCTGGCCTGG CACTACTGGG CACCCCCTGG 
CCCTTCAACT GCAACAGGCT GCCAGAGGCA GCTGACCTGG AAGCTTGTGC CCAGCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113621.1
CDS	193..1932
Translation	MKDFSDVILCMEATESSKTEFCNPAFEPESGPPCPPPVFPEDASYSVPAPWHGRRPRGLRPDCRFSWLCVLLLSSLLLLLLGLLVAIILAQLQAAPPSGASHSPLPAGGLTTTTTTPTITTSQAAGTPKGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQAGGCKGVQWMCDMWRDCTDGSDDNCSGPLFPPPELACEPVQVEMCLGLSYNTTAFPNIWVGMITQEEVVEVLSGYKSLTSLPCYQHFRRLLCGLLVPRCTPLGSVLPPCRSVCQEAEHQCQSGLALLGTPWPFNCNRLPEAADLEACAQP

Target ORF information:

RefSeq Version	NM_031433.4
Organism	Homo sapiens(human)
Definition	Homo sapiens membrane frizzled-related protein (MFRP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031433.4

ORF Insert Sequence:

ATGAAGGACT TCTCAGATGT CATCCTCTGC ATGGAGGCAA CAGAATCGAG CAAGACCGAG 
TTCTGCAATC CTGCCTTCGA GCCTGAGTCT GGGCCACCCT GCCCTCCCCC AGTTTTCCCA 
GAGGATGCCA GCTACAGCGT CCCAGCTCCC TGGCATGGTC GGCGTCCTCG AGGGCTACGG 
CCAGACTGCC GCTTCTCCTG GCTCTGTGTC CTCCTGCTCT CCAGCCTGCT CCTCCTGCTG 
CTTGGGCTGC TGGTGGCCAT CATCCTGGCC CAGCTGCAGG CTGCACCCCC ATCTGGGGCG 
TCCCATAGCC CACTGCCTGC CGGAGGCCTT ACCACGACCA CCACCACCCC CACCATCACC 
ACCTCTCAGG CAGCTGGGAC CCCTAAAGGG CAGCAGGAGT CAGGCGTGAG CCCCTCCCCA 
CAGTCCACCT GTGGAGGCCT CCTCTCTGGC CCAAGGGGCT TCTTCAGCAG CCCTAACTAC 
CCAGACCCTT ACCCCCCCAA CACCCACTGC GTGTGGCATA TCCAGGTGGC CACAGACCAT 
GCAATACAGC TCAAGATCGA AGCCCTCAGC ATAGAGAGTG TGGCCTCTTG CCTTTTTGAT 
CGCTTGGAAC TCTCCCCTGA GCCTGAAGGC CCCCTCCTCA GGGTTTGTGG AAGGGTGCCT 
CCCCCCACGC TCAACACCAA TGCCAGCCAC CTCCTGGTGG TCTTCGTCTC TGACAGCAGT 
GTGGAAGGAT TTGGTTTCCA TGCCTGGTAC CAGGCTATGG CCCCTGGGCG CGGGAGCTGT 
GCCCATGATG AGTTCCGCTG TGACCAGCTC ATCTGCCTGC TACCTGACTC AGTGTGTGAT 
GGTTTTGCCA ACTGTGCTGA CGGCAGTGAT GAGACCAATT GCAGTGCCAA GTTCTCGGGG 
TGTGGGGGGA ATCTGACTGG CCTCCAGGGC ACTTTCTCTA CTCCCAGCTA CCTGCAGCAG 
TACCCTCACC AACTGCTCTG CACCTGGCAT ATCTCGGTGC CTGCCGGACA CAGCATAGAA 
CTACAGTTCC ACAACTTCAG CCTGGAGGCT CAGGACGAGT GCAAGTTTGA CTACGTGGAG 
GTGTATGAGA CCAGCAGCTC AGGGGCCTTC AGCCTCCTGG GCAGGTTCTG TGGAGCAGAG 
CCACCCCCCC ACCTCGTCTC CTCGCACCAT GAGCTGGCTG TGCTGTTTAG GACAGATCAT 
GGCATCAGCA GTGGAGGCTT CTCAGCCACC TACCTGGCCT TCAATGCCAC GGAGAACCCC 
TGTGGGCCCA GTGAGCTCTC CTGCCAGGCA GGAGGGTGTA AGGGTGTGCA GTGGATGTGT 
GACATGTGGA GAGACTGCAC CGATGGCAGC GATGACAACT GCAGCGGCCC CTTGTTCCCA 
CCCCCAGAGC TGGCCTGTGA GCCTGTCCAG GTGGAGATGT GCCTCGGTCT GAGCTACAAC 
ACCACAGCCT TCCCTAACAT CTGGGTGGGC ATGATCACCC AGGAGGAGGT GGTAGAGGTC 
CTCAGCGGTT ACAAGAGCCT GACAAGCCTG CCCTGCTACC AGCATTTCCG GAGGCTCCTG 
TGTGGGCTGC TTGTGCCCCG TTGCACCCCA CTAGGCAGTG TTCTGCCCCC TTGCCGCTCT 
GTCTGCCAGG AAGCGGAGCA CCAGTGCCAG TCTGGCCTGG CACTACTGGG CACCCCCTGG 
CCCTTCAACT GCAACAGGCT GCCAGAGGCA GCTGACCTGG AAGCTTGTGC CCAGCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Co-inheritance of the membrane frizzled-related protein ocular phenotype and glycogen storage disease type Ib.
Ophthalmic genetics38(6)544-548(2017 Dec)
Mameesh M,Ganesh A,Harikrishna B,Al Zuhaibi S,Scott P,Al Kalbani S,Al Thihli K

Identification of MFRP Mutations in Chinese Families with High Hyperopia.
Optometry and vision science : official publication of the American Academy of Optometry93(1)19-26(2016 Jan)
Xu Y,Guan L,Xiao X,Zhang J,Li S,Jiang H,Jia X,Yin Y,Guo X,Yang Z,Zhang Q

Coexistence of KCNV2 associated cone dystrophy with supernormal rod electroretinogram and MFRP related oculopathy in a Turkish family.
The British journal of ophthalmology97(2)169-73(2013 Feb)
Ritter M,Vodopiutz J,Lechner S,Moser E,Schmidt-Erfurth UM,Janecke AR

Association of frizzled-related protein (MFRP) and heat shock protein 70 (HSP70) single nucleotide polymorphisms with primary angle closure in a Han Chinese population: Jiangsu Eye Study.
Molecular vision19128-34(2013)
Shi H,Zhu R,Hu N,Shi J,Zhang J,Jiang L,Jiang H,Guan H

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MFRP cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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